Abstract: Disclosed herein are methods of detecting or making a risk evaluation of a cancer that has a mutated PREX2 expressed thereon. The cancer may be a primary cancer, a metastatic cancer or a recurrent cancer. According to the embodiment of the present disclosure, the mutation is G258V, S1113R, E1346D or K400fs. Also disclosed herein are methods of treating the subject in need thereof.
Abstract: The purpose of the present invention is to enable, even in an endoscopic operation, an operation upon a specific operation site while monitoring the overall surgical site, such as an organ. An artificial magnetic field is generated such that a surgical site of a patient is positioned within a generated three-dimensional artificial magnetic field space. A plurality of magnetic sensors are respectively mounted in a plurality of predetermined locations of the surgical site of the patient. Data of a 3-D image of the surgical site and position information of the mounting locations of the magnetic sensors with respect to the surgical site are stored in a storage unit as position information of the mounting locations with respect to the 3-D image of the surgical site.
Abstract: According to some aspects, a cardiac pacemaker for implantation within a subject is provided, the pacemaker including a housing, at least one sensor configured to detect an activity level of the subject, and at least one processor coupled to the sensor configured to detect inactivity of the subject based on output from the at least one sensor, produce a first signal configured to increase the heart rate of the subject to a first heart rate during a first time period, wherein the first heart rate is above a resting heart rate and below 100 beats per minute, and in response to determining that the first time period has elapsed, producing a second signal configured to increase the heart rate of the subject to a second heart rate during a second time period, wherein the second heart rate is between 100 and 140 beats per minute.
Type:
Application
Filed:
October 6, 2017
Publication date:
February 6, 2020
Applicant:
The University of Vermont and State Agricultural College
Abstract: An apparatus including (i) a processor including a plurality of main buffer on board (BOB) memory controllers (MCs) and a secure engine, (ii) a plurality of simple BOB MCs, (iii) a secure delegator, and (iv) a plurality of memory modules. The secure delegator coupled to a first main BOB MC and a first simple BOB MC creates a secure channel. A second main BOB MC coupled to a second simple BOB MC creates a non-secure channel. The plurality of main BOB MCs, the secure engine and the secure delegator are provided within a trusted computing base (TCB) of the apparatus and the plurality of simple BOB MCs and the plurality of memory modules are provided outside the TCB. The secure delegator is configured to: (i) secure communication between the first main BOB MC and the secure delegator, and (ii) perform Path ORAM accesses to the plurality of memory modules.
Type:
Application
Filed:
July 30, 2019
Publication date:
February 6, 2020
Applicant:
University of Pittsburgh-Of the Commonwealth System of Higher Education
Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
Type:
Application
Filed:
October 8, 2019
Publication date:
February 6, 2020
Applicants:
NanoString Technologies, Inc., Board of Regents, The University of Texas System, Board of Regents, The University of Texas System
Inventors:
Joseph M. BEECHEM, Charles WARREN, Chris MERRITT, Jaemyeong JUNG, Dwayne L. DUNAWAY, Scott CROWDER, Kristina SORG, Gordon B. MILLS
Abstract: Radio frequency antennas sharing a ground plane are largely decoupled using one or more lumped capacitive elements set into holes within the ground plane. The holes, which are precisely placed, can extend to a side of the ground plane. A stub extends from a fringe of the hole either straight or bending in an L shape, and a capacitor connects between an end of the stub and another side of the hole. Capacitive elements can also be supported on raised solder pads above a ground plane or off to one side of the ground plane. Methods for manufacturing the decoupling apparatus are described.
Abstract: The present disclosure provides a method and system including a non-confocal microscope with an attached imaging fiber optic for direct and real time in-situ visualization of mammalian microscopic structures for diagnostic and therapeutic uses.
Type:
Application
Filed:
June 30, 2016
Publication date:
February 6, 2020
Applicant:
Indiana University Research and Technology Corporation
Abstract: A true random number generator with stable node voltage comprises a loop control logic, two inverters identical in structure, two D flip-flops identical in structure, a first PMOS transistor, a second PMOS transistor, a first NMOS transistor, a monitoring module and a post-processing module. Each inverter comprises a second NMOS transistor, a third NMOS transistor, a fourth NMOS transistor, a fifth NMOS transistor, a sixth NMOS transistor, a seventh NMOS transistor, an eighth NMOS transistor, a ninth NMOS transistor, a tenth NMOS transistor, a third PMOS transistor, a fourth PMOS transistor, a fifth PMOS transistor, a sixth PMOS transistor, a seventh PMOS transistor, an eighth PMOS transistor, a ninth PMOS transistor, a tenth PMOS transistor and an eleventh PMOS transistor. The true random number generator has the advantages of being able to eliminate the capacitive coupling effect and has high randomness.
