Abstract: A motion assistance apparatus including a proximal frame configured to support a proximal part of a user, a distal frame configured to support a distal part of the user, and a force transmitting member slidably connected to the proximal frame, and rotatably connected to the distal frame is provided.

Abstract: A recombinant adeno-associated virus (AAV) having an AAV capsid and packaged therein a heterologous nucleic acid which expresses two functional antibody constructs in a cell is described. Also described are antibodies comprising a heavy chain and a light chain from a heterologous antibody. In one embodiment, the antibodies are co-expressed from a vector containing: a first expression cassette which encodes at least a first open reading frame (ORF) for a first immunoglobulin under the control of regulatory control sequences which direct expression thereof; and a second expression cassette which comprises a second ORF, a linker, and a third ORF under the control of regulatory control sequences which direct expression thereof, wherein the second and third ORF for a second and third immunoglobulin construct. The vector co-expressing these two antibody constructs is in one embodiment an AAV, in which the 5? and 3? ITRs flank the expression cassettes and regulatory sequences.

Abstract: Provided are: a protein degradation inducing tag which is a molecule that has affinity with proteases and does not inhibit degradation of a protein by proteases; a protein degradation inducing molecule that is a conjugate of at least one protein degradation inducing tag and at least one protein binding molecule that binds to a protein; and a usage of those.

Abstract: A method comprises operating in an idle user state; determining to exit the idle user state and enter an active user state; obtaining cell loads of cells; calculating association functions based on the cell loads; determining, from among the association functions, a first association function with a maximum value; selecting a first cell associated with the first association function as a target cell; and entering the active user state by connecting to the first cell.

Abstract: In various embodiments, the present invention is directed to terpolymers of carbon monoxide (CO), olefins (alkenes), and epoxides, as well as related methods and catalysts for their making and use. These terpolymer chains are comprised of ketone repeat units, ester repeat units, and ether repeat units. The additional presence of the ester repeat units and ether repeat units have the effect of lowering terpolymer melt temperature relative to that of similar polyketone, thus separating melt temperature from decomposition temperature, making it suitable for melt processing. In a single reaction mixture, the same metal catalyst that polymerizes CO with olefins also incorporates epoxide monomers into the terpolymer in the form of ester or ester and ether linkages. As a part of the terpolymer chain, the ester groups can undergo hydrolysis, rendering these terpolymer compositions hydrolytically degradable.

Abstract: Systems and methods are provided for forecasting and managing daily electrical demands. In some embodiments, a computing platform may receive historical demand data corresponding to historical electrical demand over a first period of time. Next, the computing platform may determine a reference rate of change (ROC) and a statistical mode corresponding to a number of positive ROCs. After, the computing platform may receive current demand data corresponding to current electrical demand over a second period of time. Subsequently, the computing platform may determine an alarm condition corresponding to a daily peak electrical demand. Following, the computing platform may generate one or more commands directing a second computing platform to display the alarm condition. Afterwards, the computing platform may transmit the one or more commands directing the second computing platform to display the alarm condition.

Abstract: Provided herein are systems, methods and apparatuses for a thickness measurement device based on a capacitive array.

Abstract: A wireless charging device includes a wireless charging transmitter transmitting a charging signal to a signal gain module to generate at least one gain signal. The signal gain module includes an insulation substrate with an upper surface thereof provided with a first conductive wire. The first conductive wire makes at least one turns arranged along the inner edge of the insulation substrate. The lower surface of the insulation substrate is provided with a second conductive wire whose position corresponds to the position of the first conductive wire. A connecting element is arranged between the first conductive wire and the second conductive wire, such that the first conductive wire is electrically connected to the second conductive wire through the connecting element. The present invention provides a charging signal with high intensity to avoid the low charging efficiency caused by deflection and too long a distance.

Abstract: A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature.

Abstract: A pyrolyzed MOF catalyst for in the carbon dioxide reduction reaction and methods of making the catalyst. The catalysts are composed of highly porous transition metal organic frameworks exhibiting large pores with regular distribution of transition metals within the structure.

