Abstract: Disclosed herein is a class of molecules termed remodilins that inhibit serum response factor (SRF). By inhibiting SRF, a number of downstream pathways can be targeted. The remodilins can be used to treat glaucoma, inhibit tumor cell growth, inhibit tumor metastasis, inhibit hypoxia-induced response, and/or reduce cellular metabolism.

Abstract: Weyl semimetal-based polarimeters are disclosed that can uniquely map the polarization state of light on the Poincaré sphere.

Abstract: An animal positioned on a perforated platform can be stimulated in an automated fashion. Images of the animal's paw are captured using a bottom-view camera positioned below the platform. Based on these images, an upwards-pointing tool is moved until it is directly beneath the paw. The animal is then stimulated automatically by moving the tool upwards to contact the paw, then moving it back down to cease the contact. Images of the animal are captured using at least one side-view camera, and these images can be analyzed to ascertain the animal's response to the stimulus.

Abstract: This disclosure relates to methods of forming a ZSM-5 zeolite, the method comprising calcining one or more clay mineral compositions to form metakaolin, wherein the one or more clay mineral compositions may comprise greater than or equal to 10 wt. % halloysite; forming a slurry by combining at least the metakaolin, ZSM-5 zeolite seeds, a basic compound, and a silica source; hydrothermally treating the slurry to form a hydrothermal product; and calcining the hydrothermal product to form a ZSM-5 zeolite. This disclosure also relates processes of cracking a hydrocarbon feed comprising contacting the hydrocarbon feed with steam in the presence of a cracking catalyst comprising the ZSM-5 zeolite in a reactor under reaction conditions sufficient to cause at least a portion of the hydrocarbon feed to undergo one or more cracking reactions to produce a cracking effluent comprising light olefins, light aromatic compounds, or both.

Abstract: A vehicle control framework enables improved attitude tracking and mode switching of a vehicle by modeling the vehicle as a switched system, where the vehicle is operable for changing a geometric configuration during flight. The vehicle control framework implements a control law that accommodates modeling uncertainties and unknown external disturbances. The vehicle also enforces a switching time constrained by a minimum dwell time which can be adaptively updated based on attitude errors.

Abstract: A computer-implemented system (“DeepXSOZ”) exploits synergy between deep-learning based spatial features and shallow-learning based expert knowledge encoding to identify Seizure Onset Zones based on spatiotemporal data captured during brain imaging. DeepXSOZ implements an independent component sorting technique that a) reduces expert sorting workload by 7-fold and b) enables the usage of rs-fMRI as a low-cost outpatient pre-surgical screening tool.

Abstract: The presently disclosed subject matter relates to torrefied biomass briquettes and methods for producing the same that make use of a mixture of lightly torrefied material (LTM) and highly torrefied material (HTM) and/or make use of torrefied materials that are subjected to a hydrolysis pretreatment prior to being torrefied.

Abstract: A method and device for synthesizing binary waveforms, wherein the initial analogue waveform is first converted into the segments with discrete levels, then each said discrete level section is in turn converted into a binary pulse of the same time duration as the given segment, and the average value of the generated pulse is proportional to the average value of the given initial waveform over the time duration of the given segment.

Abstract: The present invention provides a composition for freezing control, a composition for freezing a cell, and a composition for freezing a food, which include a compound in which 2 to 5 amino acids, for example, 2, 3, 4, or 5 amino acids are connected to fluorenylmethyloxycarbony (Fmoc) through peptide bonding.

Abstract: Systems and methods for tackling a significant problem in data analytics: inaccurate dataset labeling. Such inaccuracies can compromise machine learning model performance. To counter this, label error detection algorithm is provided that efficiently identifies and removes samples with corrupted labels. The provided framework (CTRL) detects label errors in two steps based on the observation that models learn clean and noisy labels in different ways. First, one trains a neural network using the noisy training dataset and obtains the loss curve for each sample. Then, one applies clustering algorithms to the training losses to group samples into two categories: cleanly-labeled and noisily-labeled. After label error detection, one removes samples with noisy labels and retrains the model.

Abstract: Methods for modulating the release and content of extracellular vesicles from target cells using electrical stimulation are provided. Compositions comprising extracellular vesicles or extracts of extracellular vesicles and methods of administering the compositions to a subject are also provided.

