Abstract: The present invention relates to a life extension agent containing CD24-negative mesenchymal stem cells and the treatment of dementia, cerebral infarction, spinal cord injury and the like using the life extension agent.

Abstract: Systems and methods of fabricating and functionalizing patterned nanowire probes that are stable under fluid reservoir conditions and have imageable patterns are provided. Additional embodiments possess functionalized molecular groups to collect content data of desired chemical species from a fluid reservoir in order to detect even highly dilute quantities of the desire chemical species in the reservoir. Optical imaging and deconstruction methods and systems are also provided that are capable of determining the distribution of nanowires of a particular pattern to determine the mixing between or leakage from fluid reservoirs.

Abstract: Provided is optical glass containing, in terms of mol % of cations: 10 to 60% of a La3+ component; more than 0% and up to 75% of a Ga3+ component; and 5 to 75% of a Nb5+ component, in which a total amount of the La3+ component, Ga3+ component, and Nb5+ component is 60 to 100%.

Abstract: The invention discloses a trajectory planning method for six degree-of-freedom robots taking into account of end effector motion error. Specifically, the invention disclosed a method for precise planning of robot end effector continuous trajectory by combining the screw theory, the cubic spline interpolation algorithm, and particle swarm optimization algorithm.

Abstract: A delivery system and method for storing and delivering colostrum or milk to an infant are provided. In one aspect, the system includes a syringe for delivering a dose of colostrum or milk, a swab container, and a swab. The swab is contained in the swab container and the swab container connected to the syringe. In another aspect, the delivery system includes a plurality of syringes for delivering a dose of colostrum or milk and a storage container for storing the plurality of syringes having the colostrum or milk therein. The method includes loading a first syringe with a dose of colostrum or milk and placing the loaded first syringe in a first slot in a storage container. The method further includes loading a second syringe with a dose of colostrum or milk and placing the loaded second syringe in a second slot in the storage container.

Abstract: A compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein L is a cleavable linker group; X is a cargo moiety-containing group; and R1 and R2 are each independently hydrogen, alkyl, or substituted alkyl; or R1 and R2 together form a boronic ester ring or a substituted boronic ester group.

Abstract: This invention provides a fusion protein, the sequence of which, commencing at the N-terminus of the fusion protein, is identical to the sequence of amino acids in: (a) an extracellular domain of a human Notch1 receptor protein, followed by (b) an Fc portion of an antibody, wherein the extracellular domain of the human Notch1 receptor protein (i) commences with the amino acid present at the N-terminus of EGF-like repeat 10 and (ii) extends to and includes the C-terminal amino acid of EGF-like repeat 18 or 20. Also provided is a composition comprising the any of the fusion proteins of this invention and a pharmaceutically acceptable carrier, a method of treating a subject suffering from age-related macular degeneration (AMD), diabetic retinopathy, or cancer which comprises administering to the subject any of the compositions of this invention in an amount effective to treat the subject's cancer.

Abstract: Provided is a method for regenerating an aromatic amide compound into a corresponding aromatic nitrile compound, the method realizing a dehydration reaction of providing a target compound selectively at a high yield with generation of a by-product being suppressed. Also provided is a method for producing an aromatic nitrile compound that decreases the number of steps of dehydration reaction and significantly improves the reaction speed at a pressure close to normal pressure. Furthermore, the above-described production method is applied to a carbonate ester production method to provide a method for producing carbonate ester efficiently. The above-described objects are achieved by a method for producing an aromatic nitrile compound including a dehydration reaction of dehydrating an aromatic amide compound, in which the dehydration reaction uses diphenylether.

Abstract: The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (tracrRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.

Abstract: The present invention discloses a frost prevention machine fixed support with a side extending plate at a bottom, including a frost prevention machine, a connecting support, and a pedestal. The connecting support includes an anti-tilting guide barrel, a fixed pillar, a rib plate, and a connecting plate. The pedestal includes a pedestal plate, a side extending adjusting rod, a pedestal bolt, and a side extending plate. The pedestal bolt (33) is used for fixing the connecting support with the pedestal, and the side extending adjusting rod is used for driving and fixing the side extending plate.

Abstract: A photoelectric conversion device may include a substrate, a photoactive layer disposed on the substrate, and a first electrode and a second electrode respectively connected to corresponding edges of the photoactive layer. The photoactive layer may include a first oxide semiconductor layer on the substrate, and a plurality of quantum dot layers and a plurality of second oxide semiconductor layers that are alternately formed on the first oxide semiconductor layer.

