Abstract: Composition and methods for characterizing cancer cells by determining a marker of PKM2 activity. For example, methods are provided for predicting a patient response to a NF-?B, PKC?, PKM2, MEK/ERK, Pin1 or Src inhibitor therapy. Methods for treating patients with such therapies are likewise provided. Phosphorylation selective ?-catenin, MLC2, histone H3, Bub3, and PKM2-binding antibodies are also provided.

Abstract: A process for steam reforming of a hydrocarbonaceous fuel includes the steps of: providing a reactant mixture comprising H2O and the hydrocarbonaceous fuel; and contacting the reactant mixture with a Al2O3-yttria-stabilized ZrO2 (YSZ)-supported NiAl2O4 spinel catalyst under conditions wherein the reactant gas mixture is at least partially steam reformed into a product gas mixture including H2 and CO. The synthesis gas (H2 and CO) produced can be used as feed material for fuel cells. The catalyst includes a NiAl2O4 spinel-based catalytically active material; and a support material comprising: Al2O3 and ZrO2. The Al2O3-YSZ-supported NiAl2O4 catalyst can be used in steam reforming of a liquid hydrocarbonaceous fuel.

Abstract: The present invention relates to novel cluster boron compounds and their use as sodium channel blockers. In particular, the novel cluster boron compounds may be lidocaine analogs where the aromatic ring of the lidocaine molecule is replaced with a cluster boron group. The invention also provides methods for making the cluster boron compounds comprising contacting a halogenated cluster boron with an amino acetamide in the presence of a catalyst, a proton acceptor, and a ligand.

Abstract: Gene expression analysis is generally performed on heterogeneous tissue samples consisting of multiple cell types. Current methods developed to separate heterogeneous gene expression rely on prior knowledge of the cell-type composition and/or signatures—these are not available in most public datasets. We present a novel method to identify the cell-type composition, signatures and proportions per sample without need for a priori information. The method was successfully tested on controlled and semi-controlled datasets and performed as accurately as current methods that do require additional information. As such, this method enables the analysis of cell-type specific gene expression using existing large pools of publically available microarray datasets.

Abstract: The adaptive fault location method for power system networks utilizes phasor measurement units (PMUs) disposed at disparate locations to obtain synchronized phasor measurements. Three different sets of pre-fault voltage and current phasor measurements are obtained at both terminals of the line under test. The three sets of local PMU measurements at each terminal are used for online calculation of a corresponding system's Thevenin equivalent (TE). This representation of the power system pre-fault network is a reduced two-terminal equivalent. Using the method of multiple measurements with linear regression (MMLR), the three sets of PMU measurements are also employed for online calculation of the transmission line parameters (series resistance, series reactance and shunt susceptance). Online determination of the TEs and line parameters can enhance fault location accuracy by avoiding possible mismatch with the actual parameters due to system loading and other environmental conditions.

Abstract: The present invention provides a character conversion system, comprising: a parsing unit, used to parse received data, determine at least one character contained in the data, and obtain property information corresponding to each character of the at least one character; a judging unit, used to, with respect to each character, determine a pattern bitmap of the character according to the property information, and judge whether the pattern bitmap satisfies a preset condition; a conversion unit, used to, if the judging unit judges that the preset condition is satisfied, determine an original inner code of the character according to the property information, and convert the character according to the original inner code; and if the judging unit judges that the preset condition is not satisfied, identify an actual inner code of the character according to the pattern bitmap, and convert the character according to the actual inner code.

Abstract: The present invention provides a method of inhibiting the binding of anthrax lethal factor with protective antigen comprising contacting the anthrax lethal factor with a compound having the structure:

Abstract: Treatment planning methods are provided that determine the variability of relative biological effectiveness (RBE) along a beam line and calculate, among other things, what intensity of hadron beam such as a proton or a carbon ion beam should be applied to achieve a desired biological dose at treatment site of a patient afflicted with a medical condition. Typically, three or four RBE values at three or four corresponding spacially-dispersed intervals along the beam line are calculated. In one embodiment, two RBE values for the spread-out Bragg peak (SOBP) region of the treatment site; one for the proximal section and one for the declining distal section is calculated. A third and different RBE value may be determined for the distal edge region of the SOBP. A fourth value may also be calculated for a pre-SOBP region.

Abstract: An immunogenic composition comprising a siderophore covalently linked to a pharmaceutically acceptable carrier molecule wherein the antigenicity of the siderophore moiety is sufficient to stimulate an immunologic response to the siderophore when the composition is circulating in the bloodstream of a human or non-human animal and vaccine.

