Patents Assigned to University
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Patent number: 10435311Abstract: Preparing a porous hybrid media includes contacting porous media (e.g., strong base ion-exchange media) with an aqueous solution including aluminum ions to yield a aluminum-ion-containing porous media, contacting the aluminum-ion containing porous media with a reducing agent to impregnate elemental aluminum in the porous media, and oxidizing the elemental aluminum to yield a porous hybrid media including aluminum hydr(oxide) impregnated in the porous media. In some cases, a pH of an aqueous mixture including the aluminum-ion-containing porous media may be adjusted to form a floc including aluminum hydroxide, and the aluminum hydroxide-containing porous media may be contacted with a reducing agent to yield a porous hybrid media including aluminum hydr(oxide) impregnated in the porous media. The porous hybrid media may advantageously be prepared at low temperature (e.g., room temperature).Type: GrantFiled: September 28, 2017Date of Patent: October 8, 2019Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Kiril D. Hristovski, Jasmina Markovski, Paul K. Westerhoff, Shahnawaz Sinha
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Patent number: 10439433Abstract: A method of self-healing power grids after power outages includes providing an Adaptive Restoration Decision Support System (ARDSS) for generating a restoration solution using static and dynamic input data from power generator(s) powering transmission lines, from the transmission lines and loads. At a beginning of a restoration period a two-stage problem is solved including a first and second-stage problem with an optimal planning (OP) function as a mixed-integer linear programming (MILP) problem using initial static and dynamic data to determine start-up times for the power generator and energization sequences for transmission lines involved in the power outage. Only the second-stage problem is again solved with an optimal real-time (OR) function using the start-up times and energization sequences along with updated static and dynamic data to determine operating parameters for the grid.Type: GrantFiled: March 1, 2018Date of Patent: October 8, 2019Assignee: University of Central Florida Research Foundation, Inc.Inventors: Amir Golshani, Wei Sun, Qun Zhou
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Patent number: 10436793Abstract: The presently disclosed subject matter provides methods using mass spectrometry for direct profiling of N-linked glycans from a biological sample. In addition, the embodiments of the present invention also disclose novel methods, known as targeted analyte detection (TAD), for improving the detection limit of MALDI-MS. These methods take advantage of the carrier effect of the added standard analytes, which occurs due to the generic sigmoidal shape of the calibration curve. The functionality of TAD depends on the relative enhancement of sensitivity over the increase of the standard deviation at the analysis of target analytes with spiking in exogenous concentration. At certain ranges of exogenous concentration, the increment in the sensitivity overcomes the standard deviation, resulting in an improved LOD. Theoretically, exogenous concentrations approximately at 1 LODorig would generate the optimum LOD improvement.Type: GrantFiled: September 14, 2017Date of Patent: October 8, 2019Assignee: The Johns Hopkins UniversityInventors: Hui Zhang, Xingde Li, Shadi Toghi Eshghi
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Patent number: 10437909Abstract: A food safety management tool that utilizes a mathematical model based on differential equations that is generalized for describing the continuous growth-death kinetics of microbial populations in foodstuffs. The method is used to provide a way to control target microorganisms when designing product formulations of minimally processed foodstuffs or when processing foods with high pressures, temperatures, or other lethal agents to achieve effective pasteurization, disinfection, or sterilization of foodstuffs, and includes the use of model parameters to predict food formulations to inhibit the growth of microorganisms and the processing times needed to reduce microbial hazards to levels that ensure consumer safety.Type: GrantFiled: September 1, 2009Date of Patent: October 8, 2019Assignee: Brandeis UniversityInventors: Christopher J Doona, Edward W Ross, Florence E Feeherry, Kenneth Kustin
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Patent number: 10435357Abstract: Provided here are nitric oxide-releasing compounds that include at least two different NO donor functional groups of the same class. In some embodiments, such nitric oxide-releasing compounds are macromolecules such as dendrimer and co-condensed silica. Pharmaceutical compositions, wound dressings, kits and methods of treatments are also provided herein.Type: GrantFiled: January 3, 2019Date of Patent: October 8, 2019Assignees: The University of North Carolina at Chapel Hill, Novan, Inc.Inventors: Mark Schoenfisch, Yuan Lu, Nathan Stasko, Jian Bao
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Patent number: 10439090Abstract: A transparent luminescent solar concentrator is provided. In another aspect, a luminescent solar concentrator absorbs outside of visible light and emits outside of visible light. A further aspect of a luminescent solar concentrator employs nanocrystal clusters embedded in a polymeric matrix. In still another aspect, a unique ligand and luminophore host pairing is used for a solar concentrator.Type: GrantFiled: November 8, 2013Date of Patent: October 8, 2019Assignee: Board of Trustees of Michigan State UniversityInventors: Richard R. Lunt, Yimu Zhao
