Abstract: The present invention provides microfluidic devices and methods for measuring blood. The microfluidic devices of the present invention include an inlet port adapted and configured to receive a fluid sample, a microfluidic flow path in fluidic communication with the inlet port, an outlet in fluidic communication with the microfluidic flow path, the outlet: having a smaller cross-sectional area than the microfluidic flow path; and adapted for communication with a pressure sink. The microfluidic devices further include a priming circuit in fluidic communication with the microfluidic flow path such that when a priming fluid is applied under pressure to the priming circuit, the priming fluid will flow through the microfluidic flow path to the inlet port due to low resistance to laminar flow in the microfluidic flow path relative to the outlet.

Abstract: Cooling by a twist-untwist process, by a stretch-release process for twisted, coiled, or supercoiled yarns or fibers, and methods and systems thereof. High mechanocaloric cooling results from release of inserted twist or from stretch release for twisted, coiled, or supercoiled fibers, including natural rubber fibers, NiTi wires, and polyethylene fishing line. Twist utilization can increase cooling and cooling efficiencies. A cooler using twist insertion and release can be shorter and smaller in volume than a cooler that requires a large elastomeric elongation. The cooler system can be utilized in mechanochromic textiles and remotely readable tensile and torsional sensors.

Abstract: Preferred embodiments described herein relate to a pipeline framework that allows for customized analytic processes to be performed on multiple streams of videos. An analytic takes data as input and performs a set of operations and transforms it into information. The methods and systems disclosed herein include a framework (1) that allows users to annotate and create variable datasets, (2) to train computer vision algorithms to create custom models to accomplish specific tasks, (3) to pipeline video data through various computer vision modules for preprocessing, pattern recognition, and statistical analytics to create custom analytics, and (4) to perform analysis using a scalable architecture that allows for running analytic pipelines on multiple streams of videos.

Abstract: A CoVOx composite electrode and method of making is described. The composite electrode comprises a substrate with an average 0.5-5 ?m thick layer of CoVOx having pores with average diameters of 2-200 nm. The method of making the composite electrode involves contacting the substrate with an aerosol comprising a solvent, a cobalt complex, and a vanadium complex. The CoVOx composite electrode is capable of being used in an electrochemical cell for water oxidation.

Abstract: Devices for assaying a biomolecule from a sample, including: a cartridge assembly structured to accept and secure a magnetofluidic cartridge to be used for the assaying, and a magnetic particle manipulation assembly arranged proximate the cartridge assembly, the magnetic particle manipulation assembly having a pair of magnets arranged to be on opposing sides of said magnetofluidic cartridge and which are substantially aligned along a line that will be transverse to the magnetofluidic cartridge such that the line can be aligned with a well in the magnetofluidic cartridge, and methods of using and assembling such devices.

Abstract: A ring sizer including a face plate that has markings usable to provide measurements of a valve. The sizer may include a clear face plate on which the markings are provided such that the valve is visible through the face plate facilitating accurate measurements of various valve dimensions and optimal ring sizing.

Abstract: The present invention discloses an integrated automated driving system for a maritime autonomous surface ship (MASS).

Abstract: The present invention relates to a dual-scale porous silica particle-based pharmaceutical composition for preventing or treating cancer, which includes porous silica nanoparticles and porous silica microparticles. The pharmaceutical composition of the present invention promotes the generation of a larger amount of antigen-specific, cytotoxic T cells against cancer than a mesoporous silica nanoparticle (MSN) vaccine, and exhibits increased anti-tumor efficacy compared with a mesoporous silica microrod (MSR) vaccine.

Abstract: Techniques, systems, and devices are described for implementing for implementing computation devices and artificial neurons based on nanoelectromechanical (NEMS) systems. In one aspect, a nanoelectromechanical system (NEMS) based computing element includes: a substrate; two electrodes configured as a first beam structure and a second beam structure positioned in close proximity with each other without contact, wherein the first beam structure is fixed to the substrate and the second beam structure is attached to the substrate while being free to bend under electrostatic force. The first beam structure is kept at a constant voltage while the other voltage varies based on an input signal applied to the NEMS based computing element.

Abstract: Methods of using one or more fumaric acid esters or pharmacologically active salts, derivatives, analogues, or prodrugs thereof to increase expression of fetal hemoglobin (HbF) are disclosed. The methods typically include administering to a subject an effective amount of one or more fumaric acid esters optionally in combination or alternation with hydroxyurea to induce HbF expression in the subject in an effective amount to reduce one or more symptoms of a sickle cell disorder, a hemoglobinopathy, or a beta-thalassemia, or to compensate for a genetic mutation is the human beta-globin gene (HBB) or an expression control sequence thereof. Pharmaceutical dosage units and dosage regimes for use in the disclosed methods are also provided.

Abstract: The present invention provides a pharmaceutical composition for cancer treatment comprising an antibody against CCR8.

