Abstract: A system and method for noninvasively determining the oxygenation of a tissue, for example, a muscle, in vivo uses optical methods to optically interrogate the tissue in both a visible wavelength range and a near infrared (NIR) wavelength range. The illuminating light is sculpted in intensity to approximately match the absorbance spectrum, for example, with the visible light having an intensity an order of magnitude greater than the NIR light. Training data is obtained from healthy patients in both the visible and NIR ranges simultaneously and used to calculate muscle oxygenation.
Type:
Grant
Filed:
February 10, 2017
Date of Patent:
November 5, 2019
Assignee:
University of Washington
Inventors:
Kenneth Schenkman, Lorilee Arakaki, Wayne Ciesielski, Jeremy Shaver
Abstract: A composition and method of preparation of mixed valence manganese oxide, nickel-doped mixed valence manganese oxide and cobalt-doped mixed valence manganese oxide nanoparticles as well as tri-manganese tetroxide, nickel-doped tri-manganese tetroxide and cobalt-doped tri-manganese tetroxide nanoparticles for use as electrodes for aqueous energy storage devices.
Abstract: Methods for preventing feedlot bovine respiratory diseases employing an anti-inflammatory drug rupatadine are disclosed. Compositions are further disclosed. Beneficially, the methods and compositions provide safe and cost-effective management of a costly disease.
Type:
Grant
Filed:
January 5, 2018
Date of Patent:
November 5, 2019
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: The present invention relates to a wavelength-tunable type etalon comprising a liquid crystal layer, which comprises: a first substrate; a second substrate; a reflective coating film; a transparent electrode; an alignment layer, which is independently formed while covering the opposing surface of the transparent electrode; a liquid crystal layer, which is disposed in a space between each of the alignment layer s; and a sealing member, which is provided for sealing of the liquid crystal layer; and a method for manufacturing the same.
Type:
Grant
Filed:
July 12, 2017
Date of Patent:
November 5, 2019
Assignee:
Research & Business Foundation Sungkyunkwan University
Abstract: The present invention is a composition comprising a plurality of nanoparticles of at least one noble metal each coated with a plurality of linker molecules, at least some of which are attached to at least one of a plurality of glycosaminoglycan chains.
Type:
Grant
Filed:
March 11, 2016
Date of Patent:
November 5, 2019
Assignee:
Lancaster University Business Enterprises LTD
Abstract: Provided herein are engineered systems and methods for establishing DNA adenine methylation at specific genomic locations and using DNA adenine methylation as an artificial chemical “handle” on the genome. These systems and methods allow for placing the handle on specific genomic locations as well as molecular technologies to bind, spatially spread, and maintain the handle. The systems described herein comprise, in some embodiments, three functional modules that mediate m6A operations: (1) a synthetic initiator module to place m6A at specific genomic sites; (2) a synthetic readout module to program m6A recognition and m6A-dependent transcriptional logic; and (3) propagation module that implements “read-write,” a mechanism proposed to underlie chromatin spreading and epigenetic maintenance across cellular systems.
Type:
Grant
Filed:
February 6, 2018
Date of Patent:
November 5, 2019
Assignee:
Trustees of Boston University
Inventors:
Ahmad S. Khalil, Albert J. Keung, Minhee Park
Abstract: The present disclosure relates to a pre-5th-generation (5G) or 5G communication system to be provided for supporting higher data rates beyond 4th-generation (4G) communication system such as long term evolution (LTE). A method of operating a remote node in a wireless communication system includes: determining each of instantaneous channel states between host nodes and the remote node based on reference signals received from the host nodes during some of time intervals for a channel estimation; determining a host node for random access among the host nodes based on the determined instantaneous channel states; and when a value indicating a state of a channel between the determined host node and the remote node is larger than a threshold value, transmitting a signal for the random access to the host node.
Abstract: This disclosure describes, generally, a modified form of CD 16, genetically-modified cells that express the modified CD 16, and methods that involve the genetically-modified cells. The modified form of CD 16 can exhibit increased anti-tumor and/or anti- viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.
