Patents Assigned to University
  • Functionally graded shape memory polymer
    Patent number: 10471648
    Abstract: A functionally graded shape memory polymer (SMP) that has a range of transition temperatures that are spatially distributed in a gradient fashion within one single article. The SMP is formed by post-curing a pre-cured glassy SMP in a linear temperature gradient that imposes different vitrification temperature limits at different positions along the gradient. Utilizing indentation-based surface shape memory coupled with optical measurements of photoelastic response, the capability of this material to respond over a wide range of thermal triggers is correlated with the graded glass transition behavior. This new class of SMP offers great potential for such applications as passive temperature sensing and precise control of shape evolution during a thermally triggered shape recovery.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: November 12, 2019
    Assignee: Syracuse University
    Inventors: Patrick Mather, Xiaofan Luo, Andrew M. DiOrio, Kyung-Min Lee
  • Channelrhodopsins for optical control of cells
    Patent number: 10472399
    Abstract: The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: November 12, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of The University of Alberta
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Apparatus and method for photonic physiological and neurological stimulation
    Patent number: 10471276
    Abstract: An apparatus and method utilizes photonics, particularly lasers, and biometric feedback for physiological and neurological stimulation. While many areas of the body are candidates, such laser stimulation is particularly directed to the outer ear. Lasers positioned over the ear stimulate targets on the outer ear for pain and stress management and regulation of the autonomic nervous system to affect symptoms and clinical conditions. Laser positioning, wavelength, aiming, focus, power, power density, timing, and sequencing are managed and modified dynamically in real time to effect a personalized and effective treatment protocol.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: November 12, 2019
    Assignee: The Regents of the University of California
    Inventors: William Beckner, John A. Ives, Mark Bachman, Guann-Pyng Li
  • Reservoir device for intraocular drug delivery
    Patent number: 10470924
    Abstract: A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: November 12, 2019
    Assignee: The Johns Hopkins University
    Inventors: Signe Erickson, Eugene de Juan, Jr., Aaron Christopher Barnes, Terry Harrison Shelley, Michael J. Cooney
  • Microfluidic device and array disk
    Patent number: 10471426
    Abstract: The invention relates to microfluidic devices and array disks for “one-pot” isolated chemical reactions. The array disks comprise a plurality of sectors in which each sector comprises one microfluidic device. The microfluidic devices comprise a fluid delivery channel and an array of wells wherein the fluid delivery channel delivery fluid into the wells in a serpentine arrangement. In some embodiments, the fluid delivery channel is directly above the array of wells. In other embodiments, the fluid delivery channel is offset from the array of wells so that side channels branching from the fluid delivery channel delivers fluid into the wells. The well of the microfluidic device comprises a gas-permeable membrane that forms the floor, well, or at least a portion of the floor or wall of the well. In preferred embodiments, the well is cylindrical.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: November 12, 2019
    Assignee: Arizona Board of Regents on behalf of Arizona State University
    Inventors: Rhett Martineau, Jeff Houkal, Shih-Hui Chao, Weimin Gao, Shufang Ci, Deirdre Meldrum
  • Combined minimization of intersymbol interference (ISI) and adjacent channel interference (ACI)
    Patent number: 10476705
    Abstract: Adaptive windowing of insufficient cyclic prefix (CP) for joint minimization of intersymbol interference (ISI) and adjacent channel interference (ACI) is provided. The proposed subcarrier specific windowing scheme improves the signal-to-interference ratio (SIR) even when the cyclic prefix (CP) is insufficient. Average optimal window lengths depend only on the power density profiles (PDPs), and although instantaneous optimal window lengths depend on users' channel impulse responses (CIRs), fluctuation is little. Therefore, subcarrier specific windowing outperforms fixed windowing, even with outdated window lengths in the case of powerful interferers.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: November 12, 2019
    Assignee: University of South Florida
    Inventors: Berker Pekoz, Selcuk Kose, Huseyin Arslan
  • Serum-free medium
    Patent number: 10472605
    Abstract: A serum-free medium for the growth of mesenchymal stem cells comprises FGF, TGF-? and lipoprotein.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: November 12, 2019
    Assignee: National University of Ireland, Galway
