Patents Assigned to University
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Patent number: 10435418Abstract: A reaction method comprising combining a carbonyl-substituted arylboronic acid or ester and an ?-effect amine in aqueous solution at a temperature between about ?5 C to 55 C, and a pH between 2 and 8 to produce an adduct. A process is also provided comprising: contacting a boron compound having a boron atom bonded to a sp2 hybridized carbon conjugated with a cis-carbonyl, the boron having at least one labile substituent, with an ?-effect amine, in a solvent for a time sufficient to form an adduct, which may proceed to further products.Type: GrantFiled: September 11, 2017Date of Patent: October 8, 2019Assignee: The Research Foundation for the State University oInventors: Susan Bane Tuttle, Ozlem Dilek, Kamalika Mukherjee
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Patent number: 10438700Abstract: Time-varying hyperglycemic stresses are derived from actual ICU patients and applied to non-critically ill virtual patients, using any model of normal glucose-insulin physiology that fulfills certain requirements, in order to model and simulate stress hyperglycemia. Other aspects provide: 1) a methodology to perform sensitivity analyses of the parameters of ICU insulin infusion therapy protocols and to improve the protocols; and 2) a training system for clinicians about the course and management of stress hyperglycemia in the ICU or other facility.Type: GrantFiled: August 5, 2013Date of Patent: October 8, 2019Assignee: University of Virginia Patent FoundationInventors: Edward A. Ortiz, Stephen D. Patek, Marc D. Breton, Leon S. Farhi, Boris P. Kovatchev
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Patent number: 10435456Abstract: The present invention relates to the field of protein expression. More specifically, the present invention provides compositions and methods for increasing the expression and signaling of proteins on cell surfaces. In particular embodiments, the present invention provides nucleic acids and amino acid sequences useful for improving/increasing protein expression on the cell surface. In several embodiments, the sequences are operably linked to the N-terminal end of the protein of interest. The nucleic acid sequence encoding the sequence tag and the protein can comprise part of an expression vector. The protein can be expressed with the N-terminal sequence tag. In certain embodiments, the sequences of the present invention can be used with one or more chaperone or accessory proteins. In particular embodiments, the one or more chaperone/accessory proteins are encoded by the same vector or separate vectors.Type: GrantFiled: January 29, 2015Date of Patent: October 8, 2019Assignee: The Johns Hopkins UniversityInventors: Jennifer Pluznick, Blythe Shepard, Niranjana Natarajan
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Patent number: 10440752Abstract: The present disclosure relates to a 5th Generation (5G) or pre-5G system to be provided to support a higher data transfer rate after a 4G communication system such as Long Term Evolution (LTE). The present invention is for performing random access in a wireless communication system, and a base station includes a communication unit for transmitting system information including a plurality of thresholds, and a control unit for determining a random access result for each mode on the basis of a detection result on a preamble transmitted from at least one terminal.Type: GrantFiled: May 26, 2016Date of Patent: October 8, 2019Assignees: Samsung Electronics Co., Ltd., Research & Business Foundation Sungkyunkwan UniversityInventors: Seung-Hoon Park, Min-Gyu Lee, Tae-Jin Lee, Jung-Min Moon, Jungsoo Jung
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Patent number: 10434032Abstract: A tool for use in assisting soft tissue mobilization and bodily tissue amelioration, such as stimulation of superficial tissue, deep tissue mobilization, breaking up scar tissue, and soft tissue massaging, are described. The tool comprises a device for application to bodily tissue that includes a body having a substantially teardrop shape in a vertical section. In a longitudinal aspect, the body includes a first and a second portion. The first portion of the device corresponds at least in part to a substantially bulbous handle part of the teardrop shape of the vertical section and is adapted for ease of grasping and manipulation at the first end. The second portion of the device corresponds at least in part to a substantially tapered converging double-beveled linear edge of the teardrop shape of the vertical section and is adapted for facilitated application of the device to bodily tissue at the second end.Type: GrantFiled: December 15, 2015Date of Patent: October 8, 2019Assignee: The Curators of the University of MissouriInventors: Jaya Ghosh, Ellie Koehly, Yaw Sarpong, Roger de la Torre, Jonathon Buehler, Brett Hayes, Teresa Graff, Katherina Chen
