Abstract: The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. The present invention relates, in general, to perioperative renal dysfunction and, in particular, to methods of identifying individuals at risk of perioperative renal dysfunction. The present invention relates, in general, to perioperative stroke and, in particular, to methods of identifying individuals at risk of perioperative stroke.

Abstract: One embodiment is a pressure sensitive adhesive construct comprising: (a) a backing substrate; and (b) a pressure sensitive adhesive composition disposed on the backing substrate, wherein the pressure sensitive adhesive composition includes a product made from (i) at least one epoxidized vegetable oil and; (ii) a dimer acid or anhydride thereof, a trimer acid or anhydride thereof, a polymerized fatty acid or anhydride thereof, or a mixture thereof.

Abstract: The present invention provides a method for treating Usher's syndrome in a human subject including administering to the human subject an oligonucleotide having 8 to 30 linked nucleosides having a nucleobase sequence comprising a complementary region comprising at least 8 contiguous nucleobases complementary to a target region of equal length within exon 3 of an Usher RNA transcript.

Abstract: The majority of clinically used antibiotics and anticancer agents are derived from bacterial small molecules. These molecules are produced by dedicated biosynthetic gene clusters, sets of genes that are responsible for the step-wise generation of the target small molecule. Recent investigations have indicated, to the surprise of many experts, that the majority of these biosynthetic genes are inactive or ‘silent’ for unknown reasons. Thus under typical bacterial culturing conditions, these genes are not expressed and consequently the bioactive small molecule products are not synthesized. Disclosed is a method for high throughput screening of elicitors of cryptic metabolites, a method for producing cryptic metabolites, and a new family of cryptic metabolites, the acybolins, as well as their complete structural elucidation.

Abstract: An irrigation mitigation runoff system that includes an irrigation system having at least one water outlet and a sensor that detects flow of water through a boundary. A controller is operatively coupled to the irrigation system and the sensor. Responsive to the sensor detecting flow of water through the boundary above a pre-defined threshold, the controller signals the irrigation system to pause irrigation.

Abstract: Embodiments of the disclosure include methods and compositions related to treatment of one or more medical conditions with one or more negative modulators of GABAA receptors. In specific embodiments, depression and/or suicidability is treated or ameliorated or prevented with one or more negative modulators of GABAA receptors, such as a partial inverse agonist of a GABAA receptor comprising an alpha5 subunit.

Abstract: Low-profile broadband patch antennas capable of radiating circularly polarized (CP) signals utilizing a single probe in accordance with embodiments of the invention are disclosed. In many embodiments, the patch antenna includes a ground plane, a patch plate, at least one dielectric or foam substrate, and a feed probe. In several embodiments, the patch plate includes a first plate and a second plate that can be connected via first and second connecting bars. In various embodiments, the connection of the first and second plates can expose first and second slots as further discussed below. In a variety of embodiments, the feed probe can be a coaxial cable having an inner and outer conductor where the inner conductor connects to the first plate and the outer conductor connects to the ground plane.

Abstract: A catalytic glycosylation method comprising: installing thioether to an anomeric carbon of a carbohydrate; and catalytically activating the thioether with a non-oxophilic Lewis acid. The thioether may comprise an anomerically stable thioether leaving group. The catalytic glycosylation method may further comprise: utilizing an acid-sensitive ester protecting group as permanent protecting group or using a reactivity-based one-pot glycosylation that employs a single-component catalyst to accelerate an oligosaccharide assembly process. A protecting group to mask hydroxyl functionalities in the production of oligosaccharides, natural products or any molecule having a hydroxyl group comprising an acid-labile ester protecting group.

Abstract: A method and apparatus for carrying out measurements on single cells, either one or many single cells at a time in order to characterize the cellular response to stimuli in a perfused liquid. The apparatus for performing the respirometry includes a double-barrel pipette probe.

