Abstract: The invention provides an antibacterial compound of formula I: or a salt thereof, as well as an antibacterial compound of formula II: or a salt thereof, wherein R1, R2, X, Y and n have any of the values defined in the specification.

Abstract: Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.

Abstract: A power morcellation system, apparatus, and methodology. Structurally, the device includes a sturdy, pliable (e.g., able to be inserted and retracted through a 10-15 mm morcellator port), distensible, waterproof/watertight retaining bag/pouch/carrier to be deployed into the pelvic cavity of the subject. The device further includes a plurality (e.g., three (3)) of port tube channels extending outwardly from the bag, wherein the interior of each channel is in communication with the interior of the bag. Each channel has an open end (opposite from the end that terminates in the bag) through which a laparoscopic/robotic camera and other instruments (e.g., camera, control instrument) may pass. A smaller tube channel also extends outwardly from the bag and can be suited as an insufflation port channel, among other uses. The bag also includes a large opening surrounded by an elastic drawstring for receiving the specimen to be removed within the bag.

Abstract: Methods, systems, and devices are disclosed for implementing an exemplary immersion mode ice spectrometer. In order to increase sample throughput and improve accuracy of Ice Nucleating Particle (INP) freezing temperature measurement, the exemplary immersion mode ice spectrometer both increases sample cooling rates and monitors changes in optical properties of water droplets during freezing.

Abstract: Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more PEG-conjugated lipids, and optionally one or more additional materials that physically and/or chemically stabilize the particles. The nanoparticle have an average diameter of about 100 nm to about 300 nm, preferably from about 100 nm to about 250 nm, more preferably from about 100 nm to about 200 nm. The particles are mobile in mucus. The liposomes can further contain one or more therapeutic, prophylactic, and/or diagnostic agent to be delivered to a mucosal surface, such as the CV tract, the colon, the nose, the lungs, and/or the eyes. The liposomes can further contain one or more CEST agents to allow real time imaging of the particles in a live animal. The particles may also further contain an imaging agent, such as a fluorescent label.

Abstract: This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary disease, chronic pancreatitis, chronic bronchitis, asthma, mucus formation, comprising administering an effective amount of a 2-amino-N?-benzylidene-acetohydrazide compound or derivative thereof to a subject in need thereof. In certain embodiments, the 2-amino-N?-benzylidene-acetohydrazide compound is ((E)-N?-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(m-tolylamino)acetohydrazide; or (E)-N?-(3,5-dibromo-2,4-dihydroxybenzylidene)-2-(p-tolylamino)acetohydrazide.

Abstract: Methods, systems, and devices are disclosed for implementing switchable dispensing and/or delivery of scented substances. In one aspect, a device includes a cartridge structured to include one or more chambers containing one or more scented substances contained in a corresponding chamber, a housing structured to include a compartment to hold the cartridge, an opening to allow the scented substances to dispense to an outer environment from the device, and one or more transporting channels formed between the compartment and the opening, in which each of the one or more transporting channels is configured to accelerate a scented substance from the corresponding chamber to the opening, and an actuator switch arranged in a corresponding transporting channel and operable to move between an open position and a closed position based on an applied signal to selectively allow passage of the scented substance from the corresponding transporting path.

Abstract: Provided is an information providing system for a system administrator not highly skilled in the arts of natural language or artificial intelligence to be able to easily correct or add a response to an input from a user to arrange the response into an appropriate one if the response is not appropriate. When an input sentence does not hit any knowledge data, the system administrator is able to add a combination of the input sentence and a response thereto by opening a new QA quick addition screen from a knowledge maintenance screen by pressing a link of the input sentence. Furthermore, the system administrator is able to easily add the input sentence to knowledge data as a synonymous sentence of a candidate Q, which is determined to be semantically close to the input sentence, by clicking the candidate Q on the knowledge maintenance screen.

Abstract: A method for transmitting downlink data in a multicast scheme by a base station in a wireless communication system is disclosed. The method includes receiving a first request signal requesting first data from a first user equipment (UE), receiving a second request signal requesting second data from a second UE, generating a transmission message by applying an exclusive OR (XOR) operation to the first data and the second data, and transmitting the transmission message to the first UE and the second UE in the multicast scheme.

Abstract: A traffic data stream aggregate query method and system includes the steps of acquiring spatial-temporal information of a mobile object to generate a traffic data stream, dividing data space into cells, grouping adjacent cells with similar frequency into few buckets, calculating Kalman gains of the buckets based on frequencies of the buckets, and indexing the buckets using a binary partition tree to form a BPT index of the current timestamp, and serializing the BPT after the end of the current timestamp to form a historical index; and performing aggregate query, wherein an optimum estimation value of the bucket frequency is utilized to replace for calculating when the frequency of the bucket changes a lot. The system includes: an information collection module, a data processing module, an index processing module, an application service module and an index storage module.

Abstract: The present invention relates to glucose-responsive hyaluronic acid nanoparticles having boronic acid compounds chemically bonded thereto, and a composition including the same. When the nanoparticles according to the present invention are used, cancer may be diagnosed and treated using a cancer cell-specific biological mechanism, without the use of existing contrast agents and anticancer agents which have the problem of toxicity.

Abstract: Methods, devices and systems are described for digitally creating new scents or digitally dispensing gas, vapor, or liquid substances.

Abstract: A method of producing hydrochar from jackfruit peel biomass includes hydrothermal carbonization of jackfruit peel biomass by autoclaving at 150° C.-250° C. for about 3 hours to produce a hydrochar. The hydrochar can be activated by treatment with phosphoric acid (H3PO4), hydrogen peroxide (H2O2), or a combination thereof. The hydrochar produced according to the method is particularly effective at removing azo-dyes, and specifically methylene blue, from aqueous solutions such as industrial waste water.

Abstract: The present invention concerns the use of emetine compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering an emetine compound such as emetine or cephaeline, or a combination of two or more emetine compounds, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.

Abstract: Provided herein, inter alia, are a carbon fiber-reinforced polymer composite and a method for manufacturing the same. The carbon fiber-reinforced polymer composite may improve interfacial bonding force by modifying the surface of carbon fibers with an amphiphilic block copolymer and then forming a composite of the surface-modified carbon fibers with a polymer.

Abstract: Methods and apparatuses for controlling transmission control protocol (TCP) send buffers in communication systems are provided. The method includes identifying a current round-trip time (RTT) value and a minimum RTT value in the TCP and adjusting a size of the send buffer based on at least one of a current operation, the current RTT value, and the minimum RTT value in a congestion control scheme according to the TCP.

Abstract: Systems and methods for management of a computer-based cache are provided. A system can include a processor, a cache, a memory device, and a storage device. The processor can be configured to evict a page from the cache to a history index based upon a greater weight respectively assigned to a least frequently used (LFU) and least recently used policy (LRU) policy, detect a requested page that was evicted to the history index, and adjust the respective weights assigned to the policies based upon the requested page being in the history index.

Abstract: It was found that bacteria belonging to the genus Clostridium induce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genus Clostridium or a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.

Abstract: A state estimation system includes a processor configured to: obtain first input data related to a first user; obtain second input data related to a second user; perform an estimation operation for estimating a state of the first user and a training operation for optimizing a content of the estimation operation by using i) first training data which includes the first input data and the first label data associated with each other, ii) second training data which includes the first input data so as not to associate the first input data and the first label data with each other, and iii) third training data which includes the second input data and the second label data associated with each other; and output information related to the content of the estimation operation.

Abstract: This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring hyaluronic acid, death receptor 5, and/or transforming growth factor ?1 can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury.