Abstract: Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.

Abstract: System and method for fiber-optic time frequency and data joint transmission, comprising local end, relay nodes, and remote end. In each local end, relay node, and remote end, multiplexing and demultiplexing of time frequency signals, optical supervisory signals, and optical communication data services are performed by CWDM modules and OSC-band wavelength multiplexer/demultiplexers, and processing (transmitting, relaying, receiving) is performed by corresponding processing modules for joint transmission. A sub-band of standard OSC band is used for transmitting time frequency signal so that transmission of optical supervisory signal is not influenced while no extra band resource is occupied with improved utilization of wavelength resources and reduced costs.

Abstract: A permanent magnet machine includes a machine housing and a stator. The machine housing has an inner surface. The stator is disposed within the machine housing. The stator has a stator core having an exterior surface. At least one of the inner surface and the exterior surface defines a discontinuous region that is arranged to minimize points of contact between the inner surface and the exterior surface.

Abstract: In some embodiments, a method for risk identification of personal information of a service/platform provider side is provided. A specification is received related to data usage for at least one among service and application of a third party side from a device of the third party side, and is stored in data storage of the service/platform provider side. User consent information is received from a user side using at least one among the service and application. The received information is stored in the data storage of the service/platform provider side. A process is inspected and monitored related to data storing and processing in user environment or platform environment of the user side using at least one among the service and application. A monitoring function is provided for data stored in the data storage of the service/platform provider side in connection with at least one among the service and application.

Abstract: Desalination systems, apparatus, and related methods for use with saline fluids are disclosed. A disclosed desalination system includes an HDH system including a humidifier and a dehumidifier that, together, are configured to process a first saline fluid to produce freshwater in the dehumidifier. The desalination system also includes an AD system operatively coupled to the HDH system. The AD system includes a first bed, a second bed, an evaporator, and a condenser that, together, are configured to process a second saline fluid to produce freshwater in the condenser. The condenser is configured to transfer heat exhausted by the first or second bed from a vapor, obtained from the second saline fluid, to air circulating through the humidifier and the dehumidifier to drive the HDH system. The evaporator is configured to provide a cooling effect.

Abstract: Methods are provided herein for determining and administering optimized dosing of therapeutic anti-CD47 agents, in a schedule that provides safe escalation of dose while achieving a therapeutic level in a clinically effective period of time. The methods can comprise the steps of clearance, escalation, and maintenance. In one embodiment the dosing regimen administers an initial (i) sub-therapeutic dose of an anti-CD47 agent or (ii) a cytoreductive therapy to achieve a safe level of circulating tumor cells for subsequent treatment (clearance); escalating the dose of an anti-CD47 agent until a therapeutic dose is reached (escalation); and maintaining the therapeutic dose for a period of time sufficient to reduce tumor cells in the bone marrow of the patient (maintenance). In an alternative dosing regimen, a patient determined to have a safe level of circulating tumor cells at presentation is treated by the steps of escalation and maintenance without initial clearance.

Abstract: A suture anchor apparatus comprising: an anchoring member made from a metal-based material and comprising a generally elongated body having a proximal end and a distal end, wherein an outer surface of the anchoring member defines a threading that winds around the body in a plurality of turns disposed along a longitudinal axis of the body; wherein the threading has a depth of about 1 mm and a pitch of about 3 mm, and an eyelet disposed near the distal end and penetrating transversely through the body.

Abstract: A compound for treatment of pain comprising a single multivalent/multifunctional ligand with agonist activity at opioid receptors and with antagonist activity at NK-1 receptors, joined by a linker. Also disclosed is a pharmaceutical compound comprising the above compound in a pharmaceutically acceptable carrier.

Abstract: A multi-angle spinneret for forming hollow fibers is provided. The multi-angle spinneret includes a body defining a dope chamber, a bore needle channel, and multiple dope channels being oriented at a minimum of two distinct dope channel angles relative to the dope chamber. The body includes a bore needle disposed in the bore needle channel and oriented substantially perpendicular relative to the dope chamber. The bore needle extends though the dope chamber, such that a bore fluid flow through the bore needle is kept separate from a dope flow through the dope channels. A bore fluid outlet is positioned within a dope outlet of the dope chamber, such that a bore fluid flow out of the bore fluid outlet is substantially coaxial with and substantially centered within a dope flow out of the dope outlet.

Abstract: A probe beam is passed through a first optically pumped magnetometer vapor cell portion that has a first magnetic bias field orientation relative to a pump beam. The probe beam is also passed through a second optically pumped magnetometer vapor cell portion that has a second magnetic bias field orientation relative to the pump beam with the same properties as in the first portion, where the first magnetic bias field orientation is opposite to that of the second magnetic bias field orientation. This configuration reduces or eliminates linearly polarized magnetic signals (e.g., noise) from the output probe beam and passes circularly polarized magnetic signals. Thus, the intensity of the probe beam after passing through the first and second optically pumped magnetometer vapor cell portions is measured to obtain a noise suppressed signal.

Abstract: Selected compounds, compositions, and methods for inhibiting BACE are presented that have relatively high selectivity towards APP via interaction of the inhibitor with both BACE and APP.

