Abstract: Methods, apparatus and computer program product for protecting a confidential integrated circuit design process.

Abstract: Provided are SpdE polypeptides and variants and nucleic acids encoding the SpdE polypeptides and variants. Also provided are vectors including one or more nucleic acids encoding a SpdE polypeptide or variant and cells including a nucleic acid encoding the SpdE polypeptide or variant, as well as cells expressing a SpdE polypeptide or variant and compositions including such cells and a pharmaceutically acceptable carrier. Finally, methods of detecting presence and/or amount of one or more amino acids in a sample are provided. The methods include contacting the sample with a SpdE protein, measuring diguanylate cyclase activity of the SpdE protein; and comparing the diguanylate cyclase activity of the SpdE protein to a control. The methods can utilize isolated SpdE protein or a cell expressing a SpdE protein.

Abstract: A method and apparatus for caching a data block are provided. The method includes: obtaining, from a terminal, an access request for requesting access to a first data block; determining that the first data block is missed in a cache space of a storage system; detect whether a second data block satisfies a lazy condition, the second data block being a candidate elimination block in the cache space and the lazy condition being a condition for determining whether to delay replacing the second data block from the cache space according to a re-access probability; determining that the second data block satisfies the lazy condition; and accessing the first data block from a storage space of the storage system and skipping replacing the second data block from the cache space.

Abstract: A method of fabricating a semiconductor device, comprising: forming a growth restrict mask on or above a III-nitride substrate, and growing one or more island-like III-nitride semiconductor layers on the III-nitride substrate using the growth restrict mask The III-nitride substrate has an in-plane distribution of off-angle orientations with more than 0.1 degree; and the off-angle orientations of an m-plane oriented crystalline surface plane range from about +28 degrees to about ?47 degrees towards a c-plane. The island-like III-nitride semiconductor layers have at least one long side and short side, wherein the long side is perpendicular to an a-axis of the island-like III-nitride semiconductor layers. The island-like III-nitride semiconductor layers do not coalesce with neighboring island-like III-nitride semiconductor layers.

Abstract: The present invention provides a cardiomyocyte maturation promoter. The present invention provides a cardiomyocyte maturation promoter comprising one or more compounds selected from 2-methoxy-5-((Z)-2-(3,4,5-trimethoxyphenyl)vinyl)phenol, (1-ethyl-1H-benzotriazol-5-yl)methyl (2-(2-methoxy-4-methylphenyl)-4-methyl-1,3-thiazol-5-yl)carbamate, (2?beta)-22-oxovincaleukoblastine, 2-(2-(4-chlorophenyl)ethyl)-6-(2-furyl)-3H-imidazo[4,5-b]pyridine, 4,5-anhydro-1,2-dideoxy-4-methyl-2-((N-(morpholin-4-ylacetyl)-L-alanyl-O-methyl-L-tyrosyl)amino)-1-phenyl-L-threo-pent-3-ulose, 3-(3-methoxyphenyl)-N7,N7-dimethylisoquinoline-1,7-diamine, methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate, 2?-(4-aminophenyl)-1H,1?H-2,5?-bibenzimidazol-5-amine, and salts thereof.

Abstract: A compound, or a pharmaceutically acceptable salt thereof, having a formula I of: wherein Ar is an arylene or heteroarylene; R1 has a structure of: wherein W is an alkanediyl, alkenediyl, a carbonyl, or a combination thereof; X is —NR5—, wherein R5 is H or an alkyl, or —O—; and Y is optionally-substituted cycloalkyl, optionally-substituted cycloalkyl-substituted alkyl, optionally-substituted heterocycloalkyl, or optionally-substituted heterocycloalkyl-substituted alkyl; each R2 is the same or different and has a structure of: wherein Z is —NR6—, wherein R6 is H or an alkyl, —O—, —S—, or —CH2—; Z1 is (—CH2-)m wherein m is 0 to 5, or an alkenediyl having 2 to 6 carbon atoms; Cy is a 3-8-membered cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring; and each R4 is the same or different and is selected from hydroxy, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkyl, or amino; and c is 0 to 5; and each R3 is the same or different and is selected from hy

Abstract: The present invention discloses a nucleotide sequence and use thereof in increasing the density of secretory glandular trichomes in plants. The nucleotide sequence is selected from the group consisting of: 1) a nucleotide sequence according to any one of SEQ ID NOs: 1, 3 and 5; 2) a nucleotide sequence derived from the nucleotide sequence according to any one of SEQ ID NOs: 1, 3 and 5 through substitution, deletion or addition of one or more nucleotides; 3) a nucleotide sequence having at least 80% homology with any one of SEQ ID NOs: 1, 3 and 5. The present invention significantly increases the density of secretory glandular trichomes by transferring any one of the above nucleotide sequences into the plants by means of genetic engineering. Therefore, the invention shows great potential in insect resistance and production of specific metabolites, and has extremely high practical application value.

Abstract: Various methods and devices for spatial molecular analysis from tissue is provided. For example, a method of spatially mapping a tissue sample is provided with a microarray having a plurality of wells, wherein adjacent wells are separated by a shearing surface; overlaying said microarray with a tissue sample; applying a deformable substrate to an upper surface of said tissue sample; applying a force to the deformable substrate, thereby forcing underlying tissue sample into the plurality of wells; shearing the tissue sample along the shearing surface into a plurality of tissue sample islands, with each unique tissue sample island positioned in a unique well; and imaging or quantifying said plurality of tissue sample islands, thereby generating a spatial map of said tissue sample. The imaging and/or quantifying may use a nucleic acid amplification technique.