    Inventors: Francis Peter Barry, Emma Jane Mooney, Josephine Mary Murphy, Georgina Margaret Shaw, Sean Patrick Gaynard
  • Deoxynucleoside therapy for diseases caused by unbalanced nucleotide pools including mitochondrial DNA depletion syndromes
    Patent number: 10471087
    Abstract: The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA depletion syndromes, and more specifically, thymidine kinase 2 (TK2) deficiency. The pharmacological therapy involves the administration of at least one deoxynucleoside, or mixtures thereof. For the treatment of TK2 deficiency, the pharmacological therapy involves the administration of either deoxythymidine (dT) or deoxycytidine (dC), or mixtures thereof. This administration of deoxynucleosides is applicable to other disorders of unbalanced nucleotide pools, especially those found in mitochondrial DNA depletion syndrome.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: November 12, 2019
    Assignees: The Trustees of Columbia University in the City of New York, Fundació Hospital Universitari Vall d'Hebron-Institut de Recerca
    Inventors: Michio Hirano, Caterina Garone, Ramon Marti
  • Enzymes and methods for cleaving N-glycans from glycoproteins
    Patent number: 10471134
    Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: November 12, 2019
    Assignee: The Regents of the University of California
    Inventors: Daniel Garrido, J. Bruce German, Carlito B. Lebrilla, David A. Mills
  • FLUORINE SUBSTITUTION INFLUENCE ON BENZO[2,1,3]THIODIAZOLE BASED POLYMERS FOR FIELD-EFFECT TRANSISTOR APPLICATIONS
    Publication number: 20190338070
    Abstract: Four conjugated copolymers with a donor/acceptor architecture comprising 4,4-dihexadecyl-4H-cyclopenta[1,2-b:5,4-b?]dithiophene as the donor structural unit and benzo[2,1,3]thiodiazole fragments with varying degrees of fluorination have been synthesized and characterized. It has been shown that the HOMO levels were decreased after the fluorine substitution. The field-effect charge carrier mobility was similar for all polymers with less than an order of magnitude difference between different acceptor units.
    Type: Application
    Filed: May 17, 2019
    Publication date: November 7, 2019
    Applicant: The Regents of the University of California
    Inventors: Ming Wang, Guillermo C. Bazan
  • ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
    Publication number: 20190341555
    Abstract: Novel host compounds consisting of carbazole and nitrile groups are disclosed. These compounds are useful in phosphorescent OLEDs.
    Type: Application
    Filed: July 15, 2019
    Publication date: November 7, 2019
    Applicant: Universal Display Corporation
    Inventors: Lichang ZENG, Chuanjun XIA
  • SMART MIRROR
    Publication number: 20190339936
    Abstract: A mirror apparatus has a reflective panel with a front surface and an opposing back surface. A display device faces the back surface of the reflective panel such that information rendered on the display device is conveyed to the front surface of the reflective panel. Processor circuitry accepts a voice command from a user and renders the information on the display in accordance with constraints of an interface selected based on the voice command.
    Type: Application
    Filed: May 7, 2018
    Publication date: November 7, 2019
    Applicant: Imam Abdulrahman Bin Faisal University
    Inventors: Samiha Brahimi, AlHanouf Ali O. Alotaibi, Jana Alkordy, Nouf Albuali, Doha Asiri, Norah Alkhuwaiter
  • ANTIOXIDANT COMPOUNDS AND THEIR USE
    Publication number: 20190337972
    Abstract: Disclosed herein are novel amine-functionalized porphyrin compounds, as wells as pharmaceutically acceptable salts or esters thereof. The disclosed compounds can be used to impart antioxidant, anti-inflammatory, anti-microbial, and/or cell-adhesion specificity to a surface or material in need thereof, such as a surface of an indwelling medical implant, or a marine surface.
    Type: Application
    Filed: July 16, 2019
    Publication date: November 7, 2019
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Xinyan Cui, Noah Snyder, Kasey Catt, James Eles
  • CARBON NANOTUBE TERNARY SRAM CELL WITH IMPROVED STABILITY AND LOW STANDBY POWER
    Publication number: 20190341100
    Abstract: A carbon nanotube ternary SRAM cell with an improved stability and low standby power comprises a write bit line, a read bit line, a column select bit line, an inverted column select bit line, a write word line, an inverted write word line, a read word line, an inverted read word line, a first P-type CNFET, a second P-type CNFET, a third P-type CNFET, a fourth P-type CNFET, a fifth P-type CNFET, a sixth P-type CNFET, a seventh P-type CNFET, an eighth P-type CNFET, a ninth P-type CNFET, a first N-type CNFET, a second N-type CNFET, a third N-type CNFET, a fourth N-type CNFET, a fifth N-type CNFET, a sixth N-type CNFET, a seventh CNFET, an eighth N-type CNFET and a ninth N-type CNFET. The carbon nanotube ternary SRAM cell has the advantages of being lower in power consumption, capable of solving the half-select problem and the read-disturb problem and high in static noise margin.