Abstract: The present disclosure is generally related to separators for use in lithium metal batteries, and associated systems and products. Certain embodiments are related to separators that form or are repaired when an electrode is held at a voltage. In some embodiments, an electrochemical cell may comprise an electrolyte that comprises a precursor for the separator.

Abstract: Vapor wake detection is a highly advantageous method and system for detecting explosives and other illicit substances. With vapor wake detection, a canine and a handler are used; however, unlike other detection schemes, the canine leads the handler. After the handler positions the canine in a desired location, the canine detects scents in the air that come to the canine. When the canine detects a trained scent, the canine leads the handler to or follows behind the carrier of the item with the scent. Once the carrier is identified by the handler, the proper personnel are contacted. To implement vapor wake detection effectively, specific rigorous training is utilized.

Abstract: A micro-scale implantable bioelectronic medical device system that allows multichannel neurostimulation of peripheral nerve bundles so to affect a more localized and specific control over neuromodulation of body tissues and organs. Such systems can be used in medical therapeutic applications for the treatment of a wide variety of disorders of the human body and may be applied in the growing field of medical neuromodulation. Systems and processes may also provide a way of interfacing to nerve and muscle for purposes of the control of advanced robotic prosthetics as well as man-machine interfaces. Apparatus, systems and processes may be adapted in various embodiments to the stimulation of brain and other bioelectrically excitable tissues in the human body as well.

Abstract: A Fenton apparatus of the present disclosure includes a reactor vessel, gas injection inlets that allow ejection of aeration coolant perpendicular to axis of the reactor vessel to agitate a reaction composition present in the reactor vessel under vortex conditions, a jacket cooling loop encasing the reactor vessel to allow circulation of a jacket coolant selected from a group consisting of forced air, nitrogen gas, and water, a coil cooling loop coiling around the reactor vessel to allow circulation of a coil coolant selected from a group consisting of forced air, nitrogen gas, water, and carbon dioxide. Multiple programmable solenoid valves are provided to individually control injection of the aeration coolant, the jacket coolant, and the coil coolant. A controller is provided to communicate with a temperature sensor and each programmable solenoid valve.

Abstract: A sequencing capture array for identifying mutations in Multiple Myeloma is disclosed. Also disclosed are targeted next generation sequencing methods for identifying SNV, CNV, and translocation mutations in Multiple Myeloma tumor cells. A capture array representing fewer than 500 genes implicated in Multiple Myeloma can be used to analyze tumor mutations and create a personalized treatment plan for a Multiple Myeloma patient. Analytical methods are presented that allow tumor mutations to be elucidated with coverage at a sequencing depth of no more than 500×, or as low as 100×, with optimal efficiency achieved at a sequencing depth of about 300×.

Abstract: A method and system for evaluating software tools that detect malicious hardware modifications is provided. In one embodiment, among others, a system comprises a computing device and an application. The application causes the computing device to at least receive hardware description language code that represents a circuit design and calculate a signal probability for one or more nodes in the circuit design. The application also causes the computing device to identify one or more rare nodes in the circuit design and generate a Trojan sample population. The application further causes the computing device to generate a feasible Trojan population and generate a Trojan test instance based at least in part on a random selection from the Trojan feasible population. Additionally, the application causes the computing device to generate modified hardware description code from the Trojan test instance.

Abstract: A polyisobutylene-based polymer network comprising the thiol-ene reaction product of at least two thiol-terminated polyisobutylene precursor polymers and at least one multi-functional allyl-containing precursor moiety or polymer in the presence of light or heat. The at least two thiol-terminated polyisobutylene precursor polymers have at least two thiol end groups. When each polyisobutylene precursor polymer has only two thiol end groups then the allyl-containing precursor moiety or polymer has at least three functional groups, and wherein when the allyl-containing precursor moiety or polymer has two functional groups then each polyisobutylene precursor polymer has at least three thiol end groups.

Abstract: Novel tools and techniques are provided for implementing three-dimensional facial modeling and visual speech synthesis. In various embodiments, a computing system might determine an orientation, size, and location of a face in a received input image; retrieve a three-dimensional model template comprising a face and head; project the input image onto the model template to generate a three-dimensional model; define, on the model, a polygon mesh in a region of facial feature corresponding to feature in the input image; adjust parameters on the model; and display the model. The computing system might parse a text string into allophonic units; encode each allophonic unit into a point(s) in linguistic space corresponding to mouth movements; retrieve, from a codebook, indexed images/morphs corresponding to encoded points in the linguistic space; render the indexed images/morphs into an animation of the three-dimensional model; synchronize, for output, the animation with audio representations of the text string.

Abstract: Disclosed is a method for measuring an antenna downtilt based on a multi-scale detection algorithm, including: capturing an image of an antenna using an unmanned aerial vehicle, and returning data to a server in real time; obtaining a ground truth box where the antenna is located by performing the multi-scale detection algorithm of a server; segmenting the ground truth box based on an antenna target segmentation algorithm of the server; and obtaining an antenna downtilt angle based on an antenna downtilt measurement algorithm of the server and determining whether the antenna properly functions. This method avoids the danger of tower worker climbing, is fast and accurate, saves labor costs and time, and ensures the measurement of an antenna downtilt to be smoother.