Abstract: In one embodiment, assessing the quality of an adhesive bond of a composite material includes passing a vector electric field through a thickness of the composite material, measuring dielectric properties of the composite material, determining one or more dielectric parameters of the composite material, and comparing the one or more dielectric parameters with one or more reference dielectric parameters.

Abstract: Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.

Abstract: The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.

Abstract: Ringing occurring in a digital signal to be transmitted, is reduced or suppressed. A transmission module Ma includes a transmitter 200a configured to transmit a digital signal, a transmission antenna 100a constituted by a metal plate, or by a conductor formed on an insulator. The transmission antenna 100a is configured to be electromagnetically or magnetically coupled to a reception antenna 100b of a non-contact reception module Mb for digital communication. A resistor 400a is connected in series between the transmitter 200a and the transmission antenna 100a. The resistor 400a has such a resistance value that the resistor 400a entirely blunts a waveform of the digital signal outputted from the transmitter 200a so as to reduce or suppress ringing occurring in the digital signal. The blunted digital signal can be inputted into the transmission antenna 100a.

Abstract: In certain embodiments novel sparse orthogonal collimators (SOCs) for use in radiotherapy are provided. In certain embodiments the SOCs comprise 2 layer 4 bank orthogonal collimators with 2-8 leaves in each of the 4 banks. Instead of using the limited heuristic approach to create jaw-only IMRT, a novel fluence map optimization method is provided based on wavelet decomposition and this method is used for IMRT. An algorithm to simplify the fluence maps with minimal and predictable dose quality compromise is also provided.

Abstract: Disclosed are a three-dimensional tunneling field-effect transistor and a method of fabricating the same. A method of fabricating a three-dimensional tunneling field-effect transistor according to an embodiment of the present disclosure includes growing a buffer layer, an embedded source layer, an etch stop layer, an active source layer, a channel layer, and a drain layer on a substrate; depositing a metal layer on the drain layer, and then forming a pattern in a mesa structure shape; forming a vertical gate at one end of each of the etch stop layer, the active source layer, the channel layer, and the drain layer; isolating the active source layer from the substrate to form a first air bridge; isolating the drain layer from the substrate to form a second air bridge; and isolating the vertical gate from the substrate to form a third air bridge.

Abstract: Provided is an electromyogram (EMG) signal-based user authentication apparatus and method. The apparatus includes an EMG signal receiver configured to receive an EMG signal measured using an EMG sensor, a pre-processor configured to remove a partial signal from the received EMG signal according to a preset frequency band, and a controller configured to authenticate a user by comparing a pre-stored EMG signal with the EMG signal in which the partial signal has been removed.

Abstract: Provided are a method and apparatus for managing a page cache for multiple foreground applications. A method of managing a page cache includes identifying an application accessing to data stored in storage; allocating a page used by the application for the accessed data to a page cache; setting a page variable corresponding to a type of the identified application to the allocated page; and managing demoting of the allocated page based on the set page when the allocated page is a demoting target.

Abstract: Targeting RAS is one of the greatest challenges in cancer therapy. Oncogenic mutations in NRAS are present in over 25% of melanomas and patients whose tumors harbor NRAS mutations have limited therapeutic options and poor prognosis. Thus far, there are no clinical agents available to effectively target NRAS or any other RAS oncogene. An alternative approach is to identify and target critical tumor vulnerabilities or non-oncogene addictions that are essential for tumor survival. The inventors investigated the consequences of NRAS blockade in NRAS-mutant melanoma and show that decreased expression of the telomerase catalytic subunit, TERT, is a major consequence. TERT silencing or treatment of NRAS-mutant melanoma with the telomerase-dependent telomere uncapping agent 6-thio-2?-deoxy-guanosine (6-thio-dG), led to rapid cell death, along with evidence of both telomeric and non-telomeric DNA damage, increased ROS levels, and upregulation of a mitochondrial anti-oxidant adaptive response.

Abstract: Systems and methods for activation in an optical circuit in accordance with embodiments of the invention are illustrated. One embodiment includes an optical activation circuit, wherein the circuit comprises a directional coupler, an optical-to-electrical conversion circuit, a time delay element, a nonlinear signal conditioner, and a phase shifter. The directional coupler receives an optical input and provides a first portion to the optical-to-electrical conversion circuit and a second portion to the time delay element, the time delay element provides a delayed signal to the phase shifter, and the optical-to-electrical conversion circuit converts an optical signal from the directional coupler to an electrical signal used to activate the phase shifter to shift the phase of the delayed signal.

