Abstract: The present invention encompasses prodrug compositions, nanoparticles comprising one or more prodrugs, and methods of use thereof.

Abstract: A power converter comprising one or more switch blocks. Each switch block has: a plurality of switch-pairs each having two switches connected in series to each other; a plurality of primary nodes each interconnecting the switches in a respective switch-pair; and a plurality of secondary nodes, each switch-pair being connected in series to an adjacent switch-pair through a said secondary node to form a serial chain of switch-pairs, the secondary nodes including a secondary node at one end of said serial chain and a secondary node at another end of said serial chain. Each adjacent pair of said primary nodes is connectable to a flying capacitor. Each pair of said secondary nodes is connectable to one or more of the following: one or more bypass capacitors, and one or more other said switch blocks.

Abstract: Disclosed are substituted heterocycle compounds including substituted pyrazoles, substituted pyrimidines, and substitute triazoles. The substituted heterocycles disclosed herein are shown to be useful in inhibiting c-MYC and may be utilized as therapeutics for treating cancer and cell proliferative disorders.

Abstract: The present disclosure provides an orthopedic device and method for carpal fusion that provides bone to bone compression and multiple fixation points to decrease multiple degrees of freedom and motion of carpal bones. The device is biocompatible, resistant to corrosion, and sufficient in mechanical strength. Bone to bone compression and fixation points can be increased by using a first set of fasteners in a peripheral portion of the device to couple through the device into bone structure, and a second set of fasteners in a central portion of the device can be coupled through the device into the bone structure.

Abstract: A stretchable display according to one embodiment of the present invention comprises: a hybrid stretchable substrate divided into a low stretchable region and a high stretchable region having a modulus lower than that of the low stretchable region; a driving element layer including a driving element on the low stretchable region so as to control a light emitting layer, and wiring on the high stretchable region so as to be electrically connected to a part of the driving element to apply an electrical signal; and the light emitting layer provided on the driving element layer, and electrically connected to the driving element layer to emit light, wherein, between the driving element and the wiring, the wiring can overlap a stretchable mask pattern having a shape corresponding to either the low stretchable region or high stretchable region.

Abstract: Therapeutic compounds containing a phenyl core and amide link(s). Also described are pharmaceutical compositions incorporating the therapeutic compounds and a method for treating cancer with the compounds. These compounds are cytotoxic to stomach, colon, breast, and leukemia cancer cell lines via dual inhibition of Src kinases and tubulin.

Abstract: The present invention relates to an encoding apparatus for multi-level signaling, the encoding apparatus including: a candidate pattern generator (1) generating a set of candidate patterns from input data by using symbol-based inversion; a controller (2) generating a cumulated disparity value that is a result of calculating disparity indicating a degree to which transmission data up to previous transmission deviates from DC balance, storing the cumulated disparity value, and determining a transmission control code by using the cumulated disparity value and a set of disparity values that is a result of calculating disparity indicating a degree to which each of the candidate patterns deviates from DC balance; and a data selector (3) selecting one candidate pattern from the set of the candidate patterns as data to be transmitted, according to the determined transmission control code.

Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of cancer with a B1SP fusion protein in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The cancer may be prostate cancer, breast cancer, ovarian cancer, bladder cancer, kidney cancer, glioblastoma or endometrial cancer. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the B1SP fusion protein may include a sema domain, a structural stabilization domain; and a half life extending moiety.

Abstract: A method for predicting formation permeability by measuring diffusional tortuosity in several directions by pulse gradient NMR. The method comprises evaluating an anisotropic diffusion coefficient by pulsed gradient NMR, determining diffusional tortuosity from the restricted diffusion data, supplementing the NMR results with resistivity and sonic logging data, measuring anisotropic tortuosity and porosity by resistivity and sonic data and combining all components in a single fitting model. The 11-coefficient model is trained to recognize the true values of permeability by comparing the real oil permeabilities measured in a library of oil-carrying rock cores with the NMR, resistivity and sonic correlates. The fitting coefficients are extracted by minimizing the discrepancy between the laboratory measured permeabilities and the predicted values combining all rapid logging information components with the agreement-maximizing weights.

Abstract: According to an exemplary embodiment, a microneedle probe device for measuring a sap flow rate of a plant includes: a substrate, of which at least a part is inserted into a plant, and a thickness and a width are microscales; a single metal wire provided on the substrate; a power source, which applies a current to the metal wire for a predetermined time and heats the metal wire; and a processor, which calculates a flow rate of sap through a movement of heat generated in the metal wire according to a flow of the sap within the plant.

