Patents Assigned to University
  • Compositions and methods for treating pulmonary hypertension
    Patent number: 8980849
    Abstract: The present invention relates to methods of treating pulmonary hypertension in a subject including administering to the subject a therapeutically effective dose of at least one anthracycline.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: March 17, 2015
    Assignee: Georgetown University
    Inventor: Yuichiro Suzuki
  • Method for identifying colon polyps in a computed tomography colonography dataset
    Patent number: 8983154
    Abstract: A method of formatting data for identifying colon polyps in a Computed Tomography Colonography (CTC) dataset comprising the steps of: extracting colon surface data, from the CTC dataset, within a sub-volume centered on a candidate polyp (CP) seed point; identifying individual sets of points corresponding to the CP's body and CP's base within the sub-volume; selecting the points corresponding to the body; re-formatting the candidate polyp by projecting the selected points corresponding to the body on to a tangent plane; and generating a series of cutting planes based on the reformatted candidate polyp.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: March 17, 2015
    Assignee: Dublin City University
    Inventors: Paul Francis Whelan, Kevin Peter Robinson, Nicolas Sezille
  • Generating flower images and shapes with compositional pattern producing networks
    Patent number: 8982149
    Abstract: Various embodiments are disclosed for generating an image from a Compositional Pattern Producing Network (CPPN). One such method includes receiving, in the CPPN, a series of polar coordinates {r,?}; outputting, by the CPPN, a series of pixel values, each of the pixel values corresponding to one of the polar coordinates; and displaying the pixel values at the corresponding polar coordinates to produce the image.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: March 17, 2015
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: David D'Ambrosio, Sebastian Risi, Joel Lehman, Amy K. Hoover, Kenneth O. Stanley
  • Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
    Patent number: 8983580
    Abstract: A method of forming an image of tissue. The method includes beginning an invasive procedure on a patient exposing tissue. The method then includes acquiring OCT data from the exposed tissue and converting the OCT data into at least one image. The method also includes ending the invasive procedure after the converting of the data.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: March 17, 2015
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Stephen A. Boppart, Freddy T. Nguyen, Adam M. Zysk
  • Use of IMP3 as a prognostic marker for cancer
    Patent number: 8980638
    Abstract: Provided herein are methods and compositions for the prognostic evaluation of a patient suspected of having, or having, cancer by assessing the expression of IMP3 in a biological sample of a patient. Methods can be used at the time of initial diagnosis of malignant tumors to identify a group of patients with a high potential to develop progression or metastasis later. Therefore, methods not only are able to provide very useful prognostic information for patients but also can help clinicians to select a candidate patient likely to benefit from early and aggressive cancer therapy. Methods and compositions for the treatment of cancer associated with expression of IMP3 are also provided.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: March 17, 2015
    Assignee: University of Massachusetts
    Inventor: Zhong Jiang
  • Flexible substrate for OLED device
    Patent number: 8981363
    Abstract: Flexible substrates and devices including flexible substrates are provided. In an embodiment, a flexible substrate includes a first glass substrate material and a first organic light emitting device, disposed over the first flexible substrate, which includes a first emissive layer The first flexible substrate may have a thickness of not more than 300 ?m, a flexural rigidity of 10?1 Nm to 10?6 Nm, a water vapor transmission rate of not more than 10?6 g per square meter per day, a refractive index of not more than 1.6, a glass transition temperature of at least 300 C, a Young's modulus of 60 to 90 GPa, and/or an optical transmission of at least 85% for light in the range of 400 to 800 nm.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: March 17, 2015
    Assignee: Universal Display Corporation
    Inventors: Mauro Premutico, Ruiqing Ma, Chun Lin, Michael Hack
  • Hybrid method for modulating upper airway function in a subject
    Patent number: 8983610
    Abstract: A hybrid method is provided for modulating upper airway function in a subject. The method includes applying first and second therapy signals to the subject to modulate at least one extrinsic laryngeal muscle and at least one intrinsic laryngeal muscle to synergistically control laryngeal motion and vocal fold movement, respectively.