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Patent number: 10435416Abstract: A cocrystal having the formula LiX.aM, or a solvate or hydrate thereof, wherein X is a conjugate base of an organic acid, M is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.Type: GrantFiled: October 25, 2017Date of Patent: October 8, 2019Assignee: University of South FloridaInventors: Michael John Zaworotko, Naga Duggirala, Adam John Smith, Roland Douglas Shytle
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Patent number: 10435366Abstract: The present invention relates to a composition comprising a maxi-K potassium channel opener the use in the treatment of fragile X syndrome. More specifically the present invention relates to a composition comprising a fluoro-oxindole or a chloro-oxindole for use in the treatment of fragile X syndrome.Type: GrantFiled: June 19, 2012Date of Patent: October 8, 2019Assignees: Centre National de la Recherche Scientifique, Centre Hospitalier Regional d'Orleans, University d'OrleansInventors: Sylvain Briault, Olivier Perche
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Patent number: 10435740Abstract: The subject invention pertains to a method of determining methylation state and chromatin structure of target loci. The method comprises treating the genetic material obtained from the cells with DNA methyltransferase, capturing target genetic loci using a set of oligonucleotides, ligating the target loci with oligonucleotide patches that flank the target loci, treating the target loci flanked by oligonucleotide patches with bisulfite, optionally amplifying the target loci by polymerase chain reaction, sequencing the PCR products, and analyzing the sequences to determine methylation state and chromatin structure of the target loci. The current invention also provides a method to identify genes associated with a disease. The invention also provides a method to detect cells suffering from a disease in a group of cells. The current invention also provides kits suitable for carrying out the method of determining methylation state and chromatin structure of the target loci.Type: GrantFiled: April 1, 2014Date of Patent: October 8, 2019Assignee: University of Florida Research Foundation, IncorporatedInventors: Michael P. Kladde, Nancy H. Nabilsi, Carolina E. Pardo
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Patent number: 10435659Abstract: A membrane biofilm reactor including a vessel defining a volume is disclosed. The reactor also typically includes a first and second plurality of hollow fiber membranes. Each hollow fiber membrane generally has an outer surface and a lumen, and is located within the volume. The reactor further preferably includes a first and second gas feedstock. The first gas feedstock is provided through a first inlet in fluid communication with the lumens of the first plurality of hollow fiber membranes. The second gas feedstock is provided through a second inlet in fluid communication with the lumens of the second plurality hollow fiber membranes. Finally, the reactor also typically includes a biofilm formed on the outer surface of the hollow fiber membranes and made up of methanotrophs, Methanosarcina acetivorans, or both. The first gas feedstock is preferably different from the second gas feedstock.Type: GrantFiled: March 11, 2015Date of Patent: October 8, 2019Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Prathap Parameswaran, Rosa Krajmalnik-Brown, Sudeep Popat, Bruce Rittmann, Cesar Torres
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Patent number: 10440810Abstract: A system that generates short charged particle packets or pulses (e.g., electron packets) without requiring a fast-switching-laser source is described. This system may include a charged particle source that produces a stream of continuous charged particles to propagate along a charged particle path. The system also includes a charged particle deflector positioned in the charged particle path to deflect the stream of continuous charged particles to a set of directions different from the charged particle path. The system additionally includes a series of beam blockers located downstream from the charged particle deflector and spaced from one another in a linear configuration as a beam-blocker grating. This beam-blocker grating can interact with the deflected stream of charged particles and divide the stream of the charged particles into a set of short particle packets. In one embodiment, the charged particles are electrons. The beam blockers can be conductors.Type: GrantFiled: January 8, 2018Date of Patent: October 8, 2019Assignee: Cornell UniversityInventors: Amit Lal, Yue Shi, Serhan Ardanuc, June-Ho Hwang, Farhan Rana