Abstract: A series of imidazopyridine and pyrazolopyridine compounds is provided in which carbon hydrogen bonds have been replaced with isotopic carbon-deuterium bonds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions. Various embodiments provide methods of killing and/or inhibiting the growth of M. tuberculosis and/or M. avium, and methods of treating, preventing, and/or ameliorating M. tuberculosis, M. avium or other mycobacterial infections in a subject like M. leprae or M. ulcerans.

Abstract: A method of characterizing melanoma in a subject involves determining the presence or level of one or more biomarkers in a sample obtained from a sentenal lymph node (SLN) of a subject.

Abstract: Methods of sequencing and producing nucleic acid sequences are provided. Accordingly there are provided methods of sequencing a nucleic acid sequence comprising L-nucleotides comprising subjecting the nucleic acid sequence comprising the L-nucleotides to a chemical sequencing method. Also provided is a method of reverse transcribing a ribose nucleic acid sequence into a deoxyribose nucleic acid sequence comprising catalyzing reverse transcription of the ribose nucleic acid sequence with a Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4).

Abstract: Optical phase control elements are based on the Pancharatnam phase. Tunable liquid crystal devices containing the optical phase control elements may include a liquid crystal cell between a pair of substrates, a first plurality of electrodes, and a second plurality of electrodes. Each individual phase control element is defined by one electrode from the first plurality and one electrode from the second plurality.

Abstract: Various embodiments of systems and methods for mobile crowd sensing applications are disclosed herein.

Abstract: Embodiments of an improved light-direction detection (LDD) device are described herein. The LDD device includes a substrate and at least one predefined structure formed along the substrate by stacking metal layers, contacts, and vias available in the manufacturing process of the device. The predefined structure is formed along a photodiode pair to collectively define an optical sensor configured to detect direction of incident light without need for off-chip components. The device accommodates light direction detection in two or more orthogonal planes.

Abstract: A method for decoupling an angular velocity in a transfer alignment process under a dynamic deformation includes: (1) generating, by a trajectory generator, information about an attitude, a velocity, and a position of a main inertial navigation system and an output of an inertial device, and simulating a bending deformation angle {right arrow over (?)} between the main inertial navigation system and a slave inertial navigation system and a bending deformation angular velocity {right arrow over (?)}? by using second-order Markov; (2) decomposing the dynamic deformation into a vibration deformation and a bending deformation, and establishing an angular velocity model under the dynamic deformation of a wing; (3) deducing an error angle ?{right arrow over (?)} between the main inertial navigation system and the slave inertial navigation system; and (4) deducing an expression ?{right arrow over (?)} of a coupling error angular velocity, and applying that to an angular velocity matching process of transfer alignmen

Abstract: The disclosure provides a method of and an imaging system for clinical sign detection. The method uses an imaging system having an RGB image sensor and the processing device disclosed herein. An image of a patient or examinee is captured by the RGB image sensor to generate an RGB image. Clinical signs of the patient or examinee are detected by the processing device based on the RGB images.

Abstract: An orthogonally polarized Yagi-like MIMO antenna system and a triangular printed wideband Yagi based MIMO antenna system, respectively, and methods for making the antennas. The orthogonally polarized Yagi-like MIMO antenna system includes two slot round loop elements on a top side of a substrate. Each slot round loop element has two input ports and two slot reflectors. For each slot round loop element, one of the two input ports is placed orthogonally to the other input port, and one of the two slot reflectors is placed orthogonally to the other slot reflector. The triangular printed wideband Yagi based MIMO antenna system includes three round loop elements on a top side of a substrate and a circular reflector on a bottom side of the substrate. Each of the three round loop elements is placed at 120° with respect to other two round loop elements and has three parasitic directors.

Abstract: According to one embodiment, a treatment solution is provided. The treatment solution is used for treating a byproduct stemming from a process of depositing a silicon-containing material on a member using a gas which includes silicon and halogen. The treatment solution includes at least one of an inorganic base or an organic base and being basic.

Abstract: A magnetic resonance imaging apparatus according to an embodiment includes sequence controlling circuitry and processing circuitry. The sequence controlling circuitry acquires a first piece of data by executing a first pulse sequence having a first Echo Time (TE) value, to acquire a second piece of data by executing a second pulse sequence having a second TE value different from the first TE value, and to acquire a third piece of data by executing a third pulse sequence having a third TE value different from the first and the second TE values. The processing circuitry extracts a signal related to water, a signal related to a first fat, and a signal related to a second fat, on the basis of the first piece of data, the second piece of data, and the third piece of data.

Abstract: A method is presented for programming a repeating motion of a redundant robotic arm on the basis of a variable parameter convergence differential neural network. The method may include establishing an inverse kinematics equation, creating an inverse kinematics problem, introducing a repeating motion indicator, converting a time-varying convex quadratic programming problem into a time-varying matrix equation, and integrating an optimal solution to obtain an optimal solution of a joint angle. The use of the variable parameter convergence differential neural network to solve the repeating redundant mechanical motion has the advantages of high computational efficiency, high real-time performance, and enhanced robot arm robustness.