Abstract: A method for obtaining a 3-D OR-PAM image of microvasculature within a region of interest of a subject is provided. The method includes: focusing a first light pulse at a first depth beneath a first surface position within the region of interest; receiving a first PA signal in response to the first light pulse; focusing a second light pulse at a second depth beneath the first surface position within the region of interest; receiving a second PA signal in response to the second light pulse; and forming the 3-D OR-PAM image by combining the first PA signal and the second PA signal.
Type:
Grant
Filed:
May 6, 2016
Date of Patent:
October 8, 2019
Assignee:
Washington University
Inventors:
Lihong Wang, Lidai Wang, Konstantin Maslov
Abstract: Methods and computer-based systems for facilitating assessment of clinical infertility are provided. The methods and systems can be implemented to, for example, facilitate assessment of a subject for an in vitro fertilization treatment cycle, including determining probability of a live birth event. The methods and systems can be implemented to, for example, facilitate a determination of success implantation of embryos, selection of an optimal number of embryos to transfer, and determination of success in subsequent in vitro fertilization treatment cycles following an unsuccessful treatment cycle.
Type:
Grant
Filed:
August 19, 2016
Date of Patent:
October 8, 2019
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: The invention provides a peptide derived from the interleukin-13 receptor ?2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for glioma and can be formulated into compositions for medical or veterinary use. In addition, the invention provides the use of a peptide derived from the Eph family of tyrosine kinase receptors which can be also used as a vaccine for glioma and can be formulated into compositions for medical or veterinary use.
Type:
Grant
Filed:
July 8, 2016
Date of Patent:
October 8, 2019
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Abstract: Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial, Ehrlichia and Anaplasma species infections is disclosed. Also disclosed are methods to modify the organism to achieve the desired immunity through the modification of a novel genetic region involved in pathogenesis. These compounds represent a needed vaccine against an organism causing life-threatening febrile illness in humans and animals, and also represent the potential to develop new classes of drugs targeting the gene products of genes Ech_0660, Ech_0379, and Ech_0230, and their homologs of other related rickettsial pathogens.
Type:
Grant
Filed:
August 21, 2018
Date of Patent:
October 8, 2019
Assignee:
Kansas State University Research Foundation
Inventors:
Roman R. Ganta, Chuanmin Cheng, Arathy D. S. Nair, Deborah Jaworski, Suhasini Ganta
Abstract: A fracturing fluid composition that includes a chelating agent, e.g. GLDA, and a polymeric additive comprising a copolymer of acrylamido-tert-butyl sulfonate and hydrolyzed polyacrylamide diluted in an aqueous base fluid, e.g. seawater, and a method of fracking a geological formation using the fracturing fluid composition. Various embodiments of the fracturing fluid composition and the method of fracking are also provided.
Type:
Grant
Filed:
September 14, 2018
Date of Patent:
October 8, 2019
Assignee:
King Fahd University of Petroleum and Minerals
Inventors:
Mohamed Ahmed Nasr El-Din Mahmoud, Salah El-Din Elkatatny, Marwan Nagm Eldeen Mohammad
Abstract: Provided is a cocurrent loop thermosyphon system and method for operation thereof. The system includes a first rising tube having first and second ends; a condenser having first and second ends, with the first end connected to the second end of the first rising tube; a return tube having a first end connected to the second end of the condenser; a second rising tube having a first end connected to a second end of the return tube; a pump that pumps liquid within the second rising tube; and an evaporator having a first end connected to the second end of the second rising tube. The second end of the evaporator outputs vapor created by a change in state of the liquid to the first end of the first rising tube.
Type:
Grant
Filed:
October 14, 2016
Date of Patent:
October 8, 2019
Assignee:
The Research Foundation for The State University of New York
Abstract: The present invention relates to the field of protein expression. More specifically, the present invention provides compositions and methods for increasing the expression and signaling of proteins on cell surfaces. In particular embodiments, the present invention provides nucleic acids and amino acid sequences useful for improving/increasing protein expression on the cell surface. In several embodiments, the sequences are operably linked to the N-terminal end of the protein of interest. The nucleic acid sequence encoding the sequence tag and the protein can comprise part of an expression vector. The protein can be expressed with the N-terminal sequence tag. In certain embodiments, the sequences of the present invention can be used with one or more chaperone or accessory proteins. In particular embodiments, the one or more chaperone/accessory proteins are encoded by the same vector or separate vectors.
