Patents Assigned to University
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Patent number: 10493056Abstract: The present invention relates to a group of derivatives synthesized based on the ent-kaurane diterpenoid flexicaulin A and the methods to synthesize such diterpenoid derivatives. In particular, the chemical entities of such synthetic diterpene compounds in the manufacture of a medicament is for the treatment of tumors or cancers.Type: GrantFiled: September 21, 2017Date of Patent: December 3, 2019Assignee: Hong Kong Baptist UniversityInventors: Hongjie Zhang, Man Shing Ricky Wong, Lei Guo, Siu Wai Tsang, Kanglun Liu, Tongxin Zhang
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Patent number: 10494703Abstract: Composites having the composition of at least one principal strengthening phase compound and one cemented phase of principal refractory metal are disclosed. The components of the strengthening phase compound can be a boride or a mixture of a boride and one or more than one carbide. In addition, the composites are obtained by smelting the principal strengthening phase compound and the cemented phase principal refractory metal in a non-equal molar ratio.Type: GrantFiled: February 10, 2017Date of Patent: December 3, 2019Assignee: NATIONAL TSING HUA UNIVERSITYInventor: Swe-Kai Chen
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Patent number: 10496083Abstract: A method of analyzing a hazard of a software control system which is operated by a computer and based on STPA (System Theoretic Process Analysis) is provided. The method includes determining an attribute and function demands of the system, analyzing tasks of the system based on the determined attribute and the function demands, generating specification of a relation between the tasks using CTT (Concur Task Tree) method, the CTT method representing a hierarchical relation of a control flow between the tasks, determining at least one of the hazard of the system based on the specification and generating a safety constraint of the system based on the determined hazard. The determining at least one of the hazard of the system uses a guide word mapping table of CTT based STPA.Type: GrantFiled: November 30, 2017Date of Patent: December 3, 2019Assignee: SANGMYUNG UNIVERSITY SEOUL INDUSTRY-ACADEMY COOPERATION FOUNDATIONInventors: Hyuk Soo Han, EunBi Kim
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Publication number: 20190364294Abstract: Provided are an encoding device using predictive coding in a screen and a method thereof, and a decoding device and a method thereof. The encoding device is capable of generating a prediction block of a current block according to one of methods for generating a plurality of predetermined prediction blocks, and outputting at least one of encoding information and differential blocks as bitstream by entropy encoding according to whether differential blocks are encoded or not.Type: ApplicationFiled: August 7, 2019Publication date: November 28, 2019Applicants: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITYInventors: Sung Chang LIM, Hae Chul CHOI, Se Yoon JEONG, Suk Hee CHO, Hui Yong KIM, Jin Ho LEE, Ha Hyun LEE, Jong Ho KIM, Jin Soo CHOI, Jin Woong KIM, Gwang Hoon PARK, Kyung Yong KIM, Dong Gyu SIM, Seoung Jun OH
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Publication number: 20190360917Abstract: Methods of optically marking and sorting adherent cells are provided. The methods include providing a plurality of adherent cells attached to a substrate, each adherent cell of the plurality of adherent cells having an optical marker. The methods also include selectively applying light energy to a subset of the plurality of adherent cells, and detaching the plurality of adherent cells from the substrate. These methods also provide the sorting of the plurality of adherent cells.Type: ApplicationFiled: August 7, 2019Publication date: November 28, 2019Applicant: University of WashingtonInventors: Daniel T. Chiu, Chun-Ting Kuo, Jiangbo Yu
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Publication number: 20190358232Abstract: Compounds, pharmaceutical compositions, and methods for reversing fosfomycin resistance are disclosed. Embodiments of the disclosed compounds inhibit fosfomycin-inhibiting enzymes. Some embodiments of the compounds are FosA inhibitors. The disclosed pharmaceutical compositions include (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) a compound, or a pharmaceutically acceptable salt thereof, which inhibits a fosfomycin-inhibiting enzyme. A method of inhibiting growth of a fosfomycin-resistant bacterium includes contacting the bacterium with (i) fosfomycin or a pharmaceutically acceptable salt thereof and (ii) an effective amount of a disclosed compound or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: January 11, 2018Publication date: November 28, 2019Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, University of Maryland, BaltimoreInventors: Nicolas Paul Sluis-Cremer, Adam Daniel Tomich, Yohei Doi, Eric J. Sundberg, Erik H. Klontz, Steven Fletcher
