Abstract: Systems, devices, and methods for treating a glaucomatous eye are provided. Embodiments may provide a treatment probe for treating an eye of a patient. The treatment probe may have an elongate body with a contact surface at a distal end of the elongate body. A treatment fiber or light source may be housed in the treatment probe and may be configured to direct treatment energy from the contact surface. The contact surface may be configured to couple to a surface of the eye to deliver the energy into the target area. In many embodiments the contact surface may have a convex configuration with a rounded outer shape and edge that facilitates the sweeping of the probe surface across the eye during treatment delivery. In some embodiments the probe may be swept in arc motions while delivering treatment energy to the eye.

Abstract: The present invention relates to a novel indene derivative, a preparation method for the same, and a pharmaceutical composition for treating retinal disease comprising the same as an active ingredient. The novel indene derivative of the present invention, the optional isomer of the same, or the pharmaceutically acceptable salts of the same have excellent inhibitory efficiency of receptor-interacting serine-threonine-protein kinase 1 (RIPK1). Therefore, the composition containing the same as an active ingredient can be effectively used as a pharmaceutical composition for treating retinal disease.

Abstract: This invention relates to novel pharmaceutically-useful compounds, to methods for their preparation, and to pharmaceutical compositions and therapeutic methods for treating certain conditions.

Abstract: Methods and compositions are provided for preventing or reducing symptoms or disease associated with Xylella fastidiosa or Xanthomonas axonopodis in a plant. The invention provides novel bacteriophages virulent to Xylella fastidiosa or Xanthomonas axonopodis, including XfaMija and XfaMijo, and further provides methods for treating or preventing Pierce's Disease or Citrus Canker in plants.

Abstract: Disclosed are new small molecules having a substituted quinazoline core structure and the uses thereof for modulating glucocerebrosidase activity. Also disclosed are pharmaceutical compositions comprising the small molecules or activated glucocerebrosidase conjugated to the small molecules, which compositions may be administered in methods of treating diseases or disorders associated with glucocerebrosidase activity, including neurological diseases and disorders such as Gaucher's disease and Parkinson's disease.

Abstract: The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.

Abstract: An underwater rescue system, including a submersible and a rescue cage. The submersible includes a housing, a turntable and a motor. The turntable is rotatably arranged at an outer surface of the housing. The motor is fixed on the housing and connected to the turntable. The rescue cage includes a connecting rod, a first lifebuoy, a second lifebuoy and an air charging device. A lower end of the connecting rod is provided with an electromagnetic chuck attracting the turntable. An upper end of the connecting rod is connected to the first lifebuoy. A bottom of the first lifebuoy is provided with a load-bearing net. A side of the first lifebuoy is connected to the second lifebuoy by a net bag. The air charging device communicates with the first and second lifebuoys and is configured to charge air to the first and second lifebuoys.

Abstract: Data characterizing a mother video feed acquired by an endoscopic video capture device can be received. The mother video feed can be for characterizing an operative field within a patient. One or more predefined markers can be identified within the mother video feed. Each of the one or more predefined markers can be associated with a surgical instrument in the operative field. Using the data characterizing the mother video feed, a daughter video feed comprising a sub-portion of the mother video feed can be generated. At least one of a location of the daughter video feed within the mother video feed and a zoom of the daughter video feed can be based on the identified one or more predefined markers. The daughter video feed can be provided. Related apparatus, systems, techniques, and articles are also described.

Abstract: Methods of making sequence-defined polymers and sequence-defined polymers. The methods are based on the orthogonal reactivity of monomers having at least two different functional groups. The sequence-defined polymers can be used in various applications. For example, the SDPs (e.g., pH sensitive SDPs) are used in cell lysis methods or as molecular vehicles to transport drug cargo into cells.

Abstract: Organosilane functionalised carbon nanoparticles comprising a carbon dot bonded to an organosilane functionalization agent in a first orientation having one or more functional groups capable of binding mercury located at or proximal to a free end thereof.

Abstract: A dc link module for a power circuit comprising a first connector for connecting to a first power conversion circuit, a second connector for connecting to a second power conversion circuit, wherein the second power conversion circuit is connected to a load circuit arranged to at least intermittently operate as a power source to the power circuit, at least one dc link capacitors arranged between said first connector and said second connector for processing a voltage signal received at said first connector or said second connector, and at least one voltage compensation circuits arranged between said first connector and said second connector, said one or more voltage compensation circuits arranged to generate a voltage signal to compensate an ac ripple component in a dc voltage signal appearing across the at least one dc link capacitor.

