Abstract: A fundamental barrier to successful device-based therapies is the Inability to deliver a sustained amount of therapeutics that do not have a systemic toxic impact on the subject. Thus, there is a need for identifying new compositions and methods to enhance the delivery, distribution, and/or efficacy of therapeutic agents. The present disclosure relates to implantable constructs (encapsulated cells) designed to deliver antigenic therapeutic reagents, such as IL-2, and optionally one additional therapeutic.

Abstract: A system and method is provided for implementing computer-controlled systems (e.g., vehicle safety and traffic management systems) based on compliance rates. A vehicle system and method are provided that estimate compliance rates in real-time, and have the capability to dynamically modify the computer-controlled instructions generated by a computer-controlled system (e.g., vehicle safety and traffic management systems) in a manner that improves compliance, and in-turn improves overall system performance. For example, a vehicle includes sensors receiving data from a plurality of communicative connected vehicles. The received data is associated with a real-time monitoring of traffic conditions for the vehicle. The vehicle also includes a controller device estimating a compliance rate in real-time based on the received data. The controller device of the vehicle also controls an automated operation of the vehicle using a modified computer-controlled instruction based on the estimated compliance rate.

Abstract: An apparatus for accelerating neural networks, includes: a memory for storing graph input data including vertices and edges; an aggregation engine that processes the accumulation of features and generates feature vectors by taking the graph input data and performing an aggregation operation on the graph input data; an on-chip cache for caching the feature vectors; and a combination engine that generates a systolic array for matrix multiplications based on the feature vectors taken from the on-chip cache and weights taken from the memory.

Abstract: Methods for treating a neuropsychiatric disorder by administering an iboga alkaloid and a cardioprotective agent in conjunction with analysis of brain image data is described. Also described are methods to improve brain health and to slow or reverse brain aging by disorder by administering an iboga alkaloid and a cardioprotective agent, where analysis of brain image data is used to monitor and/or evaluate treatment effectiveness.

Abstract: A method for controlling motion parameters of a pepper harvester based on combination of point clouds and images, including: (1) performing space-time calibration on a radar and a camera, constructing a data collection platform, and pre-processing image and point cloud data; (2) acquiring a real-time number of pepper in front of a harvester and an average height from canopies of pepper plants to soil through a point cloud, acquiring a cutting width and a pepper fruit proportion in front of the harvester through an image, and acquiring a comprehensive lowermost location of pepper fruits by combination of the point cloud and the image; (3) acquiring real-time motion parameters of the pepper harvester; and (4) controlling a real-time rotation speed, operation speed, and height of a drum using a fuzzy PID control method based on the comprehensive lowermost location of the pepper fruits and a predicted value of a feeding quantity.

Abstract: The present disclosure provides genetically modified flowering plants that produce seedless fruit and methods for making and cultivating such plants. The genetically modified flowering plants express a modified Auxin Response Factor 8A (ARF8A) or an ortholog thereof.

Abstract: Compositions comprising an iboga alkaloid and a cardioprotective agent are provided. Use of the compositions in treating neuropsychiatric disorders are described, where the cardioprotective agent is administered before, during and/or after the iboga alkaloid.

Abstract: Methods and devices for detecting chiral properties from a sample are provided. Light may be directed towards a sample in contact with a chiral nanoparticle. Third harmonic Mie scattering (THMS) optical activity generated by the chiral nanoparticle in contact with the sample can then be detected. A device for detecting chiral properties of a sample is also contemplated that includes at least one microwell having a volume of ?about 1 microliter configured to hold a chiral nanoparticle capable of generating third harmonic Mie scattering (THMS) optical activity and a sample to be analyzed. The device includes a source of light configured to generate and direct light toward the at least one microwell containing the chiral nanoparticle and the sample and at least one detector configured to detect third harmonic Mie scattering (THMS) generated by the chiral nanoparticle in the microwell.

Abstract: The inventor has discovered that limiting mitochondrial Mg2+ uptake (mMg2+) prevents diet-induced obesity. Administration of compositions that limit mitochondrial Mg2+ uptake (mMg2+) can be used for various therapeutic and prophylactic uses.

Abstract: A sensor including a layer of amorphous selenium (a-Se) and at least one charge blocking layer is formed by depositing the charge blocking layer over a substrate prior to depositing the amorphous selenium, enabling the charge blocking layer to be formed at elevated temperatures. Such a process is not limited by the crystallization temperature of a-Se, resulting in the formation of an efficient charge blocking layer, which enables improved signal amplification of the resulting device. The sensor can be fabricated by forming first and second amorphous selenium layers over separate substrates, and then fusing the a-Se layers at a relatively low temperature.

