Abstract: The present invention relates to a fiber composite for a strain sensor and a method for producing the same. The composite includes a stretchable fiber; a conductive elastic polymer layer coated on the stretchable fiber; polymer beads disposed on the stretchable fiber or on the elastic polymer layer; and a conductive elastic polymer layer covering the polymer beads. The fiber composite is durable and stable. Therefore, a strain sensor produced using the fiber composite exhibits excellent durability, recoverability, repeatability and sensitivity, and a fast sensing speed.

Abstract: A compound that can be useful as emitters in an OLED that includes a ligand LA of Formula I is disclosed.

Abstract: We hereby disclose and claim a mathematically based system for design and implementation synthetic biology genetic circuitry architecture which uses genetic expression circuits which are linked together to achieve a therapeutic or diagnostic effect. The genetic architecture that enables the reversible and tunable desired gene product output is achieved by genetic control elements upstream and downstream of a promoter region. Reversible and tunable control is achieved through the computational design and pairing of transcriptional repression elements with their cognate transcriptional promoters to enable a broad range of therapeutic and diagnostic applications.

Abstract: Methods of minimizing dysregulation of Staufen1-associated RNA metabolism can include introducing an amount of a Staufen1 -regulating agent to a target cell sufficient to minimize the dysregulation. Therapeutic compositions for treating a neurodegenerative condition associated with Staufen1-induced dysregulation of RNA metabolism can include a therapeutically effective amount of a Staufen1-regulating agent and a pharmaceutically acceptable carrier.

Abstract: An ion beam generator includes a discharge chamber with a backplate and tubular sidewalk A source of propellant, for example, Xenon gas is provided to the discharge chamber. First and second annular magnets are disposed on or near the backplate, and configured with alternating polarities such that a pair of ring-cusps form on the backplate, without any magnetic ring-cusp formation on the sidewalk A cathode assembly extends into the discharge chamber to provide primary electrons to ionize the propellant.

Abstract: The present disclosure discloses a laboratory test device for permeation grouting of impermeable material, which comprises a slurry storage device with a stirrer, a grouting pump, electromagnetic flow meters, pressure sensors, a pressure chamber, a slurry collection tank, a pH value meter, a conductivity meter, electronic scales, an image acquisition system and a computer system. The computer system automatically acquires related data to save the labor, and the data is recorded completely so as to facilitate tests and researches. Software installed in the computer system can automatically process the data and displays a permeability coefficient in real time so as to achieve quick determination and real-time display of the permeability coefficient and facilitate development of laboratory tests and researches. Three pressure sensors are arranged on an organic glass cylinder of the pressure chamber at the equal intervals.

Abstract: A plasma polymerized thin film having low dielectric constant prepared by depositing a first precursor material represented by the following Chemical Formula 1: wherein in the above Chemical Formula 1, R1 to R14 are each independently H or a substituted or non-substituted C1-C5 alkyl group, and when the R1 to R14 are substituted, their substituents comprise an amino group, a hydroxyl group, a cyano group, a halogen group, a nitro group, or a methoxy group.

Abstract: Disclosed are new small molecules having a pyrrolopyrimidine core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules which may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, includin neurological diseases and disorders such as Gaucher's disease and Parkinson's disease. The small molecules may be utilized to generate activated glucocerebrosidase. The activated glucocerebrosidase thusly generated can be administered in enzyme replacement therapy and/or utilized in screening assays for new small molecules that bind to the activated glucocerebrosidase and/or modulate the activity of the activated glucocerebrosidase.

Abstract: Provided are a diffraction grating device, a method of manufacturing the diffraction grating device, and an optical apparatus including the diffraction grating device. The diffraction grating device includes a diffraction grating arranged on a light reflection substrate. The diffraction grating includes a plurality of diffraction elements, each diffraction element from among the plurality of diffraction elements having a height that causes a destructive interference between first light rays reflected by a top surface therefore and second light rays reflected by a bottom surface thereof, the first and second light rays being incident on the top and bottom surfaces, respectively, at an incidence angle greater than 45°.

Abstract: The present invention relates to certain heterocyclic compounds of formula (1) that have the ability to inhibit lysine biosynthesis via the diaminopimelate biosynthesis pathway in certain organisms. As a result of this activity these compounds can be used in applications where inhibition of lysine biosynthesis is useful. Applications of this type include the use of the compounds as herbicides.