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Publication number: 20190363632Abstract: A flyback converter is provided, which includes a transformer comprising a primary winding and a secondary winding, the transformer for transforming a power inputted from an input power supply and outputting the transformed power, a switching part having one end connected to the primary winding and the other end connected to the input power supply, and an auxiliary circuit including an auxiliary capacitor, and an auxiliary winding coupled to the primary winding. In addition, a clamping diode and a two-series connected switch structure is utilized for the switch stage to relieve the voltage stress of the switch. Accordingly, it is possible to reduce the voltage stress of the switch and also reduce the ripple of the input current which are the causes of EMI.Type: ApplicationFiled: May 23, 2019Publication date: November 28, 2019Applicants: KOREA AEROSPACE RESEARCH INSTITUTE, KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATIONInventors: Na Young LEE, Jae Dong CHOI, Sang Kyoo HAN, Ju Young LEE
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Publication number: 20190358345Abstract: The present invention discloses amphiphilic nonsteroid anti-inflammatory platinum nanoparticles, preparation methods therefor and applications thereof. The amphiphilic nonsteroid anti-inflammatory platinum nanoparticle includes an amphiphilic complex formed by coordinating a nonsteroid anti-inflammatory drug and a platinum antitumor drug. Compared with other platinum drugs, the amphiphilic nonsteroid anti-inflammatory platinum prepared according to the present invention can self-assemble into a nanoparticle in an aqueous solution without the addition of an additive or a surfactant. The amphiphilic platinum complex can achieve targeted accumulation of tumor tissues by means of the enhanced permeability and retention effect of the tumor tissues, thereby reducing the side effects of platinum drugs.Type: ApplicationFiled: September 4, 2017Publication date: November 28, 2019Applicant: CHINA PHARMACEUTICAL UNIVERSITYInventors: Hulin JIANG, Lei XING, Chenxi YANG
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Publication number: 20190360057Abstract: Patients with ErbB2-overexpressing cancers can be given an ErbB2 targeting agent as a therapeutic regimen but not all patients are responsive. The present invention concerns the diagnostic, prognostic and therapeutic methods and compositions for evaluating potential efficacy of an ErbB2 targeting agent in ErbB2-overexpressing cancers by evaluating PTEN expression, which is predictive of responsiveness or resistance to ErbB2 targeting agents such as trastuzumab. Low PTEN expression is predictive of a patient who will respond poorly to trastuzumab.Type: ApplicationFiled: June 18, 2019Publication date: November 28, 2019Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventors: Dihua Yu, Xiaoyan Zhou, Yoichi Nagata, Francisco J. Esteva, Aysegul A. Sahin
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Publication number: 20190362654Abstract: The invention provides an inner limiting membrane peeling model that is used in procedure training in peeling of the inner limiting membrane. The model has: a simulated retina and a simulated inner limiting membrane formed on the simulated retina. The simulated inner limiting membrane is formed of a hydrophilic polymer gel that is formed mainly of a water-soluble polymer. At least when used in the above procedure training, the model is disposed with the simulated inner limiting membrane immersed in water or an aqueous solution containing a predetermined solute.Type: ApplicationFiled: November 16, 2017Publication date: November 28, 2019Applicant: National University Corporation Nagoya UniversityInventors: Seiji Omata, Takeshi Hayakawa, Shinya Sakuma, Fumihito Arai
