Abstract: The disclosure provides compositions and methods relating to the treatment of pain, such as pain from rheumatoid arthritis. By creating conjugates of antibodies that target C5aR and siRNA's that target C5 expression, a dual mode therapeutic that targets two different aspects of C5's inflammatory signaling.
Type:
Grant
Filed:
August 3, 2015
Date of Patent:
May 7, 2019
Assignee:
The Regents of the University of Colorado, a body corporate
Abstract: Provided herein is a method for synthesizing polynucleic acids, comprising the steps of (a) providing an acidic solution substantially free of nucleic acid polymerase and lipids, but containing mononucleotides and a monovalent salt; (b) drying and resolubilizing the mixture of step (a) a plurality of times; and (c) recovering polynucleic acids from a resolubilized mixture of step (b). In certain aspects, the method further uses a low pH, e.g. about 3; it can utilize monophosphates, such as AMP rather than ATP; and it can be used with a polynucleotide template to form a sequence at least partially complementary to said template. Thus, both single-stranded and double-stranded polynucleic acids are provided. Ammonia salts have been used to obtain RNA lengths from 10 to 300 nucleotides after 16 half hour cycles and an effective temperature includes between 80° C. and 100° C.
Type:
Grant
Filed:
September 16, 2014
Date of Patent:
May 7, 2019
Assignees:
The Regents of the University of California, Sorbonne Universite
Inventors:
David W. Deamer, Marie-Christine Maurel, Laura Da Silva
Abstract: Chalcogenidometallates of group IIB, IV and V elements and, particularly, alkali metal-containing chalcogenidometallates of cadmium, lead and bismuth are provided. Also provided are methods of using the chalcogenidometallates as molecular solders to form metal chalcogenide structures, including thin films, molded objects and bonded surfaces composed of metal chalcogenides.
Type:
Grant
Filed:
December 1, 2015
Date of Patent:
May 7, 2019
Assignee:
The University of Chicago
Inventors:
Dmitriy S. Dolzhnikov, Hao Zhang, Jaeyoung Jang, Jae Sung Son, Matthew G. Panthani, Dmitri V. Talapin
Abstract: A system and method includes generating, with a configuration controller, a configuration bitstream including configuration bits to dynamically define the configuration of a reconfigurable integrated circuit by setting a state of a subset of configuration state memory units. The configuration controller accesses individual configuration state memory units of the subset according to a scan path through the configuration state memory units traversed according to a delay factor based, at least in part, on clock frequency of a clock signal produced by a configuration clock and configures the individual configuration state memory units with corresponding configuration bits of the configuration bitstream.
Type:
Grant
Filed:
April 8, 2016
Date of Patent:
May 7, 2019
Assignee:
Louisana State University Research & Technology Foundation
Abstract: Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and thereby decreasing aggegate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPis of a target protein.
Type:
Grant
Filed:
March 26, 2018
Date of Patent:
May 7, 2019
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Isabella A. Graef, Mamoun M. Alhamadsheh
Abstract: A method for rapid computation of three-dimensional displacement and Lagrange strain in a high resolution filed of phase data obtained with Displacement Encoding with Stimulated Echoes (DENSE) in magnetic resonance images of the myocardium. The method includes semi-automated segmentation of a region of a heart, phase unwrapping the images in three dimensions, and a custom radial point interpolation method (RPIM). The RPIM is a meshfree numerical analysis method that uses radial basis functions and polynomial functions to calculate the Lagrange strain of DENSE displacement data acquired from the myocardium.
Type:
Grant
Filed:
October 22, 2015
Date of Patent:
May 7, 2019
Assignee:
Washington University
Inventors:
Julia Kar, Michael K. Pasque, Brian P. Cupps
Abstract: Methods and systems for patient participatory care and monitoring are provided for applications including respiratory care, ECG monitoring, capnography, infusion pump alarm prevention/management, pressure sore prevention, incentive spirometry, consciousness monitoring during sedation, pain management and other care and monitoring modalities. A patient in-the-loop system includes an input interface for receiving data acquired from a monitoring, controlling or sensing device, a storage device for storing the data at a first location, and a processor for analyzing artifacts in the data and determining whether the patient provided a deliberate action with respect to the device as a response to a prompt or query. The processor can further initiate a variety of prompts and/or output queries stored in the storage device at a second location to the patient.
