Abstract: A surface emission laser formed of a group III nitride semiconductor includes a first conductivity type first clad layer; a first conductivity type first guide layer on the first clad layer; a light-emitting layer on the first guide layer; a second guide layer on the light-emitting layer; and a second conductivity type second clad layer on the second guide layer. The first or second guide layer internally includes voids periodically arranged at square lattice positions with two axes perpendicular to one another as arrangement directions in a surface parallel to the guide layer. The voids have a polygonal prism structure or an oval columnar structure with a long axis and a short axis perpendicular to the long axis in the parallel surface, and the long axis is inclined with respect to one axis among the arrangement directions of the voids.

Abstract: A housing has a spiral passageway which contains a catheter which may be manually extracted from the housing by means of a wheel having a polygonal or otherwise textured circumferential surface and mounted on a shaft which extends through a non-circular bearing defined in an outer portion of the housing. An inner portion of the wheel extends into the spiral passageway adjacent the wire catheter and an outer portion of the wheel outwardly from the housing whereby the upper surface of the knob can be manipulated by a member of the surgical team in one direction and the wire catheter below the knob will be advanced in the opposite direction. The non-circular bearing has a generally circular outer portion in which the textured surface of the knob is only intermittently in contact with the catheter whereby the wire catheter may be advanced, and a generally linear inner portion sloping inwardly towards the catheter.

Abstract: Provided are LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.

Abstract: The present disclosure relates to an enzyme complex of arabinose isomerase, agarase and 3,6-anhydro galactosidase and a method for producing tagatose by degrading agar using the same. By using the enzyme complex according to the present disclosure, agar obtained from marine biomass can be degraded effectively and useful physiologically active substances such as tagatose can be obtained effectively therefrom.

Abstract: Foldable antenna devices formed on rigid substrates are provided. The substrate can be planar in an unfolded state, and a metal layer can be formed on the rigid substrate to act as an antenna element. The rigid substrate(s) can include mountain folds and valley folds, or hinges, such that the antenna device is foldable from an unfolded state to a fully folded state.

Abstract: A method for a first vehicle to perform a neighbor discovery in an IP-based vehicular network is disclosed. The method includes, based on the first vehicle failed in a router discovery for a direct registration with an adjacent road-side unit (RSU), sending one or more first neighbor solicitation (NS) messages to a second vehicle; receiving, from the second vehicle, a first neighbor advertisement (NA) message as a response to the first NS message; and sending, to the second vehicle, a second NS message for registering the second vehicle as a relay vehicle based on the first NA message.

Abstract: Provided is a method of analyzing interactions between nucleic acid segments in a nucleic acid complex. Specifically, restriction enzymes that recognize four-base site are used for digestion, followed by a two-step ligation method. The overall process is simple and easy to control, realizing the efficient and sensitive detection of nucleic acid interaction segments.

Abstract: Polymer-based selective radiative cooling structures are provided which include a selectively emissive layer of a polymer or a polymer matrix composite material. Exemplary selective radiative cooling structures are in the form of a sheet, film or coating. Also provided are methods for removing heat from a body by selective thermal radiation using polymer-based selective radiative cooling structures.

Abstract: A method of treating a central nervous system disease, the method including administering an agent including a therapeutically effective amount of vitamin B12 to a patient with a central nervous system disease to treat the central nervous system disease. This disclosure also relates to a method of promoting M2 macrophage/microglia induction, inhibiting M1 macrophage/microglia induction, and/or reducing the ratio of M1 macrophage/microglia to M2 macrophage/microglia in a patient in need thereof, the method including administering an agent including a therapeutically effective amount of vitamin B12 to the patient to promote M2 macrophage/microglia induction, inhibit M1 macrophage/microglia induction, and/or reduce the ratio of M1 macrophage/microglia to M2 macrophage/microglia. This disclosure also relates to a pharmaceutical product including vitamin B12.

Abstract: The present disclosure is directed to novel therapeutic approaches for the prevention, treatment and/or delaying progression of chronic injury, progressive loss of functional parenchymal cells, or fibrosis of an organ. Specifically disclosed are agents for use in increasing homodimer-formation of ARNT in an organ in the prevention, treatment and/or delaying progression of chronic injury, progressive loss of functional parenchymal cells, or fibrosis of said organ, as further defined in the claims. In embodiments, said agent may be (i) an inhibitor of protein phosphatase 2A (PP2A) activity, (ii) an inhibitor of the transcriptional repressor complex FKBP12/YY1, or (iii) an expression construct, which is capable of over-expressing ARNT in said organ, as well as combinations of (i), (ii), and/or (iii).

