Patents Assigned to University
  • Patent number: 10434089
    Abstract: Described are methods of treating or preventing a bacterial infection by administering an antibacterial agent comprising a ?-lactamase inhibitor and one or more carbapenem to a subject.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: October 8, 2019
    Assignee: The Johns Hopkins University
    Inventor: Gyanu Lamichhane
  • Patent number: 10434152
    Abstract: Antigenic polypeptides of the growth factor receptor HER2, for breaking the tolerance of a host against self HER2. The antigenic polypeptides include HER2 polypeptides with single amino acid substitutions of lysine for glutamine, arginine for glutamine, or aspartic acid for asparagine. Gene expression constructs, vaccine compositions, and immunization methods including the substituted HER2 polypeptides. Methods for immunizing mammalian subjects with heterologous unsubstituted HER2 antigenic polypeptides, including polypeptides of feline and bear HER2. A diagnostic method of determining whether a mammalian subject is sufficiently immunocompetent to respond to immunotherapies directed at breaking tolerance to self HER2.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: October 8, 2019
    Assignee: Wayne State University
    Inventors: Wei-Zen Wei, Heather Gibson, Richard Jones, Joyce Reyes
  • Patent number: 10435355
    Abstract: Described herein, inter alia, are compositions and methods useful for inhibiting fatty acid amide hydrolase.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: October 8, 2019
    Assignees: The Regents of the University of California, Fondazione Istituto Italiano di Tecnologia
    Inventors: Daniele Piomelli, Tiziano Bandiera, Rita Scarpelli
  • Patent number: 10435423
    Abstract: Provided herein are functionalized phosphonates and methods for making same via phosphite addition to an atom alpha to an electron withdrawing group. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: October 8, 2019
    Assignee: The Board of Regents of the Nevada System of Higher Education on Behalf of the University of Nevada, Las Vegas
    Inventors: Jun Yong Kang, Hai Huang, Nagaraju Molleti
  • Patent number: 10434319
    Abstract: An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: October 8, 2019
    Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans Affairs, Topera, Inc.
    Inventors: Sanjiv M. Narayan, Carey Robert Briggs, Ruchir Sehra
  • Patent number: 10434511
    Abstract: A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly from 30 ?L plasma samples within approximately 100 minutes with markedly enhanced sensitivity and specificity. Identification of distinct subpopulation of patient-derived exosomes is demonstrated by probing surface proteins and multiparameter analyses of intravesicular biomarkers in the selected subpopulation. The expression of IGF-1R and its phosphorylation level in non-small cell lung cancer (NSCLC) patient plasma is assessed, as a non-invasive alternative to the conventional biopsy and immunohistochemistry.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: October 8, 2019
    Assignee: University of Kansas
    Inventors: Mei He, Yong Zeng, Andrew Godwin
  • Patent number: 10437572
    Abstract: Methods, systems, and computer readable media for compiling concise expressive design patterns within computer software source code are described. Some implementations can include methods and systems that resolve some problems of implementing design patterns in an OO and/or AO program. The disclosed technique facilitates writing programs that apply design patterns to its structure and behavior, in an easy manner. Some programming language constructs (associated with new keywords, syntax, and semantics) are disclosed that convey the goal of some design patterns in order to allow programmers to implement design patterns simply and concisely. These constructs are added as extensions to a compiler and a compiler-based approach to concise expressive design pattern source code is described.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: October 8, 2019
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Taher Ahmed Ghaleb, Khalid Abdullah Aljasser, Musab A. Alturki
  • Patent number: 10433754
    Abstract: Systems and methods for providing an electrical interface to a body are provided. In one embodiment, an implantable module is disclosed, comprising: an implantable electrode array, implantable within a body and capable of providing a plurality of communication channels for communicating electrical signals detected in a body; an amplifier circuit for processing electrical signals received from the electrode array; a wireless transceiver for sending and receiving telemetry data between the amplifier circuit and a wireless receiver located outside of the body; and a sealed enclosure that houses the amplifier circuit and the wireless transmitter and is biocompatible with surrounding tissue, the enclosure having a window that is transparent to a wireless medium used by the wireless transceiver.
