Abstract: The present invention relates to biomimetic membrane compositions and methods for making and using them.

Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.

Abstract: A semiconductor circuit including a clocked comparator and an offset application circuit. The clocked comparator is configured to receive a first input signal and a second input signal from a host and compare the first input signal and the second input signal. The offset application circuit is configured to apply an offset to the first input signal. The clocked comparator is configured to be driven based on a reference clock provided from the host.

Abstract: The invention relates to polypeptides specifically binding to CD38 and are therefore suitable for the diagnosis and for the therapeutic and prophylactic treatment of diseases which are characterized by increased CD38 expression. Conjugates and pharmaceutical compositions comprising the polypeptides are disclosed as well. In addition, the invention relates to the use of such polypeptides in methods for the detection of CD38 and/or CD38-expressing cells in a biological sample. A process for the purification and concentration of CD38 and/or CD38-expressing cells in which the antigen-binding polypeptides are used are also described.

Abstract: In some examples, a method performed by a drilling rig control center, includes receiving raw data for a first time segment, the raw data related to a drilling operation. In addition, the method includes deriving first drilling state measurements based on the raw data of the first time segment. Further, the method includes deriving first formation state measurements based on the raw data of the first time segment. The method also includes correlating the first derived drilling and formation state measurements of the first time segment with a second derived drilling and formation state measurements of a second time segment. Still further, the method includes generating a control response based on the correlation.

Abstract: The disclosure provides compositions comprising desaminotyrosine and methods of use thereof in enhancing type I interferon stimulation, epithelial proliferation, and treatment of inflammatory bowel disease.

Abstract: Disclosed are compounds, pharmaceutical compositions, and methods of treatment. The disclosed compounds are based on fused 1,4-diazepine and pyrrolidinedione scaffolds. The compounds may be utilized in pharmaceutical compositions and methods for treating diseases and disorders associated with cell proliferation such as cancer.

Abstract: The present invention relates to a flexible electrode and a method for manufacturing the same. According to an embodiment of the present invention, the flexible electrode includes a substrate 10, a bonding layer 20 formed by adsorbing an amino group (NH2)-containing monomolecular material on the substrate 10, and a conductive layer 30 formed by coating metal nanoparticles 31 on the bonding layer 20.

Abstract: Enteric feeding tube housings configured to secure a feeding tube to the body are disclosed. The housing includes a disc having a hole configured to accommodate the feeding tube and two or more holes configured to accommodate fasteners. Also disclosed are enteric feeding tube housings that include a disc having a hole configured to accommodate the feeding tube and two or more holes configured to accommodate fasteners, and a plurality of fasteners. Also disclosed are surgical kits that include a housing, a plurality of fasteners, and a plurality of locking devices configured to adjustably secure the fasteners in the fastener receiving holes, and method of using the disclosed devices.

Abstract: ‘NCSX2’ is a new cultivar of hybrid Spiraea that is a triploid, with red-purple new foliage color, red-purple flowers, and continuous blooming throughout the growing season from May to October. The new variety is a Spiraea normally produced as an outdoor garden or container plant.

Abstract: The present disclosure is directed to antibodies binding to and neutralizing Zika virus and methods for use thereof.

Abstract: A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

Abstract: A crystal-free radio includes an antenna; a receiver configured to communicate with the antenna; a local radio frequency (RF) oscillator configured to communicate with the receiver; and a clock circuit configured to communicate with the receiver and the local RF oscillator, the clock circuit having an electronic circuit oscillator. The local RF oscillator is a free-running oscillator. The clock circuit is configured to receive a calibration signal via a wireless network and calibrate the electronic circuit oscillator based on the received calibration signal, and the clock circuit is a crystal-free clock circuit.

Abstract: Methods and apparatus for automating the fiber laying process during the repair of composite structures made of fiber-reinforced plastic material based on the three-dimensional printing technique. Continuous fiber rovings (e.g., carbon fibers) impregnated with liquid epoxy can be directly printed onto the damaged surface of the composite structure (e.g., an aircraft component made of carbon fiber-reinforced plastic) without human manipulation in an autonomous manner.

Abstract: Disclosed herein are various bioreactor devices that mimic the mammalian joint. The bioreactor device can include a series of bioreactor chambers that contain different components of the joint, such as bone, cartilage, synovium, nerve and ligament. At least two different nutrient fluid circulation systems connect subsets of the bioreactor chambers to differentially supply nutrient fluids at concentrations optimized for the tissue that the fluid nourishes. For example, relatively hypoxic fluid can be supplied to synovium and cartilage to mimic oxygenation in the joint compartment, but normoxic fluid can be supplied to the bone and other components that have an arterial supply that provides higher oxygen concentrations. One or more or all of the bioreactor chambers can be supplied with separate inlets through which perturbation agents (such as drugs or other agents) can be introduced to model the effect of the perturbations on different components of the system.

Abstract: Methods and devices to identify contact lens wearers predisposed to contact lens discomfort are described. The methods and devices involve obtaining a tear film sample from a person and determining an amount of interleukin-17A present in the tear film sample.

Abstract: A tunable electro-optic modulation (EOM) comb generator includes a frequency locking optoelectronic oscillator (OEO) loop including RF electrical components including a phase shifter (PS1), a splitter, and optical components including an intensity modulator (IM) coupled to receive light from a light source and to couple modulated light generated to a frequency locking loop including a frequency shifter, a first phase modulator (PM1), and a periodic optical filter (POF), such as an etalon or resonator. The POF is for optically filtering the OEO loop to generate an optical output and the splitter is for generating RF electrical outputs including at least one RF output coupled to an input of the IM and another RF output coupled to an EO comb including at least a phase modulator. The EO comb combines the optical output and the another RF output to generate a broadband optical frequency comb output.

Abstract: The present application provides flexible radio frequency (RF) assemblies, components thereof and related methods. The present application includes at least one flexible substrate comprising first and second sides, a flexible framework portion comprising a first material composition and a plurality of discrete spaced interior portions comprising second material compositions that differ from that of the flexible framework portion. The framework portion extends fully about a portion of each interior portion. The framework portion comprises a flexibility that is greater than that of the interior portions. Each interior portion and the framework portion comprise a dielectric constant, a loss tangent, a volume resistivity, a surface resistivity and a magnetic relative permeability. At least one of the dielectric constant, the loss tangent, the volume resistivity, the surface resistivity and the magnetic relative permeability of at least one of the interior portions differs from that of the framework portion.

Abstract: Disclosed is a method for focusing light to a target object within scattering medium comprising the following steps: (a) illuminating a plurality of incidence beams having different incidence patterns from each other, and obtaining reflection beams which are reflected from the target object for each incidence beams by a flight time which is a arrival time of the reflection beam to a camera; (b) forming a time-gated reflection matrix using the plurality of the incidence beams and the plurality of the reflection beams; (c) applying the time-gated reflection matrix to Single Value Decomposition such that a time-gated eigenchannel corresponding to a depth of the target object is calculated; (d) illuminating an eigen incidence beam having an incidence pattern, to which the time-gated eigenchannel is applied, to the target object.

Abstract: Object and shape detection in digital images utilizing edge detection is described. In a first edge detection approach, phase transformation is utilized in the frequency domain, such as in response to Fourier transform, followed by use of a frequency-domain phase kernel and inverse-Fourier transform. Edge detection is also provided using a phase transform in the spatial domain utilizing a convolution approach. In a second edge detection approach, phase stretching is utilized, such as in combination with phase histogramming along with thresholding and morphological operations. Numerous example images are provided illustrating benefits of the disclosed technology with different applications and under different conditions.