Type:
Grant
Filed:
January 29, 2015
Date of Patent:
October 8, 2019
Assignee:
The Johns Hopkins University
Inventors:
Jennifer Pluznick, Blythe Shepard, Niranjana Natarajan
Abstract: Systems and methods for targeted therapy based on single-cell stimulus perturbation response. In one embodiment, a method for optimizing stimulus combinations for therapy includes receiving a cell sample, treating the cell sample with a plurality of stimuli by treating a different portion of the cell sample with one of the plurality of stimuli for each of the plurality of stimuli, labeling the cell sample with a plurality of metal-conjugated probes, analyzing the cell sample using a mass spectrometer, obtaining mass spectrometry data from the mass spectrometer, identifying subpopulations within the cell sample using the mass spectrometry data, computing stimulus effects, generating a nested-effects model using the mass spectrometry data, and scoring stimuli combinations using the computing device, wherein the stimulus combinations are combinations made from the plurality of stimuli.
Type:
Grant
Filed:
April 5, 2017
Date of Patent:
October 8, 2019
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: A radio frequency surface wave attenuator structure is provided. The structure may be configured to be operably coupled with a plurality of other radio frequency surface wave attenuator structures to form a metamaterial. The radio frequency surface wave attenuator structure may include a patch disposed in a first plane and defining a patch area and a backplane disposed in a second plane and extending along the second plane to be shared with the other surface wave attenuator structures. The structure may further include a via spring having a number of turns and being comprised of a conductive material. The via spring may electrically couple the patch to the backplane. The structure may further include a dielectric disposed between the patch and the backplane.
Type:
Grant
Filed:
January 31, 2018
Date of Patent:
October 8, 2019
Assignee:
The Johns Hopkins University
Inventors:
Kenneth R. Grossman, Joseph A. Miragliotta, Adam J. Maisano, Douglas B. Trigg
Abstract: A microfluidic device can include a temperature regulator positioned to generate a temperature gradient across a thermally controlled portion of the microfluidic device from a high temperature region to a low temperature region. Additionally, the microfluidic device can include a bi-directional microfluidic serpentine pathway having a first terminus and a second terminus. The bi-directional microfluidic serpentine pathway can be oriented along a longitudinal direction transverse to the temperature gradient. Further, the bi-directional microfluidic serpentine pathway can include a plurality of oscillation segments fluidly coupling the first terminus to the second terminus and forming a flow path adapted to oscillate a fluid between the high temperature region and the low temperature region. The bi-directional microfluidic serpentine pathway can have a uniform cross section to facilitate bi-directional flow.
Type:
Grant
Filed:
October 3, 2017
Date of Patent:
October 8, 2019
Assignee:
University of Utah Research Foundation
Inventors:
Raheel Samuel, Bruce Gale, Alex Jafek, James Trauba, Kenneth Aston
Abstract: A sensing system includes a sensor assembly that is communicably connected to a computer system, such as a server or a cloud computing system. The sensor assembly includes a plurality of sensors that sense a variety of different physical phenomena. The sensor assembly featurizes the raw sensor data and transmits the featurized data to the computer system. Through machine learning, the computer system then trains a classifier to serve as a virtual sensor for an event that is correlated to the data from one or more sensor streams within the featurized sensor data. The virtual sensor can then subscribe to the relevant sensor feeds from the sensor assembly and monitor for subsequent occurrences of the event. Higher order virtual sensors can receive the outputs from lower order virtual sensors to infer nonbinary details about the environment in which the sensor assemblies are located.
Type:
Grant
Filed:
April 24, 2018
Date of Patent:
October 8, 2019
Assignee:
Carnegie Mellon University
Inventors:
Yuvraj Agarwal, Christopher Harrison, Gierad Laput, Sudershan Boovaraghavan, Chen Chen, Abhijit Hota, Bo Robert Xiao, Yang Zhang
Abstract: An object of the invention is to provide a peptide having a stabilized secondary structure. The present invention provides a peptide having a secondary structure stabilized by a crosslinked structure and containing at least one combination of a special amino acid of the formula (I): (wherein, (A) represents a single bond or a linking group having, in the main chain thereof, from 1 to 10 atoms; (B) represents a group containing at least one ? bond; (C) represents a hydrogen atom or an alkyl group which may be substituted with a substituent; and X represents a group substitutable by a substitution reaction with a sulfanyl group) and an amino acid having, in the side chain thereof, a sulfanyl group; and having the crosslinked structure formed through a thioether bond between the side chain of the special amino acid residue and the sulfanyl group.
Abstract: A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.
