Abstract: The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

Abstract: The present invention relates to a method, device and software product for converting data into a data DNA sequence and restoring the DNA sequence library into raw data, and a storage medium for storing the software product. The method for converting data into a data DNA sequence comprises: dividing data into one or more data conversion units, providing a binary sequence for each data conversion unit, and converting each data conversion unit into a data DNA sequence according to a dataDNA sequence conversion rule, thus acquiring a data DNA sequence library, which makes biological storage of data in vivo possible by constructing a data DNA library.

Abstract: The present disclosure describes the design, fabrication, and demonstration of a compact spectroscopic analysis system that utilizes a linear variable filter chip attached directly over an image sensor array, and an integrated broadband LED illuminator that supplies light from the edge of the system to provide a low vertical dimension. The instrument is capable of accurately measuring the optical absorption spectra of colored liquids or the scattered spectra from solid objects that are placed in the illumination pathway. Due to the small vertical thickness of the system, the low cost of its components, and the accuracy with which it renders spectra in comparison to conventional spectrometers, we envision potential incorporation of the system into mobile communication devices, such as smartphones and tablets, as a means for providing a dedicated sensor for health diagnostic, environmental monitoring, and general-purpose color sensing applications.

Abstract: Some embodiments described herein relate to cells which have been genetically engineered to release a polypeptide when a population of the cells reaches a desired density. In some embodiments, the released polypeptide may be a therapeutic polypeptide. In some embodiments, the therapeutic polypeptide kills tumor cells or which inhibits the growth of tumor cells.

Abstract: A method for acquiring magnetic resonance imaging data with respiratory motion compensation using one or more motion signals includes acquiring a plurality of gradient-delay-corrected radial readout views of a subject using a free-breathing multi-echo pulse sequence, and sampling a plurality of data points of the gradient-delay-corrected radial readout views to yield a self-gating signal. The self-gating signal is used to determine a plurality of respiratory motion states corresponding to the plurality of gradient-delay-corrected radial readout views. The respiratory motion states are used to correct respiratory motion bias in the gradient-delay-corrected radial readout views, thereby yielding gradient-delay-corrected and motion-compensated multi-echo data. One or more images are reconstructed using the gradient-delay-corrected and motion-compensated multi-echo data.

Abstract: A defrost or thaw measuring device has a dumbbell or hourglass-shaped rotatable compartment with a cavity, the cavity being partly filled with at least two phase change materials having different melting points. The measuring device may determine the time period of thawing at two or more temperature intervals in the refrigeration space.

Abstract: A CDMS may include an ELIT having a charge detection cylinder (CD), a charge generator for generating a high frequency charge (HFC), a charge sensitive preamplifier (CP) having an input coupled to the CD and an output configured to produce a charge detection signal (CHD) in response to a charge induced on the CD, and a processor configured to (a) control the charge generator to induce an HFC on the CD, (b) control operation of the ELIT to cause a trapped ion to oscillate back and forth through the CD each time inducing a charge thereon, and (c) process CHD to (i) determine a gain factor as a function of the HFC induced on the CD, and (ii) modify a magnitude of the portion of CHD resulting from the charge induced on the CD by the trapped ion passing therethrough as a function of the gain factor.

Abstract: A single-chain insulin analogue comprises a B-chain insulin polypeptide connected to an A-chain insulin polypeptide by a C-domain polypeptide. The B-chain insulin polypeptide contains a Cysteine substitution at position B4. The A-chain insulin polypeptide contains a Cysteine substitution at position A10. The C-domain polypeptide is 4 to 11 amino acids long. The analogue mitigates the unfavorable activity of this 4th disulfide bridge in conventional two-chain insulin analogues resulting in a duration of insulin signaling similar to that of wild-type insulin. A method of treating a patient with diabetes mellitus comprises the administration of a physiologically effective amount of the protein or a physiologically acceptable salt thereof to a patient. Use of a single-chain insulin analogue of the present invention in an insulin delivery device (such as a pump or pen) or as part of a high-temperature polymer-melt manufacturing process.

Abstract: A discrete wavelength tunable laser capable of switching between a plurality of lasing channels of different wavelengths, the tunable laser comprising: a semiconductor optical amplifier (SOA); a wavelength demultiplexer (Demux), having a Demux input which receives the output from the SOA, and a plurality of Demux outputs, each Demux output defining a different spatial path for a respective lasing channel; each of the respective lasing channels being within the bandwidth of the SOA; a reflector located within each spatial path for reflecting light of the respective lasing channel; and a lasing suppression mechanism located within each lasing channel; wherein one or more desired lasing channels are selected by application of the lasing suppression mechanism in each spatial path other than the one or more spatial paths corresponding to the one or more desired lasing channels.

Abstract: Disclosed herein, in certain embodiments, are composite materials, methods, tools and abrasive materials comprising a tungsten-based metal composition, a tungsten carbide, and an alloy. In some cases, the composite materials or matrix are resistant to oxidation.

