Abstract: A torque transmitting device (10) includes a clutch housing (14) rotatable about an axis (A), a first set of clutch plates (20A) splined to the clutch housing (14), and a second set of clutch plates (20B) interleaved with the first set and rotatable about the axis (A) of rotation. A push plate assembly (28) is splined to the clutch housing (14) for rotation therewith. A roller assembly (42) includes a roller housing (48) splined to the clutch housing (14), a roller supporter (54) housed in the roller housing (48), and a roller element (62) supported by the roller supporter (54). A wedge assembly (12) includes a wedge housing (64) connected to a wedge block (24). The wedge housing (64) includes a ramp member (70) defining a ramp surface (16) with the roller element (62) contacting the ramp surface (16).

Abstract: Systems, methods, and apparatus provide an artificial knee. Such artificial knees may include a thigh link configured to move in unison with a thigh of the person, a shank link configured to be rotatably coupled to the thigh link, and a compression spring rotatably coupled to the thigh link at a first end and coupled to the shank link at a second end. The compression spring is configured to provide an extension torque between the thigh link and the shank link during a first range of motion of the thigh link and the shank link relative to each other. The compression spring is configured to provide a flexion torque between the thigh link and the shank link during a second range of motion of the thigh link and the shank link relative to each other.

Abstract: A contrast agent having a contrast protein have contrast properties and at least one targeting moiety, wherein the at least one targeting moiety is operatively linked to or incorporated within the contrast protein. Methods for targeting contrast agents and for preparing such agents are included.

Abstract: A method is performed at a computer. The computer retrieves a dataset having a plurality of fields, including a first field and a second field. The computer displays a graphical user interface, including a first region displaying the plurality of fields from the dataset, a second region having a plurality of shelves determined according to a user-selected data visualization type, and a third region for displaying one or more data visualizations. The computer receives user actions to drop the first field on a first shelf and to drop the second field on a second shelf. The first and second shelves define positional attributes of data marks. The computer displays a data visualization in the third region. Each data mark has a position in the data visualization determined according to the first shelf, a data value for the first field, the second shelf, and a data value for the second field.

Abstract: Methods, systems, and computer readable media for generating and using a web page classification model are disclosed. The method may include identifying a plurality of web pages for generating a web page classification model, assigning a label to each of the plurality of web pages, accessing Transmission Control Protocol/Internet Protocol (TCP/IP) traffic traces associated with downloading content from each of the plurality of web pages, processing TCP/IP headers from the TCP/IP traffic traces to identify and extract features that discriminate between the labels, that are uncorrelated and whose discriminatory accuracy remains stable across time and/or browser platform. The method may further include generating a web page classification model by training a trainer to learn a combination of the features that accurately discriminates between the labels. The model is usable to classify unlabeled web pages by applying the model to TCP/IP traffic traces used to access the unlabeled web pages.

Abstract: The present technology provides for methods for generation and isolation of granulosa cells and/or granulosa cell precursors from multi-potent cells, wherein the granulosa cells and/or granulosa cell precursors are useful in methods for growth and maturation of follicles or follicle-like structures. Additionally, the present technology also provides for methods of increasing steroidal hormones in a subject in need thereof.

Abstract: Molecular constructs and dual recognition constructs having a sequence encoding a TCR affinity weakening motif, and DNA and RNA sequences corresponding thereto, are presented. Modified T-cells and other cells transformed with the molecular contracts express a modified TCR that imparts a reduction, in non-specific binding, -an enhancement of binding specificity and an enhancement of binding affinity for a target antigen, compared to non-transformed (wild-type, native) T-cells, are described. The modified TCRs possess an affinity enhancing motif and an affinity weakening motif. Methods of transforming cells and methods of using enriched populations of transformed cells, in the treatment of cancer and infections arid T-cell mediated pathologies are provided. The affinity weakening motif imparts a weakened interaction, of a TCR with major histocompatibility complex proteins, such as HLA proteins in humans.

Abstract: Methods and systems to produce product compositions comprising caprylate products using chain-elongating bacteria. For example, the caprylate product in the product composition is n-caprylic acid (C8) and the n-caprylic (C8) to n-caproic (C6) acid ratio is higher than 1:1. These methods use chain elongation towards C8 rather than C6. High n-caprylate productivity and specificity was accomplished by: 1) feeding a substrate with, for example, ethanol as the carbon source or alternatively, a high ethanol-to-acetate ratio as the carbon source; 2) extracting caprylate product(s) (e.g., n-caprylate product) from the bioreactor broth; and 3) acclimating an efficient chain-elongating microbiome. The methods can produce caprylate products such as, for example, n-caprylic acid, which is a higher value chemical than C4 and C6.

Abstract: An active electronic device that enables bidirectional communication over a single antenna or path is disclosed. The device may be characterized by a forward path (from an input to an antenna port) offering high gain, and a reverse path (to a receiver port) that can be configured as an finite impulse response (“FIR”) filter. An amplifier of the device is disclosed, the amplifier allowing for tuning of output resistance using passive mixers.