Type:
Grant
Filed:
July 21, 2011
Date of Patent:
October 8, 2019
Assignees:
University of Delaware, University of Southern California
Inventors:
Joseph M. Fox, Matthew Hassink, Melissa Blackman, Zibo Li, Peter S. Conti, Ramajeyam Selvaraj
Abstract: The invention provides a positive/negative phase shift bimetallic zone plate and production method thereof, wherein the positive/negative phase shift bimetallic zone plate comprises: a first metallic material having a positive phase shift; a second metallic material having a negative phase shift at a working energy point; wherein the first metallic material and the second metallic material are alternately arranged, so that the second metallic material replaces the blank portion in a cycle of a traditional zone plate.
Type:
Grant
Filed:
May 22, 2014
Date of Patent:
October 8, 2019
Assignee:
University of Science And Technology of China
Abstract: This invention provides novel tools for surgery on single cells and substrates/devices for delivery of reagents to selected cells. In certain embodiments the substrates comprise a surface comprising one or more orifices, where nanoparticles and/or a thin film is deposited on a surface of said orifice or near said orifice, where the nanoparticles and/or a thin film are formed of materials that heat up when contacted with electromagnetic radiation. In certain embodiments the pores are in fluid communication with microchannels containing one or more reagents to be delivered into the cells.
Type:
Grant
Filed:
October 24, 2014
Date of Patent:
October 8, 2019
Assignee:
The Regents of the University of California
Inventors:
Pei-Yu E. Chiou, Ting-Hsiang S. Wu, Sheraz Kalim Butt, Michael A. Teitell
Abstract: The present invention relates to the field of stem cells. More specifically, the invention provides methods and compositions useful for forming three-dimensional human retinal tissue in vitro. In a specific embodiment, an in vitro method for differentiating hiPSCs into three-dimensional retinal tissue comprising functional photoreceptors comprises the steps of (a) culturing the hiPSCs to form aggregates; (b) transitioning the aggregates into a neural induction medium; (c) seeding the aggregates on to extracellular matrix coated cell culture substrates; (d) replacing NIM with a chemically-defined differentiation medium; (e) detaching NR domains; (f) culturing in suspension; and (g) adding animal serum or plasma component and retinoic acid.
Type:
Grant
Filed:
January 16, 2015
Date of Patent:
October 8, 2019
Assignee:
The Johns Hopkins University
Inventors:
Maria Valeria Canto-Soler, Xiufeng Zhong
Abstract: Methods for delivering discrete entities including, e.g., cells, media or reagents to substrates are provided. In certain aspects, the methods include manipulating and/or analyzing qualities of the entities or biological components thereof. In some embodiments, the methods may be used to create arrays of microenvironments and/or for two and three-dimensional printing of tissues or structures. Systems and devices for practicing the subject methods are also provided.
Type:
Grant
Filed:
October 21, 2015
Date of Patent:
October 8, 2019
Assignee:
The Regents of the University of California
Inventors:
Adam R. Abate, Adam R. Sciambi, Russell Cole, Zev Jordan Gartner
Abstract: Systems and methods for asset monitoring utilize a network, one or more data servers, one or more asset-monitoring modules, and one or more beacon modules to monitor assets deployed across a facility. The systems and methods are asset-agnostic and are able to provide statistical forecasts and degradation model for each asset monitored. The systems and methods may further apply real-time regression, including Bayesian updating techniques to provide real-time corrections to forecasts and degradation models.
Abstract: This disclosure is directed to non-aromatic difluoro analogues of resorcylic acid lactones, pharmaceutical compositions comprising non-aromatic difluoro analogues of resorcylic acid lactones, and methods of treatment comprising non-aromatic difluoro analogues of resorcylic acid lactones.
Type:
Grant
Filed:
May 27, 2016
Date of Patent:
October 8, 2019
Assignee:
University of North Carolina at Greensboro
Inventors:
Mitchell P. Croatt, Lara Fakhouri, Nicholas H. Oberlies, Cedric Pearce
Abstract: Provided is a method of treating ovotoxicity of an individual, including administering an Ulmi cortex extract to an individual in need of treatment. The present disclosure may exhibit an effect of preventing, alleviating, or treating ovarian aging or premature ovarian failure by inhibiting oxidative stress or ovotoxicity of the ovaries.
Type:
Grant
Filed:
June 28, 2018
Date of Patent:
October 8, 2019
Assignee:
Dongguk University Gyeongju Campus Industry-Academy Cooperation Foundation
Inventors:
Dong Il Kim, Ju Hee Lee, Deok Ho Kim, Jae Hyun Han, Su Hyun Kim