Patents Assigned to University
  • Cable-driven morphable manipulator
    Patent number: 9737687
    Abstract: A device includes first and second sheets of first and second elastic materials, respectively, and a control wire. The first sheet has a first thickness and a first length and is shaped to have a first cross-section having a first inner periphery and a first outer periphery. The second sheet has a second thickness and a second length and is shaped to have a second cross-section having a second inner periphery and a second outer periphery. One of the first sheet and the second sheet has a spacing disposed in along one of the first length and the second length, respectively. The first outer periphery is less than or equal to the second inner periphery. The second sheet surrounds the first sheet. The control wire has an end constrained to one of the first sheet the first material and the second sheet. The control wire is disposed within the spacing.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: August 22, 2017
    Assignee: The Johns Hopkins University
    Inventors: Mehran Armand, Michael D. Kutzer, Christopher Y. Brown, Russell H. Taylor, Ehsan Basafa
  • Memory cell and storage device
    Patent number: 9740255
    Abstract: A memory cell (101) is connected to a word line (WL), a bit line (BL), and a power supply line (PL), and includes a flip-flop storing data based on a change in resistance value of a magnetic tunnel junction element, and, a power gating field-effect transistor including a drain that is one end of a current path connected to the power supply line, and which has another end connected to the flip-flop. The ON and OFF states of the power gating field-effect transistor are controlled based on a control signal applied to a control terminal of the power gating field-effect transistor.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: August 22, 2017
    Assignee: Tohoku University
    Inventors: Takashi Ohsawa, Tetsuo Endoh
  • Inflammatory disease diagnosis and methods of treatment using lipopolysaccharides-responsive beige-like anchor
    Patent number: 9738706
    Abstract: Anti-cytokine therapy has revolutionized immunological disease treatment, but is not always effective and subject to treatment resistance as the cytokine cascade is highly redundant and multiple cytokines are involved in inflammation. Targeting a critical common regulator of inflammatory effectors is desirable. Lipopolysaccharide (LPS)-responsive beige-like anchor (LRBA) is a master regulator of multiple genes important for inflammation. Subcellular localization shows that LRBA translocated to the nucleus upon LPS stimulation and colocalized with multiple proteins associated with the endosome membrane system, indicating a critical role in membrane/vesicle trafficking essential for deposition, secretion and signal transduction of immune effectors.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: August 22, 2017
    Assignee: University of South Florida
    Inventors: Jia-Wang Wang, Richard F. Lockey
  • Antimicrobial compositions, methods of use, and methods of treatment of infections
    Patent number: 9737509
    Abstract: The present disclosure provides compositions including a compound (e.g., compounds A-D), pharmaceutical compositions including the compound, methods of treatment of a condition (e.g., an infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: August 22, 2017
    Assignee: University of South Florida
    Inventors: James William Leahy, Dennis Edward Kyle, Brian Andrew Vesely, Benjamin Joe Eduful, Ankush Kanwar, Linda Corrinne Barbeto
  • Systems and methods for CMOS-integrated junction field effect transistors for dense and low-noise bioelectronic platforms
    Patent number: 9741870
    Abstract: A complementary metal oxide semiconductor (CMOS)-integrated junction field effect transistor (JFET) has reduced scale and reduced noise. An exemplary JFET has a substrate layer of one dopant type with a gate layer of that dopant type disposed on the substrate, a depletion channel of a second dopant type disposed on the first gate layer, and a second gate layer of the first dopant type disposed on the depletion channel and proximate a surface of the transistor. The second gate layer can separate the depletion channel from the surface, and the depletion channel separates the first gate layer from the second gate layer.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: August 22, 2017
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Kenneth L. Shepard, Jacob Rosenstein, Ryan Michael Field, Dan Fleischer
  • Modified PYR/PYL receptors activated by ligands
    Patent number: 9738902
    Abstract: Modified PYR/PYL receptors activated by orthogonal ligands are provided.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: August 22, 2017
    Assignee: The Regents of the University of California
    Inventor: Sean R. Cutler
  • Method of manufacturing layered metal oxide particles and layered metal oxide particles formed thereof
    Patent number: 9738986