    Type: Application
    Filed: May 6, 2019
    Publication date: November 7, 2019
    Applicant: Wenzhou University
    Inventors: Gang Li, Pengjun Wang, Yuejun Zhang, Bo Chen
  • Method Of Fabricating All-Dielectric Flat Lens With Low Refractive Index
    Publication number: 20190339417
    Abstract: A method is disclosed of fabricating all-dielectric flat lens with low refractive index comprising: selecting dielectric substrate material and lens structure material; determining incident wavelength; calculating phase modulation corresponding to each pillar unit; periodically sampling circular area of dielectric substrate with radius to obtain plurality of sampling points; calculating phase modulation required at position each sampling point; obtaining pillar corresponding to each sampling point; arranging different dielectric pillars with low refractive index and same thickness are arranged on dielectric substrate, thereby obtaining all dielectric flat lens with low refractive index.
    Type: Application
    Filed: April 13, 2018
    Publication date: November 7, 2019
    Applicants: Sun Yat-Sen University, Sun Yat-Sen University
    Inventors: Jianwen Dong, Zhibin Fan, Yujie Chen, Zengkai Shao, Siyuan Yu
  • CANCER PREVENTION AND THERAPY BY INHIBITING SOLUBLE TUMOR NECROSIS FACTOR
    Publication number: 20190336591
    Abstract: Methods are disclosed for inhibiting the development of a tumor in a subject. The methods include administering to a subject a therapeutically effective amount of a dominant negative tumor necrosis factor (DN-TNF)-? protein and/or a nucleic acid encoding the DN-TNF-? protein. The DN-TNF-? protein and/or a nucleic acid encoding the DN-TNF-? protein can be administered alone or in combination with other agents.
    Type: Application
    Filed: December 14, 2016
    Publication date: November 7, 2019
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Nikola L. Vujanovic, Lazar Vujanovic
  • MULTI-PIXEL X-RAY SOURCE WITH TUNGSTEN-DIAMOND TRANSMISSION TARGET
    Publication number: 20190341219
    Abstract: A multi-pixel x-ray source is provided. The x-ray source includes a plurality of transmission target assemblies. The transmission target assembly includes a tungsten target and a diamond substrate. The substrate includes a first transmission surface and a second transmission surface opposite first transmission surface. The substrate further includes a first side surface and a second side surface disposed between the first and second transmission surfaces. The target covers the first transmission surface of the substrate. The transmission target assembly further includes a base. The base surrounds the first and second side surfaces of substrate, exposing a collimator surface of the second transmission surface and the target. The transmission target assembly is configured to transmit x-ray generated by the target through the target and the substrate.
    Type: Application
    Filed: May 7, 2019
    Publication date: November 7, 2019
    Applicant: Washington University
    Inventors: Tiezhi Zhang, Praneeth Kandlakunta
  • METHOD, SYSTEM AND NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM FOR PROVIDING PREDICTION ABOUT BREEDING
    Publication number: 20190340332
    Abstract: According to one aspect of the invention, there is provided a method for providing a prediction about breeding, comprising the steps of: acquiring from a user at least one of information on at least one target phenotype to be had by a subject individual and information on limiting conditions related to the subject individual; determining genotypes that satisfy the limiting conditions among genotypes that are correlated with the at least one target phenotype; and providing the user with at least one of estimated information on at least one phenotype acquirable by mating the determined genotypes and estimated information on a probability of the at least one target phenotype being acquired by mating the determined genotypes, on the basis of at least one statistical model.
    Type: Application
    Filed: August 23, 2018
    Publication date: November 7, 2019
    Applicants: Fungi and Plants Corporation, The Regents of the University of California
    Inventors: Julin Nassir Maloof, John Thompson Davis, Shinje Kim, Seungmo Kim
  • GENE THERAPY FOR TREATING WILSON'S DISEASE
    Publication number: 20190338310
    Abstract: Compositions and regimens useful in treating Wilson's Disease are provided. The compositions include recombinant adeno-associated virus (rAAV) with a transthyretin enhancer and promoter driving expression of a human ATP7B.
    Type: Application
    Filed: December 29, 2017
    Publication date: November 7, 2019
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Jenny Agnes Sidrane, Lakshmanan Govindasamy
  • Angle detection apparatus
    Patent number: RE47723
    Abstract: Provided is an angle detection device capable of detecting the angle with high sensitivity by a very simple assembly process without requiring complicated processing. The angle detection device is provided with: a rotor (5) which is formed by a disk plate body produced from a magnetic substance having uniaxial magnetic anisotropy, the disk plate body rotating around a center point within the disk plate surface; a stator (3) which is provided to face the plate surface of the disk plate body of the rotor (5), has approximately the same external shape as that of the rotor, and is divided into a plurality of fan-shaped regions, and in which an exciting coil or a detection coil is wound along the outer periphery of each of the divided regions.
    Type: Grant
    Filed: September 14, 2017
    Date of Patent: November 12, 2019
    Assignee: Kyushu University, National University Corporation
    Inventor: Ichiro Sasada