Abstract: The present invention is directed to novel compounds that are able to inhibit the interaction of paxillin or its paralogues, including leupaxin or Hic-5, with alpha.4 integrin or its binding partners that regulate signaling events downstream of the paxillin-.alpha.4 interaction. The present invention further relates to methods for therapeutic use of such compounds and pharmaceutical compositions of such compounds for the treatment of a disease or condition.

Abstract: A composite drill bit with a bit body configured at its upper extend for connection into a drillstring, comprising: a bit body (1) with at least one bit leg (3), at least one scraping-wheel (2) set with a cutter-row (4), and a set of cutters fixed thereon. The scraping-wheel (2) is mounted for rotation on the corresponding bit leg (3) with a large angular deflection ? in the range of 20°?|?|?90°. The cutters on the scraping-wheel break rock by means of successive scraping, forming a cross-cutting area on the bottomhole accompanied by the cutters on the fixed cutting unit, thus achieving high rock-breaking efficiency, even wear, high cooling performance, and a longer service life for the cutters, bearings and the drill bit.

Abstract: Design and fabrication processes and compositions for bulk metallic glass materials. Examples of bulk metallic glasses based on the described compositions may contain a high atomic percent of titanium or iron, which is alloyed with metalloid elements and refractory metals. The compositions can be designed using theoretical calculations of the liquidus temperature to have substantial amounts of refractory metals, while still maintaining a depressed liquidus temperature. The alloying elements are molybdenum, tungsten, chromium, boron, and carbon may be used. Some of the resulting alloys are ferromagnetic at room temperature, while others are non-ferromagnetic. These amorphous alloys have increased specific strengths and corrosion resistance compared to conventional high strength steels.

Abstract: A vapor deposition apparatus efficiently performs a deposition process to form a thin film with improved characteristics on a substrate, and a method manufactures an organic light-emitting display apparatus by using such vapor deposition apparatus. The vapor deposition apparatus includes a body including an upper member and a lateral member coupled to the upper member; a receiving portion disposed to face one side of the lateral member; a stage disposed in the receiving portion and supporting the substrate; a plurality of first injection portions disposed in the lateral member and injecting at least one gas into a space between the lateral member and the upper member; a second injection portion disposed in the upper member and injecting at least one gas into the space between the lateral member and the upper member; and a plasma generating portion including a coil and a power source connected to the coil.

Abstract: A support structure for x-ray windows including carbon composite ribs, comprising carbon fibers in a matrix. The support structure can comprise a support frame defining a perimeter and an aperture, a plurality of ribs comprising a carbon composite material extending across the aperture of the support frame and carried by the support frame, and openings between the plurality of ribs. A film can be disposed over, carried by, and span the plurality of ribs and disposed over and span the openings.

Abstract: Disclosed are a touch panel driving apparatus and a display device including the same, which lead to the enhancement of sensing sensitivity. The touch panel driving apparatus includes a touch control unit and a touch sensing unit. The touch sensing unit is connected to the receiving lines, and generates the digital touch information on the basis of change of a capacitance between two transmitting lines and one receiving line or generates the digital touch information on the basis of change of a capacitance of each of the receiving lines to supply the digital touch information to the touch control unit, according to the sensing control signal.

Abstract: The low cost roofing techniques provide techniques for construction of low-cost roofing. The techniques reduce the proportion of cement by employing substitute (low-cost) materials that may be readily available to mix with the cement. These substitute materials include, but are not limited to, suitable agricultural wastes, such as rice husk ash, crushed used brick rubble, and pozzolana. The techniques involve forming a plurality of supports spanning the open space between the walls of the structure and mounting a plurality of dome-shaped sheet metal elements on the supports, forming a series of ceiling vaults. The concave surface of the dome-shaped elements forms the ceiling. The convex or outer surface of the dome-shaped elements forms the inner layer of the roof. The cement mixture is deposited on the convex or outer surfaces of the dome-shaped elements to form a second layer for the roof.

Abstract: A pixel area with a two-dimensional array of pixels (10) each including a photodiode and a memory area (3a) on which memory sections for holding signals produced by the pixels for continuously recordable frames are separately provided on a semiconductor substrate. All the pixels simultaneously perform a photocharge storage operation, and the signals produced by the photocharge storage are extracted in parallel through mutually independent pixel output lines (14). In a plurality of memory sections connected to one pixel output line, a sample-and-hold transistor of a different memory section is turned on for each exposure cycle so as to sequentially hold signals in a capacitor of each memory section. After the continuous imaging is completed, all the pixel are sequentially read. Unlike CCD cameras, the present sensor does not simultaneously drive all the gate loads. Therefore, the sensor consumes less power yet can be driven at high speeds.

Abstract: An organic photovoltaic cell includes an anode and a cathode, and a plurality of organic semiconductor layers between the anode and the cathode. At least one of the anode and the cathode is transparent. Each two adjacent layers of the plurality of organic semiconductor layers are in direct contact. The plurality of organic semiconductor layers includes an intermediate layer consisting essentially of a photoconductive material, and two sets of at least three layers. A first set of at least three layers is between the intermediate layer and the anode. Each layer of the first set consists essentially of a different organic semiconductor material having a higher LUMO and a higher HOMO, relative to the material of an adjacent layer of the plurality of organic semiconductor layers closer to the cathode. A second set of at least three layers is between the intermediate layer and the cathode.