    Abstract: The present invention refers to a method of manufacturing layered metal oxide particles, the method comprising: placing a metal electrode in an electrolyte; and applying an electrical voltage to the electrode, wherein the metal electrode forms the anode, to form a metal oxide layer on the electrode surface, wherein the electrical voltage applied is higher than the breakdown voltage of the metal oxide, thereby breaking down the metal oxide layer formed on the electrode surface into metal oxide particles that react with the electrolyte to form the layered metal oxide particles. The present invention also refers to a layered metal oxide particle obtained from the method, and a method of manufacturing a crystalline metal oxide nanosheet or a crystalline metal oxide nanoribbon.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: August 22, 2017
    Assignee: Nanyang Technological University
    Inventors: Yuxin Tang, Zhili Dong, Zhong Chen
  • System for calculating center of anterior capsule and method thereof
    Patent number: 9737210
    Abstract: The present invention provides a system and a method for performing a cataract surgery. The system of the present invention includes an optical coherence tomography apparatus, an image capturing device, and a central processing unit. The method includes imaging optical coherence tomography of a patient's eye using the optical coherence tomography apparatus, capturing the patient's optical coherence tomography with the image capturing device, generating a 3D image and coordinates of the patient's eye, and determining a central location of a pupillary margin and an iridocorneal angle using a central processing unit. The center of the anterior capsule of the human crystalline lens is then calculated by matching the iridocorneal angle to the central location of the pupillary margin.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: August 22, 2017
    Assignee: the Catholic University Industry Academic Cooperation Foundation
    Inventor: Choun-ki Joo
  • Amphotericin B derivative with reduced toxicity
    Patent number: 9738677
    Abstract: Disclosed is a derivative of amphotericin B (AmB), denoted C2?epiAmB, with an improved therapeutic index over amphotericin B, pharmaceutical compositions comprising the AmB derivative, methods of making the AmB derivative and the pharmaceutical composition, and their use in methods of inhibiting growth of a yeast or fungus and treating a yeast or fungal infection. C2?epiAmB is an epimer of the parent compound. Specifically, C2?epiAmB differs from the parent compound at the C2? stereogenic center on mycosamine. This difference in structure results in (i) retained capacity to bind ergosterol and inhibit growth of yeast, (ii) greatly reduced capacity to bind cholesterol, and (iii) essentially no toxicity to human cells.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: August 22, 2017
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Brice E. Uno
  • Electricity generation using electromagnetic radiation
    Patent number: 9739473
    Abstract: In general, in one aspect, the invention relates to a system to create vapor for generating electric power. The system includes a vessel comprising a fluid and a complex and a turbine. The vessel of the system is configured to concentrate EM radiation received from an EM radiation source. The vessel of the system is further configured to apply the EM radiation to the complex, where the complex absorbs the EM radiation to generate heat. The vessel of the system is also configured to transform, using the heat generated by the complex, the fluid to vapor. The vessel of the system is further configured to sending the vapor to a turbine. The turbine of the system is configured to receive, from the vessel, the vapor used to generate the electric power.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: August 22, 2017
    Assignee: William Marsh Rice University
    Inventors: Nancy J. Halas, Peter Nordlander, Oara Neumann
  • Activation of innate immunity for enhanced nuclear reprogramming of somatic cells with mRNA
    Patent number: 9738873
    Abstract: The nuclear reprogramming of somatic cells with mRNA encoding reprogramming factors is shown to be greatly accelerated by activation of innate immune responses in the somatic cell. Methods of activating innate immunity include activation of PKR, of toll-like receptors, e.g. TLR3, etc. In some embodiments the mRNA provides the activator of innate immunity.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: August 22, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: John P. Cooke, Eduard Yakubov
  • Cyclic bent allene metal complexes
    Patent number: 9738671
    Abstract: The present invention provides stable, cyclic bent allene metal complexes and methods of conducting chemical processes, preferably olefin hydrogenation, comprising contacting an olefin substrate, preferably an unsaturated polymer, with a cyclic bent allene metal complex as described herein, under hydrogenation conditions.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: August 22, 2017
    Assignee: The Governing Council of the University of Toronto
    Inventors: Conor Pranckevicius, Douglas Wade Stephan
  • Casein coated drug-loaded iron oxide nanoparticles
    Patent number: 9737492