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Publication number: 20190360274Abstract: A split roller cone and polycrystalline diamond compact (PDC) composite drill bit, including a PDC bit module, a split roller cone bit module, and a drill bit body module. The split roller cone bit module has split structure, and during the operation, the lower roller cone body and the upper roller cone body revolve with the drill bit, and rotate around the axle neck of the palm respectively, thereby achieving the task of scraping and breaking rocks. The tooth scraping efficiencies of the small-end ring gear and the middle ring gear are improved. The split roller cone bit module, the PDC bit module, and the drill bit body module can be mass-produced.Type: ApplicationFiled: May 22, 2019Publication date: November 28, 2019Applicant: Southwest Petroleum UniversityInventors: Jialin TIAN, Yinglin YANG, Hongzhi HE, Lin YANG, Jie XIONG, Yi ZHOU, Siqi ZHOU, Genyin LI
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Publication number: 20190361214Abstract: An optical system for generating an Airy beam light sheet comprising an optical arrangement for generating a Gaussian beam, and an optical element for converting the Gaussian beam into an Airy beam light sheet, wherein a single optical element is provided for converting the Gaussian beam into an Airy beam light sheet.Type: ApplicationFiled: June 6, 2019Publication date: November 28, 2019Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWSInventors: Michael MAZILU, Tom VETTENBURG, Kishan DHOLAKIA, Miguel PRECIADO, Zhengyi YANG
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Publication number: 20190359622Abstract: The present disclosure provides compounds of any one of Formulae (I?), (I), (IA), (II?), (II), (IIA), (IIIA), (III?), (III?), (III), (IIIA), (IV), (V?), (V), (VI), (VII), (VIII?), (VIII), (IX?), (IX), and (X). The compounds described herein may be useful in treating and/or preventing abroad range of diseases (e.g., proliferative disease (e.g., cancers (e.g., non-small cell lung cancer, or glioma), inflammatory diseases, autoimmune diseases), CNS disorder (e.g., drug addiction), metabolic disorder (e.g., diabetes), or infectious disease (e.g., bacterial infection or parasitic infection (e.g., malaria))). Also provided in the present disclosure are pharmaceutical compositions, methods of synthesis of a compound described herein, kits, methods, and uses including or using a compound described herein.Type: ApplicationFiled: February 1, 2018Publication date: November 28, 2019Applicant: University of Florida Research Foundation, IncorporatedInventors: Robert William Huigens, III, Verrill M. Norwood, IV, Hendrik Luesch
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Publication number: 20190362969Abstract: A plasma sputtering device including one or a plurality of plasma generating devices each including an insulating tube having an expanding inner diameter and having a gas injection port formed in an end portion or a side portion thereof, a first electromagnet or a permanent magnet group which can apply a static magnetic field, and a high frequency antenna; a second electromagnet which is disposed in a region downstream of the plasma generating device(s) and which can form a curved magnetic force line structure; a target mechanism which includes a permanent magnet embedded therein and a cooling mechanism and which can apply a DC or high frequency voltage; a substrate stage facing the target mechanism; a second permanent magnet group around the substrate stage; and a heat insulating mechanism between a target material and the target mechanism.Type: ApplicationFiled: January 30, 2018Publication date: November 28, 2019Applicant: TOHOKU UNIVERSITYInventors: Kazunori TAKAHASHI, Jun FUKUSHIMA, Akira ANDO, Yasumasa SASAKI
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Publication number: 20190359978Abstract: This invention is in the field of molecular biology, gene expression, functional genomics, and bioinformatics and relates to novel RNA and related structures and methods of use thereof that enables modulation of gene expression and preservation of particular transcriptome targets. The invention contemplates various applications of RNA sequences derived from the genomic RNA of flaviviruses (FVs) and the application of such features in combination with heterologous sequences.Type: ApplicationFiled: December 14, 2016Publication date: November 28, 2019Applicant: The Regents of the University of Colorado, a Body CorporateInventors: Jeffrey S. KIEFT, Erich G. CHAPMAN, David A. COSTANTINO, Jay R. HESSELBERTH, Andrea MACFADDEN, Benjamin AKIYAMA