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Patent number: 10435425Abstract: Disclosed herein a sialyl donor and its use for the synthesis of gangliosides. The sialyl donor has the structure of, wherein, R1 and R2 are independently benzoyl, toluenesulfonyl, pivaloyl or acetyl optionally substituted with a halogen; and R3 is acetyl or —(O)CCH2OH. In one preferred embodiment, in the sialyl donor of formula (I), R is acetyl. Also disclosed herein is a method of synthesizing a sialoside. The method comprises steps of: coupling the sialyl donor of formula (I) with a glycosyl acceptor having a primary hydroxyl group in the presence of N-iodosuccinimide (NIS) and trifluoromethanesulfonic acid (TfOH) under suitable conditions; and isolating the sialoside, which has an ?-glycosidic linkage. According to preferred embodiments, the coupling is conducted in a solvent selected from the group consisting of, CH3CN, CH3Cl, and CH2Cl2 at a temperature between ?20° C. to ?60° C.Type: GrantFiled: July 14, 2018Date of Patent: October 8, 2019Assignee: Chung Yuan Christian UniversityInventors: Yow-Fu Tsai, Yu-Fa Wu
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Patent number: 10434505Abstract: A photocatalyst includes a composite fiber having at least two crystalline semi-conductors that provide a heterojunction structure in the composite fiber.Type: GrantFiled: June 10, 2019Date of Patent: October 8, 2019Assignee: The Hong Kong Polytechnic UniversityInventors: Wallace Woon Fong Leung, Chun Pei
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Patent number: 10440055Abstract: An example apparatus configured to perform network deception may include processing circuitry configured to generate virtual instances of decoy resources residing within a defined host network for presentation to cyber attackers, control at least one software defined network switch to monitor network traffic directed to real and decoy resources of the defined host network, and route network traffic based on detected interactions with the decoy resources. The decoy resources may have differing levels of decoy fidelity, where decoy fidelity indicates a difficulty for a cyber attacker to determine that the resource is a decoy. Additionally, generating the virtual instances of decoy resources may be performed without modification to real assets or real services residing in the defined host network. Furthermore, decoy services may be made to appear on real network assets using software defined networking without modification to the real assets or real services residing in the defined host network.Type: GrantFiled: July 28, 2017Date of Patent: October 8, 2019Assignee: The Johns Hopkins UniversityInventors: Patrick D. Allen, Steven A. Handy, Aaron M. David, James G. Castle, Mark A. Matties
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Patent number: 10434225Abstract: The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). The present invention also provides compound films composed of at least two para-xylene polymer films with a therapeutic molecule layer in between. Such compound films, when used in vivo (e.g., as a tissue separator and to treat inflammation or atrial fibrillation) allow either therapeutic molecule elution through one of the para-xylene layers, or therapeutic molecule release when the compound film is pierced, such as when it is sutured in place.Type: GrantFiled: March 29, 2016Date of Patent: October 8, 2019Assignees: Northwestern University, University of Maryland, Ann & Robert H. Lurie Children's Hospital of ChicagoInventors: Dean Ho, Erik M. Robinson, Sunjay Kaushal, Patrick M. McCarthy
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Patent number: 10436746Abstract: Electrochemical and bio sensors using metal oxide semiconductors and method of making the same are described herein. The sensor includes a gate electrode, a dielectric layer over the gate electrode, a channel layer over the dielectric layer, and source and drain electrodes formed on the channel layer to provide a field effect transistor structure. The channel layer is a metal oxide semiconductor film that has a substantially uniform thickness of at least 3 nm thick and less than 10 nm thick. The metal oxide semiconductor film is functionalized with molecules attached thereto that are open to make contact with a fluid for detection of at least one component or at least one physical or chemical property of the fluid.Type: GrantFiled: August 29, 2017Date of Patent: October 8, 2019Assignee: The Regents of the University of CaliforniaInventors: Yang Yang, You Seung Rim, Jonathan Yang
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Patent number: 10439093Abstract: A photovoltaic photodetector includes a substrate, a graphene layer, and a dielectric layer positioned between the substrate and the graphene layer. One or more first antenna electrodes includes a first metal in direct contact with the graphene layer. One or more second antenna electrodes includes a second metal in direct contact with the graphene layer. The first and second metals have different work functions. A drain electrode is electrically coupled to the one or more first antenna electrodes, and a source electrode is electrically coupled to the one or more second antenna electrodes. The photovoltaic photodetector can be configured to be operable over a wavelength region of 2 ?m to 24 ?m and has a response time of 10 ns or less.Type: GrantFiled: April 14, 2017Date of Patent: October 8, 2019Assignee: Arizon Board of Regents on behalf of Arizona State UniversityInventor: Yu Yao
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Patent number: 10436725Abstract: A method of operating a radiation inspection system includes identifying a regulatory region along a predetermined path where public access is restricted based upon criteria other than radiation exposure, measuring a radiation exposure level from a radiation source of the radiation inspection system within the regulatory region, irradiating a target within the regulatory region using the radiation source and without erecting a physical barricade, and determining a restricted area around the radiation source. The restricted area corresponds to an area where a radiation exposure rate exceeds a predetermined threshold. The radiation exposure rate may be determined by the radiation exposure level from the radiation source and a speed of the radiation inspection system. The method may include operating the radiation inspection system to dynamically adjust the restricted area so that it does not extend beyond the regulatory region. The radiation inspection system may be moveable along the predetermined path.Type: GrantFiled: June 14, 2017Date of Patent: October 8, 2019Assignees: GEORGETOWN RAIL EQUIPMENT COMPANY, University of Florida Research Foundation, IncorporatedInventors: Jeb Everett Belcher, Jessica Emily Kelley
