Abstract: In one aspect, embodiments disclosed herein relate to a lens-free imaging system. The lens-free imaging system includes: an image sampler, a radiation source, a mask disposed between the image sampler and a scene, and an image sampler processor. The image sampler processor obtains signals from the image sampler that is exposed, through the mask, to radiation scattered by the scene which is illuminated by the radiation source. The image sampler processor then estimates an image of the scene based on the signals from the image sampler, processed using a transfer function that relates the signals and the scene.

Abstract: Systems and methods for integrating ultra-fast programmable networks in microgrid are disclosed to provide flexible and easy-to-manage communication solutions, thus enabling resilient microgrid operations in face of various cyber and physical disturbances. The system is configured to establish a novel software-defined networking (SDN) based communication architecture which abstracts the network infrastructure from the upper-level applications to significantly expedite the development of microgrid applications, develop three functions of the SDN controller for microgrid emergency operations, including time delay guarantee, failover reconfiguration and rate limit and create a hardware-in-the-loop cyber-physical platform for evaluating and validating the performance of the presented architecture and control techniques.

Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer.

Abstract: Method of constructing a vault of a large storage tank for liquefied natural gas by first modeling the vault with a 3-D modeling software application, then partially building the vault with a framework and a first set of covering panels fixed on the framework where the panels do not touch each other, but leave a number of gaps between them, measuring the dimensions of the actual gaps between the panels using a 3-D scanner, producing a second set of panels according to the scanned dimensional data, and finally filled the gaps between the first set of panels with the second set of panels, which are much smaller than the first set of panels, making the building process earlier and more accurate, which are difficult issues in building large tanks for liquefied natural gas.

Abstract: Methods for detecting single nucleotide polymorphisms in nucleotide sequences using LAMP reactions are provided herein. Generally, two sets of LAMP primers, a wild-type primer that matches expected DNA sequences and an SNP primer that matches the expected SNP DNA are provided. One method includes providing the wild-type primer and the SNP primer in separate wells of a multi-well microfluidic array device, adding the sample nucleotide sequence into the wells seeded with the primers, and initiating LAMP reactions within the wells. The method includes observing the reaction differential between the primers and determining the status of the DNA with regard to that particular SNP. A second method includes providing the primers with tags in a mixture, adding the sample nucleotide sequence to the mixture, and initiating LAMP reactions.

Abstract: Some embodiments of the present invention intend to provide a method and an apparatus for diagnosing health state of a 3D printer which collects collection data in a 3D printing process by using sensors attached to the 3D printer (for example, an acceleration sensor and an acoustic emission sensor), extracts feature elements of the sensor data, applies machine learning to an equipment health state diagnosis model based on the extracted feature elements, and thereby enables diagnosing equipment health state of 3D printer components in an objective and consistent manner.

Abstract: The invention disclosed an error modeling method for six degree-of-freedom robot end effector space-curve trajectory. More specifically, the invention is focused on end effector continuous space-curve trajectory tasks, and provides an error model taking into account of the influence of interpolation algorithm and joint linkage parameter error. This method selects key trajectory points on the ideal trajectory and by inverse solution converts them to the joint space, and performs interpolation; meanwhile the linkage parameter error taken into account to obtain the actual end effector position. The distance from the planned trajectory point to the ideal trajectory curve is used as the comprehensive error to reflect the deviation from the planned trajectory to the ideal trajectory. A simple and practical error model is obtained, which provides a theoretical basis for controlling the end effector-tracking accuracy.

Abstract: We describe a bis-benzylidine piperidone, RA190, which covalently binds to the ubiquitin receptor RPN13 (ADRM1) in the 19S regulatory particle and inhibits proteasome function, triggering rapid accumulation of polyubiquitinated proteins. Multiple myeloma lines, even those resistant to bortezomib, were sensitive to RA190 via ER stress-related apoptosis. RA190 stabilized targets of human papillomavirus (HPV) E6 oncoprotein, and preferentially killed HPV-transformed cells. After p.o. or i.p. dosing of mice, RA190 distributed to plasma and major organs excepting brain, and potently inhibited proteasome function in skin and muscle. RA190 administration i.p. profoundly reduced growth of multiple myeloma and ovarian cancer xenografts, and oral RA190 treatment retarded HPV+ syngeneic mouse tumor growth, without impacting spontaneous HPV-specific CD8+ T cell responses, suggesting its therapeutic potential. The bis-benzylidine piperidone RA190 is a new orally-available proteasome inhibitor.

Abstract: Disclosed are an inductor layout and an integrated circuit device with improved isolation between inductors through shielding magnetic coupling between the inductors. first and second inductor coils are horizontally spaced apart from each other. A conductor loop is disposed in parallel above the first inductor coil and shields magnetic coupling between the first and second inductor coils in the manner that a part of magnetic flux of a first time-varying magnetic field generated by the second inductor coil is cancelled by magnetic flux of a second magnetic field generated by an induction current that flows in the conductor loop magnetically interlinked with the first time-varying magnetic field. The inductor layout can be applied to an RFIC device to reduce magnetic coupling between inductors of a power amplifier and an oscillator. Improved performance of the device and a very small RFIC can be achieved.