    Type: Grant
    Filed: September 16, 2013
    Date of Patent: October 8, 2019
    Assignee: Brown University
    Inventors: Arto V. Nurmikko, Ming Yin, William R. Patterson, Juan Aceros, David A. Borton, Christopher W. Bull, Farah Laiwalla
  • Patent number: 10435814
    Abstract: A single-crystalline metal is created on a substrate by liquefying a metal material contained within a crucible while in contact with a surface of the substrate, cooling the metal material by causing a temperature gradient effected in the substrate in a direction that is neutral along the surface of the substrate and, therein, growing the single-crystalline metal in the crucible.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: October 8, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: James D. Plummer, Kai Zhang, Xue Bai Pitner, Jonathan A. Fan
  • Patent number: 10439093
    Abstract: A photovoltaic photodetector includes a substrate, a graphene layer, and a dielectric layer positioned between the substrate and the graphene layer. One or more first antenna electrodes includes a first metal in direct contact with the graphene layer. One or more second antenna electrodes includes a second metal in direct contact with the graphene layer. The first and second metals have different work functions. A drain electrode is electrically coupled to the one or more first antenna electrodes, and a source electrode is electrically coupled to the one or more second antenna electrodes. The photovoltaic photodetector can be configured to be operable over a wavelength region of 2 ?m to 24 ?m and has a response time of 10 ns or less.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: October 8, 2019
    Assignee: Arizon Board of Regents on behalf of Arizona State University
    Inventor: Yu Yao
  • Patent number: 10434078
    Abstract: In certain embodiments methods are provided for the therapeutic or prophylactic amelioration of one or more symptoms or disorders associated with metabolic syndrome. In various embodiments the methods involve administering to a subject in need thereof, a GABA receptor agonist, in an amount sufficient to ameliorate said one or more symptoms. In certain embodiments methods are provided for the prophylaxis or treatment of type I diabetes and related pathologies that involve the use of GABA or GABA agonists in combination with certain other compounds (e.g., one more antigens (e.g., GAD) that have a therapeutic effect in type I diabetes and/or an anti-CD3 antibody, an anti-CD20 antibody, exendin-4, and/or or a pro-insulin therapeutic).
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: October 8, 2019
    Assignee: The Regents of The University of California
    Inventors: Daniel L. Kaufman, Jide Tian
  • Patent number: 10435709
    Abstract: A nucleic acid containing a dopamine receptor type 2-specific promoter (D2SP) is provided. In certain embodiments, the nucleic acid includes a dopamine receptor type 2-specific promoter (D2SP), wherein the D2SP does not include exon 1 of a D2 receptor gene, wherein the D2SP comprises a Kozak sequence, and wherein the D2SP includes a nucleotide sequence having at least 95% sequence identity to the nucleotide sequence set forth in SEQ ID NO: 1. Also provided are expression vectors, genetically modified host cells and kits that include the subject nucleic acid.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: October 8, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl A. Deisseroth, Charu Ramakrishnan, Kelly Zalocusky
  • Patent number: 10436815
    Abstract: Methods for imaging a substrate include: inducing an electrospray from a nanopipette probe; varying a distance between the nanopipette probe and a surface of the substrate until a predefined electrospray current and/or a predefined distance threshold is reached; and determining a topography of the surface of the substrate based on feedback derived from distance dependency of the electrospray current. Apparatuses for performing scanning electrospray microscopy and methods for spatially controlled deposition of material on surfaces of substrates are described.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: October 8, 2019
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Lane Baker, Elizabeth Yuill, Tyler Yarger, Alicia Friedman, John Poehlman
  • Patent number: 10434505
    Abstract: A photocatalyst includes a composite fiber having at least two crystalline semi-conductors that provide a heterojunction structure in the composite fiber.
