Abstract: Disclosure is provided for imidazole derivative compounds useful to inhibit the formation of biofilms and/or inhibit microbial growth, compositions including these compounds, devices including these compounds, and methods of using the same.
Type:
Grant
Filed:
September 24, 2013
Date of Patent:
March 29, 2016
Assignee:
North Carolina State University
Inventors:
Christian Melander, W. Steve McCall, Zhaoming Su, Roberta Melander
Abstract: An annuloplasty ring, configured for implantation in the annulus of a heart valve, comprising multiple segments each of which are geometrically shaped from a three dimensional perspective to conform to the anatomic shape of the valve annulus. In one embodiment, at least one of the multiple segments of the annuloplasty ring is configured to facilitate a reduction of tension on heart valve tissue and eliminate a substantial portion of potential pressure or force that may be applied to the atrio-ventricular node by the annuloplasty ring when inserted into a heart valve. In another embodiment, at least one of the multiple segments of the annuloplasty ring are configured to include an assembly that facilitates selective adjustment of a segment's respective length and/or shape. The adjustment of the length of one of the ring segment's results in an adjustment of at least one angle between at least one set of other ring segments, thereby causing an adjustment to the geometric characteristics of the ring.
Type:
Grant
Filed:
April 7, 2009
Date of Patent:
March 29, 2016
Assignees:
Georgia Tech Research Corporation, Emory University
Inventors:
Sai Muralidhar Padala, Ajit P. Yoganathan, Vinod H. Thourani, Jorge H. Jimenez
Abstract: A method includes receiving toolface information corresponding to a location of the bottom hole assembly (BHA) with respect to a target drilling path and drift information. The surface steerable system calculates a first toolface vector from a first location of the BHA to the target drilling path to create a convergence path to the target drilling path and calculates an adjustment of the first toolface vector to a second toolface vector to account for system drift defined by the drift information such that the BHA will converge with the target drilling path by drilling in accordance with the second toolface vector. The surface steerable system modifies at least one drilling parameter to alter a drilling direction of the BHA based on the calculated second toolface vector and transmits the at least one drilling parameter to the drilling rig to target the BHA in accordance with the second toolface vector.
Type:
Grant
Filed:
April 2, 2015
Date of Patent:
March 29, 2016
Assignees:
Hunt Advanced Drilling Technologies, LLC, Board of Regents, The University of Texas System
Inventors:
Todd W. Benson, Teddy Chen, Sashmit Bhaduri
Abstract: This invention is in the fields of cancer therapy. More particularly it concerns compounds which are useful agents for treating cell proliferative disorders, especially those disorders characterized by over activity and/or inappropriate activity of a EGFR, including EGFR-related cancers, particularly for expanding the efficacy of drugs previously developed for this purpose, and for methods of treatments using the compounds for this purpose.
Type:
Grant
Filed:
March 16, 2012
Date of Patent:
March 29, 2016
Assignee:
The Trustees Of The University of Pennsylvania
Inventors:
Alan Berezov, Mark I. Greene, Natalie Minkovsky, Zheng Cai, Hongtao Zhang
Abstract: In one embodiment, a gait-altering shoe includes a frame adapted to support a user's foot and at least one wheel that supports the frame above a walking surface, the wheel having a radius that varies as a function of angular position of the wheel.
Abstract: In one aspect, a nonvolatile magnetic logic device comprises an electrically insulating layer, a write path, and a read path. The write path comprises a plurality of write path terminals and a magnetic layer having a uniform magnetization direction that is indicative of a direction of magnetization of the magnetic layer in a steady state. A logic state is written to the nonvolatile magnetic logic device by passing a current through the plurality of write path terminals. The read path comprises a plurality of read path terminals for evaluation of the logic state. The electrically insulating layer promotes electrical isolation between the read path and the write path and magnetic coupling of the read path to the write path.
Type:
Grant
Filed:
December 4, 2013
Date of Patent:
March 29, 2016
Assignee:
Carnegie Mellon University
Inventors:
David M. Bromberg, Jian-Gang Zhu, Lawrence Pileggi, Vincent Sokalski, Matthew Moneck
Abstract: A line-contact dry electrode comprises a conductive electrode base and at least one conductive contact member extending from the conductive electrode base. The conductive contact member includes a plurality of elastic conductive branches arranged intermittently to form a comb-like electrode able to comb and push away the testee's hair and contact the testee's skin.
Abstract: The present invention provides optical agents comprising optically functional cross linked supramolecular structures and assemblies useful for tandem optical imaging and therapy. Supramolecular structures and assemblies of the present invention include optically functional shell-cross linked micelles wherein optical functionality is achieved via incorporation of one or more linking groups that include one or more photoactive moieties. The present invention further includes imaging and therapeutic methods using one or more optical agents of the present invention including optically functional shell cross-linked micelles having an associated therapeutic agent.
