Abstract: CAR cells targeting and antibodies human HLA-G are described as a new method of cancer treatment. It is proposed that HLA-G CAR cells are safe and effective in patients and can be used to treat human tumors expressing the HLA-G.

Abstract: Polycaprolactone (PCL) scaffolds having macropores interconnected with micorpores are provided. Tissue grafts that include the PCL scaffold having therapeutic cells encapsulated within the macropores are also provided. Also provided are methods of making the PCL scaffold and the tissue graft, and methods of transplanting cells into an individual using the tissue graft.

Abstract: Apparatus and method for improved cavitation-induced drug delivery is disclosed. In one embodiment, a method for delivering a treatment composition to a target tissue using ultrasound includes: directing ultrasound waveforms toward the target tissue of a patient; generating ultrasound shock fronts at the target tissue of a patient; generating a cavitation inside the target tissue of a patient by the ultrasound shock front; and delivering the treatment composition to the patient. Absorption of the treatment composition by the target tissue is increased by the cavitation inside the target tissue. In some embodiments, the treatment composition may be delivered within a time period of +/?1 week from generating the cavitation.

Abstract: A shark barrier that comprises an anchoring assembly having a pair of anchors (9) with a flexible connecting element (11) extending between the anchors. The shark barriers also includes multiple spaced apart buoyant resiliently flexible elongate members (15) that are secured at one end along a length of the connecting element of the anchoring assembly to operatively extend generally upwardly from the connecting element. The buoyant members comprise an elongate flexible spine (32) that extends through a series of tubular members (38).

Abstract: Methods and compositions for reducing the risk of cardiovascular, cerebrovascular, or renovascular adverse events are provided. Generally, the methods include administering to a subject taking an NSAID a therapeutically effective amount of a misoprostol compound. The methods can also include administering to a subject in need thereof a therapeutically effective amount of an NSAID and therapeutically effective amount of a misoprostol compound.

Abstract: An amorphous thin film stack can include a first layer including a combination metals or metalloids including: 5 at % to in 90 at % of a metalloid; 5 at % to 90 at % of a first metal and a second metal independently selected from titanium, vanadium, chromium, iron, cobalt, nickel, niobium, molybdenum, ruthenium, rhodium, palladium, tantalum, tungsten, osmium, iridium, or platinum. The three elements may account for at least 70 at % of the amorphous thin film stack. The stack can further include a second layer formed on a surface of the first layer. The second layer can be an oxide layer, a nitride layer, or a combination thereof. The second layer can have an average thickness of 10 angstroms to 200 microns and a thickness variance no greater than 15% of the average thickness of the second layer.

Abstract: Death receptor 5 (DR5) agonist compositions and methods for treating pancreatitis have been developed. The compositions include Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL), its analogues, and anti-DR5 agonistic antibodies. In certain embodiments, TRAIL analogs and anti-death receptor 5 agonistic antibodies have analgesic and disease modifying effects on the pancreas.

Abstract: Provided herein are compositions of virus like particles (VLPs) of poliovirus (PV) that have one or more stabilizing mutations that confer a higher degree of thermostability to the N-antigenic form of the VLPs. These VLPs are non-infectious, and thus safer for use in vaccine development and administration to clinical subjects.

Abstract: A compound having a Pt tetradentate structure of Formula 1, is provided. In the structure of Formula 1, rings C and D each independently represent 5- or 6-membered carbocyclic or heterocyclic ring; L1, L2, and L3 are each independently a direct bond, BR, NR, PR, O, S, Se, C?O, S?O, SO2, SiRR?, GeRR?, alkyl, cycloalkyl, or a combination thereof; the sum of n1 and n2 is 1 or 2; X is selected from NRE, O, S, and Se; X3 and X4 each independently carbon or nitrogen; and one of Q1, Q3, and Q4 is oxygen, and the remaining two of Q1, Q3, and Q4 each represents a direct bond. Formulations and devices, such as an OLEDs, that include the compound of Formula 1 are also described.

Abstract: The present invention relates to systems and methods for measuring and monitoring physiological changes in a body. More particularly, the invention relates to systems and methods for measuring and monitoring the environment in the vicinity of the lung.

Abstract: Systems, methods, and software products determine an overall motion, flexibility and/or strength envelope for an individual. Force, movement and position data of the individual is captured and processed to generate an overall motion, flexibility and/or strength envelope for the individual that defines overall motion, flexibility and/or strength of the individual. The system includes a flexibility server with memory and a processor that are adapted to receive force, movement and position data of the individual. A motion, flexibility and/or strength analyzer of the system, implemented as machine readable instructions stored in the memory and executed by the digital processor, is capable of processing the force, movement and position data to generate an overall motion, flexibility and/or strength envelope for the individual that defines the overall motion, flexibility and/or strength of the individual.

