Abstract: A method of purifying an antifreeze protein (AFP) and methods of producing AFPs are disclosed. The method of purifying an AFP includes heating a crude AFP in an aqueous medium to a temperature and for a length of time sufficient to precipitate at least some thermally unstable proteins in the crude AFP and form a precipitate and a supernatant; and removing the precipitate from the supernatant. One method of producing an AFP includes collecting a crude source of the AFP; and purifying the AFP by the purification method. Another method of producing an AFP includes growing or culturing a host configured to express a recombinant AFP in a growth medium, and collecting a crude AFP from the host and/or the growth medium. The growth medium comprises water, a protein hydrolysate or other source of amino acids, a yeast extract, a biologically metabolizable C3-C6 polyol, and one or more phosphate salts.
Type:
Grant
Filed:
December 27, 2019
Date of Patent:
October 19, 2021
Assignees:
The Board of Trustees of the California State University, California State University, Los Angeles
Abstract: A method of determining a cell cycle stage distribution of cells includes the steps of providing a cell sample; pre-treating the cell sample with a solvent; mixing the pre-treated cell sample with a matrix solution to obtain a mixture solution; depositing the mixture solution on a sample plate; obtaining a mass spectrum analysis of the deposited mixture solution; and identifying at least two marker peaks from the mass spectrum analysis, wherein a ratio between the marker peaks provides information about a cell cycle stage distribution of the cell sample, wherein the mass spectrum analysis is a matrix-assisted laser desorption/ionization time-of-flight mass spectrum test.
Abstract: The present invention relates generally to a head-mounted projection display, and more particularly, but not exclusively to a polarized head-mounted projection display including a light engine and a compact, high-performance projection lens for use with reflective microdisplays.
Type:
Grant
Filed:
November 15, 2019
Date of Patent:
October 19, 2021
Assignee:
Arizona Board of Regents on Behalf of the University of Arizona
Abstract: The present invention belongs to the field of super-hydrophobic surface technology, and discloses a durable hydrophilic-super-hydrophobic bipolar self-cleaning composite film and a preparation method therefor. The preparation method is as follows: adding an epoxy silane coupling agent into an organic solvent; after stirring and mixing well, adding an amine curing agent and distilled water to the mixture; stirring and adding micron-sized solid particles and hydrophobic nano silicon dioxide particles; continuing stirring to obtain a hydrophilic layer solution; adding a hydrophobic modifier and a hydrophilic nano silicon dioxide particles into the solvent to obtain a hydrophobic layer solution; coating a pretreated substrate surface with the hydrophilic layer solution, and performing heating treatment at 60° C. to 80° C. for 10-50 min; then coating the surface with the hydrophobic layer solution, and performing heating treatment at 100° C. to 140° C.
Abstract: The invention provides methods for treating cancers, such as melanoma and/or metastatic melanoma, using compounds that interact with and/or inhibit cellular proteins lamin A/C, ATP-dependent RNA helicase DDX1 (DDX1), heterogeneous nuclear ribonuclear protein H1/H2 (hnRNP H2), and/or heterogeneous nuclear ribonuclear protein A2/B1 (hnRNP A2/B1). The invention additionally provides a method for identifying compounds active against melanoma cells.
Type:
Grant
Filed:
December 15, 2017
Date of Patent:
October 19, 2021
Assignees:
Nova Southeastern University, Auburn University, Florida Atantic University Board Of Trustees, Torrey Pines Institute for Molecular Studies
Inventors:
Dmitriy Minond, Gregg B. Fields, Marcello Giulianotti
Abstract: A method for controlling wireless power transfer (WPT), performed by an electric vehicle (EV) device receiving power from a supply device is provided. The method includes checking service details regarding at least one method for fine positioning and pairing between the supply device and the EV device and selecting a service. Fine positioning is performed with the supply device according to a pairing method associated with the selected service. Additionally, LF pairing is performed based on the selected service; an initial alignment check is performed using pre-charging power transmission; and LPE pairing is performed based on the selected service and a result of the initial alignment check.