Type:
Grant
Filed:
November 17, 2011
Date of Patent:
March 29, 2016
Assignees:
Mallinckrodt LLC, The Texas A&M University System, Washington University
Inventors:
William L. Neumann, Richard B. Dorshow, John N. Freskos, Karen L. Wooley, Nam S. Lee, Yun Lin, Guorong Sun
Abstract: The present invention relates to the use of certain osmium containing complexes such as cytotoxic agents particularly for the treatment of cancer. There is also provided novel osmium containing complexes, as well as pharmaceutical formulations comprising such complexes.
Type:
Grant
Filed:
April 15, 2011
Date of Patent:
March 29, 2016
Assignee:
The University of Warwick
Inventors:
Ying Fu, Peter John Sadler, Abraha Habtemariam
Abstract: An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.
Type:
Grant
Filed:
March 20, 2012
Date of Patent:
March 29, 2016
Assignees:
Admittance Technologies, Inc., Board of Regents, The University of Texas System
Inventors:
Jonathan W. Valvano, Marc D. Feldman, John Porterfield, John A. Pearce, Erik Larson, Lev Shuhatovich, Kathryn Loeffler, Raffaele Cetrulo
Abstract: The present invention provides devices and associated methods to facilitate multiplexed staining on a slide. The use of multiplexed staining on a single slide allows for more accurate disease diagnosis while also conserving sample. A PDMS based cytology overlay was created that is capable of coupling on-chip morphological, cytochemical, and immunological staining. Morphological and cytochemical staining of blood smears, along with immunostaining of lymph node imprints, was carried out to demonstrate the application of this microfluidic cytology chip (?CC) device.
Type:
Grant
Filed:
March 8, 2012
Date of Patent:
March 29, 2016
Assignee:
Colorado State University Research Foundation
Inventors:
Charles Henry, Matthew Feirer, Meghan Mensack
Abstract: The invention provides nanoparticles consisting of a polymer which is a metal chelating agent coated with a magnetic metal oxide, wherein at least one active agent is covalently bound to the polymer, said nanoparticles may optionally further comprise at least one active agent physically or covalently bound to the outer surface of the magnetic metal oxide. Pharmaceutical compositions comprising these nanoparticles may be used, inter alia, for detection and treatment of tumors and inflammations.
Type:
Grant
Filed:
September 24, 2008
Date of Patent:
March 29, 2016
Assignees:
Bar Ilan University, Henry Ford Health System
Inventors:
Shlomo Margel, Benny Perlstein, Chaya Brodie, Tom Mikkelsen
Abstract: A method for joining two components includes positioning a thermoplastic polymer portion of a first component adjacent a thermoplastic polymer portion of a second component such that the first and second portions form an interface. At least one of the portions includes a microstructure having a plurality of closed cells, each cell containing a void and each cell having a maximum dimension extending across the void. The method also includes exerting pressure on the thermoplastic polymer portions to form a bond at the interface that holds the portions together. The plurality of closed cells, and especially those adjacent the surface of the thermoplastic polymer portion that form the interface, help isolate thermally and/or chemically the surface from the remainder of the portion.
Type:
Grant
Filed:
April 19, 2011
Date of Patent:
March 29, 2016
Assignees:
Dart Container Corporation, University of Washington
Abstract: Systems and methods for receiving a blurred two-dimensional image captured using an optic system. The blurred two-dimensional image is deconvoluted using a point spread function for the optic system. A stack of non-blurred two-dimensional images is generated, each non-blurred image having a z-axis coordinate. A three-dimensional image is constructed from the stack of two-dimensional images.
Abstract: Methods and systems are described for generating a data representation of a geographical region as an adjunct to conducting autonomous operations within the region. The method comprises receiving information specifying a plurality of localized caused zones having operation-defined geographical boundaries within the region; receiving heterogeneous data descriptive of the region; associating the received data with respective localized zones; fusing the received data associated with the localized zones into data representations of the localized zones; and integrating the data representations of the localized zones into a common data representation of the geographical region.
Type:
Grant
Filed:
April 30, 2010
Date of Patent:
March 29, 2016
Assignee:
The University of Sydney
Inventors:
Eric Nettleton, Ross Hennessy, Hugh Durrant-Whyte, Ali Haydar Göktogan, Peter James Hatherly, Fabio Tozeto Ramos
Abstract: Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons. The methods can also comprise administering to the mammal an effective amount of an agent that acts by increasing NAD activity in diseased and/or injured neurons. Also disclosed are methods of screening agents for treating a neuropathies and recombinant vectors for treating or preventing neuropathies.
Type:
Grant
Filed:
October 10, 2014
Date of Patent:
March 29, 2016
Assignee:
Washington University
Inventors:
Jeffrey Milbrandt, Toshiyuki Araki, Yo Sasaki