Abstract: The present disclosure relates to synthesis of porous polymer networks and applications of such materials. The present disclosure relates to a method of fabricating of a porous polymer network comprising: (a) providing: (i) a first reactant comprising a plurality of compounds comprising at least one acetyl group, said plurality of compounds comprising at least one compound type, and (ii) a second reactant comprising an alkylsulfonic acid, and (b) creating a solution of said reactants, (c) casting said solution in a form, and (d) treating said solution under such conditions so as to produce a porous polymer network.

Abstract: Disclosed herein are superconducting gantry magnets that include multiple quadrupole winding sections placed in sequence on a curve such that the effective current direction is reversed between sections. This produces alternating quadrupole field regions along the length of the bend whose individual integral strengths can be tuned by the location of the current polarity transitions. A simple transition scheme to reverse the current between sections can be implemented to allow for the use of one continuous winding and power supply. Dipole windings can be included in the superconducting gantry magnets so that the magnets produce superposed dipole and alternating quadrupole fields. The disclosed design for the windings and transition scheme to reverse current polarity can be implemented for higher order multipoles as well.

Abstract: The present invention provides an isolated or recombinant Fn14-binding protein comprising an antigen binding do main, wherein the antigen binding domain binds specifically to Fn14 or a cell expressing Fn14.

Abstract: Provided is a method for controlling smooth switching of an operation direction of a bidirectional resonant CLLC circuit, which applies to the bidirectional resonant CLLC circuit. The method includes the following steps: Step 1: detecting a current circuit state and controlling the bidirectional resonant CLLC circuit to operate in a forward operation state by means of a primary bridge and a secondary bridge, by a controller; Step 2: performing Step 3 when an externally transmitted reference signal received by the controller or an internal preset reference signal in the controller is an operation direction switching signal; Step 3: performing frequency conversion control, by the controller; Step 4: performing preparation of phase shift control and generating a driving signal of the secondary bridge, by the controller; Step 5: performing the phase shift control, by the controller; and Step 6: switching a circuit operation state to an inverse operation mode.

Abstract: The present invention relates to the use of silver(I) monophosphine complexes as Active Pharmaceutical Ingredients (API's), including anticancer agents, for the treatment, diagnosis and/or prevention of cancer. The present invention also relates to pharmaceutical compositions containing such complexes and further extends to a method of treating or diagnosing a subject/patient suffering from cancer.

Abstract: Provided herein are methods of altering enantiomeric excess. The methods may include irradiating an atropisomer that includes at least one chiral substituent to alter the enantiomeric excess of the atropisomer. The at least one chiral substituent may be removed following irradiation.

Abstract: A fluid sensing device includes an outer body having a fore side, an aft side, and an interior space, the outer body including a fluid inlet disposed at the fore side; an inner body extending at least partially out of the fluid inlet of the outer body along a longitudinal axis; one or more vents disposed aft of the fluid inlet to allow passage of fluid through the fluid sensing device; and at least one load sensor coupled to the inner body to measure a fluid drag force on the inner body, wherein the inner body is configured to induce the Coanda effect in at least a portion of a fluid contacting the inner body at an angle transverse to a longitudinal axis of the inner body.

Abstract: An apparatus measures the transverse profile of vectorial optical field beams, including at least the directional intensity complex amplitude, the phase and the polarization spatial profile. The apparatus contains a polarization separation module, a weak perturbation module, and a detection module. Characterizing the transverse profile of vector fields provides an optical metrology tool for both fundamental studies of vectorial optical fields and a wide spectrum of applications, including microscopy, surveillance, imaging, communication, material processing, and laser trapping.

Abstract: In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.

Abstract: Optical component and methods for forming optical components are described. The optical component includes a substrate having a base and a fin extending from the base, a buffer layer formed on the substrate leaving a portion of the fin exposed, and a confinement layer deposited over the buffer layer and the fin. The refractive index of the substrate is greater than the refractive index of the confinement layer, and the refractive index of the confinement layer is greater than the refractive index of the buffer layer.

Abstract: An impedance based biosensor and method for detecting a target biomolecule in a sample are provided. The biosensor has a substrate, and first and second spaced-apart electrodes disposed at the substrate. A molecular recognition element (MRE) for binding with the target is bound to the substrate between the first and second electrodes. The biosensor also has a nanoparticle having an MRE bound to its surface. In the presence of the target, the nanoparticle is immobilized between the first and second electrodes due to binding of the target biomolecule with the first MRE and binding of the target biomolecule with the second MRE. A measurable change in electrical impedance across the first and second electrodes occurs due to the immobilization of the nanoparticle between the first and second electrodes.