Type:
Application
Filed:
May 21, 2019
Publication date:
February 6, 2020
Applicant:
Wenzhou University
Inventors:
Pengjun Wang, Hongzhen Fang, Gang Li, Bo Chen
Abstract: The present disclosure relates to an apparatus and method that can be used to remotely acquire high resolution depth resolved images from a sample. The apparatus employs an adapter to an imaging device, where the adapter uses a minimum of components to produce interferometry patterns on the input facet of the imaging device. The imaging device can be a bundle endoscope terminated on a camera sensor or on several camera sensors or simply a camera sensor. In conjunction with a swept source or a broadband source, at least one camera sensor may be employed to provide optical coherence tomography (OCT) images of the sample. When the imaging device uses a bundle of optical fibers, the apparatus and method can provide OCT images tolerant to bending of the bundle.
Type:
Application
Filed:
July 25, 2019
Publication date:
February 6, 2020
Applicant:
University of Kent
Inventors:
Adrian Podoleanu, Manuel Marques, Michael Hughes
Abstract: A system for and methods of analyzing a test sample through the use of a rotary apparatus that includes a microfluidic paper-based apparatus (mPAD). The apparatus includes two or more layers that are rotatable with respect to one another. A middle layer may comprise a microfluidic apparatus having one or more reagent channels. Each of the reagent channels may include reagent dried on the surface of the channel, and, together with an adsorption pad, may be aligned vertically with a sample chamber. Male and female engagement surfaces on each of the middle layer, the top layer, and the bottom layer interlock to secure each layers in vertical alignment so that fluid flows through the apparatus to contact a test sample with a reagent and facilitate detection of a target analyte in the test sample in the sample chamber.
Type:
Application
Filed:
August 2, 2019
Publication date:
February 6, 2020
Applicants:
Colorado State University Research Foundation, United States Department of Agriculture
Inventors:
Charles S. HENRY, Rachel FEENY, Alan B. FRANKLIN, Cody CARRELL
Abstract: Embodiments for systems and methods for optical pricing under diffusion-choice models, i.e., models combining consumer choice with diffusion, are disclosed.
Type:
Application
Filed:
August 2, 2019
Publication date:
February 6, 2020
Applicant:
Arizona Board of Regents on Behalf of Arizona State University
Abstract: An optical stimulation arrangement including a light-emitting device, implantable in an environment with an associated ground voltage, the light emitting device including: a light emitting element; an anode; and a cathode; and a controller for driving the light-emitting device in a biphasic manner.
Type:
Application
Filed:
September 29, 2017
Publication date:
February 6, 2020
Applicant:
University of Newcastle Upon Tyne
Inventors:
Patrick Degenaar, Fahimeh Dehkhoda, Ahmed Soltan, Hubin Zhao, Reza Ramezani
Abstract: An embodiment in accordance with the present invention provides a device that transfers dexterous control of computers from hands to feet. The device of the present invention is a wearable foot based control interface for computers with a user interface that allows for a high level of customization. The device of the present invention provides an option to effectively control computers using ones feet. An innovative sensor design according to the present invention provides high sensitivity and robust usability. A graphic user interface according to the present invention allows for significant user customization of output commands and input sensitivity. The device of the present invention is wearable and provides comfort and intuitive usability.
Abstract: A compliant robot includes a base and a compliant robot arm. The compliant robot arm includes a first quasi-direct drive assembly operatively connected to said base such that said compliant robot arm has at least one degree of freedom for motion relative to said base. The first quasi-direct drive assembly provides passive compliance such that said compliant robot arm has a back-drivable mode of operation for interactions between said compliant robot arm and an environment.
Type:
Application
Filed:
May 17, 2019
Publication date:
February 6, 2020
Applicant:
The Regents of the University of California
Inventors:
Stephen Alan McKinley, David Gealy, Pieter Abbeel
Abstract: A computing device is provided having at least one processor (104) operative to facilitate motion correction in a medical image file (102). The at least one processor (104) is configured to generate at least one unified frame file (110) based on motion image data (204), depth map data (206) corresponding to the motion image data, and region of interest data (200). Further, at least one corrected image file derived from the medical image file (102) is generated by performing the motion correction based on the at least one unified frame file (110) using the processor (104). Subsequently, the at least one corrected image file is outputted for display to one or more display devices (122).
Type:
Application
Filed:
April 9, 2018
Publication date:
February 6, 2020
Applicant:
Indiana University Research and Technology Corporation
Inventors:
Paul Richard Territo, Paul Salama, Juan Antonio Chong
Abstract: Provided herein are methods of treating cancer or an autoimmune disease comprising administering a liposome that comprises neutral phospholipids and a P-ethoxy oligonucleotide that targets a IGF-1R-encoding polynucleotide.
Type:
Application
Filed:
April 19, 2018
Publication date:
February 6, 2020
Applicants:
Bio-Path Holdings, Inc., Thomas Jefferson University
Inventors:
Ana Ashizawa, Douglas Craig Hooper, David W. Andrews
Abstract: Disclosed is a method of determining regulatory activity of nucleotides in a genome, which includes: (1) designating a reference region of the genome; (2) designating a plurality of reporter tiles covering the reference region, where each reporter tile has a length L, the reporter tiles are offset from one another within the reference region with a step sizes, and a ratio of s to L is 1:5 or less; and (3) generating a plurality of reporter constructs corresponding to the reporter tiles.
Type:
Application
Filed:
September 29, 2017
Publication date:
February 6, 2020
Applicants:
The Regents of the University of California, Massachusetts Institute of Technology