Type:
Grant
Filed:
March 27, 2015
Date of Patent:
November 5, 2019
Assignee:
Regents of the University of Minnesota
Inventors:
Bruce Kenneth Walcheck, Dan Samuel Kaufman, Jianming Wu, Yawu Jing, Zhenya Ni
Abstract: Systems and associated methodology are presented for Arabic handwriting synthesis including partitioning a dataset of sentences associated with the alphabet into a legative partition including isolated bigram representation and classified words that contain ligature representations of the collected dataset, an unlegative partition including single character shape representation of the collected data set, an isolated characters partition, and a passages and repeated phrases partition, generating a pangram, the pangram including the occurrence of every character shape in the collected dataset and further including a special lipogram condition set based on a desired digital output of the collected dataset, and outputting a digital representation of the pangram including synthesized text.
Type:
Grant
Filed:
October 15, 2018
Date of Patent:
November 5, 2019
Assignee:
King Fahd University of Petroleum and Minerals
Abstract: Systems and methods for estimating irradiation dose for patient application based on a radiation field model and a patient anatomy model are disclosed. According to an aspect, a method includes providing a database of patient anatomy models. The method also includes providing a radiation field model of an X-ray system. Further, the method includes receiving a measure of an anatomy of a patient. The method also includes determining a patient anatomy model among the patient anatomy models that matches or is similar to the anatomy of the patient based on the measure of the patient and a corresponding measure of each of the patient anatomy models. The method also includes estimating an irradiation dose for application to the patient by the X-ray system based on the radiation field model and the determined patient anatomy model.
Abstract: Provided herein are bioactivated polymer/extracellular matrix (ECM) composites and methods of preparation and use thereof. In particular, heparinized cysteine-polymer/ECM composites, and methods of preparation and use thereof, are provided. In some embodiments, provided herein are compositions comprising a composite of: (a) extracellular matrix (ECM), and (b) a polyester covalently linked to a bioactive agent. In some embodiments, the composite is a homogeneous composite. In some embodiments, the ECM is decellularized ECM. In some embodiments, the ECM is not substantially crosslinked.
Type:
Grant
Filed:
December 18, 2015
Date of Patent:
November 5, 2019
Assignee:
Northwestern University
Inventors:
Guillermo A. Ameer, Jason A. Wertheim, Bin Jiang
Abstract: A detector that includes an all-oxide, Schottky-type heterojunction. The “metal” side of the heterojunction is formed, for example, from a dysprosium (“Dy”) doped cadmium oxide (“CdO”) (i.e., CdO:Dy). The semiconductor side of the heterojunction is formed, for example, from cadmium magnesium oxide (“CdMgO”). On the metal side of the junction, “hot” electrons are created through the excitation of surface plasmon polaritons by infrared radiation. The hot electrons are able to cross the Schottky-type barrier of the heterojunction into the conduction band of the semiconductor where they can be detected. The working wavelength of infrared radiation that is being detected can be adjusted or tuned by modifying the Dy content of Dy-doped CdO. The height of the Schottky-type barrier can also be adjusted by modifying the composition of CdMgO, which allows for the optimization of the Schottky-type barrier height for a given working wavelength.
Abstract: Methods and systems are provided that inventory a plot of trees based on data including one or more (e.g., all) of radar images of the plot, spectral images of the plot (e.g., high resolution images taken by satellite), other data (e.g., elevation, slope, aspect), and actual tree survey data physically collected about the plot and/or another plot having similar characteristics. Although the actual tree survey data collected is typically less than the amount of actual survey data used by prior approaches, the present systems and methods are still capable of inventorying the entire plot with a high degree of confidence (e.g., at least 95% confidence).
Abstract: The present invention relates to a technical field of microwave heating, and more particularly to a microwave frequency-selective heating device and a method thereof. The microwave frequency-selective heating device includes: a heating chamber with a microwave feed-in device, and a frequency controller; wherein the frequency controller is connected to the microwave feed-in device. According to the microwave frequency-selective heating device and the method of the present invention, the heating frequency is adjusted by setting the microwave adjusting device, which improves a material heating uniformity while greatly increases a material microwave absorption rate, so as to solve a heating efficiency problem of the conventional technologies. According to the present invention, the frequency for the heated material is intelligently selected by the micro-processor of the microwave adjusting device, and then fed in after being adjusted by the frequency control circuit, which is effective and convenient.