Abstract: A cryptographic infrastructure, which provides a method for generating private keys of variable length from a cryptographic table and a public key. This infrastructure provides an approximation of the one-time pad scheme. The cryptographic table is shared between a message sender and a message recipient by a secure transfer. After sharing the cryptographic table, no new private keys need to be sent—the private keys are independently generated by each party from the data contained within the shared cryptographic tables, using the public key. After public keys are exchanged, private keys may be generated and used to encrypt and decrypt messages and perform authentication cycles, establishing a secure communication environment between the sender and the recipient.

Abstract: The present technology provides compounds according to Formula I or Formula III as well as compositions including such compounds useful for the treatment of metastatic cancer and/or glaucoma.

Abstract: Described herein are microfluidic devices and methods that can separate and concentrate particles in a sample.

Abstract: An electronic device includes a processor, a volatile memory, and a non-volatile memory. The non-volatile memory stores a first operating system, and the electronic device works in a first working mode and a second working mode. When the electronic device is in the first working mode, a second operating system is run in the volatile memory. When the processor detects that the electronic device reaches a preset condition for entering the second working mode, the non-volatile memory is enabled, and non-system data in the volatile memory is moved to the non-volatile memory. The non-system data does not include the second operating system. After the movement of the non-system data is completed, the volatile memory is disabled, and the first operating system is run in the non-volatile memory, so that the electronic device enters the second working mode.

Abstract: Methods and devices for long term, cuffless, and continuous arterial blood pressure estimation using an end-to-end deep learning approach are provided. A deep learning system comprises three modules: a deep convolutional neural network (CNN) module for learning powerful features; a one- or multi-layer recurrent neural network (RNN) module for modeling the temporal dependencies in blood pressure dynamics; and a mixture density network (MDN) module for predicting final blood pressure value. This system takes raw physiological signals, such as photoplethysmogram and/or electrocardiography signals, as inputs and yields arterial blood pressure readings in real time.

Abstract: An antenna electrode including a first electrode that includes a core and a first conductive surface; a second electrode that includes a second conductive surface; and an electrical tunnel junction between the first conductive surface and the second conductive surface, the tunnel junction having a gap width greater than about 0.1 nm and less than about 10 nm.

Abstract: A method for attaching at least one optical fiber to a chip includes the steps of: providing at least one nanowaveguide of a chip including at least one nanowaveguide end to be attached to at least one off-chip fiber respectively; forming at least one oxide taper over or adjacent to each of the at least one nanowaveguide end; cleaving at least one fiber end; aligning the chip so that an end face of each of the at least one oxide taper is mechanically aligned substantially adjacent to each corresponding cleaved fiber end; and fusing each of the at least one oxide taper with each of the at least one fiber end respectively to modally couple each of the nanowaveguides to each of the at least one fiber end via each of the oxide tapers. A device for attaching at least one optical fiber to a chip is also described.

Abstract: The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.

Abstract: A suspension useful for AAV9-mediated intrathecal/intracisternal and/or systemic delivery of an expression cassette containing a hIDUA gene is provided herein. Also provided are methods and kits containing these vectors and compositions useful for treating MPSI and the symptoms associated with Hurler, Hurler-Scheie and Scheie syndromes.

Abstract: Techniques for automated titration of CPAP device for a subject include receiving multiple ultrasound images representing a cross section of an airway in a neck of the subject at corresponding different times. Multiple different positive pressure values imposed by a device on the airway of the subject are also received at each of the corresponding times. For each of the ultrasound images, a mask of pixels associated with an air-tissue interface is automatically formed, and a value of a statistic of pixels within the mask is automatically determined. A titration pressure for a continuous positive airway pressure (CPAP) device is automatically determined based on the positive pressures and the value of the statistic for each of the ultrasound images. Output data that indicates the titration pressure for the CPAP device is presented on a display device, such as by operating the CPAP device itself at the titration pressure.