Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.

Abstract: A cochlear implant device includes a deformable and stretchable flexible strip composed of a biological compatible material and positioned about a longitudinal axis so as to form a spiral. The implant device has a plurality of conductive strips with electrode windows formed so as to expose a segment of each conductive strip. A density of the electrode windows is sufficient to monitor a distance of the flexible strip from a non-conductive tissue of a patient in a 360 degree field of view about the longitudinal axis. A method of inserting a cochlear implant includes providing a multi-joint robot comprised of a series of actuator units, guiding the multi-joint robot into an inner ear of a patient, monitoring the position of the multi-joint robot relative to a non-conductive portion of the patient; and applying current to the multi joint robot so as to adjust the position of the actuator units.

Abstract: The present invention generally relates to a method for computing a Fast Fourier Transform (FFT). In one embodiment, the present invention relates to an interleaved method for computing a Fast Fourier Transform (FFT).

Abstract: The methods may include forming a first material layer on a substrate, increasing electric resistance of the first material layer, and forming a source pattern and a drain pattern, which are spaced apart from each other, on the first material layer, a band gap of the source and drain patterns greater than a band gap of a first material layer.

Abstract: The present invention is directed to a new class of synthetic carbohydrate receptor compounds comprising Formula I as described herein: (I). Other aspects of the present invention relate to pharmaceutical compositions and pharmaceutical delivery vehicles comprising the compound of Formula (I) The present invention is also directed to methods of treatment and diagnosis that involve the administration of a compound of Formula (I).

Abstract: Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes connected together by edges. For example, the image may be an ocular image showing layered structures or other features of the retina. The method may also include adding, to the graph, nodes adjacent to nodes along first and second sides of the graph. The added nodes may have edge weights less than the nodes along the first and second sides of the graph. Further, the method may include assigning start and end points to any of the added nodes along the first and second sides, respectively. The method may also include graph cutting between the start and end points for identifying a feature in the image.

Abstract: Prodrugs of steroidal C-17 benzoazoles, pyrimidinoazoles (az-abenzoazoles) and diazines. Methods of synthesis are also described, whereby a prodrug group is substituted for a functional group at A ring portion of the ABC ring structure of the steroid. Suitable pro-drug groups include amino acid groups, succinate groups, phosphate groups, or sulfamate groups. The prodrugs of the disclosed compounds allow for improved oral bioavailability of the compounds that are inhibitors of human CYP 17 enzyme as well as potent antagonists of both wild type and mutant androgen receptors (AR). The compounds and the corresponding prodrugs are useful for the treatment of conditions such as human prostate cancer, breast cancer, and prostate hyperplasia.

Abstract: The present invention provides methods of reducing or enhancing T cell activation and/or B cell activation in a subject, comprising administering to a subject an effective amount of an inhibitor or enhancer, respectively, of Semaphorin 6D (Sema6D) activity on T cells and/or B cells.

Abstract: A vibration detector (100) is disclosed herein. In a first embodiment, the vibration detector (100) includes a support member (300, 302) arranged to vibrate, and a sensor (207) arranged to detect a vibration frequency of the support member (300, 302). The vibration frequency to be detected is dependent on the support member's mechanical structure, in which the support member's mechanical structure is mechanically reconfigurable to vary the vibration frequency to be detected by the sensor (207).

Abstract: This invention relates to a method of manufacturing an organic-inorganic composite hybrid adsorbent by impregnating activated carbon nanopores with an oxide and a water treatment method using the same, and particularly, to an adsorbent including a porous adsorbent and ferrihydrite, goethite, hematite or magnetite incorporated into the porous adsorbent, and a manufacturing method thereof.

Abstract: A sorbent for CO2 wherein K2CO3 is supported on FeOOH.

Abstract: Apparatus and method for accessing the wall of a body lumen while simultaneously providing zone isolation and fluid bypass capability, the apparatus comprising: an erectable proximal isolation barrier capable of making a sealing engagement with the wall of the body lumen; an erectable distal isolation barrier capable of making a sealing engagement with the wall of the body lumen; a bypass channel secured to, and extending between, the proximal isolation barrier and the distal isolation barrier, the bypass channel comprising a lumen communicating with the region proximal to the proximal isolation barrier and with the region distal to the distal isolation barrier; and a working catheter passing through the proximal isolation barrier and terminating short of the distal isolation barrier, the working catheter providing a central lumen for providing access to the wall of the body lumen between the proximal isolation barrier and the distal isolation barrier.