Abstract: The novel synergistic combination of immune checkpoint blockade and hematopoietic stem cell transplantation and/or hematopoietic stem cell mobilization yield synergistic effects in disease therapy.

Abstract: The invention relates to a measuring cell for analysing a fluid flow, wherein the measuring cell has a channel for conducting the fluid flow, which channel is divided into different sections and the cross section thereof is perpendicular to a longitudinal axis. The invention also relates to a measuring device comprising such a measuring cell.

Abstract: A method and system for constructing a lightweight container-based user environment (CUE), and a medium, the method including: preparing, by a main process, for communication, cloning a child process, and then becoming a parent process; elevating, by the child process, permission, executing namespace isolation, and cloning a grandchild process, and setting, by the parent process, cgroups for the grandchild process; and setting, by the grandchild process, permission of the grandchild process to execute a command and a file, preparing an overlay file system, setting a hostname, restricting permission, and executing an initialization script to start the container. Multiple users are allowed to customize their own environments, enabling the users to customize their environments more flexibly, achieving privacy isolation, and making it easier and more secure to update a system. Therefore, it is particularly applicable to a high-performance computing cluster.

Abstract: A laser stripping mass-transfer device includes a microdevice laser stripping transfer module, an auxiliary conveyor module, a transition conveyor module, a transfer conveyor module, a substrate carrier module, a microdevice filling module, a curing module, an encapsulation module and a substrate transportation module. The microdevice laser stripping transfer module is configured to implement detection and stripping of the microdevices. The auxiliary conveyor module is configured to adhere the stripped microdevices. The transition conveyor module is configured to pick up and transfer the microdevices to the transfer conveyor module. The transfer conveyor module is configured to pick up and transfer the microdevices to the substrate carrier module. The substrate carrier module is configured to feed the microdevices into the microdevice filling module, the curing module, the encapsulation module, and the substrate transportation module for filling, curing, encapsulating, loading and unloading.

Abstract: In an example, an avalanche photodiode comprises a substrate and a structure comprising a first layer and a second layer, the first and second layers over and parallel to the substrate, wherein the first layer is between the substrate and the second layer. The first layer is an Aluminium Arsenide Antimonide multiplication layer, and wherein the cross-sectional area parallel to the substrate of the first layer is smaller than that of the second layer, thereby forming a recess in a sidewall of the structure.

Abstract: The invention provides a method for preparing phenols from aromatic compounds, particularly a method of preparing phenol by direct hydroxylation of benzene. The method comprises contacting benzene with nitrous oxide in the presence of a bimetallic zeolite catalyst at an ambient pressure and a reaction temperature ranging from (about) 320° C. to 440° C.

Abstract: A light projection system comprising a light modulator that comprises a plurality of pixels each capable of selectively directing a corresponding modulatable amount of light, and a processor coupled to the light modulator to control the amount of light output from each of the plurality of pixels. The processor is configured to control the light modulator to form a computer generated hologram (CGH) wavefront from the light modulator corresponding to an image to be produced in the far field. The processor is also configured to control the light modulator to selectively direct the CGH wavefront. The light modulator may comprise an angular light modulator (ALM) comprising the plurality of pixels, each of the plurality of pixels having an OFF state and an ON state, the ALM arranged to direct the amounts of light in the direction as the pixels transition between the ON state and the OFF state.

Abstract: The present invention relates to the use of an Angiotensin II type 1 (AT1) receptor blocker for promoting sleep and/or the treatment of insomnia. It is based, at least in part, on the results of experiments performed using a validated rat model of stress-induced insomnia in which candesartan was found to ameliorate sleep disturbances induced by stress. Further, it was observed that this effect seems to be caused by blockade of AT1 receptors located in several brain regions that are key components of the neural circuitry activated during insomnia. In contrast to currently marketed treatments for insomnia, the AT1 receptor blocker was found to restore normal sleep without inhibiting REM sleep and/or inducing atypical wave components in the EEG.

Abstract: The invention provides a novel adrenomedullin derivative sustainable for a long period which is capable of substantially suppressing unwanted side effects while maintaining pharmacological effects of adrenomedullin. In an exemplary embodiment, the invention relates to a compound represented by formula (I): A-CH2-B (I) [wherein A is a modifying group comprising one or more polyethylene glycol groups, and B is a peptide moiety derived from adrenomedullin or a modified form thereof with adrenomedullin activity, wherein the peptide moiety B is linked to the other moieties through a covalent bond of the nitrogen atom of the N-terminal ?-amino group of the peptide moiety B to the carbon atom of the methylene group] or a salt thereof, or a hydrate thereof.

Abstract: An improved method for bounded error estimation of vehicle states is disclosed.