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Publication number: 20190359941Abstract: The present invention relates to substituted azole derivatives in combination with cytokines in the ex vivo expansion of CD34+ hematopoietic stem and progenitor cells (HSPC) in a biological sample, more particularly the expansion of these cells obtained from non-enriched, i.e., the mononuclear fraction of the biological sample. The present invention further describes the transplantation regimen of the expanded hematopoietic graft developed through xenotransplantation studies. In a preferred embodiment, the combination comprising the azole based compounds and cytokines selected from SCF, TPO, FLT-3L and IGFBP-2 and results in the expansion of expansion of CD45+CD34+CD38?CD45RA?CD90+ hematopoietic stem cells and/or CD45+CD34+CD38?CD45RA?CD90+CD49f+ hematopoietic stem cells and/or CD45+CD34+CD38?CD45RA? hematopoietic progenitor cells from the mononucleated cells isolated from umbilical cord blood.Type: ApplicationFiled: August 18, 2017Publication date: November 28, 2019Applicants: National University of Singapore, Singapore Health Services Pte LtdInventors: Sudipto BARI, Christina Li Lin CHAI, Gigi Ngar Chee CHIU, William Ying Khee HWANG, Joo Leng LOW, Qixing ZHONG
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Publication number: 20190358173Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic such as a halogenated ether compound in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered to the subject to anesthetize the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, xenon, and mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.Type: ApplicationFiled: June 7, 2019Publication date: November 28, 2019Applicant: The Board of Regents of the University of Texas SystemInventors: Phillip C. PHAN, Allen W. BURTON
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Publication number: 20190363427Abstract: Monopole rectenna arrays distributed over a curved surface for multi-directional, multi-polarization, and multi-band ambient RF energy harvesting in accordance with embodiments of the invention are disclosed. In one embodiment, a rectenna array includes a curved grounding surface, a plurality of multi-band antennas distributed across the surface of the curved grounding surface and configured to harvest RF energy in multiple spectral bands, from multiple directions, and with multiple polarizations, a multi-band rectifier connected to an output of each of the plurality of multi-band antennas, and a direct current (DC) combiner including a plurality of inputs connected to outputs of the multi-band rectifiers and an output configured to provide DC power to a load.Type: ApplicationFiled: June 27, 2017Publication date: November 28, 2019Applicant: The Regents of the University of CaliforniaInventors: Yahya Rahmat-Samii, Bohan Zhang, Joshua M. Kovitz
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Publication number: 20190363067Abstract: The invention relates to a multilayer semiconductor integrated circuit device where a stable multilayer structure is achieved. According to the invention, a first semiconductor integrated circuit device is provided with: a first n type trough semiconductor region that penetrates trough a first p type semiconductor body in the direction of the thickness and is connected to the potential of a grounded power supply; and a second n type through semiconductor region that is connected to the potential of a positive power supply, and a second semiconductor integrated circuit device, which has a first electrode and a second electrode respectively connected to the first n type through semiconductor region and the second n type through semiconductor region, is layered on the first semiconductor integrated circuit device.Type: ApplicationFiled: February 13, 2018Publication date: November 28, 2019Applicant: KEIO UNIVERSITYInventor: Tadahiro Kuroda
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Publication number: 20190359423Abstract: An automated warehouse storage and retrieval system may comprise at least an aisle, and each of two sides of the aisle has a shelf. A rail is laid along the aisle to enable at least an automated vehicle to move thereon. The automated vehicle has a platform, and a top surface thereof comprises at least a working station and at least a pick-and-place unit. Each of two lateral sides of the platform has two openings separated by a desired distance, and each of the openings has a climbing unit installed therein. The climbing units are configured to synchronously protrude from or move back in the openings. A side of the shelf faced to the rail has a plurality of vertical supporting members arranged in parallel, and each two adjacent supporting members are separated by the distance same as the two climbing units on the same lateral side of the platform.Type: ApplicationFiled: May 23, 2018Publication date: November 28, 2019Applicants: TERA AUTOTECH CORPORATION, Department of Electrical Engineering, National Changhua University of EducationInventors: Yi-Lung Lee, Tsair-Rong Chen, Yi-Chun Lin, Shu-Ming Chen
