Patents Assigned to University
  • RF waveguide phase-directed power combiners
    Patent number: 9640851
    Abstract: High power RF phase-directed power combiners include magic H hybrid and/or superhybrid circuits oriented in orthogonal H-planes and connected using E-plane bends and/or twists to produce compact 3D waveguide circuits, including 8×8 and 16×16 combiners. Using phase control at the input ports, RF power can be directed to a single output port, enabling fast switching between output ports for applications such as multi-angle radiation therapy.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: May 2, 2017
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Christopher D. Nantista, Valery A. Dolgashev, Sami G. Tantawi
  • Culture based screening assay and methods of use thereof to identify agents which modulate tumor development, invasion and differentiation
    Patent number: 9637787
    Abstract: A 3D organotypic culture which phenocopies aggressive, invasive cancer and methods of use thereof are provided.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: May 2, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Anil K. Rustgi
  • Meters for in-vivo monitoring
    Patent number: 9636487
    Abstract: Systems and methods for use in monitoring treatment of pressure-related conditions, such as hydrocephalus, include an implantable vessel, and a meter including one or more microfluidic channels connected to the vessel. The microfluidic channels may be configured to detect at least one of pressure and fluid flow rate through the vessel and to be read out remotely by a wirelessly coupled external device. The meter may include a passive resonant (LC) circuit. A dynamic flap may be included in the microfluidic channel that may act as part of the LC circuit. An external device may also be configured to inductively couple remotely to the LC circuit, with-out physical connections to the implantable vessel or pressure meter, and to display a pressure acting on the pressure meter and/or a fluid flow through the meter.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: May 2, 2017
    Assignee: University of Virginia Patent Foundation
    Inventors: Marcel Utz, George T. Gillies, William Broaddus, John A. Jane, Matthew R. Begley
  • Dual-loop programmable and dividerless clock generator for ultra low power applications
    Patent number: 9641183
    Abstract: A programmable clock generator is provided which is particularly suitable for low power applications. The programmable clock generator is comprised of: an oscillator circuit that generates an output signal whose frequency is set by a control signal, two feedback loops for controlling output frequency and a loop select that selects which feedback loop is operational at a given time. In operation, the frequency loop operates to coarsely adjust the frequency of the output signal; whereas, the phase loop operates to finely adjust the frequency of the output signal. The clock generator is preferably implemented by transistors operating in or near the subthreshold region.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: May 2, 2017
    Assignee: The Regents Of The University Of Michigan
    Inventors: David D. Wentzloff, Muhammad Faisal
  • Ultra low power temperature insensitive current source with line and load regulation
    Patent number: 9639107
    Abstract: A temperature insensitive sub-nA current reference is presented with pA-range power overhead. The main concept is to linearly reduce the gate voltage of a sub-threshold-biased MOSFET as temperature increases, in order to compensate for exponential dependence of drain current on temperature. For example, a MOSFET-only, 20 pA, 780 ppm/° C. current reference that consumes 23 pW is disclosed, marking the lowest reported power among current references. The circuit exploits sub-threshold-biased MOSFETs and a complementary-to-absolute temperature (CTAT) gate voltage to compensate for temperature dependency. The design shows high immunity to supply voltage of 0.58%/V and a load sensitivity of 0.25%/V.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: May 2, 2017
    Assignee: The Regents Of The University Of Michigan
    Inventors: David T. Blaauw, Dennis Sylvester, Myungjoon Choi, Inhee Lee, Taekwang Jang
  • MiRNA analysis methods
    Patent number: 9637781
    Abstract: The present invention provides a PCR-free, multiplexed ligation assay for miRNA expression analysis that produces highly quantitative, 10-100 plex miRNA profiling in a single reaction. The inventive methods use a 2-step ligation assay to generate an array of miRNA specific ligation products that can be decoded and quantified by a size discrimination method such as gel electrophoresis or single molecule separation. One embodiment is a low-cost assay that can be performed using standard tools available in nearly all molecular biology laboratories. This assay requires nothing more than a gel apparatus and reader for detection. Other embodiments include use of magnetic beads and other size exclusion apparatus which give increasingly higher sensitivity, lower sample consumption, and reduced processing steps.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: May 2, 2017
    Assignee: The Johns Hopkins University
    Inventors: Tza-Huei Wang, Kelvin J. Liu, Yunke Song
  • Method for tandem mass spectrometry analysis in ion trap mass analyzer
    Patent number: 9640377
    Abstract: This invention is related to a tandem mass spectrometric analysis method in ion trap mass analyzer. Such method comprise three stages as represented by selective isolation, collision induced disassociation and mass scanning of ion. At the collision induced isolation stage, this invention is expected to endow parent ion of certain mass-charge ratio with energy through resonance excitation by changing cycle of radio frequency signals, namely frequency of radio frequency voltage imposed on the ion trap; such high-energy ions produced through resonance excitation are to be disassociated through collision with neutral molecules in the ion trap, which will further generate product ion to realize tandem mass spectrometric analysis.
