Abstract: Methods, apparatus, and other embodiments associated with classifying a region of cancerous tissue using a Histogram of Hosoya are described. One example apparatus includes a set of logics that acquires an image of a region of tissue demonstrating cancerous pathology, constructs a cell graph of the region of tissue, decomposes the cell graph into a set of subgraphs, computes a Hosoya Index for a subgraph, constructs a Histogram of Hosoya for the image based on the distribution of the subgraphs, and classifies the image based on the Histogram of Hosoya. Embodiments of example apparatus may generate and display the Histogram of Hosoya for the image. A prognosis for the patient may be provided based on the distribution of the histogram.

Abstract: In a method of manufacturing a quantum dot, a core may be formed using (utilizing) at least one cation precursor and at least one anion precursor. The core may be reacted with a shell forming precursor and a ligand forming precursor for more than one hour to form a shell enclosing the core and a ligand. A nanoparticle including the core, the shell and the ligand may be washed.

Abstract: Embodiments of the invention are directed to a method of inhibiting proliferation of a cell induced by asTF that includes exposing the proliferating cell to an inhibitor of asTF at a concentration sufficient to attenuate asTF induced proliferation. In an embodiment, the proliferating cell is a cancer cell such as a breast cancer cell. The inhibitor of asTF may be an anti-asTF antibody, such as a monoclonal antibody or an antibody fragment, a small molecule, a peptide, nucleic acid, and combinations thereof.

Abstract: Herein provided are innovative methods and techniques for improving seedling germination and plant establishment including a seed composition of at least one seed having a seed protective coating applied to the seed and a soil surfactant coating applied to the seed protective coating. The seed protective coating is positioned between the seed and the soil surfactant. The seed protective coating is formulated to keep the soil surfactant from contacting the seed and the soil surfactant coating is formulated to increase wettability of soil and being a sufficient quantity of soil surfactant to treat the soil in contact with the seed composition such that the soil is conditioned for growing the seed.

Abstract: Channel based authentication schemes for intrusion detection that operates at the physical layer are described that apply the capabilities of a pattern re-configurable antenna for improved performance. Performance gains are achieved by the schemes as a function of the number of antenna modes. The first scheme relies on a channel based fingerprint for differentiating between transmitters whereas another scheme poses the intruder detection problem as a generalized likelihood ratio (GLR) test problem that operates on the channel realizations corresponding to different modes present in a reconfigurable antenna. The benefits of these two schemes over single element antennas are demonstrated. General guidelines are provided on how to choose the different elements of the decision metric in order to realize better performance for physical layer based authentication schemes based on any diversity scheme.

Abstract: Disclosed are methods and apparatuses for creating a 3-Dimensional model for objects in an inspected luggage in a CT system. The method includes acquiring slice data of the luggage with the CT system; interpolating the slice data to generate 3D volume data of the luggage; performing unsupervised segmentation on the 3D volume data of the luggage to obtain a plurality of segmental regions; performing isosurface extraction on the plurality of segmental regions to obtain corresponding isosurfaces; and performing 3D surface segmentation on the isosurfaces to form a 3D model for the objects in the luggage. The above solutions can create a 3D model for objects in the inspected luggage in a relatively accurate manner, and thus provide better basis for subsequent shape feature extraction and security inspection, and reduce omission factor.

Abstract: The disclosure provides evidence that the abundance of this particular “oncogenic HSP90” species, which is not dictated by HSP90 expression alone, predicts for sensitivity to HSP90 inhibition therapy, and thus is a biomarker for HSP90 therapy. The disclosure also provides evidence that identifying and measuring the abundance of this oncogenic HSP90 species in tumors predicts of response to HSP90 therapy. “Oncogenic HSP90” is defined herein as the HSP90 fraction that represents a cell stress specific form of chaperone complex, that is expanded and constitutively maintained in the tumor cell context, and that may execute functions necessary to maintain the malignant phenotype. Such roles are not only to regulate the folding of overexpressed (i.e. HER2), mutated (i.e. mB-Raf) or chimeric proteins (i.e. Bcr-Abl), but also to facilitate scaffolding and complex formation of molecules involved in aberrantly activated signaling complexes (i.e. STATS, BCL6).

Abstract: Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast agents is described, and uses for such imaging markers and contrast agents in a variety of therapeutic applications and devices.

