Abstract: The disclosure provides for MOF heterolites comprised of ordered superlattices of MOFs, the manufacture thereof, and the use of the MOF heterolites for various applications, such as gas separation and/or storage, catalysis, light harvesting, and meta-materials.
Type:
Grant
Filed:
March 17, 2015
Date of Patent:
December 3, 2019
Assignee:
The Regents of the University of California
Abstract: Methods and apparatuses for ensuring data integrity and security for communications over a wide area network in smart power systems are provided. These can be particularly helpful in sub station-to-sub station and sub station-to-control-center communications, for example when a fast and secure method is required to transfer critical messages over the network such as generic object oriented substation event messages. In addition to guaranteeing data integrity, methods and apparatuses provide reliable security algorithms based on the concept of sequence hopping.
Type:
Grant
Filed:
May 24, 2019
Date of Patent:
December 3, 2019
Assignee:
The Florida International University Board of Trustees
Inventors:
Mohammad Mahmoudian Esfahani, Tarek Youssef, Osama Mohammed
Abstract: Provided herein is a capacitive torque sensor, which can completely offset forces/torques in all axial directions, except for force/torque in a direction of a central axis, by measuring variations in capacitances of four sensing cells arrayed at angular intervals of 90 degrees on the basis of a center of the sensor and can offer a sensing value for the torque in a central axis direction.
Type:
Grant
Filed:
March 22, 2018
Date of Patent:
December 3, 2019
Assignee:
Research & Business Foundation Sungkyunkwan University
Inventors:
Hyouk Ryeol Choi, Ui Kyum Kim, Yong Bum Kim, Dong-Yeop Seok, Jin Ho So
Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
Type:
Grant
Filed:
May 2, 2016
Date of Patent:
December 3, 2019
Assignee:
The Regents of the University of California
Inventors:
Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
Abstract: A nanocapsule includes a liquid hydrophobic care including an essential oil, and a shell encapsulating the core. The shell includes a copolymer having repeating units of Formula (I) and (II) wherein X, L1, R1, R2, y, and p are as described herein. A dispersion is also disclosed, wherein the dispersion includes a plurality of nanocapsules. The nanocapsules described herein are particularly useful for the treatment of bacterial biofilms.
Type:
Grant
Filed:
August 16, 2016
Date of Patent:
December 3, 2019
Assignee:
THE UNIVERSITY OF MASSACHUSETTS
Inventors:
Vincent M. Rotello, Ryan Francis Landis, Akash Gupta, Yiwei Lee
Abstract: A transceiver circuit may include: a first NMOS transistor suitable for pulling up a transmission line in response to a TX signal in a TX mode and for being turned on or off according to a voltage level of the transmission line in an RX mode; and a first PMOS transistor suitable for pulling down the transmission line in response to the TX signal in the TX mode and for being turned on or off according to the voltage level of the transmission line in the RX mode.
Type:
Grant
Filed:
January 8, 2018
Date of Patent:
December 3, 2019
Assignees:
SK hynix Inc., Seoul National University R&DB Foundation
Abstract: Embodiments classify a region of tissue demonstrating non-small cell lung cancer using quantified vessel tortuosity (QVT). One example apparatus includes annotation circuitry configured to segment a lung region from surrounding anatomy in the region of tissue represented in a radiological image and segment a nodule from the lung region by defining a nodule boundary; vascular segmentation circuitry configured to generate a three dimensional (3D) segmented vasculature by segmenting a vessel associated with the nodule, and to identify a center line of the 3D segmented vasculature; QVT feature extraction circuitry configured to extract a set of QVT features from the radiological image; and classification circuitry configured to compute a probability that the region of tissue will respond to immunotherapy and generate a classification that the region of tissue is a responder or a non-responder based, at least in part, on the probability.