Abstract: Disclosed herein is a method of enhancing the accuracy and/or sensitivity of ultrasound imaging in detecting a tumor in a subject. The method comprises administering to the subject an effective amount of a nanoparticle prior to the application of ultrasound to the subject. According to certain embodiments of the present disclosure, the nanoparticle is a magnetic nanoparticle, for example, a gold, silver, or iron oxide nanoparticle. Also disclosed herein are methods of treating a tumor in a subject by detecting the tumor via ultrasound with the aid of a nanoparticle, and then administering to the subject an anti-cancer treatment based on the location of the tumor revealed by the ultrasound image.

Abstract: A nerve stimulating apparatus includes a plurality of stimulating units configured to respectively apply stimuli to a plurality of nerve regions branching from a particular nerve region of a living body, and a stimulation timing controller configured to set generating timings of respectively generating the stimuli at the plurality of stimulating units. The stimulation timing controller sets the generating timings of generating the stimuli at the plurality of stimulating units based on response results of the particular nerve region, the response results being obtained in response to the stimuli that are respectively generated at the plurality of stimulating units and that are respectively applied to the plurality of nerve regions, and the response results being measured by a biometric information measuring apparatus that measures biometric information.

Abstract: The present disclosure relates to an organic compound having the following structure, and an organic light emitting diode (OLED) and an organic light emitting device including the organic compound. The organic compound is a bipolar compound having a p-type moiety and an n-type moiety and has high energy level and proper energy bandgap for an emissive layer of the OLED. As the organic compound is applied into the emissive layer, the OLED can maximize its luminous properties as holes and electrons are recombined uniformly over the whole area in an EML.

Abstract: The present disclosure relates to methods and systems for assessing the risk of glaucoma in a subject. In certain embodiments, the present disclosure provide a method of assessing the risk of primary open angle glaucoma in a subject, the method comprises determining a risk score for primary open angle glaucoma in the subject on the basis of the genetic content of the subject at a plurality of selected genetic loci or markers and thereby assessing the risk of primary open angle glaucoma in the subject, wherein the selected genetic loci or markers comprise (i) genetic loci or markers having an association with glaucoma, and/or (ii) genetic loci or markers having an association with increased intraocular pressure, and/or (iii) genetic loci or markers having an association with an increased vertical cup to disk ratio, and/or (iv) genetic loci or markers having an association with a multi-trait test of glaucoma, intraocular pressure and vertical cup to disc ratio. Other embodiments are described.

Abstract: A processor-implemented data processing method includes: generating compressed data of first matrix data based on information of a distance between valid elements included in the first matrix data; fetching second matrix data based on the compressed data; and generating output matrix data based on the compressed data and the second matrix data.

Abstract: The present disclosure relates to a spin-orbit torque-based switching device and a method of fabricating the same. The spin-orbit torque-based switching device of the present disclosure includes a spin torque generating layer provided with a tungsten-vanadium alloy thin film exhibiting perpendicular magnetic anisotropy (PMA) characteristics and a magnetization free layer formed on the spin torque generating layer.

Abstract: Provided is a method of inhibiting tumor progression in a subject suffering from gastric cancer, including administering to said subject a pharmaceutical composition including an inhibitor of targeting PHF8-c-Jun-PKC?-Src-PTEN axis, or a pharmaceutically acceptable salt thereof. A method of determining a tumor progression state in a subject suffering from gastric cancer is also provided, which comprises providing a sample from the subject; detecting PHF8 expression level in the sample from the subject; and determining the tumor progression state of gastric cancer by the PHF8 expression level, wherein the PHF8 expression level is positively detected from moderate to strong expression indicating the subject suffering a late stage of gastric cancer.

Abstract: The present invention sets forth small novel abscisic acid (ABA) receptor agonist scaffolds and compounds with potent in vivo activity. In some aspects, the present invention provides agricultural formulations and methods comprising the ABA receptor agonists described herein, such as methods of managing crop water use and improving stress tolerance (e.g., drought tolerance). In some preferred embodiments, the inventive compounds have improved properties relative to the current “best in-class” molecules quinabactin and its derivatives.

Abstract: The present invention relates to an enzyme-carrier complex, and more particularly to the adsorption and stabilization of an enzyme on the surface of a carrier, and an enzyme-carrier complex with secured enzyme stability so that an enzyme immobilized by a hydrophobic interaction exhibits long-term enzymatic activity.

Abstract: A measuring device includes a stimulation instructing unit and an estimating unit. The stimulation instructing unit is configured to instruct a stimulating device to generate a plurality of stimulations corresponding to at least three fiducial points of brain anatomy data, the at least three fiducial points having been defined in the brain anatomy data. The estimating unit is configured to estimate, based on sensor output signals output from sensors configured to measure a brain activity signal of a subject who is a target to be measured, parts where brain activities occur due to the plurality of stimulations.