Abstract: The present invention provides a method of preparing [123I]Iodooctyl fenbufen amide with a radiochemical yield of 15%, a specific activity of 37 GBq/?mol and radiochemical purity of 95%. The present invention further provides a method of applying [123I]Iodooctyl fenbufen amide as tracer of single photon emission computer tomography (SPECT) to estimate the distribution of cyclooxygenase. By the binding characteristics of the iodine isotope-labeled compounds and the positive correlation of inflammation to tumor lesion, the present invention can estimate the tumor development and metastasis.

Abstract: A reconfigurable computer architecture is disclosed. The reconfigurable computer architecture has a plurality of logic elements, a plurality of connection switching elements, and a plurality of volatile and/or non-volatile configuration random access memories (RAMs). Each of the configuration RAMs is electrically coupled to at least one of the plurality of logic elements or at least one of the connection switching elements.

Abstract: A 2-aryl-pyridylazole compound and derivatives useful in slowing the growth of cancer cells are disclosed. Also disclosed are methods of synthesizing the compound, methods of using pharmaceutical compositions containing the compound as an ingredient to slow the growth of cancer cells, and methods of treating cancer patients with pharmaceutical compositions containing the compound as an ingredient.

Abstract: Compounds according to Formula (I), as well salts thereof: wherein R1 and R2 are as defined herein, are useful as antiproliferative agents and kinase inhibitors. Synthetic methods for preparing the compounds of Formula (I) are also provided.

Abstract: A method of acquiring scatter data and image projection data in computed tomography is provided that includes attenuating a radiation source using a pattern of blockers arranged to provide blocked and unblocked regions of the radiation source, and acquiring image data and scatter data of a target using an imaging device. A scatter map in the projection image can be estimated by interpolation and/or extrapolation of the projection image using an appropriately programmed computer, subtracting the estimated scatter map from the projection image to obtain scatter-corrected projections, reconstructing a CBCT volume using a total variation regularization algorithm, and applying an iterative regularization process to suppress the noise level on the reconstructed CBCT volume.

Abstract: A promoter, which may be used to transform a plant and/or express a gene substantially uniformly in substantially all organs and/or tissues of a plant, and which may include a constitutive expression promoter for transforming a monocot plant. A vector including a promoter, which may include a recombinant plant expression vector. A method of producing a target protein using a vector, and a method of producing a transformed cell and/or plant using a vector. A transformed plant, a transformed seed and a transformed cell are included, which may be formed by the method of producing the same using a vector.

Abstract: A method is disclosed for reducing the level of gossypol in cottonseed. The method generally includes selectively inducing RNA gene silencing in the seed of a transgenic cotton plant, to interfere with expression of the ?-cadinene synthase gene or the ?-cadinene-8-hydroxylase gene in the seed of the cotton plant without substantially affecting expression of that gene in the foliage, floral parts, and roots of the plant. The transgenic cotton plant comprises at least one of a ?-cadinene synthase gene trigger sequence and/or a ?-cadinene-8-hydroxylase gene trigger sequence operably linked to one or more a seed-specific promoter gene sequences, and the trigger sequence(s) is/are able to induce RNA gene silencing when expressed in cottonseed of the plant.

Abstract: To identify conserved and variable regions of the 16 S rRNA, an instant evolution experiment was performed on the entire 16 S rRNA. Analysis of these mutants identified regions that are required for function. These conserved sequences may be used as targets for pharmaceuticals that are taxonomically specific and which are refractory to the development of drug resistance.

Abstract: Disclosed herein is a GO-Gd-DTPA (gadolinium-diethylenetriamine pentaacetic-graphene oxide) complex, which is formed by an ester bond of graphene oxide (GO) and gadopentetic acid (Gd-DTPA). Since the GO-Gd-DTPA can stably exist in the body because it has high stability in water, it is expected that it can be effectively used as an MRI contrast agent.

Abstract: A photoelectric cell includes at least one photoelectric conversion module. The photoelectric module includes a first photoelectric conversion element and a second photoelectric conversion element. The first photoelectric conversion element is made of a first thermoelectric material having positive thermoelectric coefficient and comprises a first absorbing part and a first non-absorbing part. The second photoelectric conversion element is made of a second thermoelectric material having negative thermoelectric coefficient and comprises a second absorbing part and a second non-absorbing part. The first absorbing part is electrically connected with the second absorbing part.

Abstract: The high impact strength conductive adhesive is a mixture formed from a bisphenol A-based epoxy resin, a curing agent, and silver flakes. In one embodiment, the bisphenol A-based epoxy resin forms about 10.5 wt % of the mixture and the curing agent forms about 14.5 wt % of the mixture, the balance being silver flakes. In this embodiment, the curing agent is preferably an oligomeric polyamine curing agent, such as amidoamine-polyoxypropylenediamine t-butyl phenol. Each silver flake preferably has a tap density of between about 4.0 g/cm3 and about 5.8 g/cm3, and a surface area of between about 0.8 m2/g and about 0.3 m2/g. In an alternative embodiment, the bisphenol A-based epoxy resin forms about 11.7 wt % of the mixture and the curing agent forms about 16.3 wt % of the mixture, the balance being silver flakes.