    Type: Grant
    Filed: July 4, 2014
    Date of Patent: May 2, 2017
    Assignee: Fudan University
    Inventors: Fuxing Xu, Liang Wang, Chuanfan Ding
  • Production method of polyurethane porous membrane to be used for at least one of applications of cell culture and cancer cell growth inhibition
    Patent number: 9637722
    Abstract: A polyurethane porous membrane is produced by a simple method to be used for at least one of applications of cell culture and cancer cell growth inhibition. The production method of the polyurethane porous membrane to be used for at least one of the applications of cell culture and cancer cell growth inhibition comprises: a first step of forming a layer of a polyurethane material which is uncured, on a substrate; and a second step of supplying water vapor to an exposed surface of the layer of the polyurethane material formed on the substrate, which is away from the substrate, so as to cure the polyurethane material and provide the layer of the polyurethane material with a porous structure having a plurality of irregularities on the exposed surface.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: May 2, 2017
    Assignees: TOYODA GOSEI CO., LTD., National University Corporation Yamagata University
    Inventors: Seitaro Taki, Hisashi Mizuno, Hiroyuki Nakagawa, Toshiyuki Hagiyama, Atsuki Yoshimura, Masaru Tanaka, Ayano Sasaki, Toshifumi Takahashi, Tsuyoshi Ohta
  • Fluid processing device
    Patent number: 9636446
    Abstract: The present invention relates to a system, apparatus, and method for separating components of a fluid, e.g. blood, which eliminates the need for expensive hardware and produces a stabilized waste product. The system comprises an apparatus or device (V) for separating components of a fluid (15?) comprising a container (5?) having at least one separation or filtration member (10?) capable of selectively separating or filtering at least one component from the fluid, and a superabsorbent material (20?) capable of absorbing the at least one component separated from the fluid, and thereby providing a processed fluid free or substantially free of said at least one component; and agitation means.