Abstract: Chimeric antigen receptors (CARs) including an scFv binding to coronavirus spike protein (S309 scFv), nucleic acids encoding the CARs, vectors including nucleic acids encoding the CARs, and cells expressing the CARs are provided. Methods of treating a subject with coronavirus are also provided, including administering to the subject a modified immune cell expressing a disclosed CAR.

Abstract: Provided herein is a class of reversible thermal gel polymers, formulations thereof, methods for using, and methods for making said reversible thermal gel polymers. Reversible thermal gel polymers and formulations are provided having versatile chemical, physical, mechanical and/or optical properties beneficial for a range of applications including medical treatment. In some embodiments, the architecture and composition of the polymer allows for tunable selection of one or more physical properties supporting a particular application.

Abstract: A road surface condition estimation apparatus includes a storage unit configured to store a road surface condition estimation model, and a road surface severity estimator configured to estimate, based on travel information, severity of a condition of a road surface on which a vehicle is travelling using the road surface condition estimation model.

Abstract: The present invention relates to a sound system suitable for the treatment of tinnitus in a patient having an audio signal generator adapted to generate an audio signal based on a preset profile of a patient's tinnitus. The profile has at least one tinnitus frequency of the tinnitus A first device broadcasts an audio signal to the patient, the audio signal broadcasting device being connected to the audio signal generator. The audio signal has a fundamental frequency between 20 Hz and 300 Hz, preferably between 40 Hz and 160 Hz. At least one harmonic of the fundamental frequency, the harmonic being equal to the at least one tinnitus frequency plus or minus 10%, preferably to the at least one tinnitus frequency plus or minus 6%, and in that the first audio signal broadcasting device is adapted to broadcast the audio signal.

Abstract: The present invention relates to the field of chemical and pharmaceutical technologies, in particular to a polypeptide and its use as a CCK receptor agonist/antagonist. Experiments show that the polypeptide provided by the present invention has a high agonistic/antagonistic activity on CCK receptors. Compared with the polypeptide CCK4, the polypeptide according to the present invention has a longer half-life and duration of efficacy in vivo. Experiments show that the polypeptide according to the present invention produces a significant improvement on the spatial memory deficiency of senile mice, memory-deficient senile mice, and Alzheimer's mice, and thus has a great application potential.

Abstract: A system for increasing power capture comprising a turbine having a rotor, a generator having a rated power limit, and an energy storage system, wherein the rotor generates a super-rated power above the rated power limit of the generator and the super-rated power is stored in the energy storage system before the generator converts the super-rated power into electric power.

Abstract: The disclosure relates to compounds that demonstrate efficacy in blocking PACAP receptors (e.g. PAC1) and associated methods of treating neurological diseases or disorders using the disclosed compounds. The neurological diseases or disorders include, but are not limited to, stress-related diseases (e.g. chronic stress, post-traumatic stress disorder (PTSD), panic disorder, anxiety, or general anxiety disorder), pain-related diseases (e.g. chronic pain, primary headache disorders, or migraines), or addiction (e.g. addiction to a substance (e.g. addiction to cocaine, amphetamines, methamphetamine, methylphenidate, nicotine, alcohol, prescription medication, marijuana, tobacco, or an opioid selected from heroin, fentanyl, codeine, hydrocodone, morphine, oxycodone, hydromorphone, and methadone)).

Abstract: A reference noise cancellation device for a transient electromagnetic field is provided. The device includes a transmitter, a transmitting loop, a reference coil, a signal coil and a receiver. The transmitter generates a measurement timing sequence to trigger the receiver to synchronously record the induction signal in the signal coil and the electromagnetic noise in the reference coil. A bipolar current waveform is generated and is injected into the transmitting loop through the first connecting line. The signal coil receives an induced magnetic field of an underground conductor and surrounding magnetic field noise. The reference coil receives surrounding electromagnetic noise. The receiver receives and records the induced magnetic field and surrounding electromagnetic noise of the underground conductor in the signal coil and the surrounding electromagnetic noise in the reference coil.

Abstract: The present invention provides a multi-wavelength spectral thermometry based on mobile narrow-band window and optimization and belongs to the field of thermal radiation temperature detection. A continuous spectrum of a thermal radiation object is collected by a spectrometer; the spectrum of the thermal radiation object is denoised, windowed and standardized; the whole detection wavelength range is traversed within an appropriate narrow-band window; through comparison with windowed and standardized black-body radiation spectra at different temperatures in a corresponding spectral window, the temperature and emissivity distribution of the thermal radiation object is calculated with high accuracy without depending on emissivity model estimation, and high universality and noise resistance are achieved.