    Type: Grant
    Filed: November 18, 2010
    Date of Patent: March 17, 2015
    Assignee: Case Western Reserve University
    Inventor: Dustin J. Tyler
  • Peptide compounds exhibiting glucagon antagonist and GLP-1 agonist activity
    Patent number: 8980830
    Abstract: Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified amino acid sequence of native glucagon, in which the first one to five N-terminal amino acids of native glucagon is deleted and in which the alpha helix is stabilized.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: March 17, 2015
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Richard D. Dimarchi, Bin Yang, Chenguang Ouyang
  • Porphyrinic compounds for use in flow cytometry
    Patent number: 8980565
    Abstract: The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compound comprising a porphyrinic macrocycle such as a porphyrin, chlorin, bacteriochlorin, or isobacteriochlorin. In particular embodiments, the detectable luminescent compound comprises a compound of the formula A-A?-Z—B?—B, wherein: A is a targeting group or member of a specific binding pair that specifically binds the detectable luminescent compound to the target compound, cell or particle; A? is a linker group or covalent bond; B? is a linker group or covalent bond; B is a water-soluble group; and Z is the porphyrinic macrocycle.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: March 17, 2015
    Assignee: North Carolina State University
    Inventor: Jonathan S. Lindsey
  • Apparatus for high-throughput cell culture with mechanical compression stimulation
    Patent number: 8980624
    Abstract: An apparatus for high-throughput cell culture with mechanical compression stimulation includes a cell culture vessel and a fluid pressure supply unit. The cell culture vessel includes at least one culture chamber, at least one pressure chamber disposed above the culture chamber, a membrane disposed between the culture chamber and the pressure chamber, and at least one pressurizing member that projects downwardly from the membrane into the culture chamber. The fluid pressure supply unit is connected fluidly to the pressure chamber, and has a fluid pressure supply device to supply a pressurized fluid to the pressure chamber so as to deform the membrane and move the pressurizing member, and a control device that is adapted to vary a pressure of the pressurized fluid in the pressure chamber.
    Type: Grant
    Filed: January 4, 2010
    Date of Patent: March 17, 2015
    Assignee: Chang Gung University
    Inventors: Min-Hsien Wu, Chun-Li Lin, Shiao-Wen Tsai, Heng-Liang Liu, Yen-Ting Liu
  • Light-emitting element
    Patent number: 8980658
    Abstract: A light-emitting element includes a n-type silicon oxide film and a p-type silicon nitride film. The n-type silicon oxide film and the p-type silicon nitride film formed on the n-type silicon oxide film form a p-n junction. The n-type silicon oxide film includes a plurality of quantum dots composed of n-type Si while the p-type silicon nitride film includes a plurality of quantum dots composed of p-type Si. Light emission occurs from the boundary between the n-type silicon oxide film and the p-type silicon nitride film by injecting electrons from the n-type silicon oxide film side and holes from the p-type silicon nitride film side.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: March 17, 2015
    Assignee: Hiroshima University
    Inventor: Shin Yokoyama
  • Non-peptidyl, potent, and selective mu opioid receptor antagonists and their use in treating opioid addiction and opioid induced constipation
    Patent number: 8980908
    Abstract: Selective, non-peptide antagonists of the mu opioid receptor (MOR) and methods of their use are provided. The antagonists may be used, for example, to identify MOR agonists in competitive binding assays, and to treat conditions related to addiction in which MOR is involved, e.g. heroin, prescription drug and alcohol addiction, as well as in the treatment of opioid induced constipation (OIC).
