Abstract: Systems, methods, and devices having improved conformal properties for biomedical signal measurement are disclosed. A device can have a first polymer substrate coupled to a conductive layer forming a conductive trace electrically coupled to a conductive pad exposed via an opening. The device can have a second polymer substrate forming a first cavity between the first polymer substrate and the second polymer substrate. The device can have a first inlet portion that receives a fluid that expands the first cavity causing the device to conform to an anatomical structure. The structure can be an atrium, such as the left atrium, of the heart of a patient. The device can conform to the walls of the tissue structure, and the conductive pad exposed via the opening can detect a signal from the wall of the tissue structure. The signal can be provided to an external measurement device for processing.

Abstract: An example of a three-dimensionally printed object includes a bulk portion having a ferritic microstructure; and a site-specific alloyed section having a pearlite microstructure. The three-dimensionally printed object may be generated using different examples of a three-dimensional (3D) printing method. Each example of the 3D printing method utilizes a two-stage heat treatment.

Abstract: Disclosed is a compound of formula (I), in which R1, R2, R3, R4, R5, X1, X2, X3, X4, and X5 are described herein. The small molecule compounds of formula (I) activate the functional activity of relaxin family peptide receptor 2 (RXFP2), thereby providing therapeutic treatments for a variety of disorders, such as a bone disorder, hypogonadism, cryptorchidism, polycystic ovary syndrome, cancer, infertility, or an ocular wound.

Abstract: A body temperature measuring probe comprises a temperature sensor, a heating assembly and a position control assembly; the position control assembly controls contact or separation between the heating assembly and temperature sensor. A method for measuring body temperature comprises: starting the temperature sensor; preheating the body temperature measuring probe to a preset temperature range; once the body temperature measuring probe is preheated to the preset temperature range, separating the heating assembly from the temperature sensor, and only making the temperature sensor participate in a thermal equilibrium process of the body temperature measurement; the temperature sensor working to obtain body temperature measurement data.

Abstract: A method of cracking a hydrocarbon including contacting the hydrocarbon with a catalyst; where on the contacting, the hydrocarbon is cracked into a plurality of compounds, each having a smaller number of carbon atoms than the hydrocarbon. The catalyst includes an aluminosilicate zeolite, the aluminosilicate zeolite includes a weight ratio of SiO2 to Al2O3 of 10-200:1. Particles of the aluminosilicate zeolite have a flake shape with an average longest dimension of 10 nanometers (nm) to 50 nm and the flakes are stacked on top of one another.

Abstract: Provided are photocurable resins comprising a poly(siloxane)-based copolymer together with a photoinitiator, and other optional ingredients such as a photocurable diluent, a photoabsorber, a photosensitizer, or a hydrophillic additive. Also provided are methods of stereolithographically printing a 3-D object from a disclosed resin. Also provided is an improved method for stereolithographically printing a 3-D object, the improvement comprising the use of a disclosed photocurable resin. Further provided is a 3-D microfluidic device such as an artificial lung prepared from a disclosed photocurable resin.

Abstract: Provided are a self voice training method for a patient with a voice disorder and a user terminal for self voice training. The user terminal for self voice training includes an input device configured to receive a training program selection command of a user, a storage configured to store voice training candidate programs for the user's voice training, a calculator configured to generate first guide content according to a first voice training program selected from among the voice training candidate programs by the user, an output device configured to output the first guide content, and a microphone configured to receive voice output by the user according to the first guide content output through the output device.

Abstract: Provided herein are novel antibacterial compounds of Formula I. The compounds can be made through enzymatic oxidative dimerization in the presence of a suitable organism and one or more metal salts. Pathogenic bacteria exposed to the compound of Formula I do not develop resistance to these compounds even after prolonged exposure. Also provided herein are methods of treating bacterial infections, and method of killing or disinfecting bacteria.

Abstract: A method of hydrogen (H2) generation includes hydrolyzing a borohydride salt in an aqueous solution including a catalyst to form gaseous hydrogen. The catalyst is a bismuth(III) oxide-doped silicon dioxide with an amount of bismuth(III) oxide from 2 wt. % to 12 wt. % based on a total weight of the bismuth(III) oxide-doped silicon dioxide. The bismuth(III) oxide is dispersed in silicon dioxide in the catalyst. The weight ratio of the catalyst to the borohydride salt present in the aqueous solution is from 0.1:2 to 7:1 and a rate of hydrolysis of the borohydride salt in the presence of the catalyst is 2 to 3 times greater than a rate of hydrolysis of the borohydride salt in the absence of the catalyst.

