Abstract: The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.

Abstract: Methods of making sequence-defined polymers and sequence-defined polymers. The methods are based on the orthogonal reactivity of monomers having at least two different functional groups. The sequence-defined polymers can be used in various applications. For example, the SDPs (e.g., pH sensitive SDPs) are used in cell lysis methods or as molecular vehicles to transport drug cargo into cells.

Abstract: Systems and methods for using positions of detected, real object boundaries to enable user interaction with a virtual object are disclosed. A system can include one or more sensors or trackers configured to detect boundaries of a transparent, real object within a three-dimensional coordinate system. A computing device configured to track positions of the detected boundaries of the real object within the three-dimensional coordinate system. The computing device may also track a position of a virtual object within the three-dimensional coordinate system. The computing device may determine whether the position of the virtual object is within the positions of the detected boundaries of the real object. The computing device may also enable user interaction with the virtual object via user interface and receive input for interacting with the virtual object in response to determining that the position of the virtual object is within the positions of the detected boundaries.

Abstract: A photodetector selection apparatus and method and a scattering coefficient measurement apparatus and method are provided. The photodetector selection apparatus for measuring a scattering coefficient may include: a light source configured to emit light to a subject; a photodetector array configured to detect the light that is reflected or scattered from the subject and measure a light intensity of the detected light; and a processor configured to select at least one photodetector from a plurality of photodetectors of the photodetector array, based on a change in the measured light intensity of each of the plurality of photodetectors according to a change in a scattering coefficient of the subject, and determine the scattering coefficient of the subject based on the light intensity that is measured by the selected at least one photodetector.

Abstract: An ice-skating measuring apparatus includes an ice-skate blade holder and an ice-skate blade. The blade holder has a front beam column and a rear beam column. The blade includes at least one sensor configured to measure forces acting on the blade, and the blade is detachable from the blade holder.

Abstract: A method of electrolytic additive manufacturing provides 3-D parts. The method can be used to form parts from particulate material in an electrolytic bath. Metal is electrolytically deposited, binding the particles. Layers of the particles are built up to form the parts. The same process can be used to form parts without the particulate material. Layers of metal are electrolytically deposited in the electrolyte bath to form the parts.

Abstract: A method of synthesizing silver nanoparticles using mint can include providing a solution including silver nitrate, providing an extract of mint, mixing the silver nitrate solution and the extract solution to form an aqueous mixture, and resting the aqueous mixture for a period of time to form the silver nanoparticles. The mint can be mint grown and harvested in Medina, Saudi Arabia.

Abstract: An optical wireless communications receiver includes a set of photodetectors and signal processing circuitry that receive and process optical communications signals to generate receive data. The receiver includes a spatial light modulator (SLM) and associated SLM controller. The SLM receives an incident optical communications signals from remote optical transmitters and selectively directs the received optical communications signals to the photodetectors to realize an SLM pattern according to SLM control signals from the SLM controller. A system controller establishes the SLM pattern and communicates a description of it to the SLM controller for use in generating the SLM control signals. The receiver may be used in a variety of applications, including so-called visible-light communications or VLC, in which data is transmitted over an optical link using light in the visible spectrum.

Abstract: This invention discloses novel polycyclic heteroaromatic compound core structures. These compounds can be used as hosts for PHOLEDs.

Abstract: A functionally graded carbide body (400) can include a group 5 metal carbide substrate having a bulk composition region (410) that contains at least 70 wt % of a rhombohedral ?-phase carbide. A ?-phase-rich region (420) having a ?-phase-rich composition can be at a surface (430) of the substrate, and a phase composition gradient region (440) can transition from the ?-phase-rich composition region at the surface to the bulk composition region at a gradient depth (450) below the surface.

Abstract: The present invention relates to the field of reutilization of biomass resources, and more particularly relates to a grafting method for rice straw fiber modification. The pulverized and pretreated straw powder is first reacted with diisocyanate under ultrasonic and microwave treatment, and the resulting product is reacted with PEG to obtain the PEG grafted straw fiber polymer compound. Grafting PEG onto the straw fiber through the bridging of the diisocyanate improves the thermoplasticity of the modified rice straw fiber. The modified straw fiber of the present invention can be hot-pressed to form self-reinforced composite materials without adding additional materials, which overcomes the waste and pollution problem of traditional straw reutilization method, achieving the goal of whole straw utilization.

Abstract: A system, device and methods for quantitatively monitoring and evaluating changes in water and hemoglobin content in the brain in a non-invasive manner are provided. The system may be used for real-time detection and monitoring of brain edema and/or for an assessment of cerebral autoregulation.

Abstract: The present invention provides methods for development of a virulent bacteriophage-based treatment for the control of plant diseases caused by Xylella fastidiosa. The invention further provides methods of isolating and propagating bacteriophage virulent to X. fastidiosa in a Xanthomonas bacterial host and for treating or reducing symptoms of X. fastidiosa infection in a plant. The invention further provides methods of isolating and propagating bacteriophage virulent to Xanthomonas axonopodis pv. citri and for treating or reducing symptoms of Xanthomonas axonopodis pv. citri infection in a plant.

Abstract: Systems, devices, and methods for treating a glaucomatous eye are provided. Embodiments may provide a treatment probe for treating an eye of a patient. The treatment probe may have an elongate body with a contact surface at a distal end of the elongate body. A treatment fiber or light source may be housed in the treatment probe and may be configured to direct treatment energy from the contact surface. The contact surface may be configured to couple to a surface of the eye to deliver the energy into the target area. In many embodiments the contact surface may have a convex configuration with a rounded outer shape and edge that facilitates the sweeping of the probe surface across the eye during treatment delivery. In some embodiments the probe may be swept in arc motions while delivering treatment energy to the eye.

Abstract: A flexible electronics assembly includes a single-piece substrate having two regions of rigidity separated by a localized region of flexibility. The localized region of flexibility has a lower rigidity than the two regions of rigidity. The two regions of rigidity are angularly deflectable from a planar configuration of the single-piece substrate to a non-planar configuration of the single-piece substrate by hinging action of the localized region of flexibility. At least one electronic component is mounted on at least one of the two regions of rigidity.

Abstract: The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface (“O interface”); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex (“L domain”); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (“M domain”), as well as membrane-enveloped versions of the multimeric assemblies.

Abstract: The present invention provides a nano-particle based structure or composition for a combinational cancer therapy. The structure has a doxorubicin (DOX) physically loaded on core-shell silver polymeric nanoparticles (AgN-Ps) with a ratio of 3.3-5.5% doxorubicin to 1% silver to 2-10% polymer. This structure enhances the cellular uptake of DOX in comparison to the current conventional combination therapy. The DOX-loaded nano-particles result in an improved the therapeutic efficiency of DOX, and reduced its toxicity, which cannot occur in case of adding DOX and AgNPs.

Abstract: Provided is random access method, performed by terminal for uplink data transmission during random access process between cellular based machine communication terminal and base station. The method includes performing random access process between cellular based machine communication terminal and base station, and the random access process includes selecting random access resource by considering coverage level and whether to support multi-tone transmission or not.

Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.

Abstract: The current disclosure describes semiconductor devices, e.g., transistors including a thin semimetal layer as a channel region over a substrate, which includes bandgap opening and exhibits semiconductor properties. Described semiconductor devices include source/drain regions that include a thicker semimetal layer over the thin semimetal layer serving as the channel region, this thicker semimetal layer exhibiting metal properties. The semimetal used for the source/drain regions include a same or similar semimetal material as the semimetal of the channel region.