Type:
Grant
Filed:
January 29, 2018
Date of Patent:
May 7, 2019
Assignee:
University of Florida Research Foundation, Incorporated
Inventors:
Nikolaus Gravenstein, Samsun Lampotang, David Lizdas, Yashwant Singh Bisht
Abstract: A process for producing a metal foam. The process includes mechanically working a metallic powder such that oxide particles are finely dispersed within a metallic matrix of the metallic particles that make up the metallic powder. The mechanically worked metallic powder is then annealed in a reducing atmosphere, which in turn reduces the oxide particles within the metallic particles such that H2O gas molecules (steam) are formed within the metallic matrix and intraparticle porosity is produced.
Type:
Grant
Filed:
July 28, 2015
Date of Patent:
May 7, 2019
Assignees:
Millersville University of Pennsylvania, The United State Of America As Represented By The Secretary Of The Army
Inventors:
Mark Andrew Atwater, Kris Allen Darling, Mark Allen Tschopp, Jr.
Abstract: Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.
Type:
Grant
Filed:
August 24, 2018
Date of Patent:
May 7, 2019
Assignees:
King Fahd University of Petroleum and Minerals, King Saud University
Inventors:
Said S. Al-Jaroudi, Ali Alhoshani, Muhammad Altaf, Anvarhusein Abdulkadir Isab
Abstract: Described herein are various embodiments of a method and system for sleep detection. For example, in one embodiment, a method is described for automatically characterizing digitized breath sounds recorded from a subject over time as indicative of the subject being one of asleep and awake. This method comprises identify individual breathing cycles in a given segment of the recorded breath sounds; calculating one or more preset breathing cycle characteristics from the identified breathing cycles; evaluating a relative regularity of the calculated characteristics for the given segment; and upon the relative regularity satisfying a preset high regularity condition, outputting a sleep status indicator that the subject was likely asleep during the segment, otherwise outputting a wake indicator that the subject was likely awake during the segment.
Abstract: A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mll2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/ll2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.
Type:
Grant
Filed:
January 3, 2017
Date of Patent:
May 7, 2019
Assignees:
Regeneron Pharmaceuticals, Inc., Yale University, Institute for Research in Biomedicine (IRB)
Inventors:
Sean Stevens, Andrew J. Murphy, Richard Flavell, Elizabeth Eynon, Jorge Galan, Tim Willinger, Markus Manz, Anthony Rongvaux, George D. Yancopoulos
Abstract: A transparent emissive device is provided. The device may include one or more OLEDs having an anode, a cathode, and an organic emissive layer disposed between the anode and the cathode. In some configurations, the OLEDs may be non-transparent. The device may also include one or more locally transparent regions, which, in combination with the non-transparent OLEDs, provides an overall device transparency of 5% or more.
Abstract: Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.
Type:
Grant
Filed:
March 27, 2015
Date of Patent:
May 7, 2019
Assignees:
Wayne State University, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors:
Tinnakorn Chaiworapongsa, Sonia S. Hassan, Roberto Romero
Abstract: A laser shock peening method and device for a bottom surface of a tenon groove of an aircraft blade. During the laser shock peening process, according to geometric characteristics of the bottom surface of a tenon groove, a circular facula of a laser beam is changed into a strip-shaped facula, at the same time as a flow-guiding injection device and a water pumping device are respectively arranged at two end surfaces of the bottom surface of the tenon groove to ensure the stability of a water confinement layer.