    Type: Grant
    Filed: May 18, 2009
    Date of Patent: May 2, 2017
    Assignee: University of Strathclyde
    Inventor: Terence Gourlay
  • Holographic light-emitting module and holographic storage system using the same
    Patent number: 9640215
    Abstract: A holographic light-emitting module includes a light source module and a light shape control module. The light source module is configured to provide a signal light beam and a reference light beam, in which polarizations of the signal light beam and the reference light beam are orthogonal. The light shape control module is configured to receive the signal light beam and the reference light beam propagated from the light source module, in which the signal light beam and the reference light beam are modulated and emitted by the light shape control module The reference light beam is surrounded by the signal light beam and located at a center of the signal light beam, and the signal light beam and the reference light beam are partially overlapped.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: May 2, 2017
    Assignee: National Central University
    Inventors: Ching-Cherng Sun, Yeh-Wei Yu
  • Composition, method, system and kit for optical electrophysiology
    Patent number: 9636424
    Abstract: The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific emission wavelengths emitted from the thick portion of treated tissue.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: May 2, 2017
    Assignees: The Research Foundation of State University of New York, University of Connecticut
    Inventors: Arkady M. Pertsov, Arvydas Matiukas, Leslie M. Loew, Joseph P. Wuskell
  • Dental device with dual saliva extraction and dual retractor
    Patent number: 9636194
    Abstract: A dental device with dual saliva extractors and dual retractors for the tongue and upper lip and method are connectable to a suction and disposal unit. The device includes a pair of extractors each of which includes a suction tip and a tubular member for connecting the tip to the sources of suction. A first of the tubular members is put into a patient's mouth with a first curved portion inserted in a lower portion of the patient's mouth over the tongue and behind the front teeth and a second curved portion separate from said first portion branched off from where the first portion crosses the lower teeth and is inserted between the upper lip and upper molars under the region of the Stenson's duct.
    Type: Grant
    Filed: May 12, 2014
    Date of Patent: May 2, 2017
    Assignee: King Saud University
    Inventor: Fahad Ibrahim Fatiny
  • Bruton's tyrosine kinase as anti-cancer drug target
    Patent number: 9637554
    Abstract: Receptor protein kinases (RPTKs) transmit extracellular signals across the plasma membrane to cytosolic proteins, stimulating formation of complexes that regulate key cellular functions. Over half of the known tyrosine kinases are implicated in human cancers and are therefore highly promising drug targets. A large-scale loss-of-function analysis of tyrosine kinases using RNA interference in the clinically relevant Erb-B2 positive, BT474 breast cancer cell line showed that Bruton's tyrosine kinase (BTK), a cytosolic, non-receptor tyrosine kinase that has been extensively studied for its role in B cell development, is required, in altered form, for BT474 breast cancer survival. This alternative form contains an amino-terminal extension that is also present in tumorigenic breast cells at significantly higher levels than in normal breast cells.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: May 2, 2017
    Assignee: The Research Foundation For The State University Of New York
    Inventors: Douglas S. Conklin, Cheryl Eifert, Antonis Kourtidis, Xianhui Wang, Leila Kokabee
  • Methods of treating cancer with glut inhibitors and oxidative phosphorylation inhibitors
    Patent number: 9636329
    Abstract: Disclosed herein are methods of treating, diagnosing, and prognosing GLUT-dependent cancers and OXPHOS-dependent cancers. In some embodiments, the methods comprise administering to a patient in need thereof a GLUT inhibitor and/or an OXPHOS inhibitor. The inhibitors may be administered before, concurrently, or after one another. Suitable GLUT-dependent cancers may include a GLUT4-dependent cancer, a GLUT8-dependent cancer, and a GLUT11-dependent cancer. Suitable GLUT inhibitors may include a GLUT4 inhibitor, a GLUT8 inhibitor, and a GLUT11 inhibitor. Suitable OXPHOS-dependent cancers may include mitochondrial OXPHOS-dependent cancers, including cancers that have developed resistance to treatment with a GLUT-inhibitor.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: May 2, 2017
    Assignee: Northwestern University
    Inventors: Malathy Shanmugam, Steven T. Rosen
  • Devices and methods for gravimetric sensing in liquid environments
    Patent number: 9638616