Abstract: A method for determining a quality of a friction stir welded seam is described. The method involves applying an impact to a welded plate and comparing its damping capacity with the damping capacity of a geometrically equivalent defect-free plate. Damping capacities that differ by a small percent difference indicate that the welded plate is also defect-free. This method is particularly advantageous when dealing with small defects, which produce miniscule changes in natural frequency which may not be measureable.

Abstract: A data recovery method framework is described, in which the data is classified as either ambient or disturbance data, and recovered by different methods to achieve good performance efficiently. An approach based on decision tree is described for identifying ambient and disturbance data. Then, an improved cubic spline interpolation based on the priority allocation strategy is described for ambient data loss, which can quickly and accurately recover ambient data. Simultaneously, a disturbance data recovery method based on singular value decomposition is described. It can achieve disturbance data recovery accurately by a single channel of measurement.

Abstract: Disclosed herein are compositions of rAAV particles and methods for administrating rAAV particles having enhanced transduction properties.

Abstract: Mixed ligand phosphinogold(I) complexes as anticancer agents. The gold(I) ion of the complexes is coordinated to a phosphine and a dithiocarbamate or halogen ligand. Also described are a pharmaceutical composition incorporating the phosphinogold(I) complex, a method of synthesizing the phosphinogold(I) complex, and a method of treating cancer. The phosphinogold(I) complexes exhibit potent cytotoxicity against lung, cervical, and liver cancer cells.

Abstract: A heat exchanging thermal liquid container system that comprises a main body at least partially defining a liquid reservoir structured and operable to retain a liquid, and a phase change material (PCM) liner comprising a PCM liner PCM having a selected melting temperature, and/or at least one PCM pod. Each of the at least one PCM pod(s) comprising a respective PCM pod PCM having a respective selected melting temperature. Wherein the PCM liner and/or the at least one PCM pod are disposable within the liquid reservoir such that when a liquid is disposed within the liquid reservoir the liquid will contact at least one of the PCM liner and the at least one PCM pod such that thermal energy can be exchanged between the liquid and the respective at least one of the PCM liner PCM and the at least one PCM pod PCM.

Abstract: The disclosure herein relates to a method for producing high-quality maltodextrin, and belongs to the technical field of maltodextrin. On the basis of a traditional enzymatic production process of maltodextrin, starch branching enzyme derived from Rhodothermus obamensis is introduced, an ?-1,4-glycosidic bond is cleaved, the cleaved short chain is ligated to a receptor chain to form an ?-1,6-branch point, so the degree of branching is increased and the maltodextrin has more cluster structures. Thereby, the aims that the stability of the maltodextrin is enhanced and the maltodextrin is not easy to retrograde are achieved, and the freeze-thaw stability of the maltodextrin is also improved. The method specifically comprises the steps of slurry preparation, spray liquefaction, starch branching enzyme action, filtration, decolorization, ion exchange, concentration, spray drying, and the like.

Abstract: A coat protein of Junonia coenia densovirus (JcDNV) is used to deliver attached peptide insect toxin across the gut epithelium of a fall armyworm, Spodoptera frugiperda. A fusion protein comprising VP4 attached to an insect toxin via a peptide linker is developed. A composition comprising a JcDNV coat protein attached to an insect toxin via a peptide linker can be used for insect pest control.

Abstract: Disclosed herein are embodiments of nanohoop compounds, methods of making, and methods of using the same. The nanohoop compounds disclosed herein have discrete ring system(s) that comprise a unique meta-substituted motif that affords a strained cavity in which myriad reaction chemistries can take place. The unique structures and properties of the nanohoop compounds disclosed herein also lend to their use in a variety of biological applications, and as interlocked structures in molecular machines.

Abstract: A scaffold-stretching system includes at least one stretchable loading chamber configured to support a scaffold material and a supply of cells, such as human skin substitute cells, and is configured to allow for cultivation of a cellular three-dimensional scaffold; and a mechanical loading system is configured for application of cyclic and static uniaxial tensile mechanical loading on the cellular three-dimensional scaffold, and is configured to mimic the in vivo environment of musculoskeletal, cardiovascular, and other tissues that experience uniaxial strains.

Abstract: A method and circuit for operating a liquid crystal device, LCD, based polarisation rotator. The method comprises the steps of tracking a capacitance value of the LCD rotator; and controlling a driver setting to the LCD rotator based on the tracked capacitance value to achieve temperature independent operation.