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Patent number: 10434475Abstract: The present invention relates to a comprehensive evaluation method for the performance of contaminated flat membranes, which relates to the field of sewage and waste resource technology. The present invention firstly analyzed the composition of the surface elements of the contaminated membrane by EDX to determine the type of membrane contamination, and then designed different cleaning schemes for organic or inorganic pollution to obtain a sample membrane. When the tensile strength of the contaminated membrane decreased more than 50% than that of the control membrane, it is a waste membrane; when the tensile strength decreased less than 50% and the membrane flux reduced more than 30%, it is a waste membrane; when tensile strength decreased less than 50%, membrane flux reduced less than 30% and the carbon footprint was more than 188 g, it is a waste membrane; otherwise was a old membrane.Type: GrantFiled: August 15, 2017Date of Patent: October 8, 2019Assignee: Jiangnan UniversityInventors: Xiufen Li, Xiaoli Song, Xinhua Wang, Yueping Ren, Xiguang Qi
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Patent number: 10436771Abstract: Systems and methods for targeted therapy based on single-cell stimulus perturbation response. In one embodiment, a method for optimizing stimulus combinations for therapy includes receiving a cell sample, treating the cell sample with a plurality of stimuli by treating a different portion of the cell sample with one of the plurality of stimuli for each of the plurality of stimuli, labeling the cell sample with a plurality of metal-conjugated probes, analyzing the cell sample using a mass spectrometer, obtaining mass spectrometry data from the mass spectrometer, identifying subpopulations within the cell sample using the mass spectrometry data, computing stimulus effects, generating a nested-effects model using the mass spectrometry data, and scoring stimuli combinations using the computing device, wherein the stimulus combinations are combinations made from the plurality of stimuli.Type: GrantFiled: April 5, 2017Date of Patent: October 8, 2019Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Benedict Anchang, Sylvia K. Plevritis
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Patent number: 10433733Abstract: A method for obtaining a 3-D OR-PAM image of microvasculature within a region of interest of a subject is provided. The method includes: focusing a first light pulse at a first depth beneath a first surface position within the region of interest; receiving a first PA signal in response to the first light pulse; focusing a second light pulse at a second depth beneath the first surface position within the region of interest; receiving a second PA signal in response to the second light pulse; and forming the 3-D OR-PAM image by combining the first PA signal and the second PA signal.Type: GrantFiled: May 6, 2016Date of Patent: October 8, 2019Assignee: Washington UniversityInventors: Lihong Wang, Lidai Wang, Konstantin Maslov
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Patent number: 10436750Abstract: The dielectric barrier discharge ionization detector includes: a dielectric tube through which a plasma generation gas is passed; a high-voltage electrode formed on the outer wall of the dielectric tube; two ground electrodes and formed on the outer wall of the dielectric tube, with the high-voltage electrode in between; a voltage supplier for applying AC voltage between the high-voltage electrode and each ground electrode to generate electric discharge within the dielectric tube and thereby generate plasma from the plasma generation gas; and a charge-collecting section for detecting an ion current formed by ionized sample-component gas produced by the plasma. The distance between one ground electrode and the high-voltage electrode is longer than a discharge initiation distance between these two electrodes, while the distance between the other ground electrode and the high-voltage electrode is shorter than the discharge initiation distance between these two electrodes.Type: GrantFiled: September 7, 2017Date of Patent: October 8, 2019Assignees: Shimadzu Corporation, Osaka UniversityInventors: Kei Shinada, Katsuhisa Kitano