Abstract: Provided is a surface structure having freezing-delaying performance and freezing layer-separating performance. The surface structure includes a microstructural layer formed in the form of microscale irregularities and a plurality of nanopores formed in the microstructural layer. A freezing-delaying layer is formed on a surface of the microstructural layer to delay a freezing phenomenon. Also, a hygroscopic material is accommodated in the nanopores, so that when a surface of the freezing-delaying layer starts to freeze, the hygroscopic material is discharged from the nanopores to form a hygroscopic material film, and thus adhesion between the freezing-delaying layer and ice is reduced to allow the ice to be detached from the freezing-delaying layer.

Abstract: Dimethoxyphenol-based monomers containing polymerizable functional groups such as [meth]acrylate groups are useful for the preparation of polymers, wherein one or more dimethoxyphenyl moieties are part of side chains pendant to the backbones of the polymers. The polymers thereby obtained may have different, improved properties, such as higher glass transition temperatures, thermal stability and solvent resistance, as compared to polymers based on other types of lignin-derived monomers.

Abstract: The present invention provides a surface modification method based on the polymerization and cross-linking solidification of dopamine and/or its derivatives, which belongs to the technical field about composite material fabrication. The principle of dopamine polymerization and the formation process of polydopamine coating layer are the foundation of the present invention. This innovative method is established after deeply analyzing the failure mechanism of polydopamine coating layer in severe environments, such as organic solvents and acidic/alkalic environments. The critical work is finding out an eligible cross-linking agent which could react with the active functional groups in polydopamine. After cross-linking reaction, the soluble low-molecular-weight dopamine oligomers could be transformed into the insoluble three-dimensional stereographic networks.

Abstract: An optical microtoroid resonator including one or more nanoparticles attached to a surface of the resonator and capable of receiving an input signal from a far-field source (via free-space transmission) and outputting light propagating within the optical apparatus. A method for coupling light into and out of an optical resonator using a nanoparticle or nanoparticles to interface with spatially separated far-field optical elements.

Abstract: Provided are a series of crocins compounds and related pharmacological applications thereof in prevention and treatment of Alzheimer's disease. The series of crocins compounds are obtained by taking the Chinese herb, namely Gardenia jasminoides Ellis, as a raw material and separating same by means of various methods. The compounds playing a role in preventing oxidative injury caused by hydrogen peroxide (H2O2) and excitatory amino acid injury caused by L-glutamic acid are screened out by in-vitro cell experiments. The results show that the crocins compounds have good effect in preventing cell injury caused by H2O2 and L-glutamic acid. The compounds have good effect in preventing and treating Alzheimer's disease due to the fact that significant rise of oxidative stress and excitatory amino acid is a key factor for nerve injury in Alzheimer's disease, and have broad development and application prospect.

Abstract: A sweat sampling and sensing device for sensing sweat on skin includes an analyte-specific sensor for sensing a first analyte in sweat; a sweat collector placed on or adjacent to skin with a plurality of pores or pathways for entry of sweat from skin into said sweat collector, said sweat collector at least partly defining a sweat volume between said analyte-specific sensor and the skin; and a pressure element capable of holding said sweat collector against the skin with a pressure and reducing the sweat volume between said sweat collector and the skin.

Abstract: Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides for a probiotic composition for enhancing a subject's, such as an insect's, resistance to a pesticide comprising: (a) a microorganism capable of expressing one or more enzymes for metabolizing the pesticide, and (b) at least one feed ingredient for a subject. The present invention also provides for a method for enhancing a subject's, such as an insect's, resistance to a pesticide comprising administering to a subject the probiotic composition.

Abstract: An electronic intravascular device is placed in tight contact with vessel walls and is used for electrical stimulation and/or electrical recording of the vessel wall and surrounding target tissue. The electrodes may operate via connectors interfacing them to external hardware or may incorporate electronics to allow wireless power, information transfer, and control. The device includes an internal skeleton, a flexible substrate attached to the exterior of the skeleton, at least one pair of electrodes located on the substrate, and power and control circuitry connected to the electrodes. The power and control circuitry may include connectors for direct powering of the electrodes or circuit elements for wireless powering of the device by RF-based, optical-based, ultrasound-based, piezoelectric, or vibrational energy harvesting methods.

Abstract: Provided herein are compositions and methods for treating, preventing, and reversing malnutrition. In particular, provided herein are compositions and methods for facilitating cognitive repair and preventing obesity (e.g. in children).

Abstract: The present invention discloses a combined energy dissipation scaffolding structure for preventing falling rock hazards for high and steep side slope during highway construction, which belongs to the field of prevention and cure against highway disaster and post-disaster reconstruction engineering in earthquake area. The combined energy dissipation scaffolding structure mainly comprises five parts: a top surface impact-resistance system closely jointed with the existing slope surface, a top surface support system composed of 3D stereographic steel frame systems, a scaffolding body structure composed of a cross beam and support steel-pipe posts at both sides, a mountain-side anchorage system for anchoring the top surface impact-resistance system and the scaffolding body structure, and an anchoring-type steel-plate concrete composite foundation, wherein a fixed base is welded with the bottom of the steel-pipe post and is driven in the foundation soils using anchor rods.