Abstract: Systems and methods for diagnosing prostate cancer. Image sets (e.g., MRI collected at one or more b-values) and biological values (e.g., prostate specific antigen (PSA)) have features extracted and integrated to produce a diagnosis of prostate cancer. The image sets are analyzed primarily in three steps: (1) segmentation, (2) feature extraction, smoothing, and normalization, and (3) classification. The biological values are analyzed primarily in two steps: (1) feature extraction and (2) classification. Each analysis results in diagnostic probabilities, which are then combined to pass through an additional classification stage. The end result is a more accurate diagnosis of prostate cancer.

Abstract: The present disclosure is directed to antibodies binding to prefusion and postfusion forms of both human S. aureus and human metapneumovirus F proteins, including neutralizing antibodies, and methods for use thereof.

Abstract: Provided herein are modified recombinant adeno-associated virus (rAAV) capsid proteins, such as modified rAAV1, rAAV5, and rAAV6 capsid proteins, rAAV particles comprising such capsid proteins, nucleic acid molecules encoding such capsid proteins, as well as compositions, kits and methods of use thereof.

Abstract: A drinking container system with multiple temperature zones, wherein the container system includes a main body having a sidewall and a bottom that define a phase change material (PCM) module receptacle, and a phase change material (PCM) module having a sidewall that defines a beverage chamber. The PCM module is disposable within the PCM module receptacle such that a beverage egress flow path is defined between the main body sidewall and the PCM module sidewall. The flow path formed in the container can make the beverage achieve the desired drinking temperature. The PCM module sidewall is at least partially filled with a phase change material and is structured and operable to provide a plurality temperature zones within the beverage chamber. Each temperature zone is operable to maintain a temperature of a respective portion of a liquid disposed within the beverage chamber within a respective temperature range.

Abstract: The present invention provides novel phenazine derivatives, such as compounds of Formula (I) (e.g., Formulae (II)-(XIX)), and pharmaceutically acceptable salts thereof. The compounds of the invention are expected to be antimicrobial agents and may act by a microbial warfare strategy (e.g., a reactive oxygen species (ROS)-based competition strategy). The present invention also provides pharmaceutical compositions, kits, uses, and methods that involve the compounds of the invention and may be useful in preventing or treating a microbial infection (e.g., a bacterial infection or mycobacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium or mycobacterium), killing a microorganism (e.g., a bacterium or mycobacterium), inhibiting the formation and/or growth of a biofilm, reducing or clearing a biofilm, and/or disinfecting a surface.

Abstract: A textile includes a substrate and a coating applied to a surface of the substrate. The coating includes a plurality of bilayers positioned one on top of the other. Each bilayer includes a first layer including a cationic polymer and a second layer comprising an anionic polymer. The cationic polymer in the first layer includes a polyethyleneimine (PEI), a poly(vinyl amine) (PVAm), a poly(allyl amine) (PAAm), a polydiallyldimethylammonium chloride (PDDA), or a chitosan (CH). The anionic polymer in the second layer includes a poly(acrylic acid) (PAA), a poly(styrene sulfonate) (PSS), a poly(methacrylic acid) (PMAA), a poly(sodium phosphate) (PSP), or a poly(vinyl sulfate) (PVS).

Abstract: A method of treating Alzheimer's Disease (AD) comprising administering to a subject in need thereof a therapeutically effective amount of a polynucleotide agent which downregulates an amount and/or activity of caspase-6 in the brain of the subject.

Abstract: The application discloses a data processing device, a data processing method and a digital signal processing device. The data processing device is used to reduce computing amount by reading and writing operation of memory. The data processing device comprises: a module for calculating reduced coefficient matrices, a storage module, a module for modifying reduced coefficient matrices, a module for triangular inversing, a module for obtaining inversion matrices and a module for correcting reverse result.

Abstract: The present invention provides a PEG-ACS/M-siRNA nanocomposite application, and method for reducing the histamine content during fishmeal storage thereof. A small interfering ribonucleic acid (siRNA) is designed and prepared according to a histidine decarboxylase gene of Morganella morganii (Morganella morganii subsp. morganii KT), and the histidine decarboxylase gene has a sequence of SEQ ID No: 1. A PEG-ACS/M-siRNA nanocomposite is prepared by using a PEGylated arginine-modified chitosan as a carrier. A PEG-ACS/M-siRNA nanocomposite is added to fishmeal in a certain ratio. The method for reducing the histamine content during fishmeal storage has a significant inhibitory effect on the histamine content during fishmeal storage, and can reduce the histamine content in fishmeal by 49%-53%, which has great significance for the control of biogenic amines in fishmeal in the feed industry.

Abstract: Multiplexed transdermal extraction and detection devices and systems for non-invasive monitoring of substances, such as glucose, are disclosed, as are methods of using these devices for substance monitoring in subjects.

Abstract: A dimpled stent design has geometrical characteristics, namely dimple width and depth, which generate dimple site specific turbulence and thrust within the blood flow to reduce or eliminate restenosis. The dimpled stent design is produced by laser processing of the stent material to produce different sizes, which may be predicted by a Multiphysics computational model, placements, and spatial layouts of dimples in the stent.