Abstract: A method of indicating the presence of a bacterial infection in a biological sample is provided. The method detects a marker for infection by providing a device, the device including a biosensor, an interaction arising between the biosensor and the marker when the marker is present in the biological sample. Contacting at least a part of the biological sample with the biosensor of the device, therefore, provides analysis of the biological sample with respect to the marker by detecting for the interaction between the biosensor and the marker. A preferred marker is the enzyme amylase.

Abstract: Methods, kits, and systems for fixation of RNA permitting its detection in intact tissue, such as, large volume of mammalian tissue are disclosed. The methods, kits, and systems utilize carbodiimide-based chemistry to stably retain RNAs in tissue clarified using CLARITY. Also provided herein are methods, kits, and systems for detection of RNAs in clarified tissue.

Abstract: Methods and apparatus for corneal imaging and sensing are provided. Apparatus capable of utilizing single or multiple frequency emissions at terahertz (THz) wavelengths to create reflectivity maps of the cornea in either a contact or non-contact modes are also provided. Methods of obtaining data from THz imaging and sensing apparatus about the corneal tissue-aqueous humor system, including information about the corneal tissue water content (CTWC) and/or the central corneal thickness (CCT) are likewise provided. Methodologies may use multiple transfer functions (frequencies) in obtaining simultaneous data about CTWC and CCT. Methods using frequency sweeping to allow for determination of CTWC and CCT may also be utilized. Methods may also be used to assess CTWC using multiple bandwidths at the same frequency, or multiple frequencies at the same bandwidth. Methods may use data from CTWC measurements to aid in the diagnosis of various corneal and brain disorders.

Abstract: Compositions and methods for treatment of acute and chronic pain are disclosed herein. These compositions include fixed dose oral formulations containing an atypical antipsychotic drug and an opioid. Also provided here are methods of treatment of pain, particularly chronic pain while attenuating the abuse-liability of prescription pain medications.

Abstract: A thermally degradable polymeric sheet, comprising: a poly(hydroxyalkanoate); and a metal selected from the group consisting of an alkali earth metal and a transition metal; where the volume fraction of the metal in the sheet is at least 0.1 vol %.

Abstract: An apparatus configured to detect a substance, and method of operating and forming the same. In one embodiment, the apparatus includes a tunable resonator including a first Bragg reflector with a first optical stop band separated by a cavity from a second Bragg reflector with a second optical stop band. The first optical stop band is offset in wavelength from the second optical stop band. The tunable resonator is configured to be illuminated by a light source and produce a first spectral optical response from a substance within the cavity. The apparatus also includes a detector positioned proximate the tunable resonator configured to provide a first photonic absorption signal representing the first spectral optical response.

Abstract: Disclosed is a device and method for a microfluidic paper-based analytical device (?PAD), for low-cost and user-friendly analytical devices capable of use for disease screening, point-of-care pathogen and biomarker detection, food and water quality testing. A microfluidic paper-based analytical device is further produced by chemical vapor deposition for multiplex heavy metal detection in water. Assay demonstrations proved that the immobilization of functional groups and multiplex heavy metal detection is suitable for real-world applications and established the approach for DNA analysis. The disclosed invention comprises multilayer capability, including the ability for various biomolecules to be immobilized with charge interaction.

Abstract: Systems and methods for mapping neuronal circuitry in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a neuronal shape graph, including obtaining functional brain imaging data from an imaging device, where the functional brain imaging data includes a time-series of voxels describing neuronal activation over time in a patient's brain, lowering the dimensionality of the functional brain imaging data to a set of points, where each point represents the brain state at a particular time in the timeseries, binning the points into a plurality of bins, clustering the binned points, and generating a shape graph from the clustered points, where nodes in the shape graph represent a brain state and edges between the nodes represent transitions between brain states.

Abstract: A multi-plane imaging system for imaging multiple reflection planes of a regular or irregular shaped three-dimensional (3D) specimen having top, side and bottom views simultaneously. The system includes an inverted watertight pyramid well having at least four reflective side surfaces for reflecting the specimen side views, wherein each of the at least four reflective sides surfaces define an angle, ?, relative to the base horizontal plane, and wherein each reflective side surface comprises a plurality of reflective zones; A specimen is positioned horizontally equidistant from the at least four reflective side surfaces and positioned vertically from the base horizontal plane a predetermined vertical distance; wherein the predetermined vertical distance, the at least four reflective side surfaces, and the angle ? comprise a reflection image plane for reflecting the specimen bottom views.