Abstract: A liquid crystal cell structure comprising transparent terahertz (THz) windows, alignment layers, protective layers, in-plane electrodes, out-of-plane electrodes, and a liquid crystal (LC) layer. The in-plane electrodes generate in-plane electric fields that are parallel to the liquid crystal layer and the out-of-plane electrodes generate out-of-plane electric fields that are perpendicular to the liquid crystal layer. The in-plane and out-of-plane electrodes have wire-grid patterns to increase THz wave transmission efficiency. The wire-grid patterned electrodes are transparent to THz waves that have parallel polarization compared to a grating vector of the wire grid pattern and are opaque to THz waves of perpendicular polarization. These two electrodes are controlled independently to tune the optical properties of the LC and improve the operating speed of THz LC devices.

Abstract: The present invention provides materials and methods useful to treat various sGC?1-expressing cancers. Materials include peptides which interfere with sGC?1's pro-survival functions, thereby resulting in apoptosis of sGC?1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits.

Abstract: The present disclosure provides methods for reducing the clinical presentations of a neurological movement disorder in a subject. Aspects of the methods include measuring cortical local field potentials (LFPs) from the subject's brain, calculating a modulation index related to brain synchronization from the LFPs, and administering deep brain stimulation to the subject if the calculated modulation index is outside of a threshold range. Also provided are devices, systems, and kits that may be used in practicing the subject methods.

Abstract: Variously configured sub-laminate modules are provided, which comprise at least a first ply and a second ply, the first ply comprising fibers extending in a first orientation, the second ply comprising fibers extending in a second orientation. The second orientation is offset relative to the first orientation, which offset defines an acute angle between the two orientations. The acute angle is less than 90 degrees and in at least one embodiment, the acute angle is approximately 25°. In certain embodiments, the acute angle further defines an unbalanced structure of the sub-laminate module. In certain embodiments, the first and second plies may be further secured relative to one another in a non-crimped configuration. Composite laminated structures formed from various embodiments of the sub-laminate modules are also provided, at least some of which may be homogenized. Various methods of manufacturing the sub-laminate modules and the composite laminated structures are also provided.

Abstract: A programmable, quantization error spectral shaping, alias-free asynchronous analog-to-digital converter (ADC) is provided. The ADC can be used for clock-less, continuous-time digital signal processing in receivers with modest Signal to Noise-plus-Distortion Ratio (SNDR) requirements and a tight power budget.

Abstract: A source cold cathode field emission array (FEA) source based on ultra-nanocrystalline diamond (UNCD) field emitters. This system was constructed as an alternative for detection of obscured objects and material. Depending on the geometry of the given situation a flat-panel source can be used in tomography, radiography, or tomosynthesis. Furthermore, the unit can be used as a portable electron or X-ray scanner or an integral part of an existing detection system. UNCD field emitters show great field emission output and can be deposited over large areas as the case with carbon nanotube “forest” (CNT) cathodes. Furthermore, UNCDs have better mechanical and thermal properties as compared to CNT tips which further extend the lifetime of UNCD based FEA.

Abstract: Combinations of agents that have a synergistic effect for the treatment of a tumor are disclosed herein. These combinations of agents can be used to treat tumors, wherein the cells of the cancer express a mutated BRAF. Methods are disclosed for treating a subject diagnosed with a tumor that expresses a mutated BRAF. The methods include administering to the subject (1) a therapeutically effective amount of an antibody or antigen binding fragment thereof that specifically binds high molecular weight melanoma associated antigen (HMW-MAA), also known as CSPG4; and (2) a therapeutically effective amount of a BRAF inhibitor. In some embodiments, the tumor is melanoma. In some embodiments the method includes selecting a subject with primary or secondary resistance to a BRAF inhibitor. In further embodiments, treating the tumor comprises decreasing the metastasis of the tumor. In additional embodiments, the BRAF inhibitor comprises PLX4032 or PLX4720.

Abstract: Buddleja ‘Pink Micro Chip’ is a new and distinct variety of butterfly bush that has the following unique combination of desirable features that are outstanding in a new variety. ‘Pink Micro Chip’ has low vigor resulting in very dwarf stature. ‘Pink Micro Chip’ is asexually propagated using softwood or semi-hardwood cuttings. ‘Pink Micro Chip’ demonstrates a dense, spreading growth habit. ‘Pink Micro Chip’ is lacking male flower parts (anthers), resulting in male (pollen) sterility. ‘Pink Micro Chip’ produces female structures that are essentially sterile, resulting in lack of seed formation. ‘Pink Micro Chip’ has red-purple flower color.