Abstract: Single crystals of a new noncentrosymmetric polar oxysulfide SrZn2S2O (s.g. Pmn21) grown in a eutectic KF—KCl flux with unusual wurtzite-like slabs consisting of close-packed corrugated double layers of ZnS3O tetrahedra vertically separated from each other by Sr atoms and methods of making same.

Abstract: There is provided a method of sensitising a eukaryotic cell to ultrasound stimulation, said method comprising increasing the mechano-sensitivity of a transmembrane ion channel of the cell to ultrasound by introducing a plurality of entire exogenous gas vesicles proximal to the surface of the cell.

Abstract: A system comprises a waveguide apparatus comprising a plurality of input waveguides, a multimode waveguide, and a guided-wave transition coupling the plurality of input waveguides to the multimode waveguide. The system further comprises at least one light source configured to excite in turn each of a plurality of the input waveguides, or each of a plurality of combinations of the input waveguides, thereby generating a plurality of different light patterns in turn at an output of the waveguide apparatus. The waveguide apparatus is configured to direct each of the plurality of different light patterns to a target region. The system further comprises at least one detector configured to detect light transmitted, reflected or emitted from the target region in response to each of the different light patterns, and to output signals representing the detected light.

Abstract: The disclosure extends to biodegradable hollow nanoparticles, and systems, methods, devices, and processes for producing the same. The disclosure includes a method of preparing a hollow mesoporous nanoparticle by providing a plurality of silica core particles. Each of the plurality of silica core particles comprises a diameter within a range of about 600 nanometers to about 30 nanometers. The method further includes synthesizing a mesoporous silica shell around the plurality of silica core particles forming a plurality of mesoporous coated silica core particles. Further, the method provides for etching the plurality of mesoporous coated silica core particles with an aqueous solution of sodium carbonate and water to remove the silica core particle from the plurality of mesoporous coated silica core particles forming a plurality of hollow mesoporous particles. The method also includes diffusing a payload into the plurality of hollow mesoporous particles in an aqueous solution.

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for Fc?RIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

Abstract: The present disclosure is directed to antibodies binding to and neutralizing Poxvirus and methods for use thereof.

Abstract: The invention relates to methods for modulating the immune function through targeting of CLIP molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmune disease, cancer, Alzheimer's disease, allergic disease, transplant and cell graft rejection, HIV infection and other viral, bacterial, and parasitic infection, and AIDS. Methods are also provided for preparing a peptide having the property of being able to displace CLIP by feeding one or more peptide sequences into software that predicts MHC Class II binding regions in an antigen sequence and related products.

Abstract: The present disclosure discloses a feedback field-effect array device capable of converting between volatile and non-volatile operations and an array circuit using the same. According to one embodiment of the present disclosure, the array circuit may include a plurality of feedback field-effect array devices, wherein the source region of the feedback field-effect electronic device and the drain region of an access electronic device may be connected to each other in series, the feedback field-effect electronic device may be connected to a bit line and a first word line, the access electronic device may be connected to a source line and a second word line, and any one of first and second gate voltages may be applied to the first word line to store data in a first logic state or data in a second logic state.

Abstract: A variable-size fully-automatic 3D printing system based on a cylindrical coordinate system includes a base provided with a retractable work platform; the base is provided with a vertical support side plate on a side thereof; an upper end of the support side plate is connected to a top plate, and the top plate is located directly above the base; a lower side of the top plate is connected to a sleeve via a column seat; a lower end of the sleeve is provided with a protrusion; a lower end of the protrusion is connected with a cross beam; a lower side of the cross beam is provided with a ball screw a, one end of the ball screw a is connected to a power end of a first servo motor disposed at an outer end of the cross beam.

Abstract: Methods are disclosed for reducing the proliferation of a tumor cell, increasing apoptosis of a tumor cell, and/or decreasing migration of a tumor cell. These methods include contacting the tumor cell with an effective amount of solubilized ECM or a soluble fraction of extracellular matrix (ECM), thereby reducing the proliferation of the tumor cell, increasing apoptosis of the tumor cell, and/or decreasing migration of the tumor cell. Methods are also disclosed for treating a subject with a tumor. The methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a soluble fraction of an ECM and a pharmaceutically acceptable carrier, thereby treating the tumor in the subject. In specific non-limiting examples, the tumor is a glioma and/or the ECM hydrogel is a urinary bladder ECM hydrogel.