Type:
Grant
Filed:
January 30, 2018
Date of Patent:
December 3, 2019
Assignee:
Case Western Reserve University
Inventors:
Anant Madabhushi, Mehdi Alilou, Vamsidhar Velcheti
Abstract: A compound represented by formula (I) or formula (1I): in formula (I), R3 represents an electron donating group, R4 represents a hydrogen atom, a substituted or unsubstituted aryl group or an electron donating group, L3 represents a substituted or unsubstituted heteroarylene group or a substituted or unsubstituted arylene group, L4 represents a single bond, a substituted or unsubstituted heteroarylene group or a substituted or unsubstituted arylene group, L3 and L4 may bond together to form a ring with the carbon atoms to which they are bonded, in formula (II), R5 represents an electron donating group, R6 represents a hydrogen atom, a substituted or unsubstituted aryl group or an electron donating group, L5 represents a substituted or unsubstituted heteroarylene group or a substituted or unsubstituted arylene group, L6 represents a single bond, a substituted or unsubstituted heteroarylene group or a substituted or unsubstituted arylene group.
Type:
Grant
Filed:
January 29, 2019
Date of Patent:
December 3, 2019
Assignees:
KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION, NIPPON SODA CO., LTD.
Inventors:
Takuma Yasuda, In Seob Park, Yu Seok Yang, Hiroshi Sumiya, Yukio Fukushima
Abstract: The present invention concerns novel probiotic compositions that increase nitrate- and nitrite-reduction in animals such as ruminants. The present invention thus provides compositions and methods for reducing nitrate/nitrite toxicity in such animals, or prophylactically protecting such animals from the effects of toxicity, such as methemoglobinemia. A novel strain of an unspeciated bacterial strain related to Paenibacillus species with nitrate- and nitrite-reducing capabilities is described. In conjunction with nitrate-supplemented diets, the probiotics of the present invention can also be utilized to reduce methanogenesis in livestock. Furthermore, the probiotic compositions of the present invention can be used to reduce the number and kind of food-borne pathogens, such as Escherichia coli and Campylobacter jejuni.
Type:
Grant
Filed:
August 11, 2016
Date of Patent:
December 3, 2019
Assignees:
The Secretary of Agriculture, The Texas A&M University System
Inventors:
Robin C. Anderson, Elizabeth A. Latham, William E. Pinchak
Abstract: The present disclosure provides compositions and methods for binding and/or cleaving a single stranded target nucleic acid. Subject compositions include a Cas9 polypeptide, a guide nucleic acid, and a PAMmer. A subject PAMmer is a single stranded oligonucleotide having a protospacer adjacent motif (PAM) sequence and at least one of: a specifity segment positioned 5? of the PAM sequence, and an orientation segment positioned 3? of the PAM sequence. In some embodiments, the Cas9 polypeptide is a variant Cas9 polypeptide having reduced nuclease activity relative to a corresponding wild type Cas9 polypeptide. In some cases, methods of binding are for visualizing single stranded target nucleic acids using a detectable label. In some cases, methods of binding are for isolating, collecting, and/or analyzing at least one of: (i) bound single stranded target nucleic acids; and (ii) polypeptides associated with bound single stranded target nucleic acids.
Type:
Grant
Filed:
June 7, 2018
Date of Patent:
December 3, 2019
Assignee:
The Regents of the University of California
Inventors:
Jennifer A. Doudna, Samuel H. Sternberg, Mitchell O'Connell, Benjamin Oakes
Abstract: In one aspect, cobalt complexes are described herein. In some embodiments, such cobalt complexes employ bis(phosphine) or bis(imine) ligand and are operable as catalysts for borylation of arenes and aromatic heterocycles.
Type:
Grant
Filed:
December 9, 2014
Date of Patent:
December 3, 2019
Assignee:
The Trustees of Princeton University
Inventors:
Paul J. Chirik, Scott Semproni, Jennifer Obligacion, Margaret Scheuermann
Abstract: Improved neuromodulation control of neurological abnormalities associated with effector organs in vertebrate beings using direct current stimulation for modulating spinal cord excitability, having a peripheral-current supplying component for providing direct current peripheral nerve stimulation and a spinal-current supplying component providing direct current for spinal stimulation, and a controller managing such functions.