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Patent number: 10435757Abstract: Provided herein are methods of measuring C19MC miRNA amount and/or expression in a post-natal cell and/or tissue. Provided herein are methods of measuring CpG methylation of the upstream C19MC miRNA promoter region in a post-natal cell and/or tissue. Also provided herein are methods of treating a cell, population thereof, and/or a subject in need thereof by administering a C19MC miRNA inhibitor or CRISPR to suppress the expression of specific miRNA within the C19MC or the entire C19MC cluster, population thereof, and/or the subject in need thereof.Type: GrantFiled: June 15, 2017Date of Patent: October 8, 2019Assignee: University of South FloridaInventors: Hana Totary-Jain, Ezinne Francess Mong
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Patent number: 10436777Abstract: A method for detecting an analyte in a sample, the method comprising contacting the analyte in a sample with nanoparticles comprising a capture probe for capturing said analyte, the capture probe being configured to act as a center for controlled aggregation of nanoparticles with said analyte to form an aggregate of predefined form, detecting the analyte by detecting the shape and/or size of the aggregate is provided. Also provided are nanoparticles comprising a capture probe for capturing an analyte, wherein the capture probe is configured to act as a center for controlled aggregation of nanoparticles with the analyte to form an aggregate of particular detectable size and/or shape, and an assay.Type: GrantFiled: December 5, 2012Date of Patent: October 8, 2019Assignee: University College Dublin, National University of Ireland, DublinInventors: Gil Lee, Mark Platt
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Patent number: 10436815Abstract: Methods for imaging a substrate include: inducing an electrospray from a nanopipette probe; varying a distance between the nanopipette probe and a surface of the substrate until a predefined electrospray current and/or a predefined distance threshold is reached; and determining a topography of the surface of the substrate based on feedback derived from distance dependency of the electrospray current. Apparatuses for performing scanning electrospray microscopy and methods for spatially controlled deposition of material on surfaces of substrates are described.Type: GrantFiled: August 12, 2016Date of Patent: October 8, 2019Assignee: Indiana University Research and Technology CorporationInventors: Lane Baker, Elizabeth Yuill, Tyler Yarger, Alicia Friedman, John Poehlman
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Patent number: 10434032Abstract: A tool for use in assisting soft tissue mobilization and bodily tissue amelioration, such as stimulation of superficial tissue, deep tissue mobilization, breaking up scar tissue, and soft tissue massaging, are described. The tool comprises a device for application to bodily tissue that includes a body having a substantially teardrop shape in a vertical section. In a longitudinal aspect, the body includes a first and a second portion. The first portion of the device corresponds at least in part to a substantially bulbous handle part of the teardrop shape of the vertical section and is adapted for ease of grasping and manipulation at the first end. The second portion of the device corresponds at least in part to a substantially tapered converging double-beveled linear edge of the teardrop shape of the vertical section and is adapted for facilitated application of the device to bodily tissue at the second end.Type: GrantFiled: December 15, 2015Date of Patent: October 8, 2019Assignee: The Curators of the University of MissouriInventors: Jaya Ghosh, Ellie Koehly, Yaw Sarpong, Roger de la Torre, Jonathon Buehler, Brett Hayes, Teresa Graff, Katherina Chen
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Patent number: 10435413Abstract: Cavitand compositions that comprise void spaces are disclosed. The void spaces may be empty, which means that voids are free of guest molecules or atoms, or the void spaces may comprise guest molecules or atoms that are normally in their gas phase at standard temperature and pressure. These cavitands may be useful for industrial applications, such as the separation or storage of gasses. Novel cavitand compounds are also disclosed.Type: GrantFiled: March 22, 2013Date of Patent: October 8, 2019Assignee: Georgetown UniversityInventors: Kevin Travis Holman, Christopher Kane
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Patent number: 10434089Abstract: Described are methods of treating or preventing a bacterial infection by administering an antibacterial agent comprising a ?-lactamase inhibitor and one or more carbapenem to a subject.Type: GrantFiled: January 23, 2018Date of Patent: October 8, 2019Assignee: The Johns Hopkins UniversityInventor: Gyanu Lamichhane
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Patent number: 10436779Abstract: There is provided a biosensor for detecting pathogens in a sample. The detection is based on colorimetry. The biosensor comprises one or more particle supports and a magnetic material attached to a planar support. The biosensor embodies magnetic particles that are functionalized using a chemical substrate specific to the pathogens to be detected. The sensor may allow for a simultaneous detection of a plurality of pathogens in the sample. Also, the sensor may be disposable. Moreover, the sensor may be integrated in a portable detection device.Type: GrantFiled: September 28, 2015Date of Patent: October 8, 2019Assignee: Alfaisal UniversityInventor: Mohammed Zourob