Abstract: The present disclosure is directed to refreshable biosensors and methods for synthesizing and refreshing same. In some embodiments, the refreshable biosensor comprises a plasmonic nanoparticle and a biorecognition element, wherein the biorecognition element is encapsulated with at least one of an organosilica polymer layer or a metal organic framework (MOF).

Abstract: A room temperature nitrogen dioxide gas sensor comprising tin(IV) oxide decorated with gold nanoparticles is described. The tin(IV) oxide may have an average layer thickness of 10-1,000 nm, and is topped with dispersed gold nanoparticles having an average longest dimension of 200-650 nm. The room temperature nitrogen dioxide gas sensor may be used to detect and measure levels of nitrogen dioxide gas at room temperature and at concentrations of 100 ppb-1800 ppm, with a high stability. A method of making the room temperature nitrogen dioxide sensor is also described, and involves sputtering to deposit a tin(IV) oxide layer and a gold layer on a substrate, followed by annealing.

Abstract: A phononic material and a method of using a phononic material for use in interacting with a fluid or solid flow are provided. The phononic material includes an interface surface and a subsurface feature. The interface surface is adapted to move in response to a pressure associated with at least one wave in a flow exerted on the interface surface. The subsurface feature extends from the interface surface. The subsurface feature comprises a phononic crystal or locally resonant metamaterial adapted to receive the at least one wave having the at least one frequency based upon the pressure from the flow via the interface surface and alter the phase of the at least one wave. The interface surface is adapted to vibrate at a frequency, phase and amplitude in response to the manipulated/altered phase of the at least one wave.

Abstract: A part includes a continuous fiber substantially encased in a formation material. The fiber and formation material are arranged in a plurality of alternating layers such that the formation material of a first one of the alternating layers adheres to the formation material of a second one of the alternating layers over the length of the continuous fiber. The part may include a thin-walled hollow member such as a duct. In some embodiments a part comprises a continuous fiber prepared by an additive manufacturing process comprising the steps of: depositing a composite material on a print bed using a print head, the composite material comprising a continuous fiber and a formation material in intimate contact with the continuous fiber; moving the print head and/or the print bed during the depositing of the composite material; and consolidating the composite material.

Abstract: The present invention relates to novel methods of preparation of substituted pyridines and the compounds produced therefrom. In particular, the present invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products.

Abstract: Provided herein are compounds and methods for treating a disorder associated with aberrant A? peptide levels, including Alzheimer's disease.

Abstract: The present disclosure relates to compositions and methods for inhibiting the growth of, decreasing the amount of, and abolishing the growth of mutans streptococci.

Abstract: A system configured to facilitate virtual outfit fitting is described. The system includes a smart closet device having components including a display door and a plurality of image sensors. A first image sensor of the plurality of image sensors is configured to move across a horizontal axis and a vertical axis of enclosure of the smart closet device to capture a plurality of images of a first outfit hung on an outfit hanging column. The smart closet device also includes a computing unit to generate a three-dimensional (3D) model of the first outfit based on the plurality of images. The computing unit is further configured to update an outfit database by storing the generated 3D model of the first outfit in an outfit database. The computing unit generate an image of a user wearing the output in response to receiving a selection of the first output from the user.

Abstract: The present disclosure provides modified site-directed modifying polypeptides, and ribonucleoproteins comprising the modified polypeptides. The modified site-directed modifying polypeptides are modified for passive entry into target cells. The modified site-directed modifying polypeptides are useful in a variety of methods for target nucleic acid modification, which methods are also provided.

Abstract: The disclosure relates to a method for fermentation integrated with separation and purification of acetone, butanol, and ethanol (ABE) or butanol alone, comprising the following steps: 1) obtaining ABE by fermentation using an acetone-butanol-producing bacterium or obtaining butanol using a butanol-producing bacterium; 2) using a “vapor-stripping-vapor-permeation” method (briefly VSVP) for online separation and purification of ABE or purifying butanol from the fermentation broth; wherein the VSVP method comprises the following steps: introducing a gas bubble into the fermentation broth comprising active cells for fermentation to vaporize ABE or Butanol; subjecting the gas along with the vaporized ABE or Butanol to a membrane separation unit to pass through the membrane; recovering ABE or Butanol, or subjecting ABE or Butanol to a next separation device.

Abstract: De novo designed polypeptides that bind to IL-2 receptor ??c heterodimer (IL-2R??c), IL-4 receptor ??c heterodimer (IL-4R??c), or IL-13 receptor ? subunit (IL-13R?) are disclosed, as are methods for using and designing the polypeptides.