Abstract: A wireless communication method and device include: a transmitting device dividing a to-be-transmitted signal into a plurality of packets by using a pre-agreed key; acquiring a preset equivocation threshold; according to the equivocation threshold, determining a power parameter adjustment factor for each of the packets; for each of the packets, performing power adjustment on a signal of the packet according to a power parameter adjustment factor of the packet; and transmitting the to-be-transmitted signal after power adjustment. After receiving the signal, the receiving device groups the signals according to the pre-agreed key, and calculates the power of each packet; determines a test statistic according to the power of each packet, and determines the test statistic whether the quantity is greater than or equal to a preset statistic threshold. If so, it determines that the signal is a tag signal, and if not, that it is a regular signal.

Abstract: Methods for reducing the concentration of one or more contaminants in water using zero-valent iron media. In the method, a mixed aluminum (III) and iron (II) salt solution is added to water containing one or more contaminants that is in contact with a zero-valent iron media that comprises (a) a reactive solid comprising zero-valent iron and one or more iron oxide minerals in contact therewith and (b) magnetite to provide an aqueous reaction medium. The aqueous reaction medium is contacted with the zero-valent iron media for a period of time sufficient to reduce the concentration of one or more of the contaminants.

Abstract: A method for establishing a computer-aided data interpretation model for immune diseases by immunomarkers and visualization is revealed. First combine a plurality of immunomarkers into an immunomarker panel. Then collect test data of a plurality of subjects measured by the immunomarker panel, and disease diagnosis information of the subjects for establishment of an immunomarker-panel testing database. Next new subjects are tested by the immunomarker panel. The data obtained and the corresponding information in the immunomarker-panel testing database are processed by unsupervised machine learning algorithm to get a computer-aided data interpretation model showing comparison of case distribution patterns. The method provides real-time analysis of multiple data to medical professionals for their reference. Thereby the correctness, the timeliness and the reproducibility of the interpretation result for the diagnosis and treatment of immune diseases are all improved.

Abstract: A spin transfer torque magnetic random access memory (STT-MRAM) device according to the present embodiment comprises: an STT-MRAM memory array which includes a data storage unit for storing data, a defect area address storage unit for storing an address of a defect area, and a spare area for storing data of a failed area; and a bypass determination unit which includes a volatile information storage element for storing the address of the defect area, stored in the defect area address storage unit and provided thereto, and when memory array access occurs, compares an access address with the address of the defect area stored in the volatile information storage element and causes the memory array access to bypass to the spare area.

Abstract: A method for intracellular delivery of single proteins or other cargo molecules by encapsulation within nanocapsules formed by interfacial polymerization of one or more types of monomers and selected protease cleavable cross-linkers is provided. The thin positively charged capsules are readily brought into the cytosol of target cells by endocytosis. The capsules are degraded by the action of endogenous proteases or co-delivered proteases on the cross-linkers releasing the functional cargo unaltered. The cross-linkers can be adapted to be cleavable by specific enzymes selected from available intracellular enzymes within the target cell or co-delivered or self-cleaving when the cargo itself is a protease. The nanocapsules produced by the methods have been shown to have long-term stability, high cell penetration capability, low toxicity and efficient protease-modulated specific degradability without affecting cargo protein function.

Abstract: A low-profile CTS flat-plate array antenna includes a radiating layer, a mode switching layer and a feed network layer which are sequentially arrayed from top to bottom. The mode switching layer comprises a first metal plate and a mode switching cavity array arranged on an upper surface of the first metal plate and comprising 22n mode switching cavities arrayed in 2n rows and 2n columns, wherein n is an integer greater than or equal to 1. Each mode switching cavity includes a first rectangular cavity, a second rectangular cavity, a third rectangular cavity, a fourth rectangular cavity and a fifth rectangular cavity which are sequentially connected from left to right. The 2n mode switching cavities located in each row are sequentially connected end to end.

Abstract: An electromagnetic wave measurement apparatus includes: a probe light generation unit configured to generate probe light of two wavelengths; and an electro-optic probe configured to receive the probe light generated by the probe light generation unit and a detection target electromagnetic wave, wherein the probe light generation unit performs a fluctuation operation to cause a frequency difference of the probe light to fluctuate, and the content of the fluctuation operation is set so as to conform to specifications regarding frequency fluctuation of the detection target electromagnetic wave.

Abstract: Lanthionine ketimine phosphonate (LK-P), lanthionine ketimine ester phosphonate (LKE-P), other lanthionine ketimine, lanthionine ketimine phosphonate, and lanthionine ketimine ester derivatives, and methods of making and using the same, are described.

Abstract: A multi-walled storage tanks use pressure differences between walls/shells to maximize fluid mass storage for tank size by reducing or minimizing the distance between the outer most layers of a multi-layer storage device, and keeping the middle one(s), particularly the innermost space, as large as possible, while having shell walls of substantially the same material and thickness, with no wall being thicker than the inner shell wall.