Abstract: N-substituted sulfonylphenyl-5-mitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provided as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer.

Abstract: A method of preparing a silicon oxide (Six)-carbon composite for a negative-electrode active material of a lithium secondary battery, includes mixing silicon (Si) particles and a polymer material with an organic solvent, thus preparing a mixture solution, optionally electrospinning the mixture solution thus preparing a composite having a one-dimensional structure, and heat-treating the mixture solution or the composite having a one-dimensional structure. The silicon oxide (SiOx)-carbon composite can reduce volume expansion upon lithium ion insertion and can increase ionic conductivity and electronic conductivity and thus can maintain high capacity, making it possible to apply it to a lithium ion battery to thus improve electrochemical characteristics of the battery.

Abstract: The present invention provides modular extracellular sensors, nucleic acids encoding such sensors, and cells expressing such sensors, and methods of employing such sensors and cells for detecting extracellular ligands. In certain embodiments, the extracellular sensors comprise a ligand binding domain, a transmembrane domain, a protease domain, a protease cleavage site, and a transcription factor. In other embodiments, a pair of extracellular receptors is provided where both receptors contain a ligand binding domain and transmembrane domain, and one receptor contains a protease cleavage site and a transcription factor and the other receptor contains a protease domain.

Abstract: System and method for monitoring the condition of electricity conductor support systems, i.e. towers, in a power network distribution system employing a tower structure integrity sensor assemblage. The system allows for identifying particular portions of a structural system for maintenance attention. The tower sensors allow identification of structural failures of electricity transmission towers.

Abstract: Techniques and architecture are disclosed for preserving optical surfaces (e.g., windows, coatings, etc.) in a flowing gas amplifier laser system, such as a diode-pumped alkali laser (DPAL) system. In some instances, the disclosed techniques/architecture can be used, for example, to protect optical surfaces in a DPAL system from: (1) chemical attack by pump-bleached alkali vapor atoms and/or ions; and/or (2) fouling by adherence thereto of reaction products/soot produced in the DPAL. Also, in some instances, the disclosed techniques/architecture can be used to substantially match the geometry of the pumping volume with that of the lasing volume, thereby minimizing or otherwise reducing the effects of amplified spontaneous emission (ASE) on DPAL output power. Furthermore, in some cases, the disclosed techniques/architecture can be used to provide a DPAL system capable of producing a beam output power in the range of about 20 kW to 10 MW, or greater.

Abstract: A network system for increasing data throughput and decreasing transmission delay from a source node to a sink node via a relay node. The network system may comprise a source node configured to encode a plurality of data packets using rateless coding and transmit the plurality of data packets; at least one relay node configured to receive at least one of the plurality of data packets from the source node, and if the at least one relay node has received a sufficient quantity of the plurality of data packets, regenerate, re-encode, and relay the plurality of data packets; and a sink node configured to receive one or more of the plurality of data packets from the at least one relay node, and if the sink node has received the sufficient quantity of the plurality of data packets, regenerate and decode the plurality of data packets.

Abstract: The subject invention provides materials and methods of fabricating and using an electrochemical biosensor for continuous detection of biological analytes. In a specific embodiment, the biosensor detects a given analyte when the analyte binds with a molecularly imprinted polymer (MIP) matrix immobilized atop a sensing substrate eliminating the need for a redox probing agent commonly found in electrochemical biosensors. Furthermore, the detection sensitivity of the biosensor is enhanced by modifying the electrode surface with a plurality of nanoscopic metallic structures. Advantageously, technologies provided herein can be used in a variety of low-power electronics for wearable applications.

Abstract: A method for regulating arterial vascular tone in a subject, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein A and B are each individually selected from O or S; a is 1 to 4; and Ar is optionally substituted aryl or optionally substituted heteroaryl.

Abstract: A new and distinct Aronia cultivar named ‘UCONNAM166’ is disclosed, characterized by a distinctly upright plant form, reaching a mature height between 4 to 5 feet. Vigorous but controlled plant growth. Multicolored Fall foliage. Plants are adaptable to a variety of landscape uses, including hedging or mass planting. Triploid plants produce very few, or no fruits. The new variety is a Aronia, normally produced as an outdoor landscape plant.