Type:
Grant
Filed:
April 21, 2020
Date of Patent:
October 19, 2021
Assignees:
Hyundai Motor Company, Kia Motors Corporation, Myongji University Industry and Academia Cooperation Foundation
Abstract: An antenna assembly, a wireless-communication-enabled device and an intelligent home or office appliance including such antenna assembly. The antenna assembly includes an antenna including an antenna body and a feeder, and at least one functional module arranged to operate with a function different from that provided by the antenna; wherein the at least one functional module includes at least one electrical connection module arranged to connects with an external electrical connector.
Abstract: Compositions that include certain phenyl substituted cyclohexenyl compounds are administered to a subject in a method for treating obesity or an associated disease or disorder or in a method of reducing food consumption or body weight.
Type:
Grant
Filed:
February 12, 2019
Date of Patent:
October 19, 2021
Assignee:
Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.
Abstract: The present disclosure provides for a photoredox-responsive material, processes of making the photoredox-responsive material, and methods of use thereof.
Type:
Grant
Filed:
March 29, 2018
Date of Patent:
October 19, 2021
Assignee:
Washington University
Inventors:
Jonathan C. Barnes, Angelique F. Greene, Kevin Liles, Abigail Delawder
Abstract: The present disclosure discloses a system for measuring a charge-to-mass ratio of an electrostatic atomization nozzle and a measurement method using the same. The system includes an electrostatic atomization nozzle, an upper cylinder, a lower cylinder, an ammeter, a liquid level tube, an ultrasonic level meter, a water storage tank, and a liquid pump. The electrostatic atomization nozzle, the upper cylinder, and the lower cylinder are sequentially connected from top to bottom. The ammeter is connected to the lower-cylinder flange. The liquid level tube is communicated with the lower cylinder. The ultrasonic level meter is mounted on an upper end of the liquid level tube. The water storage tank is located below a lower-cylinder water outlet pipe. The liquid pump can deliver a liquid in the water storage tank to the electrostatic atomization nozzle. Measurement data of the ammeter is acquired and processed by a computer in real time.
Abstract: The present disclosure relates to multispecific antibodies targeting the human immunodeficiency virus-1 (HIV-1) envelope, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof in treatment and prevention of HIV infection.
Type:
Grant
Filed:
October 17, 2017
Date of Patent:
October 19, 2021
Assignees:
University of Maryland, College Park, The United States of America, As Represented By, International AIDS Vaccine Initiative
Inventors:
Javier Guenaga, Yuxing Li, James Steinhardt, John R. Mascola
Abstract: Techniques to diagnose internal short circuits (ISCs) of a lithium-ion battery (LIB) are disclosed. The short circuit resistance data can help to detect the ISCs of a LIB as fast as possible. For the proposed detection techniques, a resistor-based circuit and an inductor-based circuit are disclosed for single-cell LIBs as well as for LIBs having multiple cells. Two topologies of the resistor-based circuits are disclosed to detect the ISCs of multi-cell LIBs.
Type:
Grant
Filed:
August 12, 2019
Date of Patent:
October 19, 2021
Assignee:
University of Florida Research Foundation, Incorporated
Abstract: An apparatus comprises: a photonic cavity; a substrate comprising a waveguide layer, wherein the waveguide layer comprises waveguides configured to direct light towards the photonic cavity; and a wafer comprising: a top side, and a nanowire array affixed to the top side. A method of performing a surface-enhanced Raman scattering (SERS) analysis, the method comprises: directing, using a waveguide layer of a SERS device, an incident light towards a photonic cavity of the SERS device; permitting, using the photonic cavity, a fluid to flow freely into and out of the SERS device; causing, within the photonic cavity, an interaction among the incident light, the fluid, and a nanowire array of the SERS device to create scattered light; converting the scattered light into an electrical signal; and analyzing the electrical signal to determine whether a contaminant exists in the fluid.
