Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.
Type:
Grant
Filed:
May 22, 2017
Date of Patent:
August 20, 2019
Assignee:
Rutgers, the State University of New Jersey
Inventors:
David S. Perlin, Steven Park, David W. Denning
Abstract: The invention features a composition comprising a self-healing interpenetrating network hydrogel comprising a first network and a second network. The first network comprises covalent crosslinks and the second network comprises ionic or physical crosslinks. For example, the first network comprises a polyacrylamide polymer and second network comprises an alginate polymer.
Type:
Grant
Filed:
June 3, 2016
Date of Patent:
August 20, 2019
Assignees:
President and Fellows of Harvard College, Seoul National University Industry Foundation
Inventors:
Jeong-Yun Sun, Xuanhe Zhao, Widusha R. K. Illeperuma, Kyu H. Oh, Joost J. Vlassak, Zhigang Suo, Jianyu Li, David J. Mooney
Abstract: Disclosed is a system and method for the placement of elongate medical members within a patient's body using coaptive ultrasound that combines magnetic guidance with ultrasound visualization of the medical member in the patient's body. A coaptive ultrasound probe adaptor magnetically attracts an elongate medical member within the patient with sufficient force so as to allow the operator to manually guide the member to its intended location. The adaptor mates with an ultrasound probe to provide the medical operator ultrasound feedback of the position of the member, thus allowing internal placement without the need for more specialized medical equipment.
Abstract: A metal nanolaminate includes a plurality of units stacked in a longitudinal direction of the metal nanolaminate. Each of the units includes a first layer and a second layer stacked in the longitudinal direction. The first layer includes a first metal material formed of a first metallic element and the second layer includes the first metal material and a second metal material formed of a second metallic element. Each of the first layer and the second layer has a thickness of at least 5 nm but less than 100 nm in the longitudinal direction.
Type:
Grant
Filed:
April 28, 2017
Date of Patent:
August 20, 2019
Assignees:
Korea Institute of Science and Technology, Korea University Research and Business Foundation
Abstract: A composition for prevention or treatment of pulmonary fibrosis comprising chromenone derivatives represented by Formula I of the present invention or pharmaceutically acceptable salts thereof as an active ingredient, produces altered heat shock protein 27 (HSP27) dimers, thereby preventing normal HSP27 non-phosphorylated polymers from performing a chaperone function and reducing a cell protection function that chaperone originally performs. Thus the inventive composition has a remarkable inhibitory effect on pulmonary fibrosis, in particular, an irradiation-induced pulmonary fibrosis phenomenon.
Type:
Grant
Filed:
May 22, 2018
Date of Patent:
August 20, 2019
Assignees:
College of Medicine Pochon Cha University Industry—Academic Cooperation, EWHA University—Industry Collaboration Foundation, Industry-Academic Cooperation Foundation, Yonsei University
Abstract: Provided herein are methods of manufacturing a ceramic article. The methods may include providing a liquid-state pre-ceramic polymer component, disposing the liquid-state pre-ceramic polymer component on a support, curing the liquid-state pre-ceramic polymer component, and subjecting the pre-ceramic polymer to pyrolysis. Apparatuses and systems for manufacturing a ceramic article also are provided.
Type:
Grant
Filed:
May 27, 2017
Date of Patent:
August 20, 2019
Assignee:
Florida State University Research Foundation, Inc.
Abstract: The invention analyzed a protein sequence using the Udwary-Merski algorithm and identified a tetradomain fragment (DH1-DH2-UMA) which consists of two predicted DH-like domains and two pseudodomains N-terminal to them. This arrangement of domains and pseudodomains is fundamentally the opposite of what is typically observed in the DH cassettes of actinobacterial polyketide synthases or mammalian fatty acid synthases, both of which feature C-terminal pseudodomains. The invention modified E. coli by over expressing DH1-DH2-UMA in E. coli resulting in an increase in the overall production of all the fatty acids normally present in the E. coli fatty acid profile.
Abstract: A composite hollow particle comprising titanium dioxide and a metal ion in the shell which covers a hollow core. A method of making the composite hollow particle and a method of employing the composite hollow particle in production of hydrogen gas under visible light are provided.
Type:
Grant
Filed:
December 13, 2016
Date of Patent:
August 20, 2019
Assignee:
King Abdulaziz University
Inventors:
Reda Mohamedy Mohamed Ouf, Mohammad W. Kadi, Ibraheem Ahmed Mkhalid
Abstract: The invention pertains to materials and methods for identifying and/or isolating isomers, particularly, of biomolecules, such as polypeptides and proteins. The methods of identifying and/or isolating isomers of a molecule according to the invention comprise subjecting a sample to ionization prior to IMS followed by MS. In some embodiments, the sample is subjected to metallization during the ionization step.
Type:
Grant
Filed:
February 9, 2018
Date of Patent:
August 20, 2019
Assignee:
The Florida International University Board of Trustees
Inventors:
Francisco Fernandez Lima, Kevin Jeanne Dit Fouque
Abstract: Disclosed herein are novel amine-functionalized porphyrin compounds, as wells as pharmaceutically acceptable salts or esters thereof. The disclosed compounds can be used to impart antioxidant, anti-inflammatory, anti-microbial, and/or cell-adhesion specificity to a surface or material in need thereof, such as a surface of an indwelling medical implant, or a marine surface.