Abstract: A pumping heart simulator is described. The pumping heart simulator can include an inflow pump, an outflow pump, and a control apparatus. The inflow pump can have a first magnetic motor that facilitates flow of fluid from a bottom portion of a fluid reservoir to three inlet valves of a heart via the inflow pump. The outflow pump can have a second magnetic motor that facilitates flow of fluid from two outlet valves of the heart to a top portion of the fluid reservoir via the outflow pump. The control apparatus can alternately activate the first magnetic motor and the second magnetic motor. Related apparatuses, systems, methods, techniques and articles are also described.

Abstract: The present invention provides a method for performing high dynamic range low inter-pixel spatial and wavelength crosstalk optical image detection in a camera comprising an Optical Array Device (OAD), a point Photo Detector (PD) and a Photo Detector Array (PDA) sensor. The method comprises imaging incident light from an object onto an image plane of the Optical Array Device (OAD) to form an incident image map; selecting by the OAD and the Point Photo Detector and by the OAD and the Photo Detector Array a plurality of pixels on the incident image map for time-frequency coding; time-frequency coding the selected pixels by the OAD; detecting by the point PD the optical irradiance values of the time-frequency coded pixels output from the OAD; and performing signal processing on the detected optical irradiance values to determine the light intensity of each of the selected pixels.

Abstract: A memory system performs analog sanitization of memory using a partial programming operation to overwrite existing data taking into account the relative voltage levels in the memory cells. By taking into account the relative voltage levels, the timing of a partial programming operation can be controlled to provide matched voltage levels in the memory cells so that conventional computer forensic techniques for data recovery are ineffective.

Abstract: The present disclosure provides a bandpass filter based on effective localized surface plasmons (ELSPs) and an operation method thereof. The bandpass filter includes a metal ground plane on a lower portion and a dielectric substrate in a middle as well as microstrips and dielectric resonators on an upper portion, where the microstrips at two terminals are symmetric with each other; each dielectric resonator includes a cuboid dielectric body and two metal strips, where the two metal strips each the same as the cuboid dielectric body in length are respectively located in a middle of an upper surface and lower surface of the dielectric body; and two microstrips are respectively connected to the metal strips on lower surfaces of two dielectric resonators, so as to be used as ports for feeding.

Abstract: The present disclosure relates to evaluating an ovaling mode in a cylindrical object and determining a quality of the cylindrical object by analysis of the ovaling mode. In an embodiment, the present disclosure relates to a method for determining a structural quality of a cylindrical element, comprising measuring, as a result of a single applied force, surface vibrations of the cylindrical element via four or more surface transducers arranged on the cylindrical element along a circumference of the cylindrical element, the four or more surface transducers being equally spaced along the circumference, processing digital signals corresponding to each of the four or more surface transducers in order to generate a composite digital signal, transforming the composite digital signal to a frequency domain, comparing the transformed composite digital signal to a reference composite digital signal, and determining, based on the comparing, the structural quality of the cylindrical element.

Abstract: Aspects of this disclosure relate to driving a capacitive micromachined ultrasonic transducer (CMUT) with a pulse train of unipolar pulses. The CMUT may be electrically excited with a pulse train of unipolar pulses such that the CMUT operates in a continuous wave mode. In some embodiments, the CMUT may have a contoured electrode.

Abstract: A concrete composition that includes (i) a treated palm oil fuel ash, wherein the treated palm oil fuel ash is the only binder present, (ii) a fine aggregate, (iii) a coarse aggregate, and (iv) an alkali activator containing an aqueous solution of sodium hydroxide and sodium silicate. A cured concrete made from the concrete composition is also disclosed with advantageous compressive strength properties.

Abstract: A microdevice containing a plurality of nanowires on a biocompatible surface, and methods of making and using the same are provided. Aspects of the present disclosure include forming a plurality of microdevices on a substrate where each microdevice includes a plurality of nanowires. The nanowires may be loaded with an active agent by disposing the active agent onto the surface of the nanowires. Also provided herein are kits that include the subject microdevices.

Abstract: A sensing device including a transistor, at least one response electrode, and a selective membrane is provided. The transistor includes a gate end, a source end, a drain end, and a semiconductor layer, wherein the source end and the drain end are located on the semiconductor layer, and the gate end is located between the source end and the drain end. The at least one response electrode is disposed opposite to the gate end of the transistor and spaced apart from the transistor. The selective membrane is located on the at least one response electrode or on the transistor.

Abstract: A logic-memory cell includes a spin-orbit torque device having first, second and third terminals configured such that current between the second and third terminals is capable of changing a resistance between the first and second terminals. In the cell, a first transistor is connected between a logic connection line and the first terminal of the spin-orbit torque device and a second transistor is connected between the logic connection line and the third terminal of the spin-orbit torque device.