Abstract: The subject invention is concerned with systems and methods advantageously applying finite element analysis to establish design rules for a highly sensitive piezo-resistive pressure sensor with an output that is high enough to be detectable by simple and inexpensive circuits and therefore ensure wearability. Four frequently reported micro-feature shapes in micro-patterned piezo-resistive sensors are provided, where the micro-dome and micro-pyramid yield the highest sensitivity. Investigations of different conductivity values of micro-patterned elastomers show that coating the elastomer with a conductive material (e.g., a metallic coating) leads to higher current response when compared to composited conductive elastomers. Advantageous geometric parameters and spatial configurations of micro-pyramid design of piezo-resistive sensors are provided.

Abstract: In one aspect, methods of generating human monoclonal antibodies that specifically binds to an allergen are provided. In some embodiments, the monoclonal antibodies are generated from sequences identified from isolated single B cells from a human subject who is allergic to the allergen.

Abstract: An image processing device is trained to cluster a plurality of patch images into a plurality of clusters, select a first patch image from each of the plurality of clusters as a reference patch image and select a second patch image from each of the plurality of clusters as a query patch image, and perform quantization on the reference patch image and the query patch image using different numbers of bits.

Abstract: Methods of mineralizing hemp fiber to provide hemp fibers mineralized with calcium carbonate are described. Also described are mineralized hemp fibers and compositions including the mineralized hemp fibers. The mineralized hemp fibers can be hemp fibers with calcium carbonated deposited on the hemp fiber surface. The compositions including the mineralized hemp fibers can be cementitious or non-cementitious. Also described are methods of preparing “green” concrete comprising mineralized hemp.

Abstract: A method for treatment of a patient suffering from a cancer, an autoimmune disease, an infection, a neurodegenerative disease or any combination thereof is disclosed. Compositions and uses are also disclosed. The method includes providing fresh immune effector cells (IECs) armed with one or more multispecific antibodies, wherein the multispecific antibodies are bound to the fresh IECs; and administering an effective amount of a composition of cells to the patient, wherein the composition of cells comprises the multispecific antibody bound fresh IECs. The fresh IECs cab comprise a cell selected from the group consisting of peripheral blood mononuclear cells (PBMC), antigen-presenting cells. T cells (optionally fresh Bi Ab armed T cells (FBATs)). NK cells, monocytes, polymorphonuclear neutrophils (PMNs), and any combination thereof. Providing the fresh IECs can comprise isolating fresh IECs from the patient.

Abstract: A sensor having a plurality of sensing elements which sense six degrees of freedom of force on a touch layer. The sensor includes a computer which causes prompting signals to be sent to the sensing elements and reconstructs six degrees of freedom of force on the layer from data signals received from the sensing elements. A method for sensing forces. A robotic hand. having a finger having a tip with sensors on the tip. Alternatively, the sensor includes a ribbon cable.

Abstract: An energy absorbing structure and method of making thereof is disclosed. The energy absorbing structure comprises an energy absorbing lattice structure having an irregular, but not random, lattice pattern. The irregular lattice pattern of the energy absorbing lattice structure may be a Voronoi cell pattern, which may be derived from a bovid skull horncore morphology. Other lattice patterns may be used, such as two-dimensional tessellations forming a distribution of asymmetric polygons or three-dimensional tessellations to form a distribution of asymmetric polyhedral shapes. The energy absorbing structure may further comprise one or more substrates to one or more sides of the energy absorbing lattice structure. The energy absorbing structure may be formed through additive manufacturing and has a variety of applications including, but not limited to, helmet liners, protective gear, shoe soles, packaging material, vehicle panels, or phone cases.

Abstract: A method for water drainage of a substrate includes creating, on a surface of the substrate, a designated hydrophobic region having hydrophobic surfaces of a hydrophobic film. Electronic circuitries are fabricated in the designated hydrophobic region of the substrate. The method further includes creating, on the surface of the substrate, a designated hydrophilic region having hydrophilic surfaces of the substrate. A drainage channel is formed in the designated hydrophilic region. The method further includes facilitating, based on capillary imbibition of the drainage channel, fluid flow from the designated hydrophobic region to a drainage/evaporation port to prevent damage of the electronic circuitries by moisture accumulation in the designated hydrophobic region.

Abstract: Described herein is a method. The method may include receiving, by a first device, data of a first layer of the first device, the data for transmission over a network to a second device. The method may include encrypting, by the first device, the data at the first layer, to generate first encrypted data. The method may include encrypting, by the first device, the first encrypted data at a second layer, to generate second encrypted data. The method may include transmitting, by the first device, the second encrypted data via the network to the second device.

Abstract: An assay system and method for generating quantitative data for a subject and a method for treating prostate cancer in a subject by determining an expression level of a biomarker panel in a sample obtained from the subject, the biomarker panel including the genes CDC45, CENPI, CLSPN, ERCC6L, EXO1, NCAPG, BUB1B, CDK1, NUSAP1, RAD51, and RRM2 and optionally E2F7 and/or GSG2, wherein the expression level is obtained by measuring expression of the biomarker panel in the sample, and wherein the subject has a cancer, or is suspected of having a cancer. The cancer may be, for example, prostate cancer, brain cancer, lung cancer, breast cancer, bladder cancer, or ovarian cancer.