Abstract: An example of a system may include a lead including a distal electrode portion. The distal electrode portion may be configured to at least partially encircle a sympathetic chain in a lumbar region or thoracic region. The distal electrode portion may include at least one electrode oriented toward the sympathetic chain when the distal electrode portion at least partially encircles the sympathetic chain. The distal portion may include at least one anchoring site configured for use to mechanically secure the distal electrode portion to tissue proximate to the sympathetic chain. The lead may have a strain relief proximate to the distal electrode portion.

Abstract: A system and methodologies for pattern representation and recognition are provided. A method includes acquiring a representation associated with discriminating information associated with a subject, retrieving an association between a stored representation and an identity of the subject, determining a discrimination score as a function of the representation and the stored representation based on a neighbor similarity score and relationship contextualization process parameters, and executing one or more control actions based on the discrimination score.

Abstract: A method for capturing CO2 comprising dissolving at least one pure amino acid (AA) in water without the use of a catalyst for establishing protonation of an amino group of the amino acid, adding at least one base solution to the amino acid and water solution to deprotonate the protonated amino group of the amino acid and forming an amino acid-XOH—H2O wherein X is sodium or potassium, and subjecting CO2 to the amino acid-XOH—H2O to form new nanomaterials is provided. A regenerable nanofiber is disclosed comprising a NaHCO3 nanofiber, a KHCO3 nanofiber, or an amino acid nanofiber made from subjecting a CO2 gas to an amino acid aqueous solvent. Preferably, the amino acid aqueous solvent is one or more of a Gly-NaOH—H2O, an Ala-NaOH—H2O, a Phe-NaOH—H2O, a Gly-KOH—H2O, an Ala-KOH—H2O, and a Phe-KOH—H2O.

Abstract: The present invention relates to the field of Wilson Disease. More specifically, the present invention provides methods and compositions useful for treating Wilson Disease by targeting liver nuclear receptors. In a specific embodiment, a method for treating Wilson Disease in a subject comprises the step of administering to the subject an effective amount of a liver X receptor (LXR) agonist.

Abstract: A dark field endoscopic microscope includes an illumination system, an objective lens unit arranged in an optical path of the illumination system, an optical fiber bundle optically coupled to the objective lens unit, and an observation system arranged in an optical return path from the optical fiber bundle. The illumination system provides oblique off-axial illumination while axial rays are at least attenuated.

Abstract: A photovoltaic device, comprises (1) a first conductive layer, (2) an optional blocking layer, on the first conductive layer, (3) a semiconductor layer, on the first conductive layer, (4) a light-harvesting material, on the semiconductor layer, (5) a hole transport material, on the light-harvesting material, and (6) a second conductive layer, on the hole transport material. The light-harvesting material comprises a perovskite absorber, and the second conductive layer comprises nickel. The semiconductor layer may comprise TiO2 nanowires. The light-harvesting material may comprise a perovskite absorber containing a pseudohalogen.

Abstract: Provided herein are polymers and methods for their use in binding a phosphate containing biological macromolecules. Specifically, the methods and uses provided herein may be used to inhibit thrombin binding to polyphosphate or as an antithrombotic agent for the treatment of stroke, acute coronary syndrome, pulmonary embolism, atrial fibrillation, venous and arterial thromboembolism, disseminated intravascular coagulation (DIC), deepvein thrombosis (DVT), peripheral artery disease, trauma-induced coagulopathy, extracorporeal circulation, cancer-associated thrombosis, sepsis, septic shock, Systemic Inflammatory Response Syndrome (SIRS), or inflammation.

Abstract: The presently-disclosed subject matter includes labels for use in the identification of shed ALCAM in s sample from a subject. Further included are methods for characterizing, monitoring, evaluating treatment efficacy, or evaluating the progression of cancer in a subject that comprise providing a biological sample from the subject, determining the presence or amount of shed ALCAM in the biological sample, and then comparing the presence or the amount of the shed ALCAM to a reference. Differences between the presence or amount of shed ALCAM relative to the reference can be used to diagnose, prognosticate, treat, monitor, or otherwise characterize a cancer in a subject. Further provided are kits comprising a reagent and/or antibody for diagnosing, prognosticating, monitoring, or otherwise characterizing a cancer in a subject.

Abstract: Ion mobility spectrometry (IMS) systems, devices, and associated methods of operation are disclosed herein. In one embodiment, an IMS system includes an ionization region configured to receive and ionize a sample into ionized molecules and a detector configured to detect ionized molecules. The IMS system also includes a drift region in between and directly coupled to both the ionization region and the detector. The drift tube includes a first ion gate proximate the ionization region and a second ion gate proximate the detector. The first and second ion gates are configured to alternately introduce a batch of ionized molecules toward the detector while the other is maintained open, thereby allowing accurate measurement of a drift time of the ionized molecules corresponding to a drift length that is a distance between the first and second ion gates.