    Abstract: Devices and methods for gravimetric sensing are disclosed. A gravimetric sensor includes a piezoelectric resonator and an encapsulating layer formed on the surface of the resonator. The encapsulating layer defines a channel within the encapsulating layer on the surface of the resonator. The sensor is fabricated by forming a piezoelectric resonator, forming a sacrificial layer on a surface of the piezoelectric resonator, forming an encapsulating layer over the sacrificial layer on the resonator, and etching the sacrificial layer to remove the sacrificial layer and form a channel on the surface of the resonator. The sensor is used by supplying the liquid to the channel of the gravimetric sensor, operating the piezoelectric resonator, detecting a change in a resonant frequency of the resonator, and determining a presence of the analyte in the liquid from the change in resonant frequency of the resonator.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: May 2, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Chiara Zuniga, Matteo Rinaldi, Gianluca Piazza
  • Methods of administering dantrolene for the acute treatment of cardiac arrhythmias
    Patent number: 9636327
    Abstract: The present description relates to methods of administering effective amounts of an anti-arrhythmic agent, e.g., dantrolene, azumolene or a pharmaceutically acceptable salt thereof, for the acute treatment of cardiac arrhythmias, e.g., atrial fibrillation, premature ventricular contraction, ventricular tachycardia or ventricular fibrillation, and prevention of subsequent cardiac arrhythmias, wherein the methods effectuate a reduction in morbidity and mortality.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: May 2, 2017
    Assignee: University Health Network
    Inventor: Kumaraswamy Nanthakumar
  • Synthetic platelets
    Patent number: 9636383
    Abstract: A synthetic platelet includes a biocompatible flexible nanoparticle that includes an outer surface and a plurality of peptides conjugated to the surface, the peptides including a plurality of von Willebrand factor-binding peptides (VBPs), collagen-binding peptides (CBPs) and an active platelet GPIIb-IIIa-binding peptides (GBPs).
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: May 2, 2017
    Assignee: Case Western Reserve University
    Inventors: Anirban Sen Gupta, Madhumitha Ravikumar
  • Transmitting method and receiving method for simultaneous information and energy transfer
    Patent number: 9641224
    Abstract: A transmitting method and receiving method for simultaneous information and energy transfer comprises: determining a first pre-allocated parameter set of a first baseband signal based on a first optimized parameter set and according to a first optimized target and a first constraint condition set; determining a second pre-allocated parameter set of a second baseband signal based on a first optimized result and a second optimized parameter set and according to a second optimized target and a second constraint condition set; and processing the baseband signals into corresponding radio-frequency signals according to the first pre-allocated parameter set and the second pre-allocated parameter set and transmitting the radio-frequency signals through an antenna; the first baseband signal and the second baseband signal each being an information baseband signal or an energy baseband signal.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: May 2, 2017
    Assignee: South University of Science and Technology of China
    Inventors: Yi Gong, Zidong Han, Yue Zhang
  • In situ spacing-correcting heat pulse sensor and method for measuring sap flow or water flux
    Patent number: 9638558
    Abstract: In situ spacing-correcting heat pulse sensor for measuring sap flow or water flux includes: a holder; a temperature probe or two (sometimes there will be more than two) mounted on the holder; and a heating probe mounted on the holder; wherein two or three thermometric elements are provided axially in the same temperature probe, all the thermometric elements are connected to a data collector, a heating wire is mounted in the heating probe, and the heating wire is connected to a power supply. A measuring method thereof is also provided. In practice, by arranging at least two thermometric elements in each temperature probe, measurement errors of sap flow in plant or soil water flux caused by factors such as deflection of the temperature probe or the heating probe are reduced. Furthermore, the sensor is simple in structure, low in cost, convenient in utilization, and accurate in measurement.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: May 2, 2017
    Assignee: China Agricultural University
    Inventors: Gang Liu, Minmin Wen, Robert Horton, Ruiqi Ren, BingCheng Si, Jianping Wang, Baoguo Li
  • Surgical cutting device and methods of using same
    Patent number: 9636134
    Abstract: A vibrational assembly for operative coupling to a surgical cutting element. The vibrational assembly receives a portion of the surgical cutting element and imparts vibration to the surgical cutting element within a single plane. In combination, the vibrational assembly and the surgical cutting element form a surgical cutting device.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: May 2, 2017
    Assignee: University of Alaska Anchorage
    Inventor: Samuel Werner