Abstract: This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end of the catheter. The air block permits introduction of other catheters or instrumentation through its central lumen and on into a lumen of the catheter while minimizing fluid loss or gain into the catheter. The air block further prevents air from entering the catheter and provides for removal of the air or other gas from the central lumen before it can enter the catheter where it could cause harm to the patient. The air block can be attached to various standard proximal catheter terminations including Luer fittings and hemostasis valve outer barrels.

Abstract: A digital control laser automatic tooth preparation method and device and a tooth positioner are provided. The device includes an intra-oral three-dimensional scanner, a dental laser, an oral working end, an oral and maxillofacial cone beam CT scanner, a computer, a tooth positioner, a negative-pressure suction device and a real-time monitoring device. The computer is connected respectively with the intra-oral three-dimensional scanner, the dental laser, the oral working end, the oral and maxillofacial cone beam CT scanner, the negative-pressure suction device, and the real-time monitoring device. The dental laser is connected with the oral working end of the digital control laser tooth preparation control system through a light guiding arm (1). The oral working end of the digital control laser tooth preparation control system is connected with the tooth positioner and the real-time monitoring device. The negative-pressure suction device is connected with the tooth positioner.

Abstract: A photodetector selection apparatus and method and a scattering coefficient measurement apparatus and method are provided. The photodetector selection apparatus for measuring a scattering coefficient may include: a light source configured to emit light to a subject; a photodetector array configured to detect the light that is reflected or scattered from the subject and measure a light intensity of the detected light; and a processor configured to select at least one photodetector from a plurality of photodetectors of the photodetector array, based on a change in the measured light intensity of each of the plurality of photodetectors according to a change in a scattering coefficient of the subject, and determine the scattering coefficient of the subject based on the light intensity that is measured by the selected at least one photodetector.

Abstract: An image processing device includes: an acquisition unit that acquires a probability distribution of luminance of a pixel in a plurality of perspective images including the luminance of the pixel which is superposition of luminance components resulting from respective objects, based on an occurrence frequency of a perspective image in which the luminance of the pixel has respective values of a plurality of values; a distribution estimation unit that estimates a mixture distribution indicating the acquired probability distribution; a component estimation unit that estimates a component corresponding to a smallest expectation value distribution of which an expectation value is the smallest among a plurality of partial distributions that form the estimated mixture distribution, and forming at least a portion of the luminance of the pixel; a removal unit that removes the estimated component from the luminance of the pixel included in the perspective image.

Abstract: A system, device and methods for quantitatively monitoring and evaluating changes in water and hemoglobin content in the brain in a non-invasive manner are provided. The system may be used for real-time detection and monitoring of brain edema and/or for an assessment of cerebral autoregulation.

Abstract: A method of electrolytic additive manufacturing provides 3-D parts. The method can be used to form parts from particulate material in an electrolytic bath. Metal is electrolytically deposited, binding the particles. Layers of the particles are built up to form the parts. The same process can be used to form parts without the particulate material. Layers of metal are electrolytically deposited in the electrolyte bath to form the parts.

Abstract: A visual stress assessment device is provided comprising a plurality of coloured light sources, each adapted to produce light of a predetermined hue, and a white light source. The white light source and the coloured light sources each comprise a plurality of light emitting diodes. A chamber is provided having an interior comprising a viewable region configured to provide a sample for inducing visual stress, wherein said viewable region is arranged to be illuminated by the white light source and the coloured light sources. A controller is configured to selectively operate the white light source and coloured light sources such that only one or both of a first of the coloured light sources and a second of the coloured light sources are operated simultaneously with the white light source, whereby their respective emitted light is observable in the viewable region by a user at a predetermined hue and saturation.

Abstract: Optomechanical device for frequency doubling enhancement are described. The devices include a substrate through which light of a first wavelength is introduced, a first reflector mirror, a conductive layer disposed on the first reflector mirror, and a second mirror spaced apart from the conductive layer, thereby forming an optical cavity between the second mirror and the conductive layer. The devices also include a power source coupled to the second mirror and the conductive layer and a monolayer of non-linear optical material disposed within the optical cavity, the monolayer being configured to produce light of a second wavelength upon interaction with the light of the first wavelength. The second mirror is deformable upon introduction of voltage from the power source and deformation of the second mirror changes a length of the optical cavity, thereby enhancing a power output of the light of the second wavelength produced by the monolayer.

Abstract: The present invention provides a nano-particle based structure or composition for a combinational cancer therapy. The structure has a doxorubicin (DOX) physically loaded on core-shell silver polymeric nanoparticles (AgN-Ps) with a ratio of 3.3-5.5% doxorubicin to 1% silver to 2-10% polymer. This structure enhances the cellular uptake of DOX in comparison to the current conventional combination therapy. The DOX-loaded nano-particles result in an improved the therapeutic efficiency of DOX, and reduced its toxicity, which cannot occur in case of adding DOX and AgNPs.