Abstract: Improved electrochemical impedance spectroscopy assays are provided by electrodepositing metallic nanoparticles onto the working electrode for electrochemical impedance spectroscopy. The metallic nanoparticles provide improved assay sensitivity. Electrodeposition of the metallic nanoparticles firmly affixes them to the working electrode, thereby making it easier to clean the working electrode from one assay to the next assay without undesirably removing the metallic nanoparticles.

Abstract: The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds.

Abstract: A fluid valve is provided that includes a first planar substrate having a smooth surface or a surface with features, an elastomer disposed on the first substrate, a second planar substrate disposed on another side of the elastomer, where the second substrate has a smooth surface or features, where the first and second substrate are more rigid than the elastomer, where the first substrate, the second substrate or the elastomer has a fluid channel, where the channel is open when the first or second substrate are in a first thermal state or a first compression state, where the channel is closed or partially closed when the first or second substrate are in a second thermal state or a second compression state, where the second thermal state is a different temperature than the first thermal state, where the second compression state is a different pressure than the first compression state.

Abstract: Reflectionless electronic filters, as well as a method for designing such filters is disclosed, along with a method of realizing critical subcircuits within those filters that mimic the behavior of tee- and pi-networks having negative elements, though the critical subcircuits themselves are entirely passive. This allows a much broader range of transmission responses to be realized in reflectionless form than in the prior art, and especially with lower ripple factor for deeper rejection in equal-ripple Chebyshev responses. Reflectionless filters preferably function by absorbing the stop-band portion of the spectrum rather than reflecting it back to the source, which has significant advantages in many different applications.

Abstract: Recombinant polypeptides, pharmaceutical compositions comprising recombinant polypeptides, and methods of treating autoimmune and/or inflammatory diseases using the pharmaceutical compositions are disclosed. The polypeptides are based upon the trimerization and/or MIF binding domains of CD74.

Abstract: Devices, methods, and systems for providing a restartable ignition system for a hybrid rocket system. In one embodiment, an ignition device includes a housing and at least two electrodes. The housing includes a first side and a second side and defines a bore with an axis extending therethrough between the first and second sides, the bore defining an internal surface of the housing. The at least two electrodes extend through the housing to the internal surface. The at least two electrodes are configured to be spaced apart so as to provide an electrical potential field along the internal surface between the at least two electrodes. Such housing is formed with and includes multiple flat layers such that the multiple flat layers provide ridges along the internal surface. With this arrangement, the internal surface with the ridges are configured to concentrate an electrical charge upon being subjected to the electrical potential field.

Abstract: This disclosure describes an example device that includes a first contact line, a second contact line, a spin-orbital coupling channel, and a magnet. The spin-orbital coupling channel is coupled to, and is positioned between, the first contact line and second contact line. The magnet is coupled to the spin-orbital coupling channel and positioned between the first contact line and the second contact line. A resistance of the magnet and spin-orbital coupling channel is a unidirectional magnetoresistance.

Abstract: An oil-water separation membrane is described. The oil-water separation membrane comprises a porous metal sheet with a photocatalyst layer on one side and a layer of nanoparticles and a surfactant on the other side. The layer of nanoparticles and surfactant create a superoleophobic and superhydrophilic coating that allows passage of an aqueous phase and rejection of an oil phase. The photocatalyst layer, combined with UV irradiation, enables degradation of organic contaminants in the aqueous phase. The oil-water separation membrane may be used as part of an oil-water separation system, and a filtered water product may be recycled through the membrane to increase the removal of organic contaminants.

Abstract: This invention relates to methods and systems for controlling appliances, particularly climate control appliances such as air conditioning units used in buildings. Embodiments of the invention provide methods and systems which provide a framework of semi-autonomous sensors and actuators which can achieve climate control without the need for centralised or explicit coordination. In certain embodiments, the climate control system is capable of identifying suitable pairings of sensors and actuators and taking into account actions of other actuators. The embodiments have particular application in buildings where large numbers of individual sensors and actuators are deployed in an ad-hoc or unplanned manner over time, but can communicate with each other. The embodiments of the invention can provide improved efficiency, reduced infrastructure costs, improved flexibility and can be deployed across multiple sites.

Abstract: A dual linear polarized dipole antenna (and arrays of such antennas) having high isolation between ports. The antenna may include a pair of crossed (collocated) bent (angled) dipole antenna elements which are excited by a unique dual-polarized feeding structure. The antenna elements may be printed. Stripline feeding along with substantially symmetrical and substantially identical radiative (e.g., “radiating”) elements results in high level of port isolation. Sub-ground planes may be positioned about the stripline on both sides of a balun block to limit or reduce parasitic stripline radiation, thereby improving polarization purity. Polarization purity may be additionally reinforced by a principal ground plane which isolates the radiative elements from the baluns. The antennas and antenna arrays may be used, for example, for weather observation and air surveillance.

Abstract: Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.