Type:
Grant
Filed:
November 2, 2017
Date of Patent:
December 3, 2019
Assignee:
The Research Foundation of the City University of New York
Abstract: A sulfur adsorbent comprising boric acid deposited on an activated carbon support, and a method of separating at least a portion of sulfur compounds from a sulfur-containing mixture with the sulfur adsorbent. Various combinations of embodiments of the sulfur adsorbent and the method are also provided.
Type:
Grant
Filed:
March 28, 2018
Date of Patent:
December 3, 2019
Assignee:
King Fahd University of Petroleum and Minerals
Abstract: Disclosed herein are devices and methods for detecting blood glucose levels in a subject that involve passively quantifying mid-infrared emissions from the eye of the subject.
Abstract: A method for determining locations of supporting points for a machine tool is proposed. Multiple test coordinate sets in relation to the machine tool are used in cooperation with corresponding deformation index values for multiple components of the machine tool to obtain a deformation index equation that relates to assessed deformation of the components in response to different coordinates for the supporting points. The deformation index equation is used to acquire an optimal coordinate set for the supporting points.
Type:
Grant
Filed:
July 18, 2018
Date of Patent:
December 3, 2019
Assignee:
National Chung Cheng University
Inventors:
De-Shin Liu, Zhen-Wei Zhuang, Jen-Chang Lu
Abstract: Methods of cortical mapping in real-time are provided. Aspects of the methods include performing real-time processing of signals indicative of a subject's brain activity by applying one filter or more to the signals, wherein the processing is in the absence of averaging based on time. Systems for cortical mapping in real-time are also provided. The methods and systems are useful in research, diagnostic, and therapeutic applications.
Type:
Grant
Filed:
January 30, 2013
Date of Patent:
December 3, 2019
Assignee:
The Regents of the University of California
Abstract: Systems and methods in accordance with embodiments of the invention utilize technology to facilitate student question creation. Interactive platforms such as mobile phones or tablets can allow questions to be written, saved, and communicated electronically. In one embodiment, a method for collaboratively generating a question includes generating question data in response to input of a question and answer choices on a first device, sending the question data to a repository, sending the question data from the repository to a second device, displaying the question and answer choices on the second device, generating revised question data in response to input that changes the question, sending the revised question data to the repository, sending the revised question data to a third device, displaying the question and answer choices on the third device, receiving input of the selection of answer choices on the third device, and providing feedback whether the selection is correct.
Type:
Grant
Filed:
October 2, 2018
Date of Patent:
December 3, 2019
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: The present disclosure relates to a method for performing phosphorous-31 spectroscopic magnetic resonance fingerprinting (MRF). The method comprises performing a pulse sequence using a series of varied sequence blocks to a volume in a subject where the volume contains phosphate metabolites. A series of signal evolutions are acquired from the volume in the subject to form MRF data. The MRF data is then compared to simulated MRF signal to determine parameters associated with phosphate metabolites and the chemical exchange rates between these metabolites. These parameters and exchange rates can be used in diagnosing a metabolic disorder in a subject.
Type:
Grant
Filed:
May 8, 2017
Date of Patent:
December 3, 2019
Assignee:
Case Western Reserve University
Inventors:
Charlie Y. Wang, Mark A. Griswold, Xin Yu
Abstract: Anaplasma Marginale surface protein OmpA and homologous genes from Anaplasmatacaea family members are used in compositions suitable for vaccines to treat or prevent infections caused by tick-born bacteria of the Anaplasmatacaea family. OmpA proteins or peptide fragments may be used in combination with other Anaplasmatacaea surface proteins to elicit an immune response. Furthermore, antibodies to OmpA proteins can be used in diagnostic methods to determine whether an individual has contracted an Anaplasmatacaea infection.