Abstract: The present invention is a multilayered composite comprising porous metal oxide particles that are covalently bonded by way of inorganic ether groups to one or more sites of a first polyhydroxyl-functionalized polymer. This first polymer is in turn covalently bonded by way of inorganic ether groups to one or more sites of a second polyhydroxyl-functionalized polymer. The multilayered composites can be prepared by contacting porous inorganic-oxide particles with a sufficient amount of OH-reactive crosslinking agent to form metal oxide particles imbibed with the crosslinking agent, and then contacting the inorganic-oxide particles with a solution of polyhydroxyl-functionalized polymer under reactive conditions.

Abstract: Provided is a light emitting diode having a nanostructure capping pattern and a method of manufacturing the same. A light-emitting structure including a first semiconductor layer, a second semiconductor layer, and an active layer between the first and second semiconductor layers is provided. A nanostructure is provided on the light-emitting structure and a nanostructure capping pattern covering the nanostructure is provided. A refractive index of the nanostructure capping pattern is higher than that of air and lower than that of the nanostructure.

Abstract: The present invention provides a server comprising: a selection unit configured to select a target content from each digital file among a plurality of digital files according to a selection instruction received from a terminal; an extraction unit configured to extract privilege information corresponding to the target content from file key information corresponding to each digital file among the plurality of digital files, so as to obtain a plurality of privilege information; an authorization information generation unit configured to generate authorization information according to the plurality of the privilege information; and a processing unit configured to, when an authorization request is received from the terminal, transmit the authorization information to the terminal so that the terminal performs predetermined operations on the target content according to the authorization information. The present invention further provides a terminal and a digital copyright management method.

Abstract: Provided are a vulcanizate of a chloroprene rubber composition containing carbon black that generates a smaller amount of heat when used and a method for producing the same by a simpler and more convenient method. First, an unvulcanized rubber composition at least containing a chloroprene polymer and carbon black is vulcanization-molded, to give a semivulcanized molded article having a cure characteristic value, as determined by the method specified in JIS K6300-2: 2001, in the range of t10 to t80. Then, the semivulcanized molded article obtained by semivulcanized film-forming step is additionally vulcanized in the state as it is deformed entirely and the deformation is removed, to give vulcanizate in a desired shape.

Abstract: The invention provides for methods for treating a hair loss disorder in a subject by administering a FGF13 inhibitor. The invention further provides for methods for treating a hair growth disorder in a subject by administering a FGF13 activator.

Abstract: The present invention provides a method of manufacturing a semiconductor device. The method at least comprises the following steps. First, the semiconductor device, which comprises a gate, a gate dielectric layer, an active layer, a source and a drain, is manufactured. However, the semiconductor device has a plurality of defects, and the active layer is a metal oxide thin film. After annealing the semiconductor device, it will be transferred into a chamber. A final step of injecting a supercritical fluid carried with a co-solvent into the chamber is then performed to modify the abovementioned defects.

Abstract: A recognition method includes: retrieving a component image from an image source; utilizing SVD (singular value decomposition) to decompose the component image; and utilizing the decomposed component image for image recognition. In an embodiment, the recognition method further includes: utilizing a light compensation method to calculate at least one light compensation coefficient; utilizing the light compensation coefficient to process the component image to obtain a light-compensated component image; and utilizing the light-compensated component image for image recognition.

Abstract: The present invention provides a novel production method of a cellulose nanofiber and a novel cellulose nanofiber. The method for producing a cellulose nanofiber comprises defibrating pulp by a single- or multi-screw kneader in the presence of water, the single or multi-screw kneader having a screw circumferential speed of 45 m/min. Or more.

Abstract: A method for making a strip shaped graphene layer includes the following steps. First, a carbon nanotube structure on a surface of a metal substrate is provided. The carbon nanotube structure includes at least one drawn carbon nanotube film. The at least one drawn carbon nanotube film includes a number of carbon nanotube segments, each of the number of carbon nanotube segments being substantially parallel to each other and separated from each other by a strip-shaped gap. Second, carbon ions are implanted into the metal substrate through the strip-shaped gaps. Third, the metal substrate is annealed to obtain the strip shaped graphene layer.

Abstract: Triphenylene derivatives having a structure of formula (1) are provided. Ar represents an aromatic compound, n is 1 to 3, and each of R and R1 to R13 is a member independently selected from the group consisting of hydrogen, halo, cyano, trifluoromethyl, amino, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C3-C20 cycloalkyl, C3-C20 cycloalkenyl, C1-C20 heterocycloalkyl, C1-C20 heterocycloalkenyl, aryl and heteroaryl. The compound of the present invention may function as a host emitter or dopant in the emitter layer of OLED device. An OLED device is also herein provided.

Abstract: The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence, status or metastasis of cancer by detecting plasma Hsp90? having the amino acid sequence of SEQ ID NO:1 as a tumor marker. In addition, the present invention also relates to a method for the treatment of cancer and metastasis.