Abstract: A semiconductor heterostructure device includes a middle layer including an inner conducting channel and an outer current blocking region. A depleted heterojunction current blocking region (DHCBR) is within the outer current blocking region. The DHCBR includes a first depleting impurity specie including a Column II acceptor, and a second depleting impurity comprising oxygen which increases a depletion of the DHCBR so that the DHCBR forces current to flow into the conducting channel during electrical biasing under normal operation of the semiconductor heterostructure device.

Abstract: The present invention discloses a high-power machine drive system based on a modular multilevel converter (MMC), which belongs to the technical field of power generation, power transformation, or power distribution. The high-power machine drive system consists of a modular multilevel converter and a multi-pulse cycloconverter. The MMC outputs k phases of high-frequency AC voltages with a phase difference of 2?/k, and the multi-pulse cycloconverter outputs a low-frequency voltage to drive a corresponding machine. According to the present invention, the MMC is combined with the multi-pulse cycloconverter, and by adopting the MMC that operates at a high frequency, the capacity, the volume, and the weight of the energy storage capacitor of the MMC are reduced, the voltage level at the DC side of the MMC is increased, and the capacity of the drive system is increased.

Abstract: Disclosed are devices and methods for body temperature management using a heat transfer catheter carrying a heat transfer fluid to heat or cool a desired, focused portion of a patient's body. In accordance with certain aspects of the invention, the heat transfer catheter may include hollow nodes that have greater rigidity than the remainder of the catheter to aid in placement of the heat transfer catheter within and navigation of the desired portion of the patient's body. Methods of using such heat transfer catheter to effect temperature management of the patient's body are also disclosed.

Abstract: Embodiments of an improved light-direction detection (LDD) device are described herein. The LDD device includes a substrate and at least one predefined structure formed along the substrate by stacking metal layers, contacts, and vias available in the manufacturing process of the device. The predefined structure is formed along a photodiode pair to collectively define an optical sensor configured to detect direction of incident light without need for off-chip components. The device accommodates light direction detection in two or more orthogonal planes.

Abstract: Nitric oxide-releasing materials, methods of making nitric oxide-releasing materials, and uses of nitric oxide-releasing materials are provided. The nitric oxide-releasing materials include a mesoporous silica core and an outer surface having a plurality of nitric oxide donors. In an exemplary aspects, the nitric oxide-releasing material includes a mesoporous diatomaceous earth core, and an outer surface having a plurality of S-nitroso-N-acetyl-penicillamine groups covalently attached thereto. Uses of the nitric oxide-releasing materials can include coatings for medical devices such as catheters, grafts, and stents; wound gauzes; acne medications; and antiseptic mouthwashes; among others.

Abstract: A digital image measurement device and method for the surface deformation of specimen based on sub-pixel corner detection is disclosed. This digital image measurement device is composed of a new type of image pressure cell, a complementary metal-oxide-semiconductor (CMOS) camera, a camera bracket, a flexible lens hood, a computer and matching measurement software. This method discretizes the specimen into several four-node finite elements by printing grids on the specimen and takes corners of the grids as the nodes of the finite elements; tracks the deformation of the feature points in real time by edge detection and corner detection based on sub-pixel; captures the deformation of the whole surface of the specimen by the two flat mirrors which are at an 120° angle behind the specimen; achieves the observation of the deformation of the whole surface by conducting splicing and error correction on the three images.

Abstract: The present invention provides an antibody to a fibrosis-related molecule and medical application thereof. The antibody of the present invention is an antibody that binds to CHL1 protein and an antibody that neutralizes the binding of the CHL1 protein to a fibroblast.

Abstract: Devices, components and fabrication methods are provided for improving the efficiency of OLED displays. An outcoupling component such as a microlens array (MLA) is attached to an OLED, with a relatively small distance between the MLA and the OLED. Cross-talk and back scattering are reduced by the use of colored lenses, focusing layers, and other methods.

Abstract: Aberrant cross talk between Notch ligand (e.g. Jag1) and Notch receptor (e.g. Notch1) has been implicated in tumorigenesis in the colon. Inhibition of Notch pathway is therefore an attractive approach for treating diseases with upregulated Jag1 e.g. colorectal cancer (CRC). Pan-notch inhibitors like gamma secretase inhibitors (GSIs) have been developed to inhibit Notch and its downstream events. However, severe gastrointestinal toxicity profiles impede the clinical development of GSIs. The present invention develops novel oligopeptides that specifically inhibit Jag1-Notch1 pathway without interfering DLL1-Notch1 or DLL4-Notch1, which demonstrates a clear advantage over pan-notch inhibitors.