Abstract: A system and method for outage prediction for electrical distribution utilities using high-resolution weather forecasts, geographic data (e.g., land use and vegetation around overhead-lines) and utility infrastructure data (e.g., transformer fuses, etc.) to predict distributed outage occurrences (e.g., number of outages over a 2-km gridded map) in advance of a storm.

Abstract: A trans-disciplinary system for cell-free biosynthesis includes a cell-free transcription-translation (TX-TL) tool and modular, generalizable microfluidic architectures. Both components of the system are independently functional and are combinable into a cell-free biosynthesis platform. In the first component, modular plasmid libraries are used to program bacterial cell-free TX-TL systems. Each plasmid holds one gene or operon, and all the genes are controlled by the same promoter, so that the stoichiometry of enzyme synthesis is determined by the stoichiometry of plasmids in the reaction. In the second part, in order to facilitate high throughput mixing and matching of gene units from the modular plasmid libraries, a modular, reconfigurable, flexible, and scalable microfluidic architecture is employed.

Abstract: The invention relates to a method and system for generating droplets of an aqueous solution on a microfluidic chip with an air continuous phase. Specifically, the droplet generator according to the present invention is integrated into a microfluidic chip to generate and introduce droplets of an aqueous solution into the microfluidic chip. The droplets travelling in a network of chip channels may be captured in on-chip traps in a manner defined by hydrodynamic resistances of chip channels. A biological reaction may be performed on a droplet trapped on the microfluidic chip.

Abstract: The present disclosure relates to methods and products for imaging or labelling cells. Certain embodiments of the present disclosure provide a method of intracellular imaging of a cell. The method comprises exposing the cell to a complex comprising a phenylpyridine iridium (III) (and/or a functional derivative thereof) and a tetrazolato compound and imaging the complex in the cell.

Abstract: The present disclosure is generally related to capturing a scene and projecting a virtual window to one or more observers. A virtual window may mimic the experience a viewer has when looking through a real window. In some embodiments, for a single observer looking at a digital display or digital screen, a head-tracking camera on the same side of the screen as the observer can determine the position of the observer relative to the screen. The camera may be a 3D camera, stereoscopic camera, a wide angle lens camera, or an array of cameras (e.g., two or more). A camera on the other side of the screen can then image the view on the other side observer is relative to the window of the screen and software can determine the correct portion of the view that should be displayed on the screen to the observer.

Abstract: An active sequential xampling receiver for spectrum sensing is disclosed. The receiver includes a dynamically adjustable analog front end to perform sub-Nyquist energy sensing across a broad radio frequency (RF) spectrum. In an exemplary aspect, the receiver includes a dynamic modulator which modulates the broad RF spectrum to dynamically select sub-bands (e.g., RF channels) and fold their spectral content into a narrower baseband signal for energy detection. A controller adjusts the dynamic modulator to maximize utility of the spectrum detection based on past energy observations.

Abstract: Provided herein are noninvasive stimulation methods and apparatus for the treatment of injury to tissues using a novel pulsed laser system that combines the benefits of near-infrared laser light and optoacoustic waves. In certain embodiments, short, high-energy laser light pulses generate low intensity ultrasound waves that travel deep into brain tissues to stimulate neural function and treat neurological dysfunctions. In certain embodiments, a patient interface is provided wherein optoacoustic waves are produced by a plurality of optical absorbers overlying all of a plurality of optical fibers while in other embodiments optoacoustic waves are generated both inside the tissue and outside the tissue via a plurality of optical absorbers overlying some but not all of the optical fibers thus enabling an option of varying proportions of optoacoustic waves generated inside and outside of tissue.

Abstract: A perfusion bioreactor chamber for engineering a broad spectrum of tissues. The bioreactor allows controlled distribution of fluid through or around scaffolding materials of various shapes, structures and topologies during prolonged periods of cultivation.

Abstract: The present invention includes a composition and method for the treatment of an eye disease comprising a therapeutically effective amount of an autophagy stimulator that treats or slows the progression of the eye disease by enhancing or stimulating autophagy or correcting an autophagy deficiency.

Abstract: A computer-implemented method for tuning associations between genetic variants of sequence elements of a subject genome and a target biological characteristic to a target population is described. The method notionally partitions the subject genome into discrete contiguous genome segments and derives a tuning function for each genome segment. The tuning function tunes the associations to the target population, and derivation of the tuning function for each genome segment excludes sequence elements in that same genome segment to avoid overfitting.