Type:
Grant
Filed:
August 17, 2016
Date of Patent:
August 20, 2019
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Inventors:
Xinyan T. Cui, Noah Snyder, Kasey Catt, James Eles
Abstract: Hoxb5 identifies long-term hematopoietic stem cells. Expression of Hoxb5 distinguishes between LT-HSCs and non-LT-HSCs, and the marker identifies substantially all LT-HSC in the bone marrow. By utilizing fluorescent proteins under the endogenous expression control of Hoxb5, LT-HSC can be monitored and isolated, including without limitation detection and monitoring of HSC in bone morrow; production of LT-HSC from pluripotent stem cells such as iPS cells; for analysis of early stage LT-HSC; in screening methods for expansion and manipulation of LT-HSC, and the like.
Type:
Grant
Filed:
June 7, 2017
Date of Patent:
August 20, 2019
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
James Y. Chen, Masanori Miyanishi, Irving L. Weissman
Abstract: A method for forming an organic thin film transistor is provided. An organic semiconductor layer, a source electrode, a drain electrode, a gate electrode, and an insulating layer are formed on an insulating substrate. A method for forming the organic semiconductor layer is provided. An evaporating source is provided, and the evaporating source and the insulating substrate are spaced from each other. The carbon nanotube film structure is heated to gasify the organic semiconductor material to form the organic semiconductor layer on a depositing surface.
Type:
Grant
Filed:
April 14, 2017
Date of Patent:
August 20, 2019
Assignees:
Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
Abstract: The porous polymer compound has a three dimensional skeleton and pores and/or voids that are partitioned and formed by the three dimensional skeleton. The three dimensional skeleton comprises multiple sugar derivatives represented by formula (1) and multiple cations that interact with the hydroxyl groups and/or ether bonds of the sugar derivatives, and the three-dimensional skeleton is formed by each of the cations interacting with two or more sugar derivatives. Also provided are a method of separating a compound to be separated using the porous polymer compound; a single crystal of the porous polymer compound; a method of preparing a sample for crystal structure analysis using the single crystal; a method of determining a molecular structure of a compound to be analyzed using the sample for crystal structure analysis; and a method of determining an absolute configuration of a chiral compound using the sample for crystal structure analysis.
Abstract: In this study, for the first time, protective efficacy of gD against ILTV challenge was evaluated. Immunization with recombinant Newcastle disease virus expressing ILTV gD induced a higher level of neutralizing antibodies and offered complete protection to chickens against lethal ILTV challenge. Uses of recombinant NDV as a vaccine vector are also described.
Type:
Grant
Filed:
July 21, 2014
Date of Patent:
August 20, 2019
Assignee:
University of Maryland, College Park
Inventors:
Siba K. Samal, Mallikarjuna Kanabagatte Basavarajappa, Sweety Samal
Abstract: Some embodiments of the present invention provide apparatus having a particle beamline for passage of charged particles of radiation therealong, comprising: a first beam tracker structure comprising at least one position sensitive detector (PSD) for determining a location with respect to a cross-sectional area of the beam line at which particles pass through the PSD; energy discrimination apparatus for determining an energy of particles that have passed through the first beam tracker structure; and support means for supporting a subject in a path of a particle along the beamline between the first beam tracker structure and the energy discrimination apparatus, the apparatus being configured to be operated in a selected one of a first mode and a second mode, the apparatus being configured, in the first mode of operation, to control an energy of the beam of charged particles passing through the first beam tracker structure such that a Bragg peak of charged particle absorption is located within the subject, and i
Type:
Grant
Filed:
June 9, 2015
Date of Patent:
August 20, 2019
Assignee:
University of Lincoln
Inventors:
Nigel Allinson, Grainne Riley, Chris Waltham, Michela Esposito, Tony Price, Phil Allport, Jon Taylor, Gianluigi Casse, Phil Evans, Gavin Poludniowski, Stuart Green, Spyros Manolopoulos, Jaime Nieto-Camero, Marcus Verhoeven
Abstract: The present invention provides, inter alia, a process for incorporating a cyclopropenium ion into a polymeric system. Processes for making cross-linked polymers, linear polymers, and dendritic polymers, as well as for incorporating a cyclopropenium ion onto a preformed polymer are also provided. Further provided are stable, polycationic compounds, various polymers that contain stable cyclopropenium cations, and substrates containing such polymers. The use of these polymers in water purification systems, antimicrobial coatings, ion-transport membranes, cell supports, drug delivery vehicles, and gene therapeutic vectors are also provided.
Type:
Grant
Filed:
August 14, 2017
Date of Patent:
August 20, 2019
Assignee:
The Trustees of Columbia University in the City of New York
Inventors:
Tristan Hayes Lambert, Luis M. Campos, Jeffrey Bandar, Emma Jane Dell