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: March 17, 2015
    Assignee: Virginia Commonwealth University
    Inventors: Yan Zhang, Dana E. Selley, William Dewey
  • Strigolactone analogues and their use
    Patent number: 8980795
    Abstract: Novel compounds of formula (I) their use as germination trap for parasitic weeds, for the regulation of branching, tillering and root development, for enhancement of cambium growth, for the regulation of hyphal growth of mycorrhizal fungi and compositions comprising compounds of formula (I) and insecticides and/or fungicides.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: March 17, 2015
    Assignee: King Abdullah University of Science and Technology
    Inventors: Salim Al-Babili, Adrian Alder
  • Pattern matching based on global quantitative characterization of patterns
    Patent number: 8983208
    Abstract: Various systems, methods, and programs embodied in computer-readable mediums are provided for detecting a match in patterns. In one embodiment, a method is provided that comprises performing a fractal analysis on a first pattern in a computer system to generate a first global quantitative characterization of the first pattern. The method further comprises comparing the first global quantitative characterization with a second global quantitative characterization associated with a second pattern in the computer system to determine whether the first pattern matches the second pattern. The second global quantitative characterization is generated from the second pattern.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: March 17, 2015
    Assignee: West Virginia University
    Inventors: Charles Jaffe, Alfred H. Stiller
  • Water sprays for dust control on mining machines
    Patent number: 8979212
    Abstract: This invention refers to innovative water sprays applications to significantly improve coal and quartz dust control around a continuous miner. Significant dust control is achieved through utilizing different types of sprays at locations on the top and sides of the miner chassis to create water curtains or shrouds of water around zones of high dust concentration and zones of high concentration dust transport. This is called “multiple lines of defense” spray system (MLD.) This invention also provides a method of reducing dust around a continuous miner by configuring a spray system, located at the top or sides of the cutter boom, thereby improving control of respirable dust.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: March 17, 2015
    Assignee: Board of Trustees of Southern Illinois University
    Inventor: Yoginder P Chugh
  • Intestine immunomodulator
    Patent number: 8980289
    Abstract: The purpose of the present invention is to provide a better intestine immunomodulator. The intestine immunomodulator of the present invention comprises bacterial cells or a bacterial component of a Lactobacillus paracasei K71 strain having an international deposit No.: FERM BP-11098 as an active ingredient. Preferably, the intestine immunomodulator is used to facilitate production of secretory immunoglobulin A or to activate natural killer cells.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: March 17, 2015
    Assignees: Niigata University, Kameda Seika Co., Ltd.
    Inventors: Takashi Hara, Yuki Higuchi, Mikio Fujii
  • Fertilizer composition incorporating fibrous material for enhanced particle integrity
    Patent number: 8979970
    Abstract: Fertilizer granules and methods of producing fertilizer granules. The fertilizer granules are formed from a fertilizer composition, such as a phosphate fertilizer, includes a fibrous material for the purpose of increasing the granule strength preventing or reducing attrition or dusting formation during storage, transport, and/or handling of the fertilizer. Dust formation can be reduced fifty percent or more. The base fertilizer composition can include a phosphate fertilizer, such as monoammonium phosphate (MAP) or diammonium phosphate (DAP), and optionally one or more micronutrients or secondary nutrients, such as elemental sulfur. The fibrous material is pulp or paper sludge, for example.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: March 17, 2015
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Paul Kucera, W. Gregory Sawyer
  • Filler fluids for droplet operations
    Patent number: 8980198
    Abstract: The present invention relates to filler fluids for droplet operations. According to one embodiment of this aspect, a droplet microactuator is provided and includes: (a) a first substrate comprising electrodes configured for conducting droplet operations on a surface of the substrate; (b) a second substrate spaced from the surface of the substrate by a distance sufficient to define an interior volume between the first substrate and second substrate, wherein the distance is sufficient to contain a droplet disposed in the space on the first substrate; and (c) a droplet arranged in the interior volume and arranged with respect to the electrodes in a manner which permits droplet operations to be effected on the droplet using the electrodes.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: March 17, 2015
    Assignees: Advanced Liquid Logic, Inc., Duke University
    Inventors: Vijay Srinivasan, Michael G. Pollack, Philip Y. Paik, Vamsee K. Pamula, Richard B. Fair
  • High-throughput culture and transfer device and method
    Patent number: 8980631
    Abstract: A method and device for creating hanging drop cell aggregates. The method and device includes a plurality of pegs that allow for high throughput culture of aggregates. Also disclosed are means of transferring formed aggregates to various destinations, such as well plates, scaffolding, tissues, or wounds. Use of the device permits aggregates to be prepared or created in larger quantities than current methods, and allows for them to be transferred more efficiently.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: March 17, 2015
    Assignee: University of Virginia Patent Foundation
    Inventors: Blair Taylor Stocks, Shayn Peirce Cottler, Adam J. Katz
  • System and method for managing input/output data of peripheral devices
    Patent number: 8984184
    Abstract: A method for communicating data between peripheral devices and an embedded processor that includes receiving, at a data buffer unit of the embedded processor, the data from a peripheral device. The method also includes copying data from the data buffer unit into the bridge buffer of the embedded processor as a bridge buffer message. Additionally, the method includes creating, after storing the data as a bridge buffer message, a peripheral device message comprising the bridge buffer message, and sending the peripheral device message to a thread message queue of a subscriber.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: March 17, 2015
    Assignee: William Marsh Rice University
    Inventors: Thomas William Barr, Scott Rixner