Abstract: Recombinant nucleic acid molecules are provided that form hair pin structures and can be used to down-regulate gene expression. For example, a nucleic acid molecule can comprise a flanking and lower stem loop sequence from a mir-16 gene; an antisense target sequence; a mir-30 loop sequence; a complement of the anti-sense target sequence; and a lower stem loop complementary to the mir-16 sequence. Methods for down regulating gene expression in a cell using such recombinant nucleic acid molecules are also provided.

Abstract: A bidirectional AC-DC converter is presented with reduced passive component size and common mode electro-magnetic interference. The converter includes an improved input stage formed by two coupled differential inductors, two coupled common and differential inductors, one differential capacitor and two common mode capacitors. With this input structure, the volume, weight and cost of the input stage can be reduced greatly. Additionally, the input current ripple and common mode electro-magnetic interference can be greatly attenuated, so lower switching frequency can be adopted to achieve higher efficiency.

Abstract: The NK1 fragment of hepatocyte growth factor (HGF) binds to and activates the Met receptor, a transmembrane receptor tyrosine kinase that plays a critical role in embryonic development and organ formation. The instant application discloses NK1 variant polypeptides which act as agonists or antagonists of HGF. Further disclosed are covalently linked NK1 variant polypeptides. Many of the disclosed variant polypeptides possess improved stability characteristics.

Abstract: A freeform imaging lens defined in a (x, y, z) coordinate is provided. The freeform imaging lens comprises a first surface and a second surface opposite to the first surface. The first surface comprises a first freeform surface and a second freeform surface symmetrical about x-z plane. The first freeform surface and the second freeform surface are 5th order xy-polynomial curve surfaces. The second surface is a 10th order aspheric surface. The present disclosure also relates to a freeform imaging system using the above freeform imaging lens.

Abstract: A system for detecting object movement including a sensory network having at least one sensory device using modulated radar for detecting an object in proximity to the sensory network. The sensory network including a wireless transmission system and a base station having a computer processing system located remote from the sensory network and including a wireless transmission system to communicate with the sensory network. The base station having a computer readable program code for causing the computer processing system to analyze data received from the sensory network to determine motion characteristics of the object in proximity to the sensory network.

Abstract: Cell tubes that can be used both for pathology collection and subsequent cell processing include a tube with a cell bed at a lower portion of the tube. The tube can include a base member that can be detachable from the tube body. The tubes can be used to form cell (cytology) blocks that incorporate the cell bed. The cell bed can be an inert cell bed of paraffin.

Abstract: The invention includes a method for combating scarring in a subject, the method comprising administering to the subject an agent which positively modulates ?2-adrenergic receptor; a method for simultaneously decreasing the amount of TGF?1 and increasing the amount of TGF?3 produced by a fibroblast, the method comprising contacting the fibroblast with an agent which positively modulates ?2-adrenergic receptor; a method for reducing fibroblast differentiation, the method comprising contacting the fibroblast with an agent which positively modulates ?2-adrenergic receptor; and a method of reducing the deposition of collagen in a subject, the method comprising administering to the subject an agent which positively modulates ?2-adrenergic receptor.

Abstract: In one aspect, the invention relates to substituted (E)-N?-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: An embodiment of the invention is implemented in a web browser that facilitates the visualization of dependencies between digital information and situations where changes in one piece of information or project can affect another. In such an embodiment, the user is presented with two personalized home page windows: a hierarchy view and a graph view. The hierarchy view is used to navigate through a hierarchy of documents or other digital information. The graph view is used to graphically display certain dependencies and is further used to graphically display changes to any dependencies.

Abstract: Devices including multiple flexible substrates bearing organic light-emitting diodes (OLEDs) are provided. The flexible substrates are interconnected, and the properties of the substrates and the interconnections provide the shape of the device.

Abstract: Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, ad dipole moment are derived from the measurements.

Abstract: Methods and systems for using magnetic resonance (MR) imaging include obtaining a T1-weighted MR image and a proton-density (PD) weighted MR image from a dual-image acquisition following an inversion-recovery (IR) pulse. The T1-weighted and PD-weighted images are used to obtain a polarity function describing a positive or negative polarity at individual voxels, which is used to reconstruct a polarity-enhanced PD-weighted image from the PD-weighted image. The polarity-enhanced PD-weighted image can be used for assessing at least plaque burden and juxtaluminal calcification (JCA).