Abstract: Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes.
Abstract: An MRI scanner may include one or more gradient waveform generators, gradient amplifiers, gradient coils, an RF waveform generator, an RF amplifier, an RF coil, a superconducting magnet, an RF detector; a digitizer, and a computer system that controls the one or more gradient waveform generators and the RF waveform generator so as to generate a magnetization saturation preparation pulse sequence that includes a tip-down pulse that is insensitive to RF field inhomogeneity followed by a tip-back pulse that employs a conjugate symmetry constraint in its energy spectrum.
Abstract: Methods and systems for acquiring and/or projecting images from and/or to a target area are provided. Such a method or system can includes an optical fiber assembly which may be driven to scan the target area in a scan pattern. The optical fiber assembly may provide multiple effective light sources (e.g., via a plurality of optical fibers) that are axially staggered with respect to an optical system located between the optical fiber and the target area. The optical system may be operable to focus and/or redirect the light from the multiple light sources onto separate focal planes. A composite image may be generated based on light reflected from and/or projected onto the separate focal planes. The composite image may have an extended depth of focus or field spanning over a distance between the separate focal planes while maintaining or improving image resolution.
Type:
Grant
Filed:
February 15, 2013
Date of Patent:
August 22, 2017
Assignee:
University of Washington through its Center for Commercialization
Abstract: A method of actuating a surgical device is described. A surgical tool is inserted into a body cavity of a patient through a natural orifice. A distal end of an actuation tool is inserted through a surgical access port in the body of the patient. The distal end of the actuation tool is positioned proximal to an external wall of the body cavity opposite the surgical tool. A magnetic coupling is established between the distal end of the actuation tool and the surgical tool. When the magnetic coupling is established, distal end of the actuation tool is located at the external wall of the body cavity and the surgical tool is located at the internal wall of the body cavity. The surgical tool is manipulated using the actuation tool through the magnetic coupling.
Type:
Grant
Filed:
May 14, 2013
Date of Patent:
August 22, 2017
Assignee:
Vanderbilt University
Inventors:
Pietro Valdastri, Alan J. Herline, Christian Di Natali
Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.
Type:
Grant
Filed:
November 17, 2016
Date of Patent:
August 22, 2017
Assignee:
The Johns Hopkins University
Inventors:
Alexey Popov, Elizabeth M. Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
Abstract: A chip-scale, reusable sensor can detect aromatic hydrocarbons, such as benzene, toluene, ethylbenzene, and xylenes (BTEX), rapidly in water without sample preparation. The device is capable of real-time, continuous monitoring for BTEX solutes, which diffuse into a film, such as a polymer, on the sensors surface. In operation, BTEX analytes concentrate in the film, causing an increase in refractive index, which modulates evanescent coupling into the chips integrated photodetector array. Integration of the photodetector array simplifies system instrumentation and permits incorporation of an on-chip photocurrent reference region in the immediate vicinity of the sensing region, reducing drift due to temperature fluctuations. In some examples, the chip responds linearly for BTEX concentrations between 1 ppm and 30 ppm, with a limit of detection of 359 ppb, 249 ppb, and 103 ppb for benzene, toluene, and xylene in water, respectively.
Type:
Grant
Filed:
May 8, 2014
Date of Patent:
August 22, 2017
Assignee:
Colorado State University Research Foundation
Abstract: A structurally reinforced optically transparent panel that may be utilized as a bulletproof window or shield. The panel includes a plurality of angled reinforcement members having a reflective top and bottom surfaces. Optical lenses are disposed between the reinforcement members directing a light ray in a predetermined direction. The geometry and spacing of the reinforcement members is such that the light rays enter and exit the bulletproof panel at substantially the same angle allowing an observer to view optical images of objects behind the bulletproof panel, thus creating optical transparency. The reinforcement members are of a high strength material capable of being impenetrable by a projectile fired from a ballistic weapon or an explosion debris.
Type:
Grant
Filed:
October 10, 2016
Date of Patent:
August 22, 2017
Assignee:
The Florida State University Research Foundation, Inc.
Abstract: A system for detecting concentration of a target in a solution where sample fluid is passed into a microchannel with wall coated with the receptor that reacts and crosslinks with the target to constrict the channel and slow or stop sample flow through the microchannel. Concentration of the target is determined by measuring length of the sample filled channel.
Type:
Grant
Filed:
February 3, 2014
Date of Patent:
August 22, 2017
Assignee:
Brigham Young University
Inventors:
Adam T. Woolley, Debolina Chatterjee, Danielle Scarlet Mansfield
Abstract: A mold structure having high-precision multi-dimensional components which includes a first oxide layer superimposed on a top of a first semiconductor substrate; a second oxide layer superimposed on a top of a second semiconductor substrate; integrated designs patterned in at least one of the oxide layers; and the first and second semiconductor substrates bonded to one another into a three dimensional (3D) mold such that the first oxide layer only makes partial contact with the second oxide layer such that a portion of the first oxide layer avoids contact with the second oxide layer, the portion of the first oxide layer directly opposite a surface portion of the second semiconductor substrate that is free of the second oxide, the 3D mold selectively filled with a filling material to form a molded high-precision multi-dimensional component.