    Type: Grant
    Filed: June 10, 2019
    Date of Patent: October 8, 2019
    Assignee: The Hong Kong Polytechnic University
    Inventors: Wallace Woon Fong Leung, Chun Pei
  • Patent number: 10434177
    Abstract: Provided herein is a two-component photosensitizer, which demonstrated robust and selective killing effects for transfected HEK cells and affibody targeted A431 cancer cells when exposed to near infrared light excitation. Free MG2I is a pure and stable fluorogen; it is easy to synthesize and modify, and has no toxicity to cells. Unlike conventional photosensitizers, the dye and FAP itself has no photosensitizing effect until they are bound. Also unlike other activation methods, the activation step is achieved by adding the fluorogen, not the presence of the targeted molecule, requiring an ‘active’ activation instead of a ‘passive’ activation. This method offers the ability to locally switch-on and selective generation of singlet oxygen at the target site and can be used for a wide variety of molecular targets.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: October 8, 2019
    Assignee: Carnegie Mellon University
    Inventors: Marcel P. Bruchez, Jianjun He, Yi Wang
  • Patent number: 10434225
    Abstract: The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: October 8, 2019
    Assignees: Northwestern University, University of Maryland, Ann & Robert H. Lurie Children's Hospital of Chicago
    Inventors: Dean Ho, Erik M. Robinson, Sunjay Kaushal, Patrick M. McCarthy
  • Patent number: 10434501
    Abstract: The present invention belongs to the flue gas desulfuration field. Specifically, the present invention relates to a supported solid-phase catalyst for oxidizing the by-product magnesium sulfite in a magnesium desulfuration process, and to preparation method and use thereof. The catalyst uses an activated carbon particle as a support, and cobalt nitrate, manganese nitrate, copper nitrate and ferrous nitrate as catalytically active components. The preparation method is as follows: mixing the pre-treated activated carbon support with the catalytically active components, followed by oscillating, standing under microwave irradiation, filtrating, drying, baking, so as to obtain the supported solid-phase catalyst.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: October 8, 2019
    Assignee: North China Electric Power University Baoding
    Inventors: Lidong Wang, Juan Wang, Tieyue Qi
  • Patent number: 10436722
    Abstract: The invention provides a positive/negative phase shift bimetallic zone plate and production method thereof, wherein the positive/negative phase shift bimetallic zone plate comprises: a first metallic material having a positive phase shift; a second metallic material having a negative phase shift at a working energy point; wherein the first metallic material and the second metallic material are alternately arranged, so that the second metallic material replaces the blank portion in a cycle of a traditional zone plate.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: October 8, 2019
    Assignee: University of Science And Technology of China
    Inventors: Kun Gao, Jian Chen, Renfang Hu, Zhili Wang, Dajiang Wang, Zhiyun Pan, Wangsheng Chu, Shiqiang Wei
  • Patent number: 10435667
    Abstract: The present invention relates to the field of stem cells. More specifically, the invention provides methods and compositions useful for forming three-dimensional human retinal tissue in vitro. In a specific embodiment, an in vitro method for differentiating hiPSCs into three-dimensional retinal tissue comprising functional photoreceptors comprises the steps of (a) culturing the hiPSCs to form aggregates; (b) transitioning the aggregates into a neural induction medium; (c) seeding the aggregates on to extracellular matrix coated cell culture substrates; (d) replacing NIM with a chemically-defined differentiation medium; (e) detaching NR domains; (f) culturing in suspension; and (g) adding animal serum or plasma component and retinoic acid.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: October 8, 2019
    Assignee: The Johns Hopkins University
    Inventors: Maria Valeria Canto-Soler, Xiufeng Zhong
  • Patent number: 10434085
    Abstract: This disclosure is directed to non-aromatic difluoro analogues of resorcylic acid lactones, pharmaceutical compositions comprising non-aromatic difluoro analogues of resorcylic acid lactones, and methods of treatment comprising non-aromatic difluoro analogues of resorcylic acid lactones.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: October 8, 2019
    Assignee: University of North Carolina at Greensboro
    Inventors: Mitchell P. Croatt, Lara Fakhouri, Nicholas H. Oberlies, Cedric Pearce