Abstract: Systems and methods for articulated pose estimation are provided. Some embodiments include training a convolutional neural network for object pose estimation, which includes receiving a two-dimensional training image of an articulated object that has a plurality of components and identifying, from the two-dimensional training image, at least one key point for each of the plurality of components. Some embodiments also include testing the accuracy of the object pose estimation, which includes visualizing a three or more dimensional pose of each of the plurality of components of the articulated object from a two-dimensional testing image and providing data related to the visualization for output.

Abstract: A real time end-to-end learning system for a high frame rate video compressive sensing network is described. The slow reconstruction speed of conventional compressive sensing approaches is overcome by directly modeling an inverse mapping from compressed domain to original domain in a single forward propagation. Through processing massive unlabeled video data such a mapping is learned by a neural network using data-driven methods. Systems and methods according to this disclosure incorporate a multi-rate convolutional neural network (CNN) and a synthesizing recurrent neural network (RNN) to achieve real time compression and reconstruction of video data.

Abstract: The present invention discloses a gaze estimation method for a headset device based, on iris and pupil. In the method, only a single camera, a single infrared light source and a central calibration point which is each provided within four average regions at a screen are used, 3D modeling of the pupil and iris is performed through an extracted 2D central feature of eye movement, and a 3D gaze direction vector is established and combined with angle information of the gaze direction, so as to estimate a gaze point position of human eyes. Fully taking a characteristic of applying the headset device into account, the present invention guarantees an accuracy of the gaze point estimation in the headset device and meanwhile greatly reduces the complexity of an entire system structure and a calibration process, and provides a solution with high accuracy and little complexity for the gaze tracking in the headset device.

Abstract: A composition is disclosed herein that includes isolated ECM-derived nanovesicles and a pharmaceutically acceptable carrier. Methods are producing the ECM-derived nanovesicles are also disclosed. These ECM-derived nanovesicles can be included in pharmaceutical compositions, bioscaffolds, and devices. Methods for using these ECM-derived nanovesicles are provided.

Abstract: A multifunctional molecular platform is provided, for covalent binding of two or more therapeutic or diagnostic agents, and for their sequential release in a biological environment near desired target sites. The platform is used in the preparation of pharmaceutical compositions for treating abnormal cell proliferation, infections, and inflammation.

Abstract: This invention is in the field of medicinal pharmacology. In particular, the invention relates to protease activated receptor type 2 (PAR2) modulating compounds (e.g., mimetic peptides), compositions comprising such modulating compounds, and their use as therapeutics for the treatment of conditions involving PAR2 activity.

Abstract: A combined treatment for nerve injury is provided. Accordingly there is provided a composition comprising a hyaluronic acid, a laminin polypeptide, an antioxidant and an anti-gliotic agent. Also provided are matrices and hydrogels of the composition and methods of using same.

Abstract: Provided herein are methods for treating a disease or disorder associated with mitochondrial dysfunction through ex vivo introduction of a nucleic acid molecule into hematopoietic stem and progenitor cells (HSPCs) followed by transplantation of the HSPCs into a subject in need of treatment. The nucleic acid molecule may include a functional human frataxin (hFXN) or may include a gene editing system that when transfected into the cells removes a trinucleotide extension mutation of endogenous hFXN.

Abstract: 2-Aminothiophene derivatives, uses of the same, and methods of making the same, are described.

Abstract: The present invention discloses an optical fiber laying method by using Archimedes spiral in optical frequency domain reflection, wherein the optical fiber laying method comprises the following steps: performing two measurements continuously via a two-dimensional strain sensing device, and performing cross-correlation operation on the two one-dimensional information of the local distance domain, and obtaining the strain variation of the one-dimensional information corresponding to the two measurements from the obtained cross-correlation information; deriving the two-dimensional angle information and curvature radius information of the plane to be measured corresponding to one-dimensional information in the local distance domain based on Archimedes spiral formula; deriving the position coordinates corresponding to the two-dimensional plane based on the curvature radius information and two-dimensional angle information; corresponding the strain variation of the one-dimensional information to the position coordi

Abstract: Methods for improving the functionality and/or fertility of sperm, for example, by enhancing motility and/or extending the lifespan of sperm by subjecting the isolated sperm to a starvation protocol and/or ionophore are provided. Such methods may be used in, for example, artificial insemination to reduce the number of sperm needed for insemination and to improve conception rates.

Abstract: A compound having the following formula is disclosed. The compound is useful as an emitter in OLED applications.

Abstract: Methods of treating propionic acidemia (PA), methylmalonic acidemia (MMA) and fatty acid oxidation disorders are described. The methods include administering an anaplerotic agent that can directly enter the tricarboxylic acid cycle, such as a succinate derivative or pro-drug, for example trisuccinylglycerol (TSG). Methods of restoring tricarboxylic acid (TCA) cycle function in a cell deficient for propionyl-CoA carboxylase (PCC) or methylmalonyl-CoA mutase (MUT) by contacting the cell with a succinate derivative or pro-drug, such as TSG, are also described.

Abstract: Embodiments of the invention are directed to stable full-length cDNA clones of a clinical, Asian lineage ZIKV strain. Certain embodiments of the invention are directed to high-throughput assays for ZIKV and dengue virus (DENV) diagnosis.

Abstract: This invention is in the field of medicinal pharmacology. In particular, the invention relates to protease activated receptor type 3 (PAR3) modulating compounds (e.g., mimetic peptides), compositions comprising such modulating compounds, and their use as therapeutics for the treatment of conditions involving PAR3 activity.

Abstract: This invention provides a humanized, anti-human receptor for advance glycation end-products (RAGE) monoclonal antibody or a fragment of such antibody which binds human RAGE as well as compositions containing, and uses of, such antibody and fragments.

Abstract: The disclosure relates to the field of fusion proteins. In some aspects, the invention to artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes and uses thereof. In some aspects, the disclosures relates to compounds produced by artificial cytochrome P450 enzymes.

Abstract: A method for treating a proliferative disease, disorder, or condition comprising administering a Pt(II) tetra-selenone complex. A Pt(II)-tetra-selenone complex.

Abstract: Aspects of the invention are directed to systems and methods for generating spectral computed tomography data for spectral X-ray image reconstruction using of pixelated k-edge apertures. A method is provided for generating a spectral computed tomography. The method includes the steps of generating a plurality of X-ray beams; encoding the plurality of X-ray beams by transmitting the plurality of beams through a pixelated K-edge coded aperture structure; detecting the encoded plurality of X-ray beams; and reconstructing a spectral CT image from the encoded plurality of X-ray beams.

Abstract: This disclosure provides systems, methods, and apparatus related to laser ablation spectrometry systems. In one aspect, a system comprises a microscope, a laser, a continuous flow probe, and a gas confinement device. The laser is positioned to emit light through an objective lens of the microscope. The continuous flow probe is coupled to a spectrometer. An end of the continuous flow probe is positioned proximate a sample and between the sample and the objective lens. The gas confinement device defines a gas inlet, a chamber, a platform, a wall surrounding the platform, a plurality of vents, and a plurality of channels. Each of the plurality of vents is positioned to direct a gas substantially parallel to the platform, and each of the plurality of vents is defined in the wall. The plurality of channels is operable to provide fluid communication between the chamber and the plurality of vents.