Type:
Grant
Filed:
August 28, 2015
Date of Patent:
August 22, 2017
Assignees:
International Business Machines Corporation, Yale University
Inventors:
Emily R. Kinser, Jan Schroers, Golden Kumar
Abstract: The invention relates to improved cardiac pacemakers and methods of use thereof. In particular the cardiac pacemakers are useful for normalizing heart rates over resting heart rates in order to condition the heart to improve overall cardiac output.
Type:
Grant
Filed:
July 18, 2016
Date of Patent:
August 22, 2017
Assignee:
The University of Vermont and State Agricultural College
Abstract: The present invention provides a compound of formula (I) or the salt thereof: wherein R is at least one selected from the group consisting of unsubstituted C1-4 alkyl, C1-4 alkyl substituted by C6-18 aryl or —OR1, and —C(?O)Z. The compound is a type-S protein kinase inhibitor, which binds to an ATP-binding site and a substrate-recognition site of a protein kinase simultaneously. The present invention further provides a pharmaceutical composition, which includes a compound of formula (I) or a salt and a pharmaceutically acceptable carrier thereof. The present invention further provides a use of a compound of formula (I) or a salt thereof, which is for the manufacture of a protein kinase inhibitor as a drug.
Type:
Grant
Filed:
January 16, 2015
Date of Patent:
August 22, 2017
Assignee:
National Chiao Tung University
Inventors:
Jinn-Moon Yang, Kai-Cheng Hsu, Tzu-Ying Sung, Shen Rong Lin, Yun-Ming Wang, Kuang-Mei Hsu, Hsin-Ping Lin, Wan-Chun Liu
Abstract: The present invention discloses a composite biogenic flocculant for enhancing flocculation and dewaterability of chemically enhanced primary treatment (CEPT) sludge. The present invention also discloses method of conditioning CEPT sludge using the composite biogenic flocculant.
Abstract: The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of treating 5*. aureus infection and osteomyelitis, and methods for introducing an orthopedic implant into a patient using the monoclonal antibody, binding portion, or pharmaceutical composition of the present invention.
Type:
Grant
Filed:
May 3, 2011
Date of Patent:
August 22, 2017
Assignee:
University of Rochester
Inventors:
Edward M. Schwarz, Mark A. Sullivan, John L. Daiss
Abstract: This disclosure relates to NMDA modulators and used related thereto such as for treatment of central nervous system disorders. In certain embodiments, compounds disclosed herein are NR2C subunit-selective NMDA potentiators. In certain embodiments, the disclosure contemplates compounds and pharmaceutical compositions. In certain embodiments, the disclosure contemplates compounds disclosed herein as prodrugs, optionally substituted with one or more substituents, derivatives, or salts thereof. In certain embodiments, the disclosure relates to methods of treating or preventing nervous system disorders comprising administering an effective amount of a composition comprising compound disclosed herein to a subject in need thereof.
Type:
Grant
Filed:
August 7, 2013
Date of Patent:
August 22, 2017
Assignee:
Emory University
Inventors:
Stephen F. Traynelis, Praseeda Mullasseril, Ethel C Garnier, Dennis C. Liotta, Sommer Zimmerman
Abstract: Methods and apparatus to generate carbon nanostructures from organic materials are described. Certain embodiments provide solid waste materials into a furnace, that pyrolyzes the solid waste materials into gaseous decomposition products, which are then converted to carbon nanostructures. Methods and apparatuses described herein provide numerous advantages over conventional methods, such as cost savings, reduction of handling risks, optimization of process conditions, and the like.
Abstract: A spin orbit torque-based spintronics device that includes a ferromagnet layer having a first surface and a second surface opposed to each other, a metal layer and a spacer layer covering the first surface and the second surface of the ferromagnet layer, respectively, and an dielectric layer covering either the metal layer or the spacer layer. Also disclosed are two related spin orbit torque-based spintronics devices and methods of using these three spintronics devices.
Abstract: The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.
Type:
Grant
Filed:
March 15, 2013
Date of Patent:
August 22, 2017
Assignee:
Vanderbilt University
Inventors:
Corey R. Hopkins, Charles C. Hong, Craig W. Lindsley, Darren W. Engers
Abstract: A phase-transfer catalytic color fixation processing method for textile includes the following steps: (1) dry-dyeing a textile with disperse reactive dyes in supercritical carbon dioxide fluid under waterless condition; (2) putting the textile in a phase-transfer catalytic fixation device, taking phase-transfer catalyst as the carrier of circulated supercritical carbon dioxide fluid, transporting the ionized fixing catalytic alkaline substance from aqueous phase to hydrophobic supercritical carbon dioxide fluid phase, getting full contact with functional groups on fibers, resulting in the fixing catalytic reaction with disperse reactive dyes.
Abstract: Described herein are methods for the treatment of cognitive impairment in a subject with a neurological autoimmune disease and methods for determining whether a subject who has a central nervous system autoimmune disease is likely to acquire a cognitive impairment.
Type:
Grant
Filed:
December 14, 2011
Date of Patent:
August 22, 2017
Assignee:
The Johns Hopkins University
Inventors:
Adam Kaplin, Barbara S. Slusher, Kristen A. Rahn