Abstract: A 3-dimensional printing apparatus may include a storage unit, a dispensing unit, and a pressure control unit. The storage unit stores a printing material satisfying Bingham plastic model in which a viscosity is decreased as a pressure is increased. The dispensing unit receives the printing material from the storage unit to ejaculate the printing material. The pressure control unit controls a pressure applied to the printing material supplied in the dispensing unit to control a viscosity of the printing material. Thus, a product having soft characteristics may be manufactured.

Abstract: A device for protecting an umbilical stump-catheter interface, includes: a shield having a wall that defines a cavity for accommodating an umbilical stump, wherein the shield further includes a base for attachment to a patient; and an opening at the shield for allowing an umbilical catheter to extend therethrough. A method for protecting an umbilical stump-catheter interface, includes: providing a device having a shield with a wall that defines a cavity for accommodating an umbilical stump, wherein the shield further includes a base for attachment to a patient, and wherein the device further includes an opening at the shield; shielding the umbilical stump from an environment using the shield; and accommodating an umbilical catheter using the opening at the shield.

Abstract: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.

Abstract: A total knee replacement, comprising a femoral and a tibial component in articulating contact that can restore normal joint function. The articulation between the two components is controlled by four guide surfaces.

Abstract: A method and apparatus for determining the progressive potential of a disease is disclosed. The forward to backward propagating second harmonic generation signal derived from a second harmonic generation instrument is used to assess the collagen microstructure of imaged body tissue by way of numerical values that are in turn used to determine the progressive or metastatic potential of the disease. The disease may, for example, be a cancer such as breast cancer, lung fibrosis, colorectal adenocarcinoma, or the like. The apparatus may include in vivo instruments or laboratory diagnostic instruments with methods disclosed herein.

Abstract: The present invention provides methods for treating inflammation or a wound in a subject in need of such wound treatment or inflammation treatment by delivering a volatile anesthetic to the wound or the inflammation site.

Abstract: Provided is an automatic hair transplanter for transplanting follicles including a housing having a space therein and having a nozzle in which an opening is formed on a front surface, a needle supply magazine installed on the housing and sequentially supplying a plurality of needles containing follicles to the back of the nozzle, a needle aligner transferring and aligning a needle supplied from the needle supply magazine with the center of the nozzle, a needle actuator causing the needle aligned by the needle aligner to protrude from the nozzle, a follicle pressurizer pressurizing a follicle in the needle protruding by the needle actuator from the back to the front, a needle retrieval magazine containing the needle in which pressurization of the follicle has been finished by the follicle pressurizer and nothing remains, and a manipulator having a switch for controlling operation of the needle actuator and the follicle pressurizer.

Abstract: A method of making LDO-Co nanoparticles is described herein. A method of using LDO-Co nanoparticles, particularly in the treatment of wastewater, is described herein.

Abstract: Asymmetric bifunctional silyl (ABS) monomers comprising covalently linked pharmaceutical, chemical and biological agents are described. These agents can also be covalently bound via the silyl group to delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain ABS monomers comprising covalently linked agents and to vehicles that are covalently linked to the ABS monomers. The silyl modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting.

Abstract: The disclosure provides a method of oil delivery to a chainsaw chain blade using a gerotor pump in sequence with flow control valves to provide lubrication to the chain blade to reduce friction with the chainsaw bar guide and prevent overheating and damage to the chain blade or guide bar.

Abstract: Disclosed herein is a method comprising imaging a network section through which flow occurs; where the flow is selected from a group consisting of fluid, electrons, protons, neutrons and holes; partitioning the image into sub-regions based on metabolic need and function; where each region comprises one or more sources and one or more sinks; where the flow emanates from the source and exits into the sinks; performing a Delaunay triangulation tessellation on one or more sub-regions by connecting one or more sources and one or more sinks; where the Delaunay triangulations maximize the minimum angle of all the angles of the triangles in the triangulation; generating a Voronoi diagram from the Delaunay triangulation by subdividing the sub-regions into Voronoi cells, where each Voronoi cell contains exactly one sink or one source; and where the intersections of Voronoi cells are Voronoi cell vertices; locating a sink endpoint centroid; connecting a source to a nearest Voronoi cell vertex; connecting at least one si