Abstract: Systems and methods for intermedullary bone fracture fixation are described herein. The fixation device includes a main body having a flexible state and a rigid state. The fixation device further includes a proximal interface coupled to a proximal end of the main body to anchor the fixation device to an exterior surface of the bone and a distal interface coupled to a distal end of the main body to anchor the fixation device to an interior cavity of the bone. The fixation device further includes a locking interface to configured to convert the main body from the flexible state to the rigid state.

Abstract: Disclosed is a surface plasmon resonance sensor. The surface plasmon resonance sensor includes an optical fiber; a microfiber provided at an end of the optical fiber; and a nanostructure provided in a specific region of the microprobe. The specific region of the microprobe is present at a position separate by a predetermined distance from the end of the optical fiber, and, in the nanostructure, a conductive layer is provided at an interval of a nano size at each of both sides of an insulating layer.

Abstract: A reference image encoding method is provided, including: encoding sequence, to obtain a reconstructed image of a first and second reference images; determining whether a local area in the second reference image is suitable for updating first reference image; determining whether the first reference image is updated; when the first reference image is not updated, and it is determined the second reference image is suitable for updating the first reference image, replacing a pixel value of a corresponding area or a related area in the first reference image with a pixel value of the local area in the second reference image; and compiling, into the bitstream.

Abstract: A measurement apparatus for micro- and nano-scale materials and a measurement method thereof are provided. The measurement apparatus for the micro- and nano-scale material includes a transmission electron microscope to generate a magnetic field, and a conductive flat punch and a sample which are arranged in the magnetic field. The sample includes the micro- and nano-scale materials. When the current passes through the sample and the conductive flat punch, the conductive flat punch deflects laterally relative to the sample with controllable displacement driven by the electromagnetic force. The required lateral displacement of the present invention is controllable, so that the utilization rate of equipment is greatly increased, and the cost is reduced. In addition, the whole test is performed in the transmission electron microscope, so that a measurement process can be observed in real time.

Abstract: This document relates to methods and materials for assessed, monitored, and/or treated mammals (e.g., humans) having cancer. For example, methods and materials for identifying a mammal as having cancer (e.g., a localized cancer) are provided. For example, methods and materials for assessing, monitoring, and/or treating a mammal having cancer are provided.

Abstract: The present invention provides a sustained drug delivery system for the treatment of age-related macular degeneration (AMD), comprising corticosteroid encapsulated nanoparticles incorporated into a thermoreversible hydrogel. The corticosteroid may be triamcinolone acetate (TA), dexamethasone, or loteprednol etabonate (LE). The proposed drug delivery system is nontoxic to ARPE-19 (retinal pigment epithelium) cells and significantly reduces VEGF (vascular endothelial growth factor) expression as compared to solutions of the coticosteroids. The present invention provides sustained delivery of the corticosteroid to the posterior segment of the eye, reducing the frequency of intraocular injections necessary to maintain therapeutic concentrations.

Abstract: The disclosure in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.

Abstract: A new alga having an improved ability to produce a pigment is disclosed. When the new alga is used, a carotenoid-based pigment, specifically, a xanthophyll can be produced by consuming less energy, so that it is possible to efficiently produce the pigment at the industrial level. The pigment can be applied as a raw material for a food, a health functional food and a medicine, which include the pigment. Since a DNA fragment is not likely to be inserted into a target base sequence or a base sequence other than the target, it is expected that the procedure of constructing the mutant is not regulated as a GMO, so that it is expected that the procedure of constructing the mutant can create a big economic effect in terms of an industry which produces lutein and zeaxanthin by using microalgae.

Abstract: The invention provides a hydrogel network comprising a plurality of hydrogel objects, wherein each of said hydrogel objects comprises: a hydrogel body, and an outer layer of amphipathic molecules, on at least part of the surface of the hydrogel body, wherein each of said hydrogel objects contacts another of said hydrogel objects to form an interface between the contacting hydrogel objects. A process for producing the hydrogel networks is also provided. The invention also provides an electrochemical circuit and a hydrogel component for mechanical devices comprising a hydrogel network. Various uses of the hydrogel network are also described, including their use in synthetic biology and as components in electrochemical circuits and mechanical devices.

Abstract: A system of an amusement park attraction includes an optical sensor configured to detect light and provide optical data based on the detected light and a controller having circuitry communicatively coupled to the optical sensor. The controller is configured to receive the optical data, process the optical data to detect a first movement of a user and a second movement of a handheld or wearable object, detect a correlation between the first movement and the second movement, and associate the handheld or wearable object with the user based on the correlation.