Abstract: A system and method are described for information extraction from network traffic traces that are both encrypted and non-encrypted. The system includes a client computer and a remote computer, where the client computer communicates data over a network. The client computer sets a session key log file environment variable, such that when the client computer launches a supported browser, a session key log file (KLF) is created, computer network traffic traces are captured by retrieving data from encrypted traffic, and the KLF and captured traffic are periodically transferred to a remote server. A remote computer performs traffic mining to analyze the captured traffic traces and extract sensitive pieces of information.

Abstract: Methods are disclosed herein for efficiently generating human induced pluripotent stem cells (iPSC) containing a nucleic acid including a doxycycline promoter operably linked to a nucleic acid encoding Cas9. These methods include transfecting a human somatic cell with a nucleic acid molecule comprising a doxycycline promoter operably linked to a nucleic acid encoding a Cas9, and constitutive promoter operably linked to a tetracycline responsive element and inducing the somatic cell to form an iPSC, thereby producing an iPSC that can undergo CRISPR/Cas9-mediated recombination at a high efficiency. The human iPSC, or a cell differentiated therefrom, is cultured in the presence of doxycycline to induce expression of the Cas9. These cells can then be used to target in any gene of interest by introducing nucleic acids encoding sgRNAs. Induced pluripotent stem cells produced by these methods are also disclosed.

Abstract: The invention provides delivery methods and compositions for antiviral therapeutics. Methods and compositions are provided for targeted delivery of antiviral therapeutics into cells of interest using, for example, viral vectors such as adenovirus, AAV, and replication incompetent HSV. These and other delivery systems can be used as vehicles to deliver DNA vectors encoding a nuclease or a cell-killing gene. These delivery methods can also be used to deliver naked DNA or RNA, protein products, plasmids containing a promoter that is active only in a latent viral state which drives a cell-killing gene, or other therapeutic agents.

Abstract: The disclosure contains a method of quantifying and/or evaluating metal ions in a dentifrice, wherein the method comprises subjecting the dentifrice to X-ray absorption spectroscopy (XAS), and wherein the XAS is used to measure and/or evaluate the metal ions in the dentifrice. Also disclosed are methods of selecting and screening for dentifrices based upon the evaluation and quantification of their metal ion content.

Abstract: A client and server system that performs a reinforcement learning-based encryption and decryption method according to an aspect of the present invention may include: a key management module configured to manage an encryption key required in performing an encryption and a decryption of data; a secret sharing module configured to perform a secret sharing of a threshold value for a lifetime and availability of the data; and a threshold estimation module configured to perform an estimation of the threshold value; and can improve the availability and security of data to satisfy user demands in a self-destructing environment for privacy protection.

Abstract: A microneedle patch includes: a patch layer which is a flat layer; and a microneedle which is disposed on one surface of the patch layer, includes an air-pocket therein, and formed of a polymer having at least one of swellability and solubility. The air-pocket is disposed in a lower end of the microneedle which is in contact with the patch layer. The patch layer includes a needle layer on one surface of the patch layer, and the microneedle is disposed on an opposite surface to one surface of the needle layer which is in contact with the patch layer.

Abstract: Virtual redundancy for active-standby cloud applications is disclosed herein. A virtual machine (“VM”) placement scheduling system is disclosed herein. The system can compute, for each standby VM of a plurality of available standby VMs, a minimum required placement overlap delta to meet an entitlement assurance rate (“EAR”) threshold. The system can compute a minimum number of available VM slots for activating each standby VM to meet the EAR threshold. For each standby VM of a given application, the system can filter out any server of a plurality of servers that does not meet criteria. If a given server meets the criteria, the system can add the given server to a candidate list; sort, in descending order, the candidate list by the minimum required placement overlap delta and the number of available virtual machine slots; and select, from the candidate list of servers, a candidate server from atop the candidate list.

Abstract: Boron-doped graphene quantum dots, methods for making the boron-doped graphene quantum dots, and methods for magnetic resonance imaging using the boron-doped graphene quantum dots.

Abstract: Provided are a method of ex-vivo culture of natural killer (NK) cells by treating the cells with a reactive oxygen species (ROS) inhibitor and/or a p53 protein inhibitor; and a composition comprising the cultured NK cells. By reducing the activity of ROS and p53 proteins during ex-vivo culture, NK cells may have achieved greater expansion efficiency without altering their anti-tumor cytotoxicity.