Abstract: Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.
Type:
Grant
Filed:
August 24, 2018
Date of Patent:
May 28, 2019
Assignees:
King Fahd University of Petroleum and Minerals, King Saud University
Inventors:
Said S. Al-Jaroudi, Ali Alhoshani, Muhammad Altaf, Anvarhusein Abdulkadir Isab
Abstract: A vehicle includes a body providing structural support and defining a fuselage perimeter and including a plurality of bands, a plurality of antennas integrated into the plurality of bands, and a transceiver operatively connected to each of the plurality of antennas. The transceiver is configured to power selected sub-sets of the plurality of antennas to generate a directional antenna beam.
Type:
Grant
Filed:
May 19, 2015
Date of Patent:
May 28, 2019
Assignees:
University of North Dakota, NDSU Research Foundation
Abstract: Methods are directed to the treatment of subjects with prostate cancer, in particular those with castration resistant prostate cancer, with glucocorticoid receptor antagonists. The prostate cancer may be one that has become resistant to androgen deprivation therapy, for example, by increase in glucocorticoid receptor expression and/or activity.
Type:
Grant
Filed:
September 14, 2017
Date of Patent:
May 28, 2019
Assignee:
The University of Chicago
Inventors:
Russell Z. Szmulewitz, Suzanne D. Conzen
Abstract: A method for transmitting a discovery message in a wireless communication system supporting device-to-device (D2D) direct communication, the method performed by the device, includes: receiving discovery resource region information including multiple discovery resource partitions from a base station; determining one discovery resource partition among multiple discovery resource partitions by using discovery search information previously shared with specific D2D terminals; determining a discovery resource for transmitting a discovery message among discovery resources in the determined discovery resource partition through a predetermined resource selecting method; and transmitting the discovery message through the determined discovery resource.
Type:
Grant
Filed:
November 3, 2014
Date of Patent:
May 28, 2019
Assignees:
LG Electronics Inc., Seoul National University R&DB Foundation
Inventors:
Hakseong Kim, Seonik Seong, Kwangbok Lee
Abstract: A signal receiver circuit may include: a receiver suitable for generating a received signal based on comparison of an input signal with a reference voltage during a normal operation and based on comparison of the input signal with a target voltage during a training operation; a compensator suitable for applying a weight to the received signal to compensate for the input signal; and a weight adjuster suitable for adjusting the weight based on a level of the received signal during the training operation, wherein during the training operation, the input signal toggles between first and second levels, and the receiver is enabled when the input signal is at the first level.
Type:
Grant
Filed:
December 18, 2017
Date of Patent:
May 28, 2019
Assignees:
SK hynix Inc., Seoul National University R&DB Foundation
Inventors:
Suhwan Kim, Min-Chang Kim, Deog-Kyoon Jeong
Abstract: Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve agents are among the most toxic substances known. Variants of phosphotriesterase can prefer to hydrolyze one enantiomer of VX over the other enantiomer.
Abstract: An organic light emitting diode includes a support body, an anode electrode, a hole transport layer, an organic light emitting layer, an electron transport layer, and a cathode electrode stacked on each other in that order. The electron transport layer includes a polymer and a plurality of carbon nanotubes dispersed in the polymer, the polymer has a first surface and a second surface opposite to the first surface, and a length direction of the plurality of carbon nanotubes extends from the first surface to the second surface.
Type:
Grant
Filed:
December 20, 2017
Date of Patent:
May 28, 2019
Assignees:
Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
Inventors:
Wen Ning, Peng Liu, Kai-Li Jiang, Shou-Shan Fan
Abstract: A composition containing a macrophage inhibitor may be administered in an effective amount to prevent, inhibit or reduce restenosis, thrombus or aneurysm formation in implanted polymeric vascular grafts. The composition may be administered prior to vascular graft implantation, at the same time as vascular graft implantation, following vascular graft implantation, or any combination thereof. Examplary macrophage inhibitors include bisphosphonates, anti-folate drugs and antibodies, preferably in a controlled release or liposomal formulation.
Abstract: Described herein are fluid-manipulation-based devices. Fluid manipulations as described herein can be configured to perform assays on biological samples. In an embodiment, the device includes a reaction chamber, which can includes an integrated sample isolation module, a cell lysis module, a biological target purification module, and an assay mixing module, which can include a microbead with a capture molecule coupled thereto and a nanoparticle having a probe molecule coupled thereto via a label, which can be a spectroscopic label. In an embodiment, the capture and probe molecules can be configured to be coupled together via a biological target to form a biological molecule bead complex. Devices and methods as described herein can manipulate and analyze nanoliter volumes of fluid, microliter volumes of fluid, milliliter volumes of fluid, or greater. Embodiments of the present disclosure can enable random biological assays and rapid, simultaneous analysis of multiple biological samples.
Type:
Grant
Filed:
November 18, 2016
Date of Patent:
May 28, 2019
Assignee:
University of Florida Research Foundation, Inc.
Abstract: The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also disclosed is a composition containing a pharmaceutically acceptable carrier and at least one compound embodying the principles of the invention, and a method of treating or preventing cancer in a mammal.
Type:
Grant
Filed:
May 26, 2017
Date of Patent:
May 28, 2019
Assignees:
The United States of America, as represented by the Secretary, Department of Health and Human Services, University of Kansas, Northwestern University
Inventors:
Kevin Frankowski, Samarjit Patnaik, Sui Huang, Juan Jose Marugan, John Norton, Frank J. Schoenen, Noel Terrence Southall, Steven Titus, Wei Zheng, Chen Wang
Abstract: A system for producing an ion concentration gradient and a temperature-responsive electrolyte material which are utilizable, for example, for efficiently converting heat energy that has been discarded into reusable energy or for efficiently recovering an acid gas, such as carbon dioxide is provided. A temperature-responsive electrolyte is used to produce an ion concentration gradient by means of a temperature gradient. The temperature-responsive electrolyte is used in the state of an aqueous solution and also in the state of a solid phase.