Type:
Grant
Filed:
November 16, 2016
Date of Patent:
November 5, 2019
Assignee:
Sichuan University
Inventors:
Kama Huang, Huacheng Zhu, Yang Yang, Changjun Liu, Xing Chen
Abstract: A heavy-atom derivative of CHCA, a primary matrix molecule for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), is synthesized and purified. This new matrix molecule ?-cyano-4-hydroxy-3-iodocinnamic acid (CHICA) is characterized by 1H NMR and mass spectrometry. CHICA is shown to increase MALDI-MS yield for the test analytes human angiotensin II and sex pheromone inhibitor as compared to both CHCA and an alternative heavy-atom CHCA derivative matrix. An optimal CHICA matrix concentration is determined to be 4 mg/mL. Analyte ion yield is shown to be comparable for CHICA and CHCA for analyte concentrations below 0.001 mg/mL. For analyte concentrations above this threshold, use of CHICA resulted in higher analyte yield and significantly lower relative standard deviation.
Type:
Grant
Filed:
November 27, 2018
Date of Patent:
November 5, 2019
Assignee:
Board of Trustees of Southern Illinois University
Inventors:
Kristopher M Kirmess, Gary R Kinsel, Kyle Newton Plunkett
Abstract: A method for determining a length of a span of electrically conductive material, comprising a first voltage measurement across the entire span, and a second voltage measurement across a constant-length segment of the span. The dual measurements allow the calculation of the span length in a manner that is robust to many disturbances including ambient temperature, material temperature, and material stress and fatigue.
Type:
Grant
Filed:
May 12, 2017
Date of Patent:
November 5, 2019
Assignee:
Auburn University
Inventors:
Austin R. Gurley, David G. Beale, Royall M. Broughton
Abstract: An electromagnetic induction type Hopkinson pressure/tension bar loading device and experiment method therefor. The device not only can generate compression stress waves but also can generate tension stress waves through the electromagnetic induction principle, and is applied to the loading of a Hopkinson tension bar and a pressure bar. Thus, the loading systems for a Hopkinson tension bar and a pressure bar can simultaneously achieve the strain rate and strain range, which the traditional split Hopkinson bar experiment cannot reach, on the same device, so that the Hopkinson bar experiment technology is standardized, and the experiment devices for a tension bar and a pressure bar are integrated, thereby reducing complexity and floor space of equipment.
Type:
Grant
Filed:
August 10, 2016
Date of Patent:
November 5, 2019
Assignee:
Northwestern Polytechnical University
Inventors:
Yulong Li, Hailiang Nie, Tao Suo, Zhongbin Tang
Abstract: Methods, systems, and devices are disclosed for implementing electro-optical modulators in which a resonating cavity structure is coupled to a transmission waveguide. In one example, the resonating structure includes a ring resonator whose coupling strength is controlled via an electrical control signal. The ring resonator is made of a capacitor comprising monolayer graphene sheets separated by a thick layer of dielectric material.
Abstract: A method of predicting a disease or condition of a cornea or an anterior segment of an eye includes inputting input data into an AI model, processing the input data, and generating a set of scores and outputting a prediction. The input data may be representative of a cornea or anterior segment of an eye. Processing the input data may include processing the data through the plurality of convolutional layers, the fully connected layer, and the output layer. Each score of the set of scores may be generated by a corresponding node in the output layer. The output prediction may be related to the cornea or anterior segment of the eye represented by the input data processed through the AI model. The prediction may be determined by at least one score of the set of scores.
Type:
Grant
Filed:
July 27, 2018
Date of Patent:
November 5, 2019
Assignee:
University of Miami
Inventors:
Mohamed Abou Shousha, Amr Saad Mohamed Elsawy
Abstract: Disclosed are various examples related to ion or particle spectrometry utilizing a monolithic collimator and energy analyzer. In one example, a particle selection device includes a single substrate including a curved channel energy analyzer section and a straight channel collimator section, wherein particles pass through the collimator section and enter the energy analyzer section of the substrate. The channel outlets in the collimator section are aligned with the channel inlets of the energy analyzer section. Electric and/or magnetic fields can be applied across the channels of the energy analyzer for ion or particle discrimination. A particle detector at the outlet of the energy analyzer section can provide indications of detected ions and/or particles.
Type:
Grant
Filed:
April 4, 2017
Date of Patent:
November 5, 2019
Assignee:
West Virginia University
Inventors:
Earl Scime, Amy M. Keesee, Matthew Phillip Dugas, Steven Brian Ellison, Joseph Christopher David Tersteeg, Drew B. Elliott