Abstract: A sensing substrate including a substrate, a quantum well structure, a sensing surface and metal nanoparticles is provided. The quantum well structure is disposed on the substrate, and the quantum well structure includes at least one first metal nitride layer and second metal nitride layers. The first metal nitride layers and the second metal nitride layers are stacked on the substrate in alternation manner. The quantum well structure is located between the sensing surface and the substrate. The metal nanoparticles are disposed on the sensing surface, and the sensing surface is a rough surface. A manufacturing method of the sensing substrate and a sensor are also provided.

Abstract: The present invention provides a telescopic jacking stepwise rollback-type reel sprinkling irrigation machine, including a chassis, a locking-type reel, a sprinkling irrigation apparatus, and a stepwise driving apparatus. A locking channel in a circumferential direction is disposed on the locking-type reel. The stepwise driving apparatus includes a lifting cylinder, an upper caliper, and a lower caliper, and the upper caliper and the lower caliper are clamped to be mounted on the locking channel. Pressurized water is used in the telescopic jacking stepwise rollback-type reel sprinkling irrigation machine to drive the lifting cylinder to realize periodic lifting motion of the piston rod, so as to drive the upper caliper to move up and down to be engaged with the locking channel of the locking-type reel intermittently, thereby driving the locking-type reel to roll back intermittently to automatically reel in a sprinkling irrigation PE hose.

Abstract: In a mechanism for recycling energy from stairs (200), a step platform (210) is moveable between an upper and lower position. An energy storage device (220), coupled to the platform (210), stores energy when a downward force is applied thereto, causing the step platform (210) to move to the lower position. The energy storage device (220) also releases stored energy as the step platform (210) moves from to the upper position. A controllable locking mechanism (240) locks the step platform (210) in the lower position when the downward force has caused the step platform (210) to move into the lower position. A sensor (250) determines when a downward force has been applied to the next higher step platform (250). A controller (300) signals the controllable locking mechanism (242) to unlock the step platform (250) when the step platform (250) is in the lower position and when the downward force has been applied to the next higher step platform (250).

Abstract: A scanning tunneling microscopy based potentiometry system and method for the measurements of the local surface electric potential is presented. A voltage compensation circuit based on this potentiometry system and method is developed and employed to maintain a desired tunneling voltage independent of the bias current flow through the film. The application of this potentiometry system and method to the local sensing of the spin Hall effect is outlined herein, along with the experimental results obtained.

Abstract: A method for forming an antifuse on a substrate is provided, which comprises: forming a first conductive material on the substrate; placing the first conductive material in an electrolytic solution; performing anodic oxidation on the first conductive material to form a nanowire made of the first conductive material and surrounded by a first dielectric material formed during the anodic oxidation and to form the antifuse on the nanowire; and forming a second conductive material on the antifuse to sandwich the antifuse between the first conductive material and the second conductive material.

Abstract: Provided is a combined pharmaceutical composition of HF and an Artemisia annua sesquiterpene lactone compound for treating cancers. The active ingredients of the combined pharmaceutical composition consist of HF and an Artemisia annua sesquiterpene lactone compound. HF and ATS have significant synergistic effect. The activity of the combined pharmaceutical of HF and ATS is comparable or even higher than that of the anti-cancer drug 5-FU.

Abstract: Provided is a computing device according to an embodiment of the present disclosure including an integrated register file configured to store a first variable type and a first variable value of a first variable, and a second variable type and a second variable value of a second variable, a calculator configured to perform a first calculation on the first and second variables according to the first and second variable types, and output a first calculation result, and a type rule table comprising a plurality of entries and, when there is an entry corresponding to a type of the first calculation, and the first and second variable types, configured to output a type of the first calculation result.

Abstract: A heating and/or cooling device having one or more thermoelectric threads. The thermoelectric thread includes a plurality of individual thermoelectric elements, each thermoelectric element having a first side and a second side. A set of first side electrodes connects at least some of the thermoelectric elements at the first side, and a set of second side electrodes connects at least some of the thermoelectric elements at the second side. An electrically insulative covering at least partially surrounds the plurality of individual thermoelectric elements. The electrically insulative covering is configured to be woven into or otherwise integrated with a fabric.

Abstract: The present disclosure provides methods of modulating a feature of a behavioral state. The methods involve inhibiting or activating the activity of a bed nucleus of stria terminalis (BNST) neuron, a BNST subnucleus, or a neuronal output to or from a BNST neuron. Animals encounter environmental conditions that require rapid switching among different behavioral states to increase the likelihood of survival and reproduction.

Abstract: A modified Streptococcus aureus Cas9 (SaCas9) protein with a mutation at an N413 position, and optionally one or more of a nuclear localization sequence, a cell penetrating peptide sequence, an affinity tag and/or a fusion base editor protein, and a kit that comprises said modified protein. A method for altering the genome of a cell, the method including the step of using the modified protein of the invention.