Abstract: A method of treating neuropathy in a subject, the method comprising identifying a subject who has neuropathy; and administering to the subject a pharmaceutical composition comprising one of inorganic nitrite and a pharmaceutically acceptable salt thereof.

Abstract: An endoscopic imaging system is disclosed that includes an endoscope having a first channel and a second channel, a high-power, multi-wavelength LED array, a digital micro-mirror device that receives light directed from the high-power, multi-wavelength LED array and generates spatial frequency patterns, and dichroic mirror that separates reflectance and fluorescence images.

Abstract: A perovskite solar cell is provided with a perovskite material layer having a first surface and a second surface opposite to the first surface; an electron transport layer disposed on the first surface; and a gold-nickel oxide layer disposed on the second surface. Furthermore, a manufacturing method of the perovskite solar cell is disclosed with steps of providing a transparent substrate; forming a gold-nickel oxide layer on the transparent substrate; and forming a perovskite material layer on the gold-nickel oxide layer.

Abstract: Methods of treatment for melanoma, and compositions for use in such methods are provided. An effective dose of an agent that blocks benzamil-sensitive proteins is administered to an individual suffering from melanoma.

Abstract: A new and distinct Aronia cultivar named ‘UCONNAM165’ is disclosed, characterized by a compact, dense plants maturing to approximately 2 feet tall and 3 to 4 feet wide. Foliage is uniquely small and very shiny, emerging with a red tinge, green throughout the Spring and Summer, turning red and orange in the Fall. Plants are very useful for landscape, with a short, controlled growth and tolerating a wide range of soil conditions. Profuse flowering. The new variety is a Aronia, normally produced as an outdoor garden or container plant.

Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

Abstract: A floating buoy includes a buoy hull having a tower that extends outwardly from the hull. A plurality of sensors are mounted either on the buoy hull, within the buoy hull, and/or on the tower. The plurality of sensors includes at least one met-ocean sensor, at least one ecological sensor, and at least one wind speed measurement sensor. The floating buoy further includes an autonomous power system that is configured to provide electrical power to each of the plurality of sensors. The wind speed measurement sensor may be a Light Detection and Ranging (LiDAR) wind speed measurement sensor, a surface level wind speed sensor, an ultrasonic wind speed sensor, or SODAR.

Abstract: A compound, or a pharmaceutically acceptable salt thereof, having a structure of wherein Z is aryl or substituted aryl, heteroaryl, or substituted heteroaryl; X is —S—, —S(O)—, or S(O)2—; R20 and R21 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, or halogenated alkyl; one of R22, R23, and R24 is —O— and the others of R22, R23 and R24 are independently —CH2—, or —C(R13)— wherein R13 is alkyl, alkenyl, alkynyl, trialkylsilyl group, or —(CH2)mOR15, wherein R15 is alkyl or an aryl and m is an integer in the range of 1 to 10; and R25 is H, alkyl, substituted alkyl, halogen, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C1-C3 alkoxy, aryloxy, or —(CH2)qOR17, wherein R17 is alkyl an aryl and q is an integer in the range of 1 to 10.

Abstract: In some embodiments, the present disclosure pertains to a composition for modulating the expression of at least one gene associated with neuronal cell survival or stability. In some embodiments, the present disclosure provides for compositions for the treatment of neurodegenerative diseases comprising one or more phosphate complexes of platinum of the formulas I, II, III and IV as set forth in FIG. 1. In some embodiments, the present disclosure relates to a method of treating a neurodegenerative disorder comprising administering therapeutically effective amounts of at least one of the aforementioned compositions described supra to a subject in need thereof, such that the compounds are effective in modulating the expression of a gene selected from the group consisting of NMDA-receptor, ATF, PPT2, HPD, EGR2, SLC7A11, FosB, SQSTM1, TMEM106B, RAB27A, STOX1, and SLC39A3.

Abstract: The present invention relates to nucleic acids. In particular, it relates to aptamers capable of binding to a flavivirus structural protein or a flavivirus non-structural protein, useful as therapeutics for preventing, treating and/or diagnosing a flavivirus infection in a patient.

Abstract: Provided herein are chlorophyll polymers and conductive materials, sensors, and devices comprising the chlorophyll polymers, and methods of use and preparation thereof.