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Patent number: 10439292Abstract: Electromagnetic shielding systems, apparatuses, and method are provided. One apparatus is an example free-space absorber metamaterial that includes a first array of patches disposed at a first plane, a conductive backplane disposed at a structural surface plane, and a first dielectric spacer disposed between the first array of patches and the conductive backplane. A first bandwidth of absorption for the free-space absorber metamaterial may be based on the area of a patch in the first array of patches, the first electrical resistance of a patch in the first array of patches, and the first gap distance taken between the first array of patches and the conductive backplane.Type: GrantFiled: July 3, 2018Date of Patent: October 8, 2019Assignee: The Johns Hopkins UniversityInventors: Kenneth R. Grossman, Joseph A. Miragliotta, Adam J. Maisano, Douglas B. Trigg, Steven M. Storck
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Patent number: 10434216Abstract: The present invention relates to an ultra-thin film silk fibroin/collagen composite implant for tissue engineering and a manufacturing method therefor. The ultra-thin film silk fibroin/collagen silk fibroin/collagen composite implant according to the present invention has no cytotoxicity and can minimize the influence on cell growth, due to the combined use of a refined silk fibroin aqueous solution, collagen and various biomaterials, and thus can be widely used as an ultra-thin film implant for implanting.Type: GrantFiled: July 10, 2015Date of Patent: October 8, 2019Assignee: Industrial Cooperation Foundation Chonbuk National UniversityInventors: Gil Son Khang, Eun Young Kim, Jae Won Yang, Jeong Eun Song, Se Rom Cha
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Patent number: 10435317Abstract: Metal-free materials, manufacturing thereof, method using thereof for (in-situ or ex-situ) catalytically treating contaminated soil or waters, including remediation of groundwater contaminated by haloalkenes, haloalkanes, nitro-compounds, and nitrophenol using sulfide as a reductant. Metal-free materials are manufactured with industrial scrap syrup or biomass. Method using the metal-free materials for in-situ treatment consists with the processes of adding materials into the contaminated medium, introducing sulfide into the contaminated medium, and reductive reacting contaminants with sulfide catalyzed by the metal-free materials. Specially, the formation of in-situ reaction zone is the key point of in situ treatment by retaining the catalyst in the contaminated medium.Type: GrantFiled: March 1, 2017Date of Patent: October 8, 2019Assignee: Jilin UniversityInventors: Na Liu, Longzhen Ding, Pengpeng Zhang
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Patent number: 10438686Abstract: Methods and computer-based systems for facilitating assessment of clinical infertility are provided. The methods and systems can be implemented to, for example, facilitate assessment of a subject for an in vitro fertilization treatment cycle, including determining probability of a live birth event. The methods and systems can be implemented to, for example, facilitate a determination of success implantation of embryos, selection of an optimal number of embryos to transfer, and determination of success in subsequent in vitro fertilization treatment cycles following an unsuccessful treatment cycle.Type: GrantFiled: August 19, 2016Date of Patent: October 8, 2019Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Mylene W. M. Yao, Wing H. Wong
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Patent number: 10435757Abstract: Provided herein are methods of measuring C19MC miRNA amount and/or expression in a post-natal cell and/or tissue. Provided herein are methods of measuring CpG methylation of the upstream C19MC miRNA promoter region in a post-natal cell and/or tissue. Also provided herein are methods of treating a cell, population thereof, and/or a subject in need thereof by administering a C19MC miRNA inhibitor or CRISPR to suppress the expression of specific miRNA within the C19MC or the entire C19MC cluster, population thereof, and/or the subject in need thereof.Type: GrantFiled: June 15, 2017Date of Patent: October 8, 2019Assignee: University of South FloridaInventors: Hana Totary-Jain, Ezinne Francess Mong
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Patent number: 10440348Abstract: Embodiments are directed to an optical privatizing device (100), system and methods of use. The device includes a removable frame (101) removably attachable to a sensor housing (1A). A device includes a blurring lens (130) coupled to the removable frame (101) and configured to optically modify light passing to a depth sensor wherein the optical modified light has a privatizing blur level to neutralize a profile of an object sensed by the depth sensor within a working volume of the depth sensor to an unidentifiable state while maintaining a depth parameter sensed by the depth sensor.Type: GrantFiled: March 24, 2016Date of Patent: October 8, 2019Assignee: University of Florida Research Foundation, Inc.Inventors: Sanjeev Jagannatha Koppal, Francesco Pittaluga