Type:
Grant
Filed:
February 28, 2020
Date of Patent:
October 19, 2021
Assignee:
The Board of Regents of the University of Oklahoma
Inventors:
Binbin Weng, Mark A. Nanny, Joseph M. Suflita, Rouzbeh Ghanbarnezhad Moghanloo
Abstract: A soft-switching, high-performance single-phase alternating current (AC)-direct current (DC) converter is provided. The AC-DC converter described herein provides a new circuit topology for single-stage, single-phase or multi-phase AC-DC power conversion with power factor correction (PFC) and galvanic isolation using a high-frequency isolation transformer. The AC-DC converter improves power conversion efficiency and power density—two of the most important metrics for a power converter. It achieves soft switching for high frequency switches in the circuit, leading to higher efficiency and lower electromagnetic interference (EMI).
Type:
Grant
Filed:
June 5, 2020
Date of Patent:
October 19, 2021
Assignee:
Arizona Board of Regents on behalf of Arizona State University
Abstract: Provided herein are clear aqueous colonoscopy irrigation compositions, and methods for visualization of colonic mucosa during colonoscopy procedure. The composition comprises indigo, blue or green colored contrast dye, polydimethylsiloxane, and muscle relaxant.
Abstract: 5-HMF derivative compounds that bind covalently with hemoglobin are provided. Methods of treating sickle cell disease and other hypoxia-related disorders by administering such compounds are also provided.
Type:
Grant
Filed:
October 7, 2020
Date of Patent:
October 19, 2021
Assignees:
King Abdulaziz University, Virginia Commonwealth University
Inventors:
Abdelsattar Mansour Ebeid Omar, Moustafa El-Sayed El-Araby, Martin K. Safo
Abstract: A system for creating an endoluminal valve from a blood vessel wall, includes: a tubular assembly having a longitudinal axis, a proximal end, a distal portion with a distal end, and a first lumen extending from the proximal end to a distal port located proximate the distal portion, the distal port located along the longitudinal axis, the distal portion having a supporting surface on a same side of the tubular assembly as the distal port, the supporting surface extending in a longitudinal direction and offset from a surface of the tubular assembly proximal the distal port and configured to contact the blood vessel wall; and a tissue dissection probe disposed within the first lumen, the tissue dissection probe having a fluid delivery lumen extending to a fluid delivery port located at a distal end of the tissue dissection probe, the tissue dissection probe configured to be inserted into the blood vessel wall.
Type:
Grant
Filed:
May 16, 2018
Date of Patent:
October 19, 2021
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: In an embodiment, a system includes a plurality of sensor devices contained in a plurality of wells contained in a well-plate assembly. The sensor devices are used in a plurality of oscillators. Each oscillator generates a frequency and a resistance based on a quality of living biological cells contained in a corresponding well. The quality may include, for example, surface coupled mass, density, viscosity, and/or viscoelasticity of the living biological cells. The system also includes logic for measuring a resonant frequency and motional resistance associated with each sensor device and logic for processing the measured resonant frequency and motional resistance. Moreover, the system includes logic for displaying one or more graphs showing one or more characteristics of the living biological cells contained in the wells.
Type:
Grant
Filed:
February 17, 2017
Date of Patent:
October 19, 2021
Assignee:
University of Massachusetts
Inventors:
Abiche H. Dewilde, Berk Akinci, Joel M. Therrien, Kenneth A. Marx, Susan J. Braunhut
Abstract: An electrode and an energy storage device including the electrode, the electrode including: an active material including a material structure of metal sulfides; a conductive polymer including an ionic liquid disposed on the active material; wherein the combination of the conductive polymer and the ionic liquid is arranged to maintain integrity of the material structure and facilitate ion transportation across the material structure during an operation of charging and discharging cycle of the energy storage device.
Abstract: The present disclosure encompasses methods of error corrected sequencing (ECS) that enable detection of very rare mutations well below the error rate of convention next generation sequencing (NGS). Further, the methods disclosed herein enable multiplex targeting of genomic DNA.