Abstract: The invention discloses an experimental test method for subcritical propagation rate of rock fractures based on triaxial stress-strain curve, including: Step 1: preparing test sample core for experiment; Step 2: putting core into triaxial rock mechanics test system, applying constant radial confining pressure to core, and applying axial stress in the axial direction until the core is macroscopically damaged; recording experimental parameters of axial stress, strain and corresponding loading time of the core; Step 3: drawing stress-strain curve of the test core according to detection data points of axial stress and axial strain; Step 4: in the stress-strain curve of the test core, starting time and ending time of the subcritical propagation stage of fractures inside the core correspond to the initiation stress ?ci and damage stress ?cd, respectively, and calculating subcritical propagation rate of the subcritical fracture propagation stage of the test core.

Abstract: The invention provide a compound of formula I: or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, processes for preparing a compound of formula I or a pharmaceutically acceptable salt thereof, intermediates useful for preparing a compound of formula I or a pharmaceutically acceptable salt thereof, and therapeutic methods comprising the administration of a compound of formula I or a pharmaceutically acceptable salt thereof. The compounds and salts are useful for inhibiting glycolysis and mitochondrial function and are useful for treating cancer, autoimmune diseases, NASH, CGvHD, and obesity. The compounds and salts are are useful for treating transplant rejection.

Abstract: An earthquake event classification method using an attention-based neural network includes: preprocessing input earthquake data by centering; extracting a feature map by nonlinearly converting the preprocessed earthquake data through a plurality of convolution layers having three or more layers; measuring importance of a learned feature of the nonlinear-converted earthquake data based on an attention technique in which interdependence of channels of the feature map is modeled; correcting a feature value of the measured importance value through element-wise multiply with the learned feature map; performing down-sampling through max-pooling based on the feature value; and classifying an earthquake event by regularizing the down-sampled feature value. Accordingly, main core features inherent in many/complex data are extracted through attention-based deep learning to overcome the limitations of the existing micro earthquake detection technology, thereby enabling earthquake detection even in low SNR environments.

Abstract: A capacitive stealth composite structure includes a plurality of structural layers stacked in a thickness direction, and the number of layers of the structural layers is three or more, wherein each of the structural layers consists of a plurality of electromagnetic wave absorbing patterns and a plurality of insulation patterns alternately arranged in a horizontal direction. The electromagnetic wave absorbing patterns in each of the structural layers are aligned with the insulation patterns of an adjacent structural layer, and the insulation patterns in each of the structural layers are aligned with the electromagnetic wave absorbing patterns of an adjacent structural layer.

Abstract: A solid supported branched linker assay system, including an alpha compound and a beta compounds reversibly tethered to a solid support; a branched linker coupled to the solid support that tethers the alpha and beta compounds to the solid support; the branched linker having two cleavable linkers that are chemically distinct from one another, wherein a first chemically distinct linker tethers the ? compound to the branched linker and a second chemically distinct linker tethers the ? compound to the branched linker; and at least two means for cleaving the chemically distinct linkers, wherein a first cleavage means is configured to selectively cleave a first chemically distinct linker and a second cleavage means is configured to selectively cleave a second chemically distinct linker.

Abstract: The present invention relates to an enzyme-porous carbon composite, and more specifically, to an enzyme-porous material composite capable of realizing a much higher enzyme adsorption amount than porous silica and maintaining high stability of an immobilized enzyme.

Abstract: Quantum dragon materials and devices have unit (total) transmission of electrons for a wide range of electron energies, even though the electrons do not undergo ballistic propagation, when connected optimally to at least two external leads. Quantum dragon materials and devices, as well as those that are nearly quantum dragons, enable embodiments as quantum dragon electronic or optoelectronic devices, including field effect transistors (FETs), sensors, injectors for spin-polarized currents, wires having integral multiples of the conductance quantum, and wires with zero electrical resistance. Methods of devising such quantum dragon materials and devices are also disclosed.

Abstract: The present invention provides a biomarker for predicting effectiveness for autoimmune disease treatment, a diagnostic kit, and a use for treatment. More particularly, the present invention provides a biomarker for predicting the effectiveness of mesenchymal stem cells (MSC) comprising the chemokine receptor CXCR3 for autoimmune disease treatment; a biomarker comprising the chemokine CXCL10 for predicting the prognosis of autoimmune disease treatment; a diagnostic kit comprising an agent capable of measuring the expression of the biomarker; and a pharmaceutical composition for prevention or treatment of an autoimmune disease, which comprises mesenchymal stem cells having an upregulated expression level of the chemokine receptor CXCR3.

Abstract: A sensing system comprises an electrochemical chip having an arrangement of electrodes configured for electrochemical sensing; a microfluidic system having fluidic channels leading to ports on a surface of the sensing system, for delivering to a plant part a substrate for a reporter enzyme expressed by the plant; and an attachment system for attaching the surface of the sensing system to a surface of the plant part in a manner that the fluidic ports contact the surface of the plant part.