Abstract: As described herein, the present invention features compositions comprising an HGF/IgG complex and methods of using such compositions to reduce ischemic reperfusion injury.

Abstract: Provided is a pain estimating device with which it is possible to estimate objectively and accurately pain being experienced by a subject. A pain estimating device 110 estimates the magnitude of pain being experienced by a subject, on the basis of brainwaves of the subject, and is provided with: a measurement unit 111 which acquires a plurality of items of brainwave data or analysis data thereof by measuring brainwaves from the subject a plurality of times; and an estimation unit 112 which estimates the relative magnitude of the pain being experienced when the brainwave measurements were conducted a plurality of times, from the plurality of items of brainwave data or the analysis data thereof (for example the amplitude), on the basis of the linearity of a relationship between the brainwave data or the analysis data thereof (for example the amplitude) and the pain.

Abstract: The present invention provides a biometric information measuring device with which a diagnostic imaging result and a biomagnetism measurement result can be superimposed simply and with satisfactory accuracy, and which is easy to handle. This biometric information measuring device (1) is provided with: a biomagnetism detecting unit (2) capable of detecting biomagnetism of a subject (S); and a radiation detecting unit (3) capable of acquiring an image corresponding to irradiated radiation, as digital image data, by means of the supply of a power source. The radiation detecting unit (3) is disposed between a measuring region of the subject (S) and the biomagnetism detecting unit (2). Further, it is preferable to provide a control unit (6) capable of performing control such that the power source is not supplied to the radiation detecting unit (3) while the biomagnetism detecting unit (2) is detecting biomagnetism.

Abstract: Disclosed are methods for screening a drug for treating obesity-related diseases by using the ability of candidate drugs to inhibit the function of pentraxin-4 as an index, and a pharmaceutical composition for treating obesity-related diseases comprising a pentraxin-4 inhibitor as an active ingredient. The drug screened by the above-mentioned method and the pharmaceutical composition are useful for treating obesity-related diseases, particularly for non-alcoholic steatohepatitis (NASH).

Abstract: Hybrid polymer-inorganic nanocolloids and methods of making them are described.

Abstract: A three-axis magnetic sensor which is not physically separated from each other and made of one element is provided. A spin-orbit torque is generated through an interface junction between a magnetization seed layer and a magnetization free layer, and through this, a change in an in-plane magnetic field may be sensed in the form of current or voltage in the magnetization seed layer. Further, a tunneling insulating layer and a magnetization pinned layer are formed on the magnetization free layer. The formed structure induces a tunnel magneto-resistance phenomenon. Through this, a change in a magnetic field in a vertical direction is sensed.

Abstract: The invention relates to a sensor molecule for detecting a target molecule comprising: (a) a rod-like molecule L and a rod-like molecule R connected to each other by a joint molecule C to form a hinge; (b) a target binding molecule A bonded to the end of rod-like molecule L opposite to the joint molecule C; (c) a binding molecule A? bonded to the end of rod-like molecule R opposite the joint molecule C; wherein the target binding molecule A is arranged to bind to an epitope or nucleic acid sequence of the target molecule to be detected, and binding molecule A? is arranged to bind to the same epitope or same nucleic acid sequence, or portion thereof of the target molecule as target binding molecule A; and wherein the hinge is biased into an open position, such that target binding molecule A and binding molecule A? are biased apart by the hinge. The invention also relates to analyte dependent activation of pharmaceuticals and chemo-toxins.

Abstract: The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of Generalized Arterial Calcification of Infancy (GACI), Idiopathic Infantile Arterial Calcification (IIAC), Ossification of the Posterior Longitudinal Ligament (OPLL), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, PXE, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.

Abstract: The present invention discloses a microscopic three-dimensional measurement system and method based on a moving diaphragm. The present invention adds the diaphragm into the existing optical microscopic imaging system to limit light irradiation angle during imaging for reducing the diameter of blur circle, which extends the depth of field and the depth measurement range, so as to achieve the three-dimensional measurement of large-size objects to be measured. Through changing the position of the added diaphragm, two images with different light incident directions are obtained, which is similar to binocular stereo vision, and then the disparity map is used to predict the depth, so as to carry out the 3D scene reconstruction. Since the depth of field of the imaging system is enlarged and the imaging model has certain non-linear characteristics, the present invention uses quadratic function to express the non-linearity, which reduces the measurement error.

Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic such as a halogenated ether compound in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered to the subject to anesthetize the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, xenon, and mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.