    Abstract: This disclosure relates to nanoparticle drug delivery systems composed of casein (CN) coated nanoparticles, e.g., iron oxide nanoparticles coated with an inner layer and an out layer comprising the milk protein casein. In certain embodiments, drug molecules are incorporated into an inner polymeric layer coating the nanoparticles, which are subsequently coated with a casein containing outer layer, i.e., a layer-by-layer (LBL) construction. Oral administration of these casein coated nanoparticles are contemplated as experiments indicated sufficiently stability in conditions that simulate the conditions of the gut. Drugs that were loaded into the nanoparticle systems were released when the casein outer layer was gradually degraded in the presence of an intestinal protease meant to simulate conditions of the intestine.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: August 22, 2017
    Assignee: Emory University
    Inventors: Hui Mao, Jing Huang
  • System and method for determining neointima thickness of a blood vessel
    Patent number: 9737259
    Abstract: A system and method for providing an image capable of realizing conversion of a 3D tissue structure into which an implant is inserted into a 2D image using a contour technique are provided.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: August 22, 2017
    Assignees: Industry-Academic Cooperation Foundation, Yonsei University, Industry-Academia Cooperation Group of Sejong University
    Inventors: Myeong Ki Hong, Byeong Keuk Kim, Jin Yong Ha
  • Control arrangement for increasing the available output from a source
    Patent number: 9742290
    Abstract: A control arrangement for use in controlling the electrical supply from a power supply unit including an internal capacitance to an output is described, the control arrangement comprising an inductor, a switch arranged in parallel with internal capacitance, and a controller operable to control the operation of the switch such that closing of the switch results in the formation of an LCR circuit, the internal capacitance forming the capacitance of the LCR circuit. An associated control method is also described.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: August 22, 2017
    Assignee: University of Plymouth
    Inventor: Mohammed Ahmed
  • Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions
    Patent number: 9738628
    Abstract: In one aspect, the invention relates to substituted 1H-benzo[d][1,2,3]triazol-1-ol analgoues, derivatives thereof, and related compound; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g. various tumors and cancers, associated with ?-catenin/Tcf protein-protein interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: August 22, 2017
    Assignee: University of Utah Research Foundation
    Inventors: Haitao Ji, Binxun Yu, Min Zhang, Wenxing Guo
  • Semiconductor device with graphene layer as channel
    Patent number: 9741859
    Abstract: A field effect transistor (FET) with a graphene layer as a channel layer is disclosed. The FET provides two gate electrodes, one of which receives the gate bias, while, the other receives a reference bias. An intermediate electrode made of ohmic metal to the graphene layer is provided between the two gate electrodes. The second gate electrode receiving the reference bias suppresses the hole injection into the channel beneath the first gate electrode.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: August 22, 2017
    Assignees: Sumitomo Electric Industries, Ltd., Tohoku University
    Inventors: Yasunori Tateno, Maki Suemitsu, Hirokazu Fukidome
  • Sensor having ferrogel with magnetic particles
    Patent number: 9737244
    Abstract: A sensor for detecting a condition includes a hydrogel configured to change thickness or volume in response to the condition. Magnetic particles are arranged in the hydrogel so that a magnetic property of the hydrogel changes with changes of thickness or volume of the hydrogel. Some such sensors include a magnetic-field detector that measures the magnetic field of the hydrogel. Other such sensors include a device coil is arranged with respect to the hydrogel so that changes in the magnetic property modulate an electrical property of the sensor. A sensing system using such a sensor includes a reader spaced apart from the sensor and including a reader coil and a resonance detector coupled to the reader coil to detect a the resonant frequency of the sensor. Changes in the magnetic property detectably modulate the resonant frequency.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: August 22, 2017
    Assignees: Purdue Research Foundation, Regents of the University of Minnesota
    Inventors: Babak Ziaie, Ronald A. Siegel
  • Ethynylbenzene derivatives
    Patent number: 9738604
    Abstract: Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These compounds are useful for treating Gram-negative bacteria infections.
    Type: Grant
    Filed: September 6, 2011
    Date of Patent: August 22, 2017
    Assignee: Duke University
    Inventors: Pei Zhou, Eric J. Toone
  • HIV-1 integrase derived peptides and compositions
    Patent number: 9738878
    Abstract: Isolated peptides comprising sequences derived from the protein integrase of HIV-1, as well as their analogs, mixtures, conjugates with permeability enhancing moieties, and pharmaceutical compositions are disclosed. The peptides and compositions are capable of selectively killing HIV-1 infected cells and are used in treatment of HIV infection and AIDS.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: August 22, 2017
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Aviad Levin, Zvi Hayouka, Assaf Friedler, Abraham Loyter