Type:
Grant
Filed:
October 23, 2013
Date of Patent:
May 7, 2019
Assignees:
Wenzhou University, Jiangsu University, Southeast University
Inventors:
Wei Xue, Jinzhong Lu, Mi Luo, Yongkang Zhang, Fengze Dai
Abstract: The present invention relates to the production and culture of undifferentiated spermatogonial stem cells that can be maintained long term and are feeder free. The resultant feeder-free populations can be used in any of a number of protocols including the generation of progeny bulls. The present invention includes novel methods required for the successful enrichment of bovine spermatogonial stem cells, novel cell lines and other components used for the same, as well as the resultant stem cell compositions.
Type:
Grant
Filed:
August 25, 2016
Date of Patent:
May 7, 2019
Assignee:
Washington State University
Inventors:
Jon Michael Oatley, Melissa Joan Oatley
Abstract: A new passive wireless electric field sensor is disclosed. This sensor does not require direct attachment to a source of power which makes it passive. It is composed of a resonator loaded with varactors. The sensor is interrogated by a remotely located device transmitting and receiving the pulses of sine wave in the resonance frequency range of the sensor. Therefore, the sensor can be mounted in the vicinity of high voltage apparatus and interrogated from a safe distance.
Type:
Grant
Filed:
November 13, 2015
Date of Patent:
May 7, 2019
Assignee:
The University of Manitoba
Inventors:
Mana Yazdani, Behzad Kordi, Douglas J. Thomson
Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with telomerase inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about six to eight phenanthroindolizidine alkaloids, including at least four new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional telomerase inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. Still further, a method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. Also, a method of treating a subject suffering from cancer includes administering to the subject at least one phenanthroindolizidine alkaloid having certain formula.
Type:
Grant
Filed:
April 29, 2016
Date of Patent:
May 7, 2019
Assignee:
Macau University of Science and Technology
Abstract: Provided are methods and devices for detection of unlabeled nucleic acids. The detection methods are based on change of solubility of hydrophobic probes upon hybridization with a polynucleotide. In one embodiment, the probes are morpholino probes, having a fluorophore attached thereto. The morpholino probes are immobilized on a substrate that has fluorescence quenching functionality.
Type:
Grant
Filed:
November 13, 2014
Date of Patent:
May 7, 2019
Assignee:
New York University
Inventors:
Rastislav Levicky, Wanqiong Qiao, Yatao Liu
Abstract: In one embodiment, synthesis of Nuxia oppositifolia nanoparticles includes providing a Nuxia oppositifolia powder; dissolving the powder in a first alcohol to provide a first alcohol extract; concentrating a filtrate from the first alcohol extract under reduced pressure to provide a dried alcohol extract; dissolving the dried alcohol extract in the first alcohol to provide a second alcohol extract; successively partitioning the second alcohol extract using n-hexane to provide an n-hexane extract; dissolving the n-hexane extract in a second alcohol and water to provide a first solution; and adding an acidic solution to the first solution to form a final solution including Nuxia oppositifolia nanoparticles.
Type:
Grant
Filed:
November 29, 2017
Date of Patent:
May 7, 2019
Assignee:
King Saud University
Inventors:
Ali Ali El-Gamal, Adnan Jathlan Al-Rehaily, Manal Ahmed Gasmelseed Awad, Rabab Abd El Moneim Khalil El Dib, Shaza Mohamed Adel Al-Massarani
Abstract: A superconducting bulk magnet comprising a plurality of superconducting bulk materials combined, in which breakage of superconducting bulk materials is prevented and a strong magnetic field can be generated, that is, a superconducting bulk magnet comprising a plurality of superconducting bulk materials, each comprising a single-crystal formed RE1Ba2Cu3Oy (RE is one or more elements selected from Y or rare earth elements, where 6.8?y?7.
Type:
Grant
Filed:
November 13, 2015
Date of Patent:
May 7, 2019
Assignees:
Nippon Steel & Sumitomo Metal Corporation, National University Corporation Tokyo University of Marine Science and Technology