Abstract: 4-Hydroxyphenyl-2H-indazol-5-ol compounds are estrogen receptor beta ligands that have immunomodulatory properties and increase oligodendrocyte survival, differentiation, and remyelination. The compounds, compositions, and kits are useful in the treatment of multiple sclerosis and endometriosis.

Abstract: The present disclosure describes a computational imaging system that uses a supervised learning algorithm to jointly process the captured image data to identify task-optimal hardware settings and then uses the task-optimal hardware settings to dynamically adjust its hardware to improve specific performance. The primary application of this device is for rapid and accurate automatic analysis of images of biological specimens.

Abstract: A fermented milk for improving autonomic nervous function containing at least one lactic acid bacterial species of the genus Lactobacillus and its metabolite. The lactic acid bacterial species of the genus Lactobacillus is selected from the group consisting of Lactobacillus delbrueckii, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus gasseri, Lactobacillus rhamnosus and Lactobacillus acidophilus. The lactic acid bacterial strain of the genus Lactobacillus is preferably Lactobacillus delbrueckii subsp. bulgaricus OLL1073R-1(FERM BP-10741).

Abstract: A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel.

Abstract: Provided herein are, inter alia, methods of identifying agents that are capable of inhibiting the binding (e.g., coupling) between a ROR1 protein and a ROR2 protein. By interfering with ROR1-ROR2 coupling (binding) the agents identified using the methods provided herein inhibit non-canonical Wnt5a signaling. Thus, the agents identified by the methods provided herein may, inter alia, be useful for cancer diagnosis and therapy.

Abstract: The present invention discloses a method for preventing dsRNA bacterial solutions from being degraded by UV light and application thereof in control of silverleaf whiteflies which relates to technical field of pest control. The method for preventing dsRNA bacterial solutions from being degraded by UV light of present invention is to mix dsRNA bacterial solutions with nanomaterial solutions to prepare mixed solutions of nanomaterial as well as dsRNA bacterial solutions, wherein the nanomaterial is one of MON, Fe3O4, TiC and SiC. Nanomaterials are used to protect dsRNA bacterial solutions from being degraded by UV light, so that lethal effect of dsGawky on silverleaf whiteflies can achieve purpose of pest control. The method is easy to operate, low in cost, good in effectiveness as well as sensitivity, high in insecticidal efficiency, and has other advantages such as environmental friendliness as well as good application prospects.

Abstract: Embodiments of the instant disclosure relate to intraocular drug delivery devices for and methods of, delivering at least one therapeutic agent to an eye of a subject. Methods include implanting an intraocular implant into the eye and adjacent to a fluid-permeable membrane of the eye of the patient. Intraocular implants are supported in a position at a surface of the fluid-permeable membrane. Intraocular implants include a drug delivery component having at least one therapeutic agent embedded within a non-bioerodible, non-biodegradable polymer matrix. Devices and methods disclosed herein can further include delivering the at least one therapeutic agent to the eye of the subject according to a near zero-order elution rate of the at least one therapeutic agent.

Abstract: In an aspect, there is provided a method for diagnosing or prognosing a subject with cancer, the method comprising: providing cancer DNA sequencing data from a cancer sample comprising cancer DNA from the subject; comparing the cancer DNA sequencing data with control DNA sequencing data to determine genetic aberrations; determining, from the genetic aberrations, the clonal and subclonal populations present in the sample; constructing a phylogenetic map of the clonal and subclonal populations; assigning to the subject a risk level associated with a better or worse patient outcome or response to therapy; wherein a relatively higher risk level is associated with a higher level of evolution and number of subclonal populations and a relatively lower risk level is associated with a lower level of evolution and number of subclonal populations.

Abstract: A three-dimensional imaging method and system for surface comprehensive geophysical prospecting, the method includes: acquiring detection data of a plurality of two-dimensional profiles of a surface detection site; forming two-dimensional profile resistivity data by geophysical inversion of the detection data; performing three-dimensional coordinate conversion on the two-dimensional profile resistivity data to obtain resistivity data of a three-dimensional coordinate system; and converting the resistivity data of the three-dimensional coordinate system into a three-dimensional model by using a Kriging interpolation method.

Abstract: The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.

Abstract: Compounds and methods of treating HIV-1 in a human infected with HIV-1 or preventing HIV-1 infection in a human susceptible to infection with HIV-1 are provided. The compounds are of formula (I), (II), and (IA), wherein R1-R7, X, X?, Y, Y?, Z, and n are defined herein, and the methods comprises administering therapeutically effective amounts of these compounds to the human.