Type:
Grant
Filed:
October 16, 2018
Date of Patent:
May 28, 2019
Assignee:
Kyushu University, National University Corporation
Abstract: A superhydrophobic surface can be formed by contacting an article with a suspension of fluorinated boehmite particles to leave a film of the fluorinated boehmite particles after removal of the suspending fluid. The film can be transparent or the film can be translucent or opaque. When the film is translucent or opaque, the film can render the surface superoleophobic.
Type:
Grant
Filed:
July 24, 2015
Date of Patent:
May 28, 2019
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Wolfgang M. Sigmund, Shu-Hau Hsu, Ravi Kumar Vasudevan
Abstract: Disclosed is a triboelectric energy harvester including an electrolyte solution comprising an electrolyte, and a friction material layer configured to contact the electrolyte solution, wherein the friction material layer is configured to be used as an electrode, and wherein frictional electricity is generated in response to the electrolytic solution contacting the friction material layer.
Type:
Grant
Filed:
March 3, 2016
Date of Patent:
May 28, 2019
Assignee:
Research & Business Foundation Sungkyunkwan University
Inventors:
Sangwoo Kim, Sungsoo Kwak, Seongsu Kim, Taeyun Kim, Wanchul Seung, Hanjun Ryu, Hongjoon Yoon, Jeonghwan Lee, Juhyuck Lee
Abstract: Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.
Type:
Grant
Filed:
September 25, 2018
Date of Patent:
May 28, 2019
Assignee:
The Regents of the University of California
Inventors:
Michel M. Maharbiz, Jose M. Carmena, Mekhail Anwar, Burak A. Ozilgen, Dongjin Seo, Federica Fava
Abstract: The self-retaining nasal septum retractor includes two pivotally attached arms having handles on one end and speculum blades on the opposing end. The speculum blades are adjustably connected to the arms through pivoting joints. A user can adjust the vertical displacement and angular relation between the speculum blades and the arms to fit different patient septal/nasal structures. A self-retaining mechanism allows a user to lock the retractor in a retracted position, freeing up a hand of the user for other surgical tasks.
Abstract: A catalyst consisting essentially of at least one tertiary monophenyl amine having a formula R1R2N-aryl, where R1 and R2 are the same or different, and each is a hydrogen, an alkyl, or a cycloalkyl group, where at least one of R1 and R2 contain at least one carbon atom; at least one titanium halide having a formula TiXm, where m is from 2.5 to 4.0 and X is a halogen containing moiety; and at least one cocatalyst having a formula AlRn Y3-n where R is a hydrocarbon radical, Y is a halogen or hydrogen, and n is 1-3. Further, the catalyst is absent of a carrier or support.
Type:
Grant
Filed:
October 12, 2017
Date of Patent:
May 28, 2019
Assignees:
Saudi Arabian Oil Company, King Fahd University of Petroleum & Minerals
Inventors:
Muhammad Atiqullah, Abdel Salam Al-Sarkhi, Faisal Mohammed Al-Thenayan, Abdullah Raddad Al-Malki, Wei Xu, Anwar Hossaen
Abstract: An organic light emitting diode includes a support body, an anode electrode, a hole transport layer, an organic light emitting layer and an electron transport layer stacked on each other in that order. The electron transport layer has a first surface and a second surface opposite to the first surface. The electron transport layer includes a polymer and a plurality of first carbon nanotubes dispersed in the polymer, and partial surface of the plurality of first carbon nanotubes is exposed from the first surface and spaced apart from the organic light emitting layer.
Type:
Grant
Filed:
December 20, 2017
Date of Patent:
May 28, 2019
Assignees:
Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
Inventors:
Wen Ning, Peng Liu, Kai-Li Jiang, Shou-Shan Fan
Abstract: The present disclosure relates to a contact sensitive device and a contact sensitive device according to an exemplary embodiment of the present disclosure includes a base film, a first electrode, a second electrode, a third electrode, and a thermochromic layer. A protruding pattern is disposed on the base film. The first electrode and the second electrode are disposed on the base film and are spaced apart from each other with the protruding pattern therebetween. The third electrode is in contact with the protruding pattern. The thermochromic layer is disposed on the third electrode.
Type:
Grant
Filed:
January 16, 2018
Date of Patent:
May 28, 2019
Assignees:
LG Display Co., Ltd., Industry-Academic Cooperation Foundation, Yonsei University
Inventors:
WooYoung Shim, HanSaem Kang, KiSeok Chang, WookSung Kim, SungPil Ryu, GwangMook Kim, SungJun Cho, JaeMin Myoung
Abstract: A gravitational radiation communication system. The system includes a gravitational radiation transmitter and a gravitational radiation receiver. Each of the transmitter and the receiver includes a first cylindrical superconducting cavity, having a first length, a first diameter, and an entrance aperture for electromagnetic radiation; a second cylindrical superconducting cavity, having a second length, a second diameter, and a first aperture for gravitational radiation, the second cavity being coaxial with and adjacent the first cavity; and a superconducting movable membrane positioned between the first cavity and the second cavity and configured to provide parametric amplification of electromagnetic fields in the second cavity. The first aperture is configured to pass gravitational radiation.
Type:
Grant
Filed:
February 25, 2